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Entry version 81 (07 Oct 2020)
Sequence version 1 (11 Oct 2004)
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Protein

B-cell CLL/lymphoma 9-like protein

Gene

bcl9l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that may act as an activator (By similarity). Plays a role for mesoderm patterning in early embryogenesis.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-201722, Formation of the beta-catenin:TCF transactivating complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell CLL/lymphoma 9-like protein
Short name:
B-cell lymphoma 9-like protein
Short name:
BCL9-like protein
Alternative name(s):
Protein BCL9-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bcl9l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040927-29, bcl9l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe defects of trunk and tail development.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003140811 – 1530B-cell CLL/lymphoma 9-like proteinAdd BLAST1530

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q67FY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed during gastrulation.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000123831

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q67FY3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi271 – 871Gly-richAdd BLAST601
Compositional biasi543 – 676Pro-richAdd BLAST134
Compositional biasi923 – 1091Ser-richAdd BLAST169
Compositional biasi1414 – 1481Gln-richAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCL9 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR2B, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q67FY3

KEGG Orthology (KO)

More...
KOi
K22649

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015668, Bcl-9/Bcl-9l
IPR024670, BCL9_beta-catenin-bd_dom
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR15185, PTHR15185, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11502, BCL9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q67FY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSENKLSNH GKQVTSGAQS QLPNVNQAQQ QAPAGIQGSK GSVSGNHGVK
60 70 80 90 100
ANQISPGNPG LKSLNQTGGG GGMMKTKAKR ERSVSIDTGD QRESLTPVLE
110 120 130 140 150
PDAKVEGVMR SKRRCVLERK QPYSGDEWCS GAETEEEDEK PLSATHREHV
160 170 180 190 200
MCPSQGHSGS STTGHVSDPG GPGLGSGHGP GIRTDLHSRP PQQVVYVFTT
210 220 230 240 250
SLANSAAEAV MHGHTDSILL YHQQNVPRTK LDQSTGVGKV SNLAEHISSS
260 270 280 290 300
HSPPIGTPKS QSGTPRPASV GGVGHLPGTS TPSSTGHPDS EPAQTHRGGG
310 320 330 340 350
TSSNNGRSAV HTLGLGNSGP QSVGVSGTEG VDRPGAIPHH GAGVSPSTSP
360 370 380 390 400
SVLSALRQSE LGQRVGPGNT DGLSKEQLEH RERSLQTLRD IERLLLRSGT
410 420 430 440 450
GVAQEDPRGP NGNPNGTNVN NNNSNDGGRG LEDGEIGGGI PGNCHINNAG
460 470 480 490 500
MPGMPPVGGM KKYEEPLQSI ISQTQNLGGP GLDDSLMGPH HGMPPHSHHL
510 520 530 540 550
SSPSGLDMGP LLGPEGVTPE QLAWRKLQEE YYQEKRRQHD MNPHQHPQHF
560 570 580 590 600
RIMPEMGMPG GPPMLMRGPP PPYHSKPGDQ QWGPGPMVGG GMGGNARMMD
610 620 630 640 650
MNQEGPRGPR FLGQMRGPSG GGGYPESPGG VLGVEGLGPQ RPPRPGMGWL
660 670 680 690 700
EEIPPNMGGG GPFHGCCPPG GPGGPPQHFQ GDLDRPMTRE EIYRRIHRLD
710 720 730 740 750
LQQMSRQQQQ AGLGGPRMMD NPGGPGFPNP GMAGGPPSRG DPMDFPVSRT
760 770 780 790 800
IMGSPIGGVG GDGGPTMRDI VDSPLGGNLN MNMGMNINQQ QQLLAQKLRG
810 820 830 840 850
GPGVLGEMLN AEDISRIRAS QNGRGGANKA MIPGPEGPLQ FPNQSSFPGG
860 870 880 890 900
QVDGPYLQQP GPDMYGPDQP GPPHLSSTSR LSHIPMNTGS RVTDLGARHP
910 920 930 940 950
PDLPISVNPM GSPAIPPSHQ LKSPSLSQEP SPLMPSPSAA GLKSPSQLPQ
960 970 980 990 1000
SGPTHPPLPA ASGAGTPSST SIKSPQVMGP SLGLRSPSGS PGHLKSPSMP
1010 1020 1030 1040 1050
VASPGWTASP KAAMPSPGGP PSVKVTGNGG SSSTDTGMSL PPRSSNSTPI
1060 1070 1080 1090 1100
SQPSNSINPS MPFTSSPDAP PSQNPLSLIM SQMSKYAMPS STPLYHDAIK
1110 1120 1130 1140 1150
TIATSDDEML PDRPLQPGTN MSVGGMGNHQ SAQMLLSSQG AMGPHSGPQS
1160 1170 1180 1190 1200
PMGMVLQGGP PLSHDHPGPM LPSPNPMGIP GMPSEIMGGG GGPPDGIGPC
1210 1220 1230 1240 1250
NVSPMHTQNQ MGGFPRIQGP LHSPIGGMGQ QFPPRPDDVL PPQQMHLLSK
1260 1270 1280 1290 1300
GMSHQRPPHQ PDSFPPMPMG DGPDLSEVIR PTHRGIPEFD LSRIIPADKP
1310 1320 1330 1340 1350
SSTLQYFPKS ETMSQPQQNP HQGQPPPQVS SAQLLKQLSS SGPPHSNIPS
1360 1370 1380 1390 1400
SNPHIANLQN MMAEQQLPLH PSHCGMRPGM GMPQIGSRGM GSGGGMGPMC
1410 1420 1430 1440 1450
HPGHMMGRTG MSPQQQLQQQ HHHQQQQAMM ANNLLQHPSH PPRGMLSPQQ
1460 1470 1480 1490 1500
HPHNLIAQQN LMMMQAKQRG MALPGEHFGQ QGALMSPQGP MMGPPHSQTG
1510 1520 1530
MMGPQSLRQR SMSLDSPLGY GPGSMANMPF
Length:1,530
Mass (Da):159,872
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC29FEC9433ED28C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W4Z7F8W4Z7_DANRE
B-cell CLL/lymphoma 9-like protein
bcl9l
1,531Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1Q7J8F1Q7J8_DANRE
B-cell CLL/lymphoma 9-like protein
bcl9l
1,530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY296057 mRNA Translation: AAQ62695.1

NCBI Reference Sequences

More...
RefSeqi
NP_001005575.1, NM_001005575.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
449532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:449532

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296057 mRNA Translation: AAQ62695.1
RefSeqiNP_001005575.1, NM_001005575.1

3D structure databases

SMRiQ67FY3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123831

Proteomic databases

PaxDbiQ67FY3

Genome annotation databases

GeneIDi449532
KEGGidre:449532

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283149
ZFINiZDB-GENE-040927-29, bcl9l

Phylogenomic databases

eggNOGiENOG502QR2B, Eukaryota
InParanoidiQ67FY3
KOiK22649

Enzyme and pathway databases

ReactomeiR-DRE-201722, Formation of the beta-catenin:TCF transactivating complex

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q67FY3

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015668, Bcl-9/Bcl-9l
IPR024670, BCL9_beta-catenin-bd_dom
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR15185, PTHR15185, 1 hit
PfamiView protein in Pfam
PF11502, BCL9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCL9L_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q67FY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: October 7, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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