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Entry version 164 (11 Dec 2019)
Sequence version 2 (12 Apr 2005)
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Protein

Autophagy-related protein 16-1

Gene

ATG16L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1632852 Macroautophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q676U5

SIGNOR Signaling Network Open Resource

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SIGNORi
Q676U5

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy-related protein 16-1
Alternative name(s):
APG16-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG16L1
Synonyms:APG16L
ORF Names:UNQ9393/PRO34307
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000085978.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21498 ATG16L1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610767 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q676U5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Inflammatory bowel disease 10 (IBD10)11 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021834300T → A in IBD10; has no effect on the stability of the protein under normal conditions; enhances the cleavage and the degradation mediated by activated CASP3; results in reduced autophagy and defective clearance of intestinal pathogens; impairs interaction with TMEM59; slows TMEM59 intracellular trafficking; increases production of type I IFNs. 11 PublicationsCorresponds to variant dbSNP:rs2241880EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi17I → W: Abolishes interaction with ATG5. 1 Publication1
Mutagenesisi21L → W: Abolishes interaction with ATG5. 1 Publication1
Mutagenesisi24R → D: Abolishes interaction with ATG5. 1 Publication1
Mutagenesisi36I → W: Reduces interaction with ATG5. 1 Publication1
Mutagenesisi139S → A: Abolishes phosphorylation. Impairs interaction with ATG12-ATG5 complex. 1 Publication1
Mutagenesisi226E → R: Impairs interaction with WIPI2. 1 Publication1
Mutagenesisi230E → R: Impairs interaction with WIPI2. 1 Publication1
Mutagenesisi299D → E: Prevents cleavage by activated CASP3. 1 Publication1
Mutagenesisi540V → A: Impairs interaction with PPP1CA; when associated with A-542. 1 Publication1
Mutagenesisi542F → A: Impairs interaction with PPP1CA; when associated with A-540. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55054

MalaCards human disease database

More...
MalaCardsi
ATG16L1
MIMi611081 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000085978

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
206 NON RARE IN EUROPE: Crohn disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134902949

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q676U5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATG16L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62510482

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508481 – 607Autophagy-related protein 16-1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei139Phosphoserine; by CK21 Publication1
Modified residuei269PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.1 Publication
Phosphorylation at Ser-139 promotes association with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q676U5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q676U5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q676U5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q676U5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q676U5

PeptideAtlas

More...
PeptideAtlasi
Q676U5

PRoteomics IDEntifications database

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PRIDEi
Q676U5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
65982 [Q676U5-1]
65983 [Q676U5-2]
65984 [Q676U5-3]
65985 [Q676U5-4]
65986 [Q676U5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q676U5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q676U5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q676U5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000085978 Expressed in 193 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q676U5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q676U5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012577
HPA063900

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:25484072). Homooligomer (By similarity).

Interacts with WIPI1 (PubMed:28561066).

Interacts with WIPI2 (PubMed:24954904,PubMed:28561066).

Interacts with RB1CC1; the interaction is required for ULK1 complex-dependent autophagy (PubMed:23262492, PubMed:24954904, PubMed:23392225).

Interacts with ATG5 (PubMed:23202584, PubMed:24191030, PubMed:25484072, PubMed:26812546). Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa) (PubMed:26083323, PubMed:23202584, PubMed:24191030).

Interacts with RAB33B (PubMed:21808068).

Interacts (via WD repeats) with TMEM59; the interaction mediates unconventional autophagic activity of TMEM59 (PubMed:23376921, PubMed:27273576).

Interacts with TLR2 and NOD2 (PubMed:23376921).

Interacts (via WD repeats) with MEFV (PubMed:26347139).

Interacts with PPP1CA; the interaction dephosphorylates ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex (PubMed:26083323).

Interacts (via N-terminal) with CLTC (PubMed:20639872).

Interacts with NOD2 (PubMed:20637199).

Interacts with TUFM (PubMed:22749352).

Interacts with TRIM16.

By similarity16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120375, 700 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-200 ATG12-ATG5-ATG16L1 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q676U5

Database of interacting proteins

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DIPi
DIP-27552N
DIP-50290N

Protein interaction database and analysis system

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IntActi
Q676U5, 45 interactors

Molecular INTeraction database

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MINTi
Q676U5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000375872

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q676U5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q676U5

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati320 – 359WD 1PROSITE-ProRule annotationAdd BLAST40
Repeati364 – 403WD 2PROSITE-ProRule annotationAdd BLAST40
Repeati406 – 445WD 3PROSITE-ProRule annotationAdd BLAST40
Repeati447 – 484WD 4PROSITE-ProRule annotationAdd BLAST38
Repeati486 – 525WD 5PROSITE-ProRule annotationAdd BLAST40
Repeati532 – 573WD 6PROSITE-ProRule annotationAdd BLAST42
Repeati575 – 607WD 7PROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 43Interaction with ATG51 PublicationAdd BLAST31
Regioni207 – 230WIPI2-binding1 PublicationAdd BLAST24
Regioni230 – 242RB1CC1-binding2 PublicationsAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 230Sequence analysisAdd BLAST153

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi296 – 299Caspase cleavage4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat ATG16 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0288 Eukaryota
ENOG410XQYA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112569

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q676U5

KEGG Orthology (KO)

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KOi
K17890

Database of Orthologous Groups

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OrthoDBi
404224at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q676U5

TreeFam database of animal gene trees

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TreeFami
TF315541

Family and domain databases

Database of protein disorder

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DisProti
DP02148

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013923 Autophagy-rel_prot_16
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08614 ATG16, 1 hit
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q676U5-1) [UniParc]FASTAAdd to basket
Also known as: APG16L beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS
60 70 80 90 100
VLAQKLQAEK HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH
110 120 130 140 150
KKRGELAQLV IDLNNQMQRK DREMQMNEAK IAECLQTISD LETECLDLRT
160 170 180 190 200
KLCDLERANQ TLKDEYDALQ ITFTALEGKL RKTTEENQEL VTRWMAEKAQ
210 220 230 240 250
EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI EVIVDETSDH
260 270 280 290 300
TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT
310 320 330 340 350
HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE
360 370 380 390 400
VFGEKCEFKG SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL
410 420 430 440 450
RHTLTGHSGK VLSAKFLLDN ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS
460 470 480 490 500
SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES IVREMELLGK ITALDLNPER
510 520 530 540 550
TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV VFSPDGSYVA
560 570 580 590 600
AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK

AVLWAQY
Length:607
Mass (Da):68,265
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A5816AE2CF03CA0
GO
Isoform 2 (identifier: Q676U5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-284: Missing.

Show »
Length:588
Mass (Da):66,296
Checksum:i168A0E53B2190149
GO
Isoform 3 (identifier: Q676U5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-470: IKTVFAGSSCNDIVCTEQCVMSGHFDKK → EEIQSLCLCICLDVSVEVCVCTSEPAFM
     471-607: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:470
Mass (Da):53,220
Checksum:i7598952D2C1F2A79
GO
Isoform 4 (identifier: Q676U5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-213: Missing.
     334-368: Missing.

Show »
Length:428
Mass (Da):47,686
Checksum:iE4F476255CDCA0A7
GO
Isoform 5 (identifier: Q676U5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-213: Missing.
     266-284: Missing.

Show »
Length:444
Mass (Da):49,486
Checksum:i7F0FE84A72D619F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVC7E7EVC7_HUMAN
Autophagy-related protein 16-1
ATG16L1
624Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAY7C9JAY7_HUMAN
Autophagy-related protein 16-1
ATG16L1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JK97C9JK97_HUMAN
Autophagy-related protein 16-1
ATG16L1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1B2C9J1B2_HUMAN
Autophagy-related protein 16-1
ATG16L1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8C6C9J8C6_HUMAN
Autophagy-related protein 16-1
ATG16L1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAF9F8WAF9_HUMAN
Autophagy-related protein 16-1
ATG16L1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15448 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB55412 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151K → R in BAB55412 (Ref. 6) Curated1
Sequence conflicti328V → A in BAB55412 (Ref. 6) Curated1
Sequence conflicti529P → T in BAB55412 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021834300T → A in IBD10; has no effect on the stability of the protein under normal conditions; enhances the cleavage and the degradation mediated by activated CASP3; results in reduced autophagy and defective clearance of intestinal pathogens; impairs interaction with TMEM59; slows TMEM59 intracellular trafficking; increases production of type I IFNs. 11 PublicationsCorresponds to variant dbSNP:rs2241880EnsemblClinVar.1
Natural variantiVAR_053386307E → K. Corresponds to variant dbSNP:rs1866878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01338970 – 213Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST144
Alternative sequenceiVSP_013386266 – 284Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_013390334 – 368Missing in isoform 4. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_013387443 – 470IKTVF…HFDKK → EEIQSLCLCICLDVSVEVCV CTSEPAFM in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_013388471 – 607Missing in isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY398617 mRNA Translation: AAR32130.1
EF079889 mRNA Translation: ABN48554.1
EF079890 mRNA Translation: ABN48555.1
AY358182 mRNA Translation: AAQ88549.1
AK026330 mRNA Translation: BAB15448.1 Sequence problems.
AK027854 mRNA Translation: BAB55412.1 Different initiation.
AK123876 mRNA Translation: BAC85713.1
AC013726 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71034.1
BC071846 mRNA Translation: AAH71846.1
AL834526 mRNA Translation: CAD39182.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2502.2 [Q676U5-2]
CCDS2503.2 [Q676U5-1]
CCDS54438.1 [Q676U5-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001177195.1, NM_001190266.1
NP_001177196.1, NM_001190267.1
NP_060444.3, NM_017974.3 [Q676U5-2]
NP_110430.5, NM_030803.6 [Q676U5-1]
NP_942593.2, NM_198890.2 [Q676U5-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347464; ENSP00000318259; ENSG00000085978 [Q676U5-5]
ENST00000373525; ENSP00000362625; ENSG00000085978 [Q676U5-4]
ENST00000392017; ENSP00000375872; ENSG00000085978 [Q676U5-1]
ENST00000392020; ENSP00000375875; ENSG00000085978 [Q676U5-2]
ENST00000625501; ENSP00000487542; ENSG00000281089 [Q676U5-1]
ENST00000626623; ENSP00000487298; ENSG00000281089 [Q676U5-5]
ENST00000630066; ENSP00000487446; ENSG00000281089 [Q676U5-2]
ENST00000630204; ENSP00000487455; ENSG00000281089 [Q676U5-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55054

UCSC genome browser

More...
UCSCi
uc002vtx.3 human [Q676U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY398617 mRNA Translation: AAR32130.1
EF079889 mRNA Translation: ABN48554.1
EF079890 mRNA Translation: ABN48555.1
AY358182 mRNA Translation: AAQ88549.1
AK026330 mRNA Translation: BAB15448.1 Sequence problems.
AK027854 mRNA Translation: BAB55412.1 Different initiation.
AK123876 mRNA Translation: BAC85713.1
AC013726 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW71034.1
BC071846 mRNA Translation: AAH71846.1
AL834526 mRNA Translation: CAD39182.1
CCDSiCCDS2502.2 [Q676U5-2]
CCDS2503.2 [Q676U5-1]
CCDS54438.1 [Q676U5-5]
RefSeqiNP_001177195.1, NM_001190266.1
NP_001177196.1, NM_001190267.1
NP_060444.3, NM_017974.3 [Q676U5-2]
NP_110430.5, NM_030803.6 [Q676U5-1]
NP_942593.2, NM_198890.2 [Q676U5-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GDKX-ray2.70C/F11-43[»]
4GDLX-ray2.88C11-43[»]
4NAWX-ray2.20C/G/K/O11-43[»]
4TQ0X-ray2.70B/D/F1-69[»]
5D7GX-ray3.00B/D/F/H1-69[»]
5NPVX-ray3.10B/D11-307[»]
5NPWX-ray3.10B/D/F/H11-307[»]
5NUVX-ray1.55A303-607[»]
SMRiQ676U5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120375, 700 interactors
ComplexPortaliCPX-200 ATG12-ATG5-ATG16L1 complex
CORUMiQ676U5
DIPiDIP-27552N
DIP-50290N
IntActiQ676U5, 45 interactors
MINTiQ676U5
STRINGi9606.ENSP00000375872

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiQ676U5
PhosphoSitePlusiQ676U5
SwissPalmiQ676U5

Polymorphism and mutation databases

BioMutaiATG16L1
DMDMi62510482

Proteomic databases

EPDiQ676U5
jPOSTiQ676U5
MassIVEiQ676U5
MaxQBiQ676U5
PaxDbiQ676U5
PeptideAtlasiQ676U5
PRIDEiQ676U5
ProteomicsDBi65982 [Q676U5-1]
65983 [Q676U5-2]
65984 [Q676U5-3]
65985 [Q676U5-4]
65986 [Q676U5-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55054

Genome annotation databases

EnsembliENST00000347464; ENSP00000318259; ENSG00000085978 [Q676U5-5]
ENST00000373525; ENSP00000362625; ENSG00000085978 [Q676U5-4]
ENST00000392017; ENSP00000375872; ENSG00000085978 [Q676U5-1]
ENST00000392020; ENSP00000375875; ENSG00000085978 [Q676U5-2]
ENST00000625501; ENSP00000487542; ENSG00000281089 [Q676U5-1]
ENST00000626623; ENSP00000487298; ENSG00000281089 [Q676U5-5]
ENST00000630066; ENSP00000487446; ENSG00000281089 [Q676U5-2]
ENST00000630204; ENSP00000487455; ENSG00000281089 [Q676U5-4]
GeneIDi55054
KEGGihsa:55054
UCSCiuc002vtx.3 human [Q676U5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55054
DisGeNETi55054
EuPathDBiHostDB:ENSG00000085978.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATG16L1
HGNCiHGNC:21498 ATG16L1
HPAiHPA012577
HPA063900
MalaCardsiATG16L1
MIMi610767 gene
611081 phenotype
neXtProtiNX_Q676U5
OpenTargetsiENSG00000085978
Orphaneti206 NON RARE IN EUROPE: Crohn disease
PharmGKBiPA134902949

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0288 Eukaryota
ENOG410XQYA LUCA
GeneTreeiENSGT00940000153936
HOGENOMiHOG000112569
InParanoidiQ676U5
KOiK17890
OrthoDBi404224at2759
PhylomeDBiQ676U5
TreeFamiTF315541

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SignaLinkiQ676U5
SIGNORiQ676U5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATG16L1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATG16L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55054
PharosiQ676U5 Tbio

Protein Ontology

More...
PROi
PR:Q676U5
RNActiQ676U5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000085978 Expressed in 193 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ676U5 baseline and differential
GenevisibleiQ676U5 HS

Family and domain databases

DisProtiDP02148
Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR013923 Autophagy-rel_prot_16
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08614 ATG16, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA16L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q676U5
Secondary accession number(s): A3EXK9
, A3EXL0, B6ZDH0, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: December 11, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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