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Entry version 130 (11 Dec 2019)
Sequence version 2 (18 May 2010)
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Protein

Mucin-17

Gene

MUC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in maintaining homeostasis on mucosal surfaces.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-17
Short name:
MUC-17
Alternative name(s):
Small intestinal mucin-3
Short name:
MUC-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC17
Synonyms:MUC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169876.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16800 MUC17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608424 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q685J3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 4393ExtracellularSequence analysisAdd BLAST4368
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4394 – 4414HelicalSequence analysisAdd BLAST21
Topological domaini4415 – 4493CytoplasmicSequence analysisAdd BLAST79

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140453

Open Targets

More...
OpenTargetsi
ENSG00000169876

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31315

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q685J3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MUC17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439228

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032625426 – 4493Mucin-17Add BLAST4468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2077N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4116N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi4135 ↔ 4147PROSITE-ProRule annotation
Disulfide bondi4140 ↔ 4158PROSITE-ProRule annotation
Disulfide bondi4160 ↔ 4169PROSITE-ProRule annotation
Glycosylationi4205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4305N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei4243 – 4244CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q685J3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q685J3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q685J3

PeptideAtlas

More...
PeptideAtlasi
Q685J3

PRoteomics IDEntifications database

More...
PRIDEi
Q685J3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65991 [Q685J3-1]
65992 [Q685J3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q685J3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q685J3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169876 Expressed in 47 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q685J3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q685J3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031634

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302716

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q685J3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q685J3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati185 – 2451Add BLAST61
Repeati246 – 3002Add BLAST55
Repeati301 – 3613Add BLAST61
Repeati362 – 4184Add BLAST57
Repeati420 – 4775Add BLAST58
Repeati479 – 5386Add BLAST60
Repeati539 – 5977Add BLAST59
Repeati598 – 6548Add BLAST57
Repeati656 – 7159Add BLAST60
Repeati716 – 77410Add BLAST59
Repeati775 – 83111Add BLAST57
Repeati833 – 89212Add BLAST60
Repeati893 – 95113Add BLAST59
Repeati952 – 101014Add BLAST59
Repeati1011 – 106915Add BLAST59
Repeati1070 – 112116Add BLAST52
Repeati1122 – 118717Add BLAST66
Repeati1188 – 124618Add BLAST59
Repeati1247 – 130519Add BLAST59
Repeati1306 – 136420Add BLAST59
Repeati1365 – 142321Add BLAST59
Repeati1424 – 148222Add BLAST59
Repeati1483 – 154123Add BLAST59
Repeati1542 – 160024Add BLAST59
Repeati1601 – 165625Add BLAST56
Repeati1658 – 171726Add BLAST60
Repeati1718 – 177627Add BLAST59
Repeati1777 – 183528Add BLAST59
Repeati1836 – 189529Add BLAST60
Repeati1896 – 195130Add BLAST56
Repeati1953 – 201231Add BLAST60
Repeati2013 – 207132Add BLAST59
Repeati2072 – 212733Add BLAST56
Repeati2129 – 218834Add BLAST60
Repeati2189 – 224735Add BLAST59
Repeati2248 – 230636Add BLAST59
Repeati2307 – 236537Add BLAST59
Repeati2366 – 242438Add BLAST59
Repeati2425 – 248339Add BLAST59
Repeati2484 – 254040Add BLAST57
Repeati2542 – 260141Add BLAST60
Repeati2602 – 265342Add BLAST52
Repeati2654 – 271943Add BLAST66
Repeati2720 – 277044Add BLAST51
Repeati2772 – 283745Add BLAST66
Repeati2838 – 289646Add BLAST59
Repeati2897 – 295547Add BLAST59
Repeati2956 – 301448Add BLAST59
Repeati3015 – 307349Add BLAST59
Repeati3074 – 313250Add BLAST59
Repeati3133 – 319151Add BLAST59
Repeati3192 – 324752Add BLAST56
Repeati3249 – 330853Add BLAST60
Repeati3309 – 336754Add BLAST59
Repeati3368 – 342655Add BLAST59
Repeati3427 – 348556Add BLAST59
Repeati3486 – 354457Add BLAST59
Repeati3604 – 366258Add BLAST59
Repeati3663 – 372759Add BLAST65
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4131 – 4170EGF-likePROSITE-ProRule annotationAdd BLAST40
Domaini4184 – 4291SEAPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 372759 X approximate tandem repeatsAdd BLAST3543

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi84 – 3836Ser-richAdd BLAST3753
Compositional biasi3975 – 3980Poly-Ser6

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IK1M Eukaryota
ENOG41126RR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154419

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172388

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q685J3

KEGG Orthology (KO)

More...
KOi
K22016

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTWSVNV

Database of Orthologous Groups

More...
OrthoDBi
1531730at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q685J3

TreeFam database of animal gene trees

More...
TreeFami
TF337883

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.960, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01390 SEA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00200 SEA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82671 SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS50024 SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q685J3-1) [UniParc]FASTAAdd to basket
Also known as: Major, Mb-MUC17

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRPGTMALC LLTLVLSLLP PQAAAEQDLS VNRAVWDGGG CISQGDVLNR
60 70 80 90 100
QCQQLSQHVR TGSAANTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS
110 120 130 140 150
DTPGVSSTRM TPTESRTTSE STSDSTTLFP SSTEDTSSPT TPEGTDVPMS
160 170 180 190 200
TPSEESISST MAFVSTAPLP SFEAYTSLTY KVDMSTPLTT STQASSSPTT
210 220 230 240 250
PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP VEISTPVTIS
260 270 280 290 300
AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA
310 320 330 340 350
ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE
360 370 380 390 400
MSTLSITPVD TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV
410 420 430 440 450
STILVASSEA STTSTIPVDS KTFVTTASEA SSSPTTAEDT SIATSTPSEG
460 470 480 490 500
STPLTSMPVS TTPVASSEAS NLSTTPVDSK TQVTTSTEAS SSPPTAEVNS
510 520 530 540 550
MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST PVTTSSEASS
560 570 580 590 600
SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF
610 620 630 640 650
VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS
660 670 680 690 700
TTPVDSNTPV TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV
710 720 730 740 750
ASSEASTLST TPVDTSTPVT TSTEASSSPT TADGASMPTS TPSEGSTPLT
760 770 780 790 800
SMPVSKTLLT SSEASTLSTT PLDTSTHITT STEASCSPTT TEGTSMPIST
810 820 830 840 850
PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS TEVSSSPTPA
860 870 880 890 900
EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST
910 920 930 940 950
EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD
960 970 980 990 1000
TSTPVTTSTE ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA
1010 1020 1030 1040 1050
STLSTTPVDS NTPLTTSTEA SSPPPTAEGT SMPTSTPSEG STPLTRMPVS
1060 1070 1080 1090 1100
TTMVASSETS TLSTTPADTS TPVTTYSQAS SSSTTADGTS MPTSTYSEGS
1110 1120 1130 1140 1150
TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS SPTTAEGTSI
1160 1170 1180 1190 1200
PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP
1210 1220 1230 1240 1250
PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV
1260 1270 1280 1290 1300
TTSAETSSSP TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT
1310 1320 1330 1340 1350
TPVDTKGPVV TSNEVSSSPT PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA
1360 1370 1380 1390 1400
SSAISILSTT PVDNSTPVTT STEACSSPTT SEGTSMPNSN PSEGTTPLTS
1410 1420 1430 1440 1450
IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA EGISIPTSTP
1460 1470 1480 1490 1500
SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE
1510 1520 1530 1540 1550
GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ
1560 1570 1580 1590 1600
ASSSPTTADG TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS
1610 1620 1630 1640 1650
KTQVTASTEA SSSTTAEGSS MTISTPSEGS PLLTSIPVST TPVASPEAST
1660 1670 1680 1690 1700
LSTTPVDSNS PVITSTEVSS SPTPAEGTSM PTSTYTEGRT PLTSITVRTT
1710 1720 1730 1740 1750
PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP NSTPSEGTTP
1760 1770 1780 1790 1800
LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT
1810 1820 1830 1840 1850
STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT
1860 1870 1880 1890 1900
PAEGTSIATS TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT
1910 1920 1930 1940 1950
YAQVSSSPTT ADGSSMPTST PREGRPPLTS IPVSTTTVAS SEINTLSTTL
1960 1970 1980 1990 2000
ADTRTPVTTY SQASSSPTTA DGTSMPTPAY SEGSTPLTSM PLSTTLVVSS
2010 2020 2030 2040 2050
EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS ERTTPLAGMP
2060 2070 2080 2090 2100
VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG
2110 2120 2130 2140 2150
SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS
2160 2170 2180 2190 2200
MQTSTYSDRR TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS
2210 2220 2230 2240 2250
SPTTSEGTSM PTSTPSEGST PFTSMPVSTM PVVTSEASTL SATPVDTSTP
2260 2270 2280 2290 2300
VTTSTEATSS PTTAEGTSIP TSTLSEGTTP LTSIPVSHTL VANSEVSTLS
2310 2320 2330 2340 2350
TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL TRMPVSTTMV
2360 2370 2380 2390 2400
ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT
2410 2420 2430 2440 2450
SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP
2460 2470 2480 2490 2500
PSEGTTPLAS MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA
2510 2520 2530 2540 2550
EDIVVPISTA SEGSTLLTSI PVSTTPVASP EASTLSTTPV DSNSPVVTST
2560 2570 2580 2590 2600
EISSSATSAE GTSMPTSTYS EGSTPLRSMP VSTKPLASSE ASTLSTTPVD
2610 2620 2630 2640 2650
TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV STMPVASSEA
2660 2670 2680 2690 2700
STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS
2710 2720 2730 2740 2750
TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS
2760 2770 2780 2790 2800
TPLTSILVST LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM
2810 2820 2830 2840 2850
PTSTPSETST PLTSMPVNHT PVASSEAGTL STTPVDTSTP VTTSTKASSS
2860 2870 2880 2890 2900
PTTAEGIVVP ISTASEGSTL LTSIPVSTTP VASSEASTLS TTPVDTSIPV
2910 2920 2930 2940 2950
TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV AGSEASTLST
2960 2970 2980 2990 3000
TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA
3010 3020 3030 3040 3050
SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS
3060 3070 3080 3090 3100
IPVSTTPVAI PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY
3110 3120 3130 3140 3150
SEGSTPLTGV PVSTTPVTSS AISTLSTTPV DTSTPVTTST EAHSSPTTSE
3160 3170 3180 3190 3200
GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE DSTLSATPVD TSTPVTTSTE
3210 3220 3230 3240 3250
ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS ILSTTPVDSN
3260 3270 3280 3290 3300
TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST
3310 3320 3330 3340 3350
LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT
3360 3370 3380 3390 3400
PVVSSEASTL STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP
3410 3420 3430 3440 3450
LASMPVSTTP VVSSEVNTLS TTPVDSNTLV TTSTEASSSP TIAEGTSLPT
3460 3470 3480 3490 3500
STTSEGSTPL SIMPLSTTPV ASSEASTLST TPVDTSTPVT TSSPTNSSPT
3510 3520 3530 3540 3550
TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT PVDSNTFVTS
3560 3570 3580 3590 3600
SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS
3610 3620 3630 3640 3650
VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS
3660 3670 3680 3690 3700
EAGTASTLPV DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP
3710 3720 3730 3740 3750
VSTTRVTSSE GSTLSTPSVV TSTPVTTSTE AISSSATLDS TTMSVSMPME
3760 3770 3780 3790 3800
ISTLGTTILV STTPVTRFPE SSTPSIPSVY TSMSMTTASE GSSSPTTLEG
3810 3820 3830 3840 3850
TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG DTSTPLLTST
3860 3870 3880 3890 3900
KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL
3910 3920 3930 3940 3950
DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST
3960 3970 3980 3990 4000
ADVFPATTGA VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA
4010 4020 4030 4040 4050
PLTYVTMSTA PSTPRTTSRG CTTSASTLSA TSTPHTSTSV TTRPVTPSSE
4060 4070 4080 4090 4100
SSRPSTITSH TIPPTFPPAH SSTPPTTSAS STTVNPEAVT TMTTRTKPST
4110 4120 4130 4140 4150
RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC QNTASRCKNG
4160 4170 4180 4190 4200
GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT
4210 4220 4230 4240 4250
EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD
4260 4270 4280 4290 4300
VLLRTKYTPE YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG
4310 4320 4330 4340 4350
TQVQNITVTQ YDPEEDCRKM AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS
4360 4370 4380 4390 4400
KNCNLGKCQM SLSGPQCLCV TTETHWYSGE TCNQGTQKSL VYGLVGAGVV
4410 4420 4430 4440 4450
LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP APGTFQNIGF
4460 4470 4480 4490
DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF
Length:4,493
Mass (Da):451,741
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i883D68DDB0D6E3C1
GO
Isoform 2 (identifier: Q685J3-2) [UniParc]FASTAAdd to basket
Also known as: Minor, s-MUC17

The sequence of this isoform differs from the canonical sequence as follows:
     4241-4262: RLGSVVVEHDVLLRTKYTPEYK → HDVFQHHWHPSAKHYGDPVRP
     4363-4493: Missing.

Show »
Length:4,361
Mass (Da):436,777
Checksum:i334BF9C863B8B7F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPM4E7EPM4_HUMAN
Mucin-17
MUC17
4,262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28D → G in CAE54435 (PubMed:16737958).Curated1
Sequence conflicti28D → G in CAE54436 (PubMed:16737958).Curated1
Sequence conflicti65A → T in CAE54435 (PubMed:16737958).Curated1
Sequence conflicti65A → T in CAE54436 (PubMed:16737958).Curated1
Sequence conflicti132S → P in CAE54435 (PubMed:16737958).Curated1
Sequence conflicti132S → P in CAE54436 (PubMed:16737958).Curated1
Sequence conflicti3481T → S in AAL89737 (PubMed:11855812).Curated1
Sequence conflicti3491T → N in AAL89737 (PubMed:11855812).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040047227K → Q. Corresponds to variant dbSNP:rs10229731Ensembl.1
Natural variantiVAR_040048272G → E. Corresponds to variant dbSNP:rs10259584Ensembl.1
Natural variantiVAR_061489427A → T. Corresponds to variant dbSNP:rs56103274Ensembl.1
Natural variantiVAR_061490571P → L. Corresponds to variant dbSNP:rs34834039Ensembl.1
Natural variantiVAR_061491925P → R. Corresponds to variant dbSNP:rs149445753Ensembl.1
Natural variantiVAR_040049942R → S. Corresponds to variant dbSNP:rs10238201Ensembl.1
Natural variantiVAR_040050982T → M. Corresponds to variant dbSNP:rs4729646Ensembl.1
Natural variantiVAR_0400511130I → T. Corresponds to variant dbSNP:rs4729647Ensembl.1
Natural variantiVAR_0400521242S → T. Corresponds to variant dbSNP:rs10265276Ensembl.1
Natural variantiVAR_0400531246T → N. Corresponds to variant dbSNP:rs4729652Ensembl.1
Natural variantiVAR_0400541246T → S. Corresponds to variant dbSNP:rs4729651Ensembl.1
Natural variantiVAR_0400551249P → A. Corresponds to variant dbSNP:rs4729653Ensembl.1
Natural variantiVAR_0400561348L → P1 PublicationCorresponds to variant dbSNP:rs4269454Ensembl.1
Natural variantiVAR_0400571375C → R1 PublicationCorresponds to variant dbSNP:rs4367469Ensembl.1
Natural variantiVAR_0614921480V → A1 PublicationCorresponds to variant dbSNP:rs7780935Ensembl.1
Natural variantiVAR_0614932096A → T. Corresponds to variant dbSNP:rs28593004Ensembl.1
Natural variantiVAR_0614942159R → G. Corresponds to variant dbSNP:rs28555173Ensembl.1
Natural variantiVAR_0614953299S → N. Corresponds to variant dbSNP:rs35988443Ensembl.1
Natural variantiVAR_0400584334D → N. Corresponds to variant dbSNP:rs6946812Ensembl.1
Natural variantiVAR_0400594482R → Q. Corresponds to variant dbSNP:rs9656065Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0326484241 – 4262RLGSV…TPEYK → HDVFQHHWHPSAKHYGDPVR P in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0326494363 – 4493Missing in isoform 2. 1 PublicationAdd BLAST131

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ606307 mRNA Translation: CAE54435.1
AJ606308 mRNA Translation: CAE54436.1
AC105446 Genomic DNA No translation available.
AF016693 mRNA Translation: AAB71686.1
AF430017 mRNA Translation: AAL89737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34711.1 [Q685J3-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
PC4396

NCBI Reference Sequences

More...
RefSeqi
NP_001035194.1, NM_001040105.1 [Q685J3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306151; ENSP00000302716; ENSG00000169876 [Q685J3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140453

UCSC genome browser

More...
UCSCi
uc003uxp.2 human [Q685J3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ606307 mRNA Translation: CAE54435.1
AJ606308 mRNA Translation: CAE54436.1
AC105446 Genomic DNA No translation available.
AF016693 mRNA Translation: AAB71686.1
AF430017 mRNA Translation: AAL89737.1
CCDSiCCDS34711.1 [Q685J3-1]
PIRiPC4396
RefSeqiNP_001035194.1, NM_001040105.1 [Q685J3-1]

3D structure databases

SMRiQ685J3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302716

PTM databases

iPTMnetiQ685J3
PhosphoSitePlusiQ685J3

Polymorphism and mutation databases

BioMutaiMUC17
DMDMi296439228

Proteomic databases

jPOSTiQ685J3
MassIVEiQ685J3
PaxDbiQ685J3
PeptideAtlasiQ685J3
PRIDEiQ685J3
ProteomicsDBi65991 [Q685J3-1]
65992 [Q685J3-2]

Genome annotation databases

EnsembliENST00000306151; ENSP00000302716; ENSG00000169876 [Q685J3-1]
GeneIDi140453
KEGGihsa:140453
UCSCiuc003uxp.2 human [Q685J3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140453
DisGeNETi140453
EuPathDBiHostDB:ENSG00000169876.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MUC17
HGNCiHGNC:16800 MUC17
HPAiHPA031634
MIMi608424 gene
neXtProtiNX_Q685J3
OpenTargetsiENSG00000169876
PharmGKBiPA31315

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK1M Eukaryota
ENOG41126RR LUCA
GeneTreeiENSGT00940000154419
HOGENOMiHOG000172388
InParanoidiQ685J3
KOiK22016
OMAiKTWSVNV
OrthoDBi1531730at2759
PhylomeDBiQ685J3
TreeFamiTF337883

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MUC17 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MUC17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140453
PharosiQ685J3 Tbio

Protein Ontology

More...
PROi
PR:Q685J3
RNActiQ685J3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169876 Expressed in 47 organ(s), highest expression level in intestine
ExpressionAtlasiQ685J3 baseline and differential
GenevisibleiQ685J3 HS

Family and domain databases

Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PfamiView protein in Pfam
PF01390 SEA, 1 hit
SMARTiView protein in SMART
SM00200 SEA, 1 hit
SUPFAMiSSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS50024 SEA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q685J3
Secondary accession number(s): O14761, Q685J2, Q8TDH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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