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Protein

NACHT, LRR and PYD domains-containing protein 9A

Gene

Nlrp9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in inflammation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 156ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 9A
Alternative name(s):
NALP-theta
Gene namesi
Name:Nlrp9a
Synonyms:Nalp9a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2675292 Nlrp9a

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863351 – 949NACHT, LRR and PYD domains-containing protein 9AAdd BLAST949

Proteomic databases

PRIDEiQ66X03

Expressioni

Tissue specificityi

Oocyte specific.1 Publication

Gene expression databases

CleanExiMM_NLRP9A

Structurei

3D structure databases

ProteinModelPortaliQ66X03
SMRiQ66X03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94PyrinAdd BLAST94
Domaini143 – 465NACHTPROSITE-ProRule annotationAdd BLAST323
Repeati695 – 716LRR 1Add BLAST22
Repeati724 – 745LRR 2Add BLAST22
Repeati752 – 772LRR 3Add BLAST21
Repeati781 – 802LRR 4Add BLAST22
Repeati809 – 829LRR 5Add BLAST21

Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000294064
HOVERGENiHBG063656
InParanoidiQ66X03
KOiK22663

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 2 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50837 NACHT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66X03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDSSGYGLL QYLQKLSDEE FQRFKEHLRK EPEKFKLKPI SWTKIKNTSK
60 70 80 90 100
EDLVMQLYTH YPGKAWDMVL SLFLQVNRED LSTMAQTERR DKQTKYKEFM
110 120 130 140 150
KNTFQHIWTM ETNTYIPDRS YHEFIEVQYR ALQDIFDCES EPVTVVVSGS
160 170 180 190 200
RGGGKTTFLR KAMLDWASRN LLQNRFQYVF HFSVFSLNNI TELSLAELIS
210 220 230 240 250
STLPESSETV DDILSDPKRI LFILDGFDYL KFDLELRTNL CNDWRKKLPI
260 270 280 290 300
QIVLSSLLQK IMLPECSLLL ELGNASLSNI IPLLQYPREI IMSGFSEQTI
310 320 330 340 350
EIYCVSFFNT QTGVEIFKNL KSIKPLFNLC RCPHLCWMIC STIKWQYERR
360 370 380 390 400
EVASRFGRTL GLLYTIFMVS AFKSTYARNP SKQNRARIRT LCTLAVEGMW
410 420 430 440 450
KQVYVFDSDD LRRNGISESD KKVWLRMKFL QNQGSNIVFY HSTLQWYFAV
460 470 480 490 500
LFYFLQYKDT RHPVIGNLAQ LLGEIYAHKQ NQWFHTRILL FGMATEQVNS
510 520 530 540 550
LLEPCFGCIS SKEVRQEIIR YIKSLSQQEC NEKLVVHPQN LFFCILDNQE
560 570 580 590 600
ERFVRQLMDR FEEMTVDISD VDDMSATPYC LHRAPKVKNL HLHIQKRVFL
610 620 630 640 650
EIHDPEYGDL ELFKLGQKCS FTTNFGDGLL FCTFLHLPHL KYMNLYGTNL
660 670 680 690 700
SNDAVERLCS ALKFSTCGVE ELLLGKCDIS SEACGIIAAS LINSEVKHLS
710 720 730 740 750
LVENPLKNKG VMSLCEMLKD PSCVLESLML SYCCLTFIAC GHLYEALLSN
760 770 780 790 800
EHLSLLDLGS NFLEDTGVNL LCEALKDPNC TLKELWLPGC YLTSECCEEI
810 820 830 840 850
SAVLTCNTNL KTLKLGNNNI QDTGVKRLCE ALCHPNCEMQ CLGLDMCDFT
860 870 880 890 900
SDCCEDLALV LTTCNTLKSL NLDWNAFDHS GLEMLCKALN HKACNLEVLG
910 920 930 940
LDKSLFSEES QTLLQAVEKK NKNLKVLHFP WLKEELEKRG VRLVWNSKN
Length:949
Mass (Da):109,680
Last modified:October 11, 2004 - v1
Checksum:i6CFA098FB8DE22FA
GO
Isoform 2 (identifier: Q66X03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     788-844: Missing.
     944-949: VWNSKN → KLLEVERAGIGFPGTVVTGNNELPGMKSLPPESTRSTGGTVTSLV

Show »
Length:931
Mass (Da):107,345
Checksum:i0B5EB9E17EA053B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181H → Y in AAQ63459 (Ref. 2) Curated1
Sequence conflicti616G → D in AAQ63459 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025022788 – 844Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_025023944 – 949VWNSKN → KLLEVERAGIGFPGTVVTGN NELPGMKSLPPESTRSTGGT VTSLV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596202 mRNA Translation: AAU06323.1
AY364009 mRNA Translation: AAQ63459.1
CCDSiCCDS39845.1 [Q66X03-1]
RefSeqiNP_001041684.1, NM_001048219.2
NP_001041685.1, NM_001048220.2
UniGeneiMm.11889

Genome annotation databases

GeneIDi233001
KEGGimmu:233001
UCSCiuc012fge.1 mouse [Q66X03-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNLR9A_MOUSE
AccessioniPrimary (citable) accession number: Q66X03
Secondary accession number(s): Q6UQE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2004
Last modified: July 18, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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