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Entry version 116 (12 Aug 2020)
Sequence version 1 (11 Oct 2004)
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Protein

B-cell CLL/lymphoma 9-like protein

Gene

Bcl9l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-201722, Formation of the beta-catenin:TCF transactivating complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell CLL/lymphoma 9-like protein
Short name:
B-cell lymphoma 9-like protein
Short name:
BCL9-like protein
Alternative name(s):
BCL9-related beta-catenin-binding protein
Protein BCL9-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bcl9l
Synonyms:B9l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1933114, Bcl9l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003140801 – 1494B-cell CLL/lymphoma 9-like proteinAdd BLAST1494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei36N6-acetyllysineCombined sources1
Modified residuei88PhosphoserineBy similarity1
Modified residuei108N6-acetyllysineCombined sources1
Modified residuei110N6-acetyllysineCombined sources1
Modified residuei116PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei137N6-acetyllysineCombined sources1
Modified residuei421PhosphoserineBy similarity1
Modified residuei511PhosphothreonineBy similarity1
Modified residuei677Asymmetric dimethylarginineCombined sources1
Modified residuei747PhosphoserineBy similarity1
Modified residuei810PhosphoserineBy similarity1
Modified residuei912PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei935PhosphoserineBy similarity1
Modified residuei939PhosphoserineCombined sources1
Modified residuei944PhosphoserineCombined sources1
Modified residuei972PhosphoserineBy similarity1
Modified residuei984PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1007PhosphoserineCombined sources1
Modified residuei1014PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q67FY2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q67FY2

PeptideAtlas

More...
PeptideAtlasi
Q67FY2

PRoteomics IDEntifications database

More...
PRIDEi
Q67FY2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q67FY2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q67FY2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, liver, lung, testis, brain, spleen, heart and skeletal muscle. Highly expressed in numerous colorectal tumors compared to corresponding non-cancerous tissues.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063382, Expressed in basioccipital bone and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q67FY2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q67FY2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with CDC73; CTNNB1 and PYGO1 (By similarity).

Interacts with CTNNB1.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
219776, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q67FY2, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000074516

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q67FY2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q67FY2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni302 – 530Necessary for interaction with CTNNB1Add BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi278 – 324Pro-richAdd BLAST47
Compositional biasi557 – 657Pro-richAdd BLAST101
Compositional biasi686 – 834Met-richAdd BLAST149
Compositional biasi952 – 1373Pro-richAdd BLAST422

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Tne C-terminal domain is important for its transactivation activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCL9 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR2B, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000110915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004973_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q67FY2

KEGG Orthology (KO)

More...
KOi
K22649

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQLMEKR

Database of Orthologous Groups

More...
OrthoDBi
156519at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q67FY2

TreeFam database of animal gene trees

More...
TreeFami
TF331144

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015668, Bcl-9/Bcl-9l
IPR024670, BCL9_beta-catenin-bd_dom
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR15185, PTHR15185, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11502, BCL9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q67FY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRILANKTRL PHPRRREAPG SPPLSPRGHC PPAPAKPMHP ENKLTNHGKT
60 70 80 90 100
GNGGAQSQHQ NVNQGPTCNL GSKGVGAGSH GAKANQISPS NSSLKNPQAG
110 120 130 140 150
VSPFSSLKGK VKRERSVSVD SGEQREAGTP SLDSEAKEVA PRSKRRCVLE
160 170 180 190 200
RKQPYSGDEW CSGPDSEEDD KPIAAAHNCN VADPAMVTPQ LGPGQTAQLP
210 220 230 240 250
LSESSAPGPQ HGPQPGLRPD VPGGGGGGVP GKPPSQFVYV FTTHLANTAA
260 270 280 290 300
EAVLQGRAES ILAYHQQNVP RAKLDQAPKV PPTPEPLPLN TPSAGTPQSQ
310 320 330 340 350
PPPLPPPPPA PGSAPPALPP EGPPEDTSQD LAPNSVGAAS TGGGTGGTHP
360 370 380 390 400
NTPTAATANN PLPPGGDPGS APGSALLGEA TPTGNGQRNL VGSEGLSKEQ
410 420 430 440 450
LEHRERSLQT LRDIERLLLR SGETEPFLKG PPGGAGEGGP PAQAPSAAQP
460 470 480 490 500
PPSAPPGGLK KYEEPLQSMI SQTQSLGGPP LEHEVPGHPQ GGDMGQQMNM
510 520 530 540 550
MMQRLGQDSL TPEQVAWRKL QEEYYEEKRR KEEQIGLHGG RPLQDMVGMG
560 570 580 590 600
GMMGRGPPPP YHSKPGDQWP PGMGAQLRGP MDVQDPMQLR PGPPFPGPRF
610 620 630 640 650
PGNQMQRVPG FGGMQSMPME VPMNAMQRPV RPGMAWNEDL PPIGGPSNFA
660 670 680 690 700
QNAVPYPGGQ GEAERFMTPR VREELLRHQL LEKRSMGMQR PLGMAGSGMG
710 720 730 740 750
QSMEMERMIQ AHRQMDPAMF PGQMTGGDGL AGTPMGIEFG GGRGLLSPPM
760 770 780 790 800
GQSGLREVDP PMGPGNLNMN MNVNMNMNMN LNVQMTPQQQ MLMSQKMRGP
810 820 830 840 850
GDMMGPQGLS PEEMARVRAQ NSSGMMGGPQ KMLMPSQFPN QGQQGFSGGQ
860 870 880 890 900
GPYQAMPQDM GNTPDMFSPD QSSVPMGTVG TARLSHMPLP PASNPPGSVH
910 920 930 940 950
LASNRGLGRR PSDLTISINQ MGSPGMGHLK SPTLSQVHSP LVTSPSANLK
960 970 980 990 1000
SPQTPSQMVP LPSANPPGPL KSPQVLSSSL GVRSPTGSPS RLKSPSMAVP
1010 1020 1030 1040 1050
SPGWVASPKT AMPSPGVSQN KQPPLSINSS STLGNVEQGA LPPSAPRNSS
1060 1070 1080 1090 1100
SAPPANPSSG LMNPSLPFTS SPDPTPSQNP LSLMMSQMSK YAMPSSTPLY
1110 1120 1130 1140 1150
HNAIKTIATS DDELLPDRPL LPPPPPPQGS GPGISNNQPN QMHMNPAAAQ
1160 1170 1180 1190 1200
SPMGMNLPGQ QPLSHEPPPT MLPSPTPLGS NIPLHPNAQG TGGSSQNSMM
1210 1220 1230 1240 1250
MAPGGPDSLN APCGPVPSSS QMMSFPPRLQ QPHGAMAPTG AGGPGLQQHY
1260 1270 1280 1290 1300
PSGMALPPED LPTQPPGPIP PQQHLMGKGM TGRMGDAYPP GVLPGVASVL
1310 1320 1330 1340 1350
NDPELSEVIR PTPTGIPEFD LSRIIPSEKP SSTLQYFPKS ENQPPKAQPP
1360 1370 1380 1390 1400
NLHLMNLQNM MAEQTPSRPP NLPGQQGVQR GLSMSMCHPG QMSLLGRTGV
1410 1420 1430 1440 1450
PPQQGMVPHG LHQGVMSPPQ GLMTQQNFML MKQRGVGGEV YTQPPHMLSP
1460 1470 1480 1490
QGSLMGPPPQ QNLMVSHPLR QRSVSLDSQM GYLPTPGSMA NLPF
Length:1,494
Mass (Da):156,680
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31A9904C5923581C
GO
Isoform 2 (identifier: Q67FY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Show »
Length:1,457
Mass (Da):152,637
Checksum:i4FD2B47ADDE92A33
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7G4A0A1W2P7G4_MOUSE
B-cell CLL/lymphoma 9-like protein
Bcl9l
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti569 – 570WP → CA in BAD24964 (PubMed:15574752).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0302091 – 37Missing in isoform 2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB128033 mRNA Translation: BAD24964.1
AY296058 mRNA Translation: AAQ62696.1
BC072555 mRNA Translation: AAH72555.1
BC082304 mRNA Translation: AAH82304.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40601.1 [Q67FY2-1]
CCDS90549.1 [Q67FY2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_084532.2, NM_030256.2 [Q67FY2-1]
XP_006510764.1, XM_006510701.3 [Q67FY2-1]
XP_006510765.1, XM_006510702.3 [Q67FY2-1]
XP_006510766.1, XM_006510703.3 [Q67FY2-1]
XP_006510767.1, XM_006510704.3 [Q67FY2-1]
XP_006510768.1, XM_006510705.3
XP_017169189.1, XM_017313700.1 [Q67FY2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000074989; ENSMUSP00000074516; ENSMUSG00000063382 [Q67FY2-1]
ENSMUST00000218183; ENSMUSP00000151837; ENSMUSG00000063382 [Q67FY2-1]
ENSMUST00000220303; ENSMUSP00000151342; ENSMUSG00000063382 [Q67FY2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80288

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:80288

UCSC genome browser

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UCSCi
uc009pdu.1, mouse [Q67FY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB128033 mRNA Translation: BAD24964.1
AY296058 mRNA Translation: AAQ62696.1
BC072555 mRNA Translation: AAH72555.1
BC082304 mRNA Translation: AAH82304.1
CCDSiCCDS40601.1 [Q67FY2-1]
CCDS90549.1 [Q67FY2-2]
RefSeqiNP_084532.2, NM_030256.2 [Q67FY2-1]
XP_006510764.1, XM_006510701.3 [Q67FY2-1]
XP_006510765.1, XM_006510702.3 [Q67FY2-1]
XP_006510766.1, XM_006510703.3 [Q67FY2-1]
XP_006510767.1, XM_006510704.3 [Q67FY2-1]
XP_006510768.1, XM_006510705.3
XP_017169189.1, XM_017313700.1 [Q67FY2-1]

3D structure databases

SMRiQ67FY2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi219776, 2 interactors
IntActiQ67FY2, 5 interactors
STRINGi10090.ENSMUSP00000074516

PTM databases

iPTMnetiQ67FY2
PhosphoSitePlusiQ67FY2

Proteomic databases

jPOSTiQ67FY2
PaxDbiQ67FY2
PeptideAtlasiQ67FY2
PRIDEiQ67FY2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32548, 130 antibodies

Genome annotation databases

EnsembliENSMUST00000074989; ENSMUSP00000074516; ENSMUSG00000063382 [Q67FY2-1]
ENSMUST00000218183; ENSMUSP00000151837; ENSMUSG00000063382 [Q67FY2-1]
ENSMUST00000220303; ENSMUSP00000151342; ENSMUSG00000063382 [Q67FY2-2]
GeneIDi80288
KEGGimmu:80288
UCSCiuc009pdu.1, mouse [Q67FY2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283149
MGIiMGI:1933114, Bcl9l

Phylogenomic databases

eggNOGiENOG502QR2B, Eukaryota
GeneTreeiENSGT00730000110915
HOGENOMiCLU_004973_0_0_1
InParanoidiQ67FY2
KOiK22649
OMAiHQLMEKR
OrthoDBi156519at2759
PhylomeDBiQ67FY2
TreeFamiTF331144

Enzyme and pathway databases

ReactomeiR-MMU-201722, Formation of the beta-catenin:TCF transactivating complex

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80288, 6 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Bcl9l, mouse

Protein Ontology

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PROi
PR:Q67FY2
RNActiQ67FY2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063382, Expressed in basioccipital bone and 222 other tissues
ExpressionAtlasiQ67FY2, baseline and differential
GenevisibleiQ67FY2, MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015668, Bcl-9/Bcl-9l
IPR024670, BCL9_beta-catenin-bd_dom
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR15185, PTHR15185, 1 hit
PfamiView protein in Pfam
PF11502, BCL9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCL9L_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q67FY2
Secondary accession number(s): Q641L9, Q6GQY0, Q6I7B5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: August 12, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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