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Protein

Purine nucleoside phosphorylase

Gene

EDIP

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33PhosphateUniRule annotation1
Binding sitei64PhosphateUniRule annotation1
Binding sitei116Phosphate; via amide nitrogenUniRule annotation1
Binding sitei201Purine nucleosideUniRule annotation1
Binding sitei220PhosphateUniRule annotation1
Binding sitei243Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:EDIPImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Structurei

3D structure databases

ProteinModelPortaliQ687I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 275PNP_UDP_1InterPro annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
HOVERGENiHBG002460
KOiK03783

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q687I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANGYTYEDY QDTAKWLLSH TEQRPQVAVI CGSGLGGLVN KLTQAQTFDY
60 70 80 90 100
SEIPNFPEST VPGHAGRLVF GILNGRACVM MQGRFHMYEG YPFWKVTFPV
110 120 130 140 150
RVFRLLGVET LVVTNAAGGL NPNFEVGDIM LIRDHINLPG FSGENPLRGP
160 170 180 190 200
NEERFGVRFP AMSDAYDRDM RQKAHSTWKQ MGEQRELQEG TYVMLGGPNF
210 220 230 240 250
ETVAECRLLR NLGADAEGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE
260 270 280
SQGKANHEEV LEAGKQAAQK LEQFVSLLMA SIPVSGHTG
Length:289
Mass (Da):32,067
Last modified:October 11, 2004 - v1
Checksum:i69471BDB2C0BDEED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529136 mRNA Translation: AAQ09092.1
RefSeqiNP_001007819.1, NM_001007818.1
UniGeneiBt.65253

Genome annotation databases

GeneIDi493724
KEGGibta:493724

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529136 mRNA Translation: AAQ09092.1
RefSeqiNP_001007819.1, NM_001007818.1
UniGeneiBt.65253

3D structure databases

ProteinModelPortaliQ687I9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493724
KEGGibta:493724

Organism-specific databases

CTDi4860

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
HOVERGENiHBG002460
KOiK03783

Enzyme and pathway databases

UniPathwayi
UPA00606

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ687I9_BOVIN
AccessioniPrimary (citable) accession number: Q687I9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 31, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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