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Entry version 97 (12 Aug 2020)
Sequence version 1 (11 Oct 2004)
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Protein
Submitted name:

CIITA IV

Gene

MHC2TA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CIITA IVImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MHC2TAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30795

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q66X48

PRoteomics IDEntifications database

More...
PRIDEi
Q66X48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q66X48, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini391 – 701NACHTInterPro annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni248 – 279DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi257 – 271PolarSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K08060

Database of Orthologous Groups

More...
OrthoDBi
28098at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR008095, MHC_II_transact
IPR007111, NACHT_NTPase
IPR041267, NLRC_HD2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 3 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01719, MHCIIACTVATR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 4 hits
PS50837, NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q66X48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGPLEGGY LEPLNSDADP LCLYHFYDQM DLAGEEEIEL YSEPDTDTIN
60 70 80 90 100
CDQFSRLLCD MEGDEETREA YANIAELDQY VFQDSQLEGL SKDIFIEHIG
110 120 130 140 150
PDEVIGESME MPAEVGQKSQ KRPFPEELPA DLKHWKPAEP PTVVAGSLLV
160 170 180 190 200
GPVSDCSTLS CLPLPALFNQ EPASGQMRLE KTDQIPMPFS SSSLSCLNLP
210 220 230 240 250
EGPIQFVPTI STLPHGLWQI SEAGTGVSSI FIYHGEVPQA SQVPPPSGFT
260 270 280 290 300
VHGLPTSPDR PGSTSPFAPS ATDLPSMPEP ALTSRANMTE HKTSPTQCPA
310 320 330 340 350
AGEVSNKLPK WPEPVEQFYR SLQDTYGAEP AGPDGILVEV DLVQARLERS
360 370 380 390 400
SSKGLERELA TPDWAERQLA QGGLAEVLLA AKEHRRPRET RVIAVLGKAG
410 420 430 440 450
QGKSYWAGAV SRAWACGRLP QYDFVFSVPC HCLNRPGDAY GLQDLLFSLG
460 470 480 490 500
PQPLVAADEV FSHILKRPDR VLLILDGFEE LEAQDGFLHS TCGPAPAEPC
510 520 530 540 550
SLRGLLAGLF QKKLLRGCTL LLTARPRGRL VQSLSKADAL FELSGFSMEQ
560 570 580 590 600
AQAYVMRYFE SSGMTEHQDR ALTLLRDRPL LLSHSHSPTL CRAVCQLSEA
610 620 630 640 650
LLELGEDAKL PSTLTGLYVG LLGRAALGSP PGALAELAKL AWELGRRHQS
660 670 680 690 700
TLQEDQFPSA DVRTWAMAKG LVQHPPRAAE SELAFPSFLL QCFLGALWLA
710 720 730 740 750
LSGEIKDKEL PQYLALTPRK KRPYDNWLEG VPRFLAGLIF QPPARCLGAL
760 770 780 790 800
LGPSAAASVD RKQKVLARYL KRLQPGTLRA RQLLELLHCA HEAEEAGIWQ
810 820 830 840 850
HVVQELPGRL SFLGTRLTPL DAHVLGKALE AAGQDFSLDL RSTGICPSGL
860 870 880 890 900
GSLVGLSCVT RFRAALSDTV ALWESLRQHG ETKLLQAAEE KFTIEPFKAK
910 920 930 940 950
SLKDVEDLGK LVQTQRTRSS SEDTAGELPA VRDLKKLEFA LGPVSGPQAF
960 970 980 990 1000
PKLVRILTAF SSLQHLDLDA LSENKIGDEG VSQLSATFPQ LKSLETLNLS
1010 1020 1030 1040 1050
QNNITDLGAY KLAEALPSLA ASLLRLSLYN NCICDVGAES LARVLPDMVS
1060 1070 1080 1090 1100
LRVMDVQYNK FTAAGAQQLA ASLRRCPHVE TLAMWTPTIP FSVQEHLQQQ

DSRISLR
Length:1,107
Mass (Da):120,936
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16A1103F13FC3663
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY699071 mRNA Translation: AAU06586.1

NCBI Reference Sequences

More...
RefSeqi
NP_000237.2, NM_000246.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4261

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY699071 mRNA Translation: AAU06586.1
RefSeqiNP_000237.2, NM_000246.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ66X48
PRIDEiQ66X48

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4261

Genome annotation databases

GeneIDi4261
KEGGihsa:4261

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4261
PharmGKBiPA30795

Phylogenomic databases

KOiK08060
OrthoDBi28098at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4261, 2 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CIITA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4261

Gene expression databases

GenevisibleiQ66X48, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR008095, MHC_II_transact
IPR007111, NACHT_NTPase
IPR041267, NLRC_HD2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF13516, LRR_6, 3 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PRINTSiPR01719, MHCIIACTVATR
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 4 hits
PS50837, NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ66X48_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66X48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 12, 2020
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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