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Entry version 114 (31 Jul 2019)
Sequence version 2 (04 Dec 2007)
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Protein

Rap1 GTPase-activating protein 2

Gene

RAP1GAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-392517 Rap1 signalling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rap1 GTPase-activating protein 2
Short name:
Rap1GAP2
Alternative name(s):
GTPase-activating Rap/Ran-GAP domain-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAP1GAP2
Synonyms:GARNL4, KIAA1039, RAP1GA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29176 RAP1GAP2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q684P5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7S → A: Abolishes phosphorylation by PKG/PRKG1. 1 Publication1
Mutagenesisi357N → A: Abolishes GAP activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23108

Open Targets

More...
OpenTargetsi
ENSG00000132359

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165432528

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAP1GAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416269

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003127161 – 730Rap1 GTPase-activating protein 2Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7Phosphoserine; by PKG/PRKG1; in vitro1 Publication1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei507PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q684P5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q684P5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q684P5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q684P5

PeptideAtlas

More...
PeptideAtlasi
Q684P5

PRoteomics IDEntifications database

More...
PRIDEi
Q684P5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65988 [Q684P5-1]
65989 [Q684P5-2]
65990 [Q684P5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q684P5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q684P5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132359 Expressed in 203 organ(s), highest expression level in Brodmann (1909) area 23

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q684P5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q684P5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022148
HPA022896

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116732, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q684P5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q684P5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini248 – 464Rap-GAPPROSITE-ProRule annotationAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi586 – 726Ser-richAdd BLAST141

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686 Eukaryota
ENOG410XTIX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160935

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231640

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q684P5

KEGG Orthology (KO)

More...
KOi
K17708

Database of Orthologous Groups

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OrthoDBi
845465at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q684P5

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q684P5-1) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA
60 70 80 90 100
PPTMKSSEFF EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP
110 120 130 140 150
YPQVILPQFG GYWIEDPENV GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC
160 170 180 190 200
KGEARAYRRH FLGKDHLNFY CTGSSLGNLI LSVKCEEAEG IEYLRVILRS
210 220 230 240 250
KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL YPKASQMIVS
260 270 280 290 300
YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL
310 320 330 340 350
QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ
360 370 380 390 400
RKRHIGNDIV AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK
410 420 430 440 450
VSVTAREDVP TFGPPLPSPP VFQKGPEFRE FLLTKLTNAE NACCKSDKFA
460 470 480 490 500
KLEDRTRAAL LDNLHDELHA HTQAMLGLGP EEDKFENGGH GGFLESFKRA
510 520 530 540 550
IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK TTFSPPVVAA
560 570 580 590 600
TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS
610 620 630 640 650
QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE
660 670 680 690 700
GEAMEEGDSG GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS
710 720 730
PTDAKSRNSP RSNLKFRFDK LSHASSGAGH
Length:730
Mass (Da):80,056
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E7584ADC2DA0B08
GO
Isoform 2 (identifier: Q684P5-2) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2a

The sequence of this isoform differs from the canonical sequence as follows:
     68-82: Missing.

Show »
Length:715
Mass (Da):78,380
Checksum:i3A8175583D2C9C3F
GO
Isoform 3 (identifier: Q684P5-3) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:711
Mass (Da):77,897
Checksum:iF90B7B7CBC1F46A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GV05A0A1B0GV05_HUMAN
Rap1 GTPase-activating protein 2
RAP1GAP2
771Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti285P → L in BAC85912 (PubMed:14702039).Curated1
Sequence conflicti304K → N in CAF31652 (PubMed:15632203).Curated1
Sequence conflicti304K → N in CAF31653 (PubMed:15632203).Curated1
Sequence conflicti726S → P in CAH10514 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037553202L → M. Corresponds to variant dbSNP:rs17762452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0298881 – 19Missing in isoform 3. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_02988968 – 82Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ628446 mRNA Translation: CAF31652.1
AJ628447 mRNA Translation: CAF31653.1
AK124640 mRNA Translation: BAC85912.1
CR627427 mRNA Translation: CAH10514.1
BC140870 mRNA Translation: AAI40871.1
BC140871 mRNA Translation: AAI40872.1
AB028962 mRNA Translation: BAA82991.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45573.1 [Q684P5-1]
CCDS45574.1 [Q684P5-2]
CCDS82035.1 [Q684P5-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001093868.1, NM_001100398.1 [Q684P5-2]
NP_001316987.1, NM_001330058.1 [Q684P5-3]
NP_055900.4, NM_015085.4 [Q684P5-1]
XP_011522043.1, XM_011523741.2 [Q684P5-3]
XP_016879859.1, XM_017024370.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254695; ENSP00000254695; ENSG00000132359 [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359 [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359 [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359 [Q684P5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23108

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23108

UCSC genome browser

More...
UCSCi
uc010ckd.4 human [Q684P5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ628446 mRNA Translation: CAF31652.1
AJ628447 mRNA Translation: CAF31653.1
AK124640 mRNA Translation: BAC85912.1
CR627427 mRNA Translation: CAH10514.1
BC140870 mRNA Translation: AAI40871.1
BC140871 mRNA Translation: AAI40872.1
AB028962 mRNA Translation: BAA82991.1
CCDSiCCDS45573.1 [Q684P5-1]
CCDS45574.1 [Q684P5-2]
CCDS82035.1 [Q684P5-3]
RefSeqiNP_001093868.1, NM_001100398.1 [Q684P5-2]
NP_001316987.1, NM_001330058.1 [Q684P5-3]
NP_055900.4, NM_015085.4 [Q684P5-1]
XP_011522043.1, XM_011523741.2 [Q684P5-3]
XP_016879859.1, XM_017024370.1

3D structure databases

SMRiQ684P5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116732, 4 interactors
IntActiQ684P5, 4 interactors
STRINGi9606.ENSP00000254695

PTM databases

iPTMnetiQ684P5
PhosphoSitePlusiQ684P5

Polymorphism and mutation databases

BioMutaiRAP1GAP2
DMDMi162416269

Proteomic databases

EPDiQ684P5
jPOSTiQ684P5
MaxQBiQ684P5
PaxDbiQ684P5
PeptideAtlasiQ684P5
PRIDEiQ684P5
ProteomicsDBi65988 [Q684P5-1]
65989 [Q684P5-2]
65990 [Q684P5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254695; ENSP00000254695; ENSG00000132359 [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359 [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359 [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359 [Q684P5-1]
GeneIDi23108
KEGGihsa:23108
UCSCiuc010ckd.4 human [Q684P5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23108
DisGeNETi23108

GeneCards: human genes, protein and diseases

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GeneCardsi
RAP1GAP2
HGNCiHGNC:29176 RAP1GAP2
HPAiHPA022148
HPA022896
neXtProtiNX_Q684P5
OpenTargetsiENSG00000132359
PharmGKBiPA165432528

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00940000160935
HOGENOMiHOG000231640
InParanoidiQ684P5
KOiK17708
OrthoDBi845465at2759
PhylomeDBiQ684P5
TreeFamiTF318626

Enzyme and pathway databases

ReactomeiR-HSA-392517 Rap1 signalling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RAP1GAP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RAP1GAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23108

Protein Ontology

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PROi
PR:Q684P5

Gene expression databases

BgeeiENSG00000132359 Expressed in 203 organ(s), highest expression level in Brodmann (1909) area 23
ExpressionAtlasiQ684P5 baseline and differential
GenevisibleiQ684P5 HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPGP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q684P5
Secondary accession number(s): B2RTY5
, Q684P4, Q6AI00, Q6ZVF0, Q9UPW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 31, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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