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Entry version 133 (12 Aug 2020)
Sequence version 1 (11 Oct 2004)
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Protein

Vascular endothelial growth factor receptor 2

Gene

Flk1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, ReceptorUniRule annotationImportedARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation
Biological processAngiogenesisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vascular endothelial growth factor receptor 2ARBA annotation (EC:2.7.10.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Flk1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei756 – 780HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cytoplasmic vesicleARBA annotation, Endoplasmic reticulumARBA annotation, EndosomeARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500426930822 – 1348Vascular endothelial growth factor receptor 2Sequence analysisAdd BLAST1327

Keywords - PTMi

Disulfide bondARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q677M1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q677M1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini234 – 312Ig-likeInterPro annotationAdd BLAST79
Domaini320 – 405Ig-likeInterPro annotationAdd BLAST86
Domaini412 – 534Ig-likeInterPro annotationAdd BLAST123
Domaini553 – 651Ig-likeInterPro annotationAdd BLAST99
Domaini658 – 744Ig-likeInterPro annotationAdd BLAST87
Domaini825 – 1155Protein kinaseInterPro annotationAdd BLAST331

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni959 – 983DisorderedSequence analysisAdd BLAST25
Regioni1280 – 1302DisorderedSequence analysisAdd BLAST23
Regioni1328 – 1348DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.ARBA annotation
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K05098

Database of Orthologous Groups

More...
OrthoDBi
236292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q677M1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR001824, Tyr_kinase_rcpt_3_CS
IPR041348, VEGFR-2_TMD
IPR009136, VEGFR2_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24416:SF45, PTHR24416:SF45, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 2 hits
PF07714, Pkinase_Tyr, 1 hit
PF17988, VEGFR-2_TMD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01834, VEGFRECEPTR2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 7 hits
SM00408, IGc2, 5 hits
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 7 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 5 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS00240, RECEPTOR_TYR_KIN_III, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q677M1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGPLRVLT VLLCLPPVFT GLFISMDQPT LSIQKSVLTI TTNDTLNITC
60 70 80 90 100
SGQRAVYWSW PNNQSNAEKR LAVTGCSDGP FCKTLTLLRV IGNDTGDYRC
110 120 130 140 150
LYGDSQAATT IYVYVQDYRS PFVTSVGDQL GIVYITKNKT VVVPCLGTVS
160 170 180 190 200
NLNVSLHAKY PEKVFVPDGK SISWDNKKGF TIPSHLISYA GMVFCEAKID
210 220 230 240 250
NESYQSVIYI VAVVGYRIYD LTMNPHYQVE LAVGEKLVLN CTVRTELNVG
260 270 280 290 300
IDFKWDYPSI KEKRATIRDL KTTAGEIKTF VSTLTIDSVN LSDKGRYTCA
310 320 330 340 350
ASSGRMNMKN SSYFIIHESP FIHLEKMENV VEMKLGDTVS IPVKFKGYPS
360 370 380 390 400
PEAKWYKNGK VMNANHTVKL GYTLVITDAT EKDAGNYTVV LTNPTNKMQK
410 420 430 440 450
RHTFTLLVNV PPQIGENALM APVDSYKYGS TQTLTCTIYA VPPPAAVLWY
460 470 480 490 500
WQLEEECTFS PQKVRLGANP YACRKWKVIS ERKGGNQVEI KQRVVTIAGK
510 520 530 540 550
TKTVSTLVIQ AANVSALYRC MATNRAGSSE RVISFHVTRG LEINLQPRSQ
560 570 580 590 600
LTEKDNTSLQ CTADKFTFEK LSWYKLSAHA LQTPFGGLPM PVCKNLDALQ
610 620 630 640 650
KLNATVSNTN GENVTLELIL RNISLQDGGD YVCIAQDKKA KTQHCLVKHL
660 670 680 690 700
TVQEPMAPTL VGNLENQTTN IGETIEVSCT VNGIPPPNIT WFKNGETLFE
710 720 730 740 750
DSGIVLKDGN KTLTIRRVRK EDGGLYTCLA CNILGCKKAE AYFSVEGAEE
760 770 780 790 800
KTNLELIILV GTAVIAMFFW LLLVIILRTV KRANGGDMKT GYLSIIMDPD
810 820 830 840 850
EVPIDEHCER LPYDASKWEF PRDRLKLGKP LGRGAFGQVI EADAFGIDKT
860 870 880 890 900
ATCRTVAVKM LKEGATHSEH RALMSELKIL IHIGHHLNVV NLLGACTKPG
910 920 930 940 950
GPLMVIVEYC KFGNLSAYLR SKRSEFVPYK TKSARFRQGK ENYIGDISTD
960 970 980 990 1000
LKQRLDSITS SQSSTSSGFV EERSLSDVEE EDAGSEDLCK NPLTMEDLIC
1010 1020 1030 1040 1050
YSFQVARGME FLASRKCIHR DLAARNILLS DNNVVKICDF GLARDIYKDP
1060 1070 1080 1090 1100
DYVRKGDARL PLKWMAPETI FDRVYTIQSD VWSFGVLLWE IFSLGASPYP
1110 1120 1130 1140 1150
GVKIDEEFCR RLKEGTRMRA PDYTTPEMYQ TMLDCWHGDP KQRPTFSELV
1160 1170 1180 1190 1200
EHLGNLLQAN VRQDGKDYVV LPLSVSLNME EDSGLSLPTS PASCKEEEEV
1210 1220 1230 1240 1250
CDPKFHYDNT AGISQYRQGS KRKSRPVSVK TFEDIPLVTT VKVVQEENQT
1260 1270 1280 1290 1300
DSGMVLASEE LKTLEERDKQ VKIPFSTLAP SKSNESVMSE ASNQTSGYQS
1310 1320 1330 1340
GYHSDDMDTM VCSSEDTELL CAQEASPTLP RVHGLVHDSP APLVSPPL
Length:1,348
Mass (Da):150,122
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6EF0F21CA839D6E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY382882 mRNA Translation: AAR26285.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004368.1, NM_001004368.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395323

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395323

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382882 mRNA Translation: AAR26285.1
RefSeqiNP_001004368.1, NM_001004368.1

3D structure databases

SMRiQ677M1
ModBaseiSearch...

Proteomic databases

PRIDEiQ677M1

Genome annotation databases

GeneIDi395323
KEGGigga:395323

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3791

Phylogenomic databases

KOiK05098
OrthoDBi236292at2759
PhylomeDBiQ677M1

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR001824, Tyr_kinase_rcpt_3_CS
IPR041348, VEGFR-2_TMD
IPR009136, VEGFR2_rcpt
PANTHERiPTHR24416:SF45, PTHR24416:SF45, 1 hit
PfamiView protein in Pfam
PF07679, I-set, 2 hits
PF07714, Pkinase_Tyr, 1 hit
PF17988, VEGFR-2_TMD, 1 hit
PRINTSiPR01834, VEGFRECEPTR2
SMARTiView protein in SMART
SM00409, IG, 7 hits
SM00408, IGc2, 5 hits
SM00219, TyrKc, 1 hit
SUPFAMiSSF48726, SSF48726, 7 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 5 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS00240, RECEPTOR_TYR_KIN_III, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ677M1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q677M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 12, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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