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Protein

Rap1 GTPase-activating protein 2

Gene

RAP1GAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-392517 Rap1 signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Rap1 GTPase-activating protein 2
Short name:
Rap1GAP2
Alternative name(s):
GTPase-activating Rap/Ran-GAP domain-like protein 4
Gene namesi
Name:RAP1GAP2
Synonyms:GARNL4, KIAA1039, RAP1GA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132359.13
HGNCiHGNC:29176 RAP1GAP2
neXtProtiNX_Q684P5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7S → A: Abolishes phosphorylation by PKG/PRKG1. 1 Publication1
Mutagenesisi357N → A: Abolishes GAP activity. 1 Publication1

Organism-specific databases

DisGeNETi23108
OpenTargetsiENSG00000132359
PharmGKBiPA165432528

Polymorphism and mutation databases

BioMutaiRAP1GAP2
DMDMi162416269

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127161 – 730Rap1 GTPase-activating protein 2Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Phosphoserine; by PKG/PRKG1; in vitro1 Publication1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei507PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1

Post-translational modificationi

In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ684P5
MaxQBiQ684P5
PaxDbiQ684P5
PeptideAtlasiQ684P5
PRIDEiQ684P5
ProteomicsDBi65988
65989 [Q684P5-2]
65990 [Q684P5-3]

PTM databases

iPTMnetiQ684P5
PhosphoSitePlusiQ684P5

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000132359 Expressed in 203 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_GARNL4
ExpressionAtlasiQ684P5 baseline and differential
GenevisibleiQ684P5 HS

Organism-specific databases

HPAiHPA022148
HPA022896

Interactioni

Protein-protein interaction databases

BioGridi116732, 4 interactors
IntActiQ684P5, 4 interactors
STRINGi9606.ENSP00000254695

Structurei

3D structure databases

ProteinModelPortaliQ684P5
SMRiQ684P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 464Rap-GAPPROSITE-ProRule annotationAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi586 – 726Ser-richAdd BLAST141

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000231640
HOVERGENiHBG016371
InParanoidiQ684P5
KOiK17708
OrthoDBiEOG091G028T
PhylomeDBiQ684P5
TreeFamiTF318626

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q684P5-1) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGRKRSVSF GGFGWIDKTM LASLKVKKQE LANSSDATLP DRPLSPPLTA
60 70 80 90 100
PPTMKSSEFF EMLEKMQGIK LEEQKPGPQK NKDDYIPYPS IDEVVEKGGP
110 120 130 140 150
YPQVILPQFG GYWIEDPENV GTPTSLGSSI CEEEEEDNLS PNTFGYKLEC
160 170 180 190 200
KGEARAYRRH FLGKDHLNFY CTGSSLGNLI LSVKCEEAEG IEYLRVILRS
210 220 230 240 250
KLKTVHERIP LAGLSKLPSV PQIAKAFCDD AVGLRFNPVL YPKASQMIVS
260 270 280 290 300
YDEHEVNNTF KFGVIYQKAR QTLEEELFGN NEESPAFKEF LDLLGDTITL
310 320 330 340 350
QDFKGFRGGL DVTHGQTGVE SVYTTFRDRE IMFHVSTKLP FTDGDAQQLQ
360 370 380 390 400
RKRHIGNDIV AIIFQEENTP FVPDMIASNF LHAYIVVQVE TPGTETPSYK
410 420 430 440 450
VSVTAREDVP TFGPPLPSPP VFQKGPEFRE FLLTKLTNAE NACCKSDKFA
460 470 480 490 500
KLEDRTRAAL LDNLHDELHA HTQAMLGLGP EEDKFENGGH GGFLESFKRA
510 520 530 540 550
IRVRSHSMET MVGGQKKSHS GGIPGSLSGG ISHNSMEVTK TTFSPPVVAA
560 570 580 590 600
TVKNQSRSPI KRRSGLFPRL HTGSEGQGDS RARCDSTSST PKTPDGGHSS
610 620 630 640 650
QEIKSETSSN PSSPEICPNK EKPFMKLKEN GRAISRSSSS TSSVSSTAGE
660 670 680 690 700
GEAMEEGDSG GSQPSTTSPF KQEVFVYSPS PSSESPSLGA AATPIIMSRS
710 720 730
PTDAKSRNSP RSNLKFRFDK LSHASSGAGH
Length:730
Mass (Da):80,056
Last modified:December 4, 2007 - v2
Checksum:i8E7584ADC2DA0B08
GO
Isoform 2 (identifier: Q684P5-2) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2a

The sequence of this isoform differs from the canonical sequence as follows:
     68-82: Missing.

Show »
Length:715
Mass (Da):78,380
Checksum:i3A8175583D2C9C3F
GO
Isoform 3 (identifier: Q684P5-3) [UniParc]FASTAAdd to basket
Also known as: Rap1GAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:711
Mass (Da):77,897
Checksum:iF90B7B7CBC1F46A6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GV05A0A1B0GV05_HUMAN
Rap1 GTPase-activating protein 2
RAP1GAP2
771Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285P → L in BAC85912 (PubMed:14702039).Curated1
Sequence conflicti304K → N in CAF31652 (PubMed:15632203).Curated1
Sequence conflicti304K → N in CAF31653 (PubMed:15632203).Curated1
Sequence conflicti726S → P in CAH10514 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037553202L → M. Corresponds to variant dbSNP:rs17762452Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298881 – 19Missing in isoform 3. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_02988968 – 82Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ628446 mRNA Translation: CAF31652.1
AJ628447 mRNA Translation: CAF31653.1
AK124640 mRNA Translation: BAC85912.1
CR627427 mRNA Translation: CAH10514.1
BC140870 mRNA Translation: AAI40871.1
BC140871 mRNA Translation: AAI40872.1
AB028962 mRNA Translation: BAA82991.1
CCDSiCCDS45573.1 [Q684P5-1]
CCDS45574.1 [Q684P5-2]
CCDS82035.1 [Q684P5-3]
RefSeqiNP_001093868.1, NM_001100398.1 [Q684P5-2]
NP_001316987.1, NM_001330058.1 [Q684P5-3]
NP_055900.4, NM_015085.4 [Q684P5-1]
XP_011522043.1, XM_011523741.2 [Q684P5-3]
XP_016879859.1, XM_017024370.1
UniGeneiHs.499659

Genome annotation databases

EnsembliENST00000254695; ENSP00000254695; ENSG00000132359 [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359 [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359 [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359 [Q684P5-1]
GeneIDi23108
KEGGihsa:23108
UCSCiuc010ckd.4 human [Q684P5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ628446 mRNA Translation: CAF31652.1
AJ628447 mRNA Translation: CAF31653.1
AK124640 mRNA Translation: BAC85912.1
CR627427 mRNA Translation: CAH10514.1
BC140870 mRNA Translation: AAI40871.1
BC140871 mRNA Translation: AAI40872.1
AB028962 mRNA Translation: BAA82991.1
CCDSiCCDS45573.1 [Q684P5-1]
CCDS45574.1 [Q684P5-2]
CCDS82035.1 [Q684P5-3]
RefSeqiNP_001093868.1, NM_001100398.1 [Q684P5-2]
NP_001316987.1, NM_001330058.1 [Q684P5-3]
NP_055900.4, NM_015085.4 [Q684P5-1]
XP_011522043.1, XM_011523741.2 [Q684P5-3]
XP_016879859.1, XM_017024370.1
UniGeneiHs.499659

3D structure databases

ProteinModelPortaliQ684P5
SMRiQ684P5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116732, 4 interactors
IntActiQ684P5, 4 interactors
STRINGi9606.ENSP00000254695

PTM databases

iPTMnetiQ684P5
PhosphoSitePlusiQ684P5

Polymorphism and mutation databases

BioMutaiRAP1GAP2
DMDMi162416269

Proteomic databases

EPDiQ684P5
MaxQBiQ684P5
PaxDbiQ684P5
PeptideAtlasiQ684P5
PRIDEiQ684P5
ProteomicsDBi65988
65989 [Q684P5-2]
65990 [Q684P5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254695; ENSP00000254695; ENSG00000132359 [Q684P5-1]
ENST00000366401; ENSP00000389824; ENSG00000132359 [Q684P5-2]
ENST00000540393; ENSP00000439688; ENSG00000132359 [Q684P5-3]
ENST00000542807; ENSP00000444890; ENSG00000132359 [Q684P5-1]
GeneIDi23108
KEGGihsa:23108
UCSCiuc010ckd.4 human [Q684P5-1]

Organism-specific databases

CTDi23108
DisGeNETi23108
EuPathDBiHostDB:ENSG00000132359.13
GeneCardsiRAP1GAP2
H-InvDBiHIX0013424
HIX0039496
HGNCiHGNC:29176 RAP1GAP2
HPAiHPA022148
HPA022896
neXtProtiNX_Q684P5
OpenTargetsiENSG00000132359
PharmGKBiPA165432528
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000231640
HOVERGENiHBG016371
InParanoidiQ684P5
KOiK17708
OrthoDBiEOG091G028T
PhylomeDBiQ684P5
TreeFamiTF318626

Enzyme and pathway databases

ReactomeiR-HSA-392517 Rap1 signalling

Miscellaneous databases

ChiTaRSiRAP1GAP2 human
GeneWikiiRAP1GAP2
GenomeRNAii23108
PROiPR:Q684P5

Gene expression databases

BgeeiENSG00000132359 Expressed in 203 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_GARNL4
ExpressionAtlasiQ684P5 baseline and differential
GenevisibleiQ684P5 HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPGP2_HUMAN
AccessioniPrimary (citable) accession number: Q684P5
Secondary accession number(s): B2RTY5
, Q684P4, Q6AI00, Q6ZVF0, Q9UPW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 10, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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