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UniProtKB - Q684R7 (FREM1_MOUSE)

Entry version 127 (07 Apr 2021)
Sequence version 1 (11 Oct 2004)
Previous versions | rss
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Protein

FRAS1-related extracellular matrix protein 1

Gene

Frem1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.1 Publication

Miscellaneous

Was termed QBRICK because it contains 12 repeats: 'Q' stands for queen and is taken from the queen being the 12th in a suit of playing card, and 'BRICK' stands for the repeating unit.
Frem1 also corresponds to a N-ethyl-N-nitrosourea-induced allele called 'bat'. Homozygous bat mice display similar phenotype than heb mice.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium, Lectin, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 1
Alternative name(s):
Protein QBRICK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Frem1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2670972, Frem1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Frem1 are the cause of head blebs (heb) which is a spontaneous mutation that is characterized by absent or malformed eyes, which are often open at birth. Cryptophthalmos is noted in all heb homozygous animals, as is occasional hindlimb polydactyly.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi207D → E: Impairs cell adhesion ability in vitro. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001012330 – 2191FRAS1-related extracellular matrix protein 1Add BLAST2162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1039N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1584N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2163 ↔ 2177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q684R7

PRoteomics IDEntifications database

More...PRIDEi		Q684R7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		266856 [Q684R7-1]
266857 [Q684R7-2]
266858 [Q684R7-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q684R7, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q684R7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q684R7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epidermis and hair follicles. Expressed in many developing epidermal appendages, including the whisker and sensory vibrissae, cranial and trunk hair follicles, meibomian glands, teeth, footpads, eyelash primordia and invaginating mammary glands. Limb expression localizes to sheets of dermal cells on the apical and basal surfaces of the digits but, unlike FRAS1, is excluded from the apical ectodermal ridge. Usually expressed at higher level in dermal cells underlying the differentiating epithelial components, especially underlying the epidermis of the head, limbs, and eyelids. Expression in the eyelid dermis is apparent as early as 13 dpc. Postnatal expression in the skin is limited to the dermal papillae. In the kidney, it is expressed from 12.5 dpc in the mesenchyme surrounding the branching ureteric tree, with a strong expression in the more proximal regions of these tubules rather than at the proliferating and branching ends of the ureteric buds. In hair follicle, it is selectively expressed in the vibrissal hair primordia during development. Preferentially expressed in the whisker pad epithelia of 12.5 dpc embryos, in both the epithelial and mesenchymal cells of developing hair follicles. In the early stages of hair follicle development (i.e. stages 0-1), it is expressed in both hair placodes and dermal condensations. In stage 2, it is detected in dermal condensations and adjacent epithelia, but not in the upper region of the hair follicles. Expressed at the tip of developing hair follicles in the later stages (i.e. stages 3-5).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the embryos of all stages examined and in some adult tissues including eye, kidney, ovary, urinary bladder and testes; however, the overall expression levels in adult tissues are relatively low compared with those in embryonic tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000059049, Expressed in lung and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q684R7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q684R7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FREM2.

By similarity

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-61243N

Protein interaction database and analysis system

More...IntActi		Q684R7, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000071627

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q684R7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q684R7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati300 – 394CSPG 1PROSITE-ProRule annotationAdd BLAST95
Repeati419 – 506CSPG 2PROSITE-ProRule annotationAdd BLAST88
Repeati527 – 621CSPG 3PROSITE-ProRule annotationAdd BLAST95
Repeati648 – 779CSPG 4PROSITE-ProRule annotationAdd BLAST132
Repeati801 – 892CSPG 5PROSITE-ProRule annotationAdd BLAST92
Repeati912 – 1007CSPG 6PROSITE-ProRule annotationAdd BLAST96
Repeati1049 – 1151CSPG 7PROSITE-ProRule annotationAdd BLAST103
Repeati1172 – 1273CSPG 8PROSITE-ProRule annotationAdd BLAST102
Repeati1294 – 1391CSPG 9PROSITE-ProRule annotationAdd BLAST98
Repeati1412 – 1504CSPG 10PROSITE-ProRule annotationAdd BLAST93
Repeati1525 – 1614CSPG 11PROSITE-ProRule annotationAdd BLAST90
Repeati1650 – 1742CSPG 12PROSITE-ProRule annotationAdd BLAST93
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1749 – 1848Calx-betaAdd BLAST100
Domaini2072 – 2186C-type lectinPROSITE-ProRule annotationAdd BLAST115

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi205 – 207Cell attachment site3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3597, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156990

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q684R7

Identification of Orthologs from Complete Genome Data

More...OMAi		MVYVTDG

Database of Orthologous Groups

More...OrthoDBi		13258at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q684R7

TreeFam database of animal gene trees

More...TreeFami		TF316876

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.2030, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
IPR016187, CTDL_fold
IPR032825, FREM1

The PANTHER Classification System

More...PANTHERi		PTHR45739:SF7, PTHR45739:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03160, Calx-beta, 1 hit
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141072, SSF141072, 1 hit
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS51854, CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q684R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHSPGCTGPK AQWFLLLQLL LLHLDRVSAT FISINRGLRV MKGSSAFLSG 
        60         70         80         90        100
DHLRVAVPKE KDACRLEVVM NEPVTQRVGK LSPQVFDCHF LPNEVKYVHN 
       110        120        130        140        150
GCPILDEDSV KLRLYRFTET DTFMETFLLR VYLVEPDCNI IRMSSNVLEV 
       160        170        180        190        200
TEFYGLSQAI DKNLLQFDYD RTASLDCTIR LDPLRTQLPA HGKLVVVNRK 
       210        220        230        240        250
SEGPRGDQPH SFFSETELGA GLKCPDGSCA LELKQVASLK VSCEEFLLTG 
       260        270        280        290        300
FHYQHMQPPS PNIDYIPIQL DLTDRRSKTV YKSESAWLPV YIRVGIPNQV 
       310        320        330        340        350
PRAAFMAMFV LEVDQFILTP LTTSVLDCEE DETPKPLLVF NITKAPLQGY 
       360        370        380        390        400
VTHLLDHTRP ISSFTWKDLS DMQVAYQPPN SSHPERRHYT MELEVYDFFF 
       410        420        430        440        450
ERSAPITVHI SIRTADTNAP RVSWNTGLNL LEGQSRAITW EQFQIVDNDD 
       460        470        480        490        500
IGAVQLVTIG GLQHGRLTVR EGKGFLFTVT DLQAGVVRYH HDDSDTTKDF 
       510        520        530        540        550
VAFRIFDGHH SSHHKFPINI LPKDDSPPFL ITNVVIELEE GKTILIQGSM 
       560        570        580        590        600
LRASDMDSSD DYIFFNITKF PQAGEIMKKP GPRLIGYPVP GFLQRDLFSG 
       610        620        630        640        650
IIYYRHFGGE IFEDSFEFVL WDSHEPPNLS VPQVVTIHIT PVDDQLPKEA 
       660        670        680        690        700
PGISRHLVVK ETEVAYITKK HLHFLDMESR DGELIYTVTR PPCFSFSHRH 
       710        720        730        740        750
LDAGKLFMVD SIPKLTKNPT APGLSSFTQG LILISANQHT CSSQFASQHA 
       760        770        780        790        800
VNHMKVAYMP PMQDIGPSPR HVQFTVSVSN QHGGALHGIC FNITVLPVDN 
       810        820        830        840        850
QVPEVFTNTL RVVEGGQCTI STEHILVSDV DTPLDSISLS LKERPLHGGV 
       860        870        880        890        900
ELDGFPLNPR GTFSWRDLNT LKVWYQHDGS EVLQDEIFLE VTDGTNSAAF 
       910        920        930        940        950
VLHIEVFPVN DEPPILKADL IPMMHCSEGG EVTITPEYIS ATDADSDDLE 
       960        970        980        990       1000
LLFLIAREPQ HGVVRKAGLH VDRFSQGDVI SGAVTYKHTG GEIGLEPCSD 
      1010       1020       1030       1040       1050
TVVLVVSDGE ADPLMNGCCY DGPDSSVPLH KSFPTYQLNI TVHPVDNQPP 
      1060       1070       1080       1090       1100
SIIIGRMLTV DEGFSAALTT HHLTVVDWDT APDDLKFMLA SQPQFGYLEN 
      1110       1120       1130       1140       1150
ALPSAGFEKS NIGIRIASFQ WTDMKASHIN YVQSRHLRVE PTADQFTVYA 
      1160       1170       1180       1190       1200
TDGKHRSLET TFHVIINPTN DEAPDLAVQN ITVYEGHMVE LDSSIISATD 
      1210       1220       1230       1240       1250
RDIPKDPLLF SIALKPQHGL LVDAAISKDS HQIKQLQHEI HSFSVDLLKN 
      1260       1270       1280       1290       1300
GMKLVYAHDD SESSADNFVI QLSDGKHKIL KTISVNITPV NDETPTLSKK 
      1310       1320       1330       1340       1350
AEISMAVGDT RVLSSAVLSA TDKDSPREKI HYVFERLPQN GQLQLKIGRD 
      1360       1370       1380       1390       1400
WVPLSTGMQC TQEDVDLNLL RYTHAGKTDS QDGDSFTFYL WDEDNRSPAF 
      1410       1420       1430       1440       1450
DCHIIIEDMG KGDIVIHAKP LVVVKGDRGL LTTATLLAVD GADKPEELLY 
      1460       1470       1480       1490       1500
LITSPPRHGQ VEYVHSPGVP IASFSQMDIA GQTVCYIHKS RTAVPTDSFR 
      1510       1520       1530       1540       1550
FTISNGLQTQ RGVFEITLQT VDSALPVLTK NKRLRLAEGA MGLLSADHLQ 
      1560       1570       1580       1590       1600
LTDPDTPPEN LTFFLAQLPR HGYLFLRGKA LQHNFTQRDV DSGGVAYQHS 
      1610       1620       1630       1640       1650
GGGAREDYFT FLATDRKNQG FVVDGKVQKE PVRFTIQVDQ LDKAAPRITH 
      1660       1670       1680       1690       1700
LHSPTQVGLL KNGCYGIYIT SRVLKASDPD TEDDQIIFKI LRGPLYGRLE 
      1710       1720       1730       1740       1750
NTTTGEFIHE RFSQKDLSHK TILYIINPSL QVTSDILEFQ AMDPTGNTAT 
      1760       1770       1780       1790       1800
PQSLDLRWSY IEWAQTAYEV CENVGLLPLE VTRRGYPMDS AFVGVEVNQV 
      1810       1820       1830       1840       1850
SATVGKDFTV TPSKLLQFDP GMSTKMWNIA ITYDGLEEDD EVFEVILNSP 
      1860       1870       1880       1890       1900
VNAVLGTQTK AAVKILDSKG GRCHPSNSFN QSKHSTWGKG PWHPLPSGSS 
      1910       1920       1930       1940       1950
SLTTSGSPLL ERPPPSFTSG DALQGFGLTD LTQRKTMTQG NGKSVLPSSV 
      1960       1970       1980       1990       2000
CRNGTDTIYN YHGIVSLKLE GDRFSAHKRK AKISIVSQPQ RTIKVAELPL 
      2010       2020       2030       2040       2050
ADKVESTTDL HFLRQGLRPL FPKNCSVDLK GLFHFEESTH RLYQCDGISW 
      2060       2070       2080       2090       2100
KAWSPQTKGL EDRSCPGGWL LHSGYCHILV TRQKGTWTTA TRACREQHQG 
      2110       2120       2130       2140       2150
DLVTVLSRRH MQWLWAMSGR KPFWIGLKNQ PRTGHWEWIG GEPVAFTNWR 
      2160       2170       2180       2190 
RGAPLHPKPG KNCALVQKRG QWQTKNCSKG KAHNFVCSRK L
Length:2,191
Mass (Da):244,544
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7D18FD3E32FD3C3
GO
Isoform 2 (identifier: Q684R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     729-747: Missing.

Show »
Length:2,172
Mass (Da):242,557
Checksum:i871EAAAF66E08C80
GO
Isoform 3 (identifier: Q684R7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1500-1544: RFTISNGLQT...RLAEGAMGLL → SRWGHKSPCR...CRLWTAPCLC
     1545-2191: Missing.

Show »
Length:1,544
Mass (Da):172,191
Checksum:i9E2B1C13F4F06715
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5Z7E9Q5Z7_MOUSE
FRAS1-related extracellular matrix ...
Frem1
2,173Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7D5I3F7D5I3_MOUSE
FRAS1-related extracellular matrix ...
Frem1
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH88732 differs from that shown. Reason: Frameshift.Curated
The sequence BAC35069 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015032729 – 747Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0150331500 – 1544RFTIS…AMGLL → SRWGHKSPCRLPCLSLPDLP SAMDCRPSVGCLKSHCRLWT APCLC in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0150341545 – 2191Missing in isoform 3. 1 PublicationAdd BLAST647

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ616838 mRNA Translation: CAE83577.1
AB160986 mRNA Translation: BAD89014.1
AK052629 mRNA Translation: BAC35069.1 Different initiation.
BC088732 mRNA Translation: AAH88732.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38791.1 [Q684R7-1]
CCDS57281.1 [Q684R7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001185740.1, NM_001198811.1 [Q684R7-2]
NP_808531.2, NM_177863.4 [Q684R7-1]
XP_006538076.1, XM_006538013.3 [Q684R7-2]
XP_006538077.1, XM_006538014.2 [Q684R7-2]
XP_006538078.1, XM_006538015.1 [Q684R7-2]
XP_011248357.1, XM_011250055.2 [Q684R7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000071708; ENSMUSP00000071627; ENSMUSG00000059049 [Q684R7-1]
ENSMUST00000107230; ENSMUSP00000102849; ENSMUSG00000059049 [Q684R7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		329872

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:329872

UCSC genome browser

More...UCSCi		uc008tkm.2, mouse [Q684R7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ616838 mRNA Translation: CAE83577.1
AB160986 mRNA Translation: BAD89014.1
AK052629 mRNA Translation: BAC35069.1 Different initiation.
BC088732 mRNA Translation: AAH88732.1 Frameshift.
CCDSiCCDS38791.1 [Q684R7-1]
CCDS57281.1 [Q684R7-2]
RefSeqiNP_001185740.1, NM_001198811.1 [Q684R7-2]
NP_808531.2, NM_177863.4 [Q684R7-1]
XP_006538076.1, XM_006538013.3 [Q684R7-2]
XP_006538077.1, XM_006538014.2 [Q684R7-2]
XP_006538078.1, XM_006538015.1 [Q684R7-2]
XP_011248357.1, XM_011250055.2 [Q684R7-2]

3D structure databases

SMRiQ684R7
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-61243N
IntActiQ684R7, 2 interactors
STRINGi10090.ENSMUSP00000071627

PTM databases

GlyGeniQ684R7, 6 sites
iPTMnetiQ684R7
PhosphoSitePlusiQ684R7

Proteomic databases

PaxDbiQ684R7
PRIDEiQ684R7
ProteomicsDBi266856 [Q684R7-1]
266857 [Q684R7-2]
266858 [Q684R7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42751, 88 antibodies

Genome annotation databases

EnsembliENSMUST00000071708; ENSMUSP00000071627; ENSMUSG00000059049 [Q684R7-1]
ENSMUST00000107230; ENSMUSP00000102849; ENSMUSG00000059049 [Q684R7-2]
GeneIDi329872
KEGGimmu:329872
UCSCiuc008tkm.2, mouse [Q684R7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		158326
MGIiMGI:2670972, Frem1

Phylogenomic databases

eggNOGiKOG3597, Eukaryota
GeneTreeiENSGT00940000156990
InParanoidiQ684R7
OMAiMVYVTDG
OrthoDBi13258at2759
PhylomeDBiQ684R7
TreeFamiTF316876

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		329872, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Frem1, mouse

Protein Ontology

More...PROi		PR:Q684R7
RNActiQ684R7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000059049, Expressed in lung and 185 other tissues
ExpressionAtlasiQ684R7, baseline and differential
GenevisibleiQ684R7, MM

Family and domain databases

Gene3Di2.60.40.2030, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
IPR016187, CTDL_fold
IPR032825, FREM1
PANTHERiPTHR45739:SF7, PTHR45739:SF7, 1 hit
PfamiView protein in Pfam
PF03160, Calx-beta, 1 hit
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF141072, SSF141072, 1 hit
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS51854, CSPG, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFREM1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q684R7
Secondary accession number(s): Q5H8C2, Q5M7B3, Q8C732
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 11, 2004
Last modified: April 7, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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