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Entry version 98 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

RNA replication protein

Gene

ORF1

Organism
Grapevine virus A (isolate Is 151) (GVA)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi663IronPROSITE-ProRule annotation1
Metal bindingi665IronPROSITE-ProRule annotation1
Metal bindingi720IronPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei7292-oxoglutaratePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Helicase, Hydrolase, Nucleotidyltransferase, Oxidoreductase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Iron, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA replication protein
Including the following 2 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
Helicase (EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGrapevine virus A (isolate Is 151) (GVA)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri651358 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaAlsuviricetesTymoviralesBetaflexiviridaeTrivirinaeVitivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiVitis vinifera (Grape) [TaxID: 29760]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000679 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004010891 – 1707RNA replication proteinAdd BLAST1707

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 242Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST177
Domaini645 – 738Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST94
Domaini892 – 1051(+)RNA virus helicase ATP-bindingAdd BLAST160
Domaini1052 – 1182(+)RNA virus helicase C-terminalAdd BLAST131
Domaini1469 – 1580RdRp catalyticPROSITE-ProRule annotationAdd BLAST112

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.590, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR027450, AlkB-like
IPR037151, AlkB-like_sf
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR027417, P-loop_NTPase
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13532, 2OG-FeII_Oxy_2, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51471, FE2OG_OXY, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q67704-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISVSSQRV AVSNLYTNGS EESVKAIKEL KSKRLLETET RLDGLFDYYI
60 70 80 90 100
PDTLREILTG YGMEFSVHSF QGHAHPVSKM IENHMLYRVA PNYFSSNTLV
110 120 130 140 150
VSCKESKIKR LRLKNANNRN LNFTQYNRLV HANHHHRYEN AFRELDVGNL
160 170 180 190 200
TNLINKEDQS ECIFIHDEVQ YWSLDEMQRF LGSLSKVDRV VYSIIYPSEV
210 220 230 240 250
EAGYSQSLFP EAYTFDLKDR RLVWYPDGKA EGAYTQPVNP WLLRCSKTED
260 270 280 290 300
SKGRSWTITK LQTIGAHHLF SAIKGSYLTE ESYKYDNFTI INPNDVLKGK
310 320 330 340 350
RGGKPLYLRA RMIKPTLLYL LALKKSDSNS AVAKLRMLSS REENMDEALF
360 370 380 390 400
VAQLAKQIKD TALYDKMGNP NLRSILSESF YDIAGSLFTR LFNRPEYDAR
410 420 430 440 450
CLEKFIRSCE TTEIHVERRY MEGIRRGASF KVQNVMDWVE DDSANALSEV
460 470 480 490 500
NFLDISWNDR VSEPYGIECI HGEGSRIRVP LSRILRAHEL IAGVQTDVEI
510 520 530 540 550
NFPRYVCSSR ALIHFRQYLI KLGRFSFMES RAIKDIEDIQ AGLEEGVITE
560 570 580 590 600
EEAELRLLPT TKPKITEIHM DDDTPGTSGE SDVEKFKSVR SLCREEIYSE
610 620 630 640 650
KLKGREVAFY SRHSKEYKYN GGSHRSLGWD EALNELTQEL GLDDSYDHCL
660 670 680 690 700
IQRYTAGGSI GFHADDEPCY LPGGSVVTVN LHGDATFEVK ENQSGKIEKK
710 720 730 740 750
ELHDGDVYVM GPGMQQTHKH RVTSHTDGRC SITLRNKTVD YEARKGDEDS
760 770 780 790 800
EYEEDKAELD EGIDYLQKNQ GNMCSLKAFA DHMQLSTPSV IAIVNGASPQ
810 820 830 840 850
TLREIEDGGY SLATLVNLSK ALDFPIAIHG ERGYAETPGS YRRLHLKITS
860 870 880 890 900
GHVEPFEGVT SKGGFREAML LGDGVGVGHF RVDKAKADRL AQSFYNGNTG
910 920 930 940 950
VLLGKYNKGK MHTGEIEEPK EVLTAFGFAG SGKSHWCQTI LKHCSVEKVL
960 970 980 990 1000
VISPRKVLRD DWVAKISKKH RVVTFEVAFM DDYGCKDIVI DEIGLLPPGY
1010 1020 1030 1040 1050
IDLVIAAHQP RTLVLLGDPL QSTYHSKRDN VVLEASQEDV FNRVRGKLPY
1060 1070 1080 1090 1100
LCYSHRLPRN CKLFEIECMG AESEKRVVYR SNRLKDEPTI CATRAMKEEK
1110 1120 1130 1140 1150
GSGWYTVSET QGLSFKSCLI YLDEHWAKKE DEDVMVALTR SRGEIGIHVT
1160 1170 1180 1190 1200
PALKKKLITN AKSTLLKKVL KGETYRRSEI VAMVRKHIPE TTVLFEESRL
1210 1220 1230 1240 1250
AETVDYEARL AGDPYLKSLL ALYDEIEMED IEIEEPVTLE PTKTHLALST
1260 1270 1280 1290 1300
KMNELAPFDL KAKEHREQHT EAGRTEQIDE NGYQGEVGDP MTHKALYLRH
1310 1320 1330 1340 1350
TSDDTATFMM SVKKRLRFRN YEANRRKYKT CHGIGHQMFS VFKDTYQLKE
1360 1370 1380 1390 1400
IDSLPELERC EMEFMKKRIE KSTGLIEKHA GRSDPDWPSN YLKIFLKQQT
1410 1420 1430 1440 1450
CTKMEKRGVD AKAGQTIACF AHSVLCRFGP ILRQTEKALR ELLPEKLMIY
1460 1470 1480 1490 1500
SQKKYMDLDK WAKTWVESMM GTDSDYEAFD RSQDEKVLDL EVEVLRFFLW
1510 1520 1530 1540 1550
PEDLIREYEE LKLMMGCALG DLAVMRFSGE FGTFFFNTVC NMVFSCMRYH
1560 1570 1580 1590 1600
IDRNTPMCFA GDDMYSPGIL RVKKDYEATL DQLTLKAKVH ISEEPLFCGW
1610 1620 1630 1640 1650
RMSPFGIIKE PNLILDRWKI ALRSGNLSLC LVNYAIEASF GYRLSEHLYD
1660 1670 1680 1690 1700
VNIDVDAQQE LVREIVIKKH LLPKKISDLF SEDECERHSD GDEDFLSNDV

ARLYRIE
Length:1,707
Mass (Da):195,502
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70494B3CCF312DE4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75433 Genomic RNA Translation: CAA53182.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S77910

NCBI Reference Sequences

More...
RefSeqi
NP_619662.1, NC_003604.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
940186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:940186

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75433 Genomic RNA Translation: CAA53182.1
PIRiS77910
RefSeqiNP_619662.1, NC_003604.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi940186
KEGGivg:940186

Family and domain databases

Gene3Di2.60.120.590, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR027450, AlkB-like
IPR037151, AlkB-like_sf
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR027417, P-loop_NTPase
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF13532, 2OG-FeII_Oxy_2, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51471, FE2OG_OXY, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_GVAIS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q67704
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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