UniProtKB - Q66X19 (NAL4E_MOUSE)
Protein
NACHT, LRR and PYD domains-containing protein 4E
Gene
Nlrp4e
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 154 – 161 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- inflammatory response Source: UniProtKB-KW
Keywordsi
Biological process | Inflammatory response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: NACHT, LRR and PYD domains-containing protein 4EAlternative name(s): NALP-epsilon |
Gene namesi | Name:Nlrp4e Synonyms:Nalp4e, Nlrp4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3056600, Nlrp4e |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286332 | 1 – 978 | NACHT, LRR and PYD domains-containing protein 4EAdd BLAST | 978 |
Proteomic databases
MaxQBi | Q66X19 |
PaxDbi | Q66X19 |
PRIDEi | Q66X19 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000045693, Expressed in primary oocyte and 21 other tissues |
Genevisiblei | Q66X19, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000075794 |
Miscellaneous databases
RNActi | Q66X19, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 93 | PyrinPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 148 – 471 | NACHTPROSITE-ProRule annotationAdd BLAST | 324 | |
Repeati | 594 – 617 | LRR 1Add BLAST | 24 | |
Repeati | 694 – 717 | LRR 2Add BLAST | 24 | |
Repeati | 746 – 773 | LRR 3Add BLAST | 28 | |
Repeati | 802 – 825 | LRR 4Add BLAST | 24 | |
Repeati | 859 – 882 | LRR 5Add BLAST | 24 | |
Repeati | 916 – 940 | LRR 6Add BLAST | 25 |
Sequence similaritiesi
Belongs to the NLRP family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502SGVH, Eukaryota |
GeneTreei | ENSGT00940000162284 |
HOGENOMi | CLU_002274_2_1_1 |
InParanoidi | Q66X19 |
OMAi | PSSHLWI |
OrthoDBi | 1580402at2759 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS51450, LRR, 4 hits PS50837, NACHT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q66X19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASFFSDFGL MWYLEELNKK EFMKFKELLQ QEILQLGLKH ISWTEVKKAS
60 70 80 90 100
REDLANLLLK HYEEKKAWDM TFKIFQKMNR QDLMERAGRE IAGHSKLYQV
110 120 130 140 150
HLKKKLTHDY ARKFNIKDQD SLKQKFTQDD CDHFENLLIS KATGKKPHMV
160 170 180 190 200
FLQGVAGIGK SLMLTKLMLA WSEGMVFQNK FSYIFYFCCQ DVKKMKRASL
210 220 230 240 250
AELISKEWPN ASAPIEEILS QPEKLLFVID NLEVMECDMS EWESELCDDC
260 270 280 290 300
MEKQPVNILM SSLLRRKMLP ESSFLVSATP ETFEKIEDRI ECTNVKMMAG
310 320 330 340 350
FNESSIKVYF YSLFQDRNRT QEIFSLVREN EQLFSVCQVP VLCWMVATCL
360 370 380 390 400
KKEIEKGRDP VSICRRITSL YTTYIFNLFI PHSAQYPSKK SQDQLQGLCS
410 420 430 440 450
LAAEGMWTDT FVFAEEALRR NGIMDSDIST LLDVRILEKS KESEKSYIFL
460 470 480 490 500
HPSIQEVCAA IFHLLKSHVD HPSQDVKSIE ALIFTFLKKV KIQWIFFGSF
510 520 530 540 550
IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNK ELQEQIDGMK
560 570 580 590 600
LFYCLFEMDD EAFLPQVMNC MEQIKFVAKD YSDVIVAAHC LQHCSTLKKL
610 620 630 640 650
SLSTQNILSE GQEHSYTEKL LICWHHVCSV LTSSKDIHVL QVKDTNFNER
660 670 680 690 700
AFLVLYSHLK YPSCILKVLE VNNVTLLCDN RLLFELIQNQ RLQLLNLSLT
710 720 730 740 750
FLSHNDVKLL CDVLNQAECN IEKLMVADCN LSPDDCKVFV SVLISSKMLK
760 770 780 790 800
HLNLSSNNLD KGISSLSKAL CHPDCVLKNL VLAKCSLSEE CWHYLSEVLR
810 820 830 840 850
RNKTLTHLDI SFNDLKDEGL KVLCGALTLP DSVLISLSVR YCLITTSGCQ
860 870 880 890 900
DLAEVLRNNQ NLRNLQISNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA
910 920 930 940 950
LTGACCEDLA SSFTHCKTLL GINLQENALD HSGLVALFEA MKQQQCTVNL
960 970
RGLRITDFDK ETQEFLMAEK EKNPYLSI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 135 | E → G in AAU06318 (PubMed:15317747).Curated | 1 | |
Sequence conflicti | 590 | C → S in AAU06318 (PubMed:15317747).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY596197 mRNA Translation: AAU06318.1 AC150900 Genomic DNA No translation available. |
CCDSi | CCDS20928.1 |
RefSeqi | NP_001004194.2, NM_001004194.2 |
Genome annotation databases
Ensembli | ENSMUST00000076470; ENSMUSP00000075794; ENSMUSG00000045693 |
GeneIDi | 446099 |
KEGGi | mmu:446099 |
UCSCi | uc009fod.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY596197 mRNA Translation: AAU06318.1 AC150900 Genomic DNA No translation available. |
CCDSi | CCDS20928.1 |
RefSeqi | NP_001004194.2, NM_001004194.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000075794 |
Proteomic databases
MaxQBi | Q66X19 |
PaxDbi | Q66X19 |
PRIDEi | Q66X19 |
Genome annotation databases
Ensembli | ENSMUST00000076470; ENSMUSP00000075794; ENSMUSG00000045693 |
GeneIDi | 446099 |
KEGGi | mmu:446099 |
UCSCi | uc009fod.2, mouse |
Organism-specific databases
CTDi | 446099 |
MGIi | MGI:3056600, Nlrp4e |
Phylogenomic databases
eggNOGi | ENOG502SGVH, Eukaryota |
GeneTreei | ENSGT00940000162284 |
HOGENOMi | CLU_002274_2_1_1 |
InParanoidi | Q66X19 |
OMAi | PSSHLWI |
OrthoDBi | 1580402at2759 |
Miscellaneous databases
BioGRID-ORCSi | 446099, 1 hit in 17 CRISPR screens |
ChiTaRSi | Nlrp4e, mouse |
PROi | PR:Q66X19 |
RNActi | Q66X19, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045693, Expressed in primary oocyte and 21 other tissues |
Genevisiblei | Q66X19, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS51450, LRR, 4 hits PS50837, NACHT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAL4E_MOUSE | |
Accessioni | Q66X19Primary (citable) accession number: Q66X19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families