UniProtKB - Q66X05 (NAL4F_MOUSE)
Protein
NACHT, LRR and PYD domains-containing protein 4F
Gene
Nlrp4f
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 153 – 160 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- inflammatory response Source: UniProtKB-KW
Keywordsi
Biological process | Inflammatory response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: NACHT, LRR and PYD domains-containing protein 4FAlternative name(s): NALP-kappa |
Gene namesi | Name:Nlrp4f Synonyms:Nalp4f |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2145528, Nlrp4f |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286338 | 1 – 959 | NACHT, LRR and PYD domains-containing protein 4FAdd BLAST | 959 |
Proteomic databases
EPDi | Q66X05 |
PRIDEi | Q66X05 |
PTM databases
iPTMneti | Q66X05 |
PhosphoSitePlusi | Q66X05 |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000041908 |
Miscellaneous databases
RNActi | Q66X05, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 92 | PyrinAdd BLAST | 92 | |
Domaini | 147 – 470 | NACHTPROSITE-ProRule annotationAdd BLAST | 324 | |
Repeati | 593 – 616 | LRR 1Add BLAST | 24 | |
Repeati | 632 – 656 | LRR 2Add BLAST | 25 | |
Repeati | 686 – 709 | LRR 3Add BLAST | 24 | |
Repeati | 715 – 738 | LRR 4Add BLAST | 24 | |
Repeati | 743 – 766 | LRR 5Add BLAST | 24 | |
Repeati | 812 – 835 | LRR 6Add BLAST | 24 | |
Repeati | 841 – 864 | LRR 7Add BLAST | 24 | |
Repeati | 869 – 892 | LRR 8Add BLAST | 24 |
Sequence similaritiesi
Belongs to the NLRP family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502SGVH, Eukaryota |
InParanoidi | Q66X05 |
PhylomeDBi | Q66X05 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 1 hit PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50837, NACHT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q66X05-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASFISDFGL IWYLRELNKK EFMKFKDFLI QEILELKLKQ VSSTKVKKAS
60 70 80 90 100
REDLANLLLK CGENQAWDMT FRILQKINRK DLTERATGAI VGNPNLYRDH
110 120 130 140 150
LKKKLTHDCP KKFNVRIQDF IKETFIQNDX DAFENLLISK GTERKPHMVF
160 170 180 190 200
LKGMAGVGKT LMLKNLMLAW SKGLVFQNKF SYAFYFCCQD VKQLKTASLA
210 220 230 240 250
ELISREWPSP SAPIEEILSQ PEKLLFIIDS LEGMEWDLTK QESELCDDCM
260 270 280 290 300
EKQPVSTLLS SLLRRKMLPE SSLLLSTTPE TFEKMEDRIQ CTDVKTATAF
310 320 330 340 350
DERSMKIYFH RLFQDRKRAQ EAFSLVRENK QLFTICQVPL LCWMVATCLK
360 370 380 390 400
EEIEKGGDPV SLCRRTTSLY TTHIFSLFIP QSAQYPSKKS QDQLQGLCSL
410 420 430 440 450
AAEGMWTDTF VFGKEALRRN GIFDSDIPTL LDIGMLGKIR EFENSYIFLH
460 470 480 490 500
PSVQEVCAAI FYMLKRHVEH PSQDVKNIET VLFMFLKKVK TQWIFLGCFI
510 520 530 540 550
FGLLQKSEQE KLGVFFGHRL SKNIHHKLYQ CLETLSGNAE LQEQIDGMRL
560 570 580 590 600
FSCLFEMEDE AFLVKAMNCM QQINFVAKNY SDFIVAAYCL KHCSTLKKLS
610 620 630 640 650
FSTENVLNEG DQSYMEELLI CWNNMCSVFV RSKDIQELRI KDTNFNEPAI
660 670 680 690 700
RVLYESLKYP SFTLNKLVAN NVSFGDNHVL FELIQNSSLQ YLDLSCSFLS
710 720 730 740 750
HNEVKLLCDI LNQAECNIEK LMIAHCKLSP DDCKIFGSIL MSSKSLKVLN
760 770 780 790 800
LASNNLNQGI SSLCKALCHP HCTLEYLVPR SNHCIVNFLL KLSCCGITER
810 820 830 840 850
GCQDLAEVLK NNQNLKYLHV SYNKLKDTGV MLLCDAIKHP NCHLKDLQLE
860 870 880 890 900
ACEITDASNE ELCYAFMQCE TLQTLNLMGN AFEVSRMVFF PRKSELMLFI
910 920 930 940 950
FLHLSRLWIT DFDNEFQAFL LSVKKKNHFL TIRGSVEADG EKKGGDSDAR
TMGELSNEI
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketL7N1W9 | L7N1W9_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 937 | Annotation score: | ||
A0A1Y7VN33 | A0A1Y7VN33_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 65 | Annotation score: | ||
A0A1Y7VM62 | A0A1Y7VM62_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 181 | Annotation score: | ||
A0A1Y7VNE6 | A0A1Y7VNE6_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 84 | Annotation score: | ||
A0A1Y7VJ74 | A0A1Y7VJ74_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 112 | Annotation score: | ||
A0A1Y7VJD8 | A0A1Y7VJD8_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 806 | Annotation score: | ||
A0A1Y7VJR6 | A0A1Y7VJR6_MOUSE | NACHT, LRR and PYD domains-containi... | Nlrp4f | 172 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY596201 mRNA Translation: AAU06322.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY596201 mRNA Translation: AAU06322.1 |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000041908 |
PTM databases
iPTMneti | Q66X05 |
PhosphoSitePlusi | Q66X05 |
Proteomic databases
EPDi | Q66X05 |
PRIDEi | Q66X05 |
Organism-specific databases
MGIi | MGI:2145528, Nlrp4f |
Phylogenomic databases
eggNOGi | ENOG502SGVH, Eukaryota |
InParanoidi | Q66X05 |
PhylomeDBi | Q66X05 |
Miscellaneous databases
ChiTaRSi | Nlrp4f, mouse |
PROi | PR:Q66X05 |
RNActi | Q66X05, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 1 hit PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50837, NACHT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAL4F_MOUSE | |
Accessioni | Q66X05Primary (citable) accession number: Q66X05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | October 11, 2004 | |
Last modified: | October 7, 2020 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families