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Entry version 119 (12 Aug 2020)
Sequence version 1 (11 Oct 2004)
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Protein

Pleckstrin homology domain-containing family G member 5

Gene

Plekhg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (PubMed:29084947). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (PubMed:21543326). Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648, NRAGE signals death through JNK
R-MMU-194840, Rho GTPase cycle
R-MMU-416482, G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 5
Short name:
PH domain-containing family G member 5
Alternative name(s):
Synectin-binding RhoA exchange factor
Short name:
SYX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plekhg5
Synonyms:Kiaa0720, Syx
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2652860, Plekhg5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Animals develop normally and show no clear neurologic symptoms as adults. However, electrophysiologic studies indicated that mutant mice have decreased motor nerve conduction velocities and delayed compound action potentials. Mutant mice perform slightly less well than control mice in the rotarod test (PubMed:23777631). Deficient mice have no motoneuron loss during their first year. A loss of motoneurons starts at 12 months and this decrease is more prominent in 24-month-old animals. Biogenesis of autophagosomes is impaired in Plekhg5-deficient motoneurons resulting in a reduced number of retrogradely transported autophagosomes (PubMed:29084947).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003071351 – 1073Pleckstrin homology domain-containing family G member 5Add BLAST1073

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei793PhosphothreonineCombined sources1
Modified residuei798PhosphoserineCombined sources1
Modified residuei909PhosphothreonineCombined sources1
Modified residuei911PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q66T02

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q66T02

PRoteomics IDEntifications database

More...
PRIDEi
Q66T02

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q66T02

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q66T02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neurons and glial cells of the peripheral nervous system, with highest levels of expression in the brain and sciatic nerve endoneurium. Isoform 2 is expressed at detectable levels only in malignant cells.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Regulated during development, with the highest level at postnatal days 10 to 14, suggesting a role in myelination of the peripheral nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039713, Expressed in primary visual cortex and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q66T02, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q66T02, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GIPC1/synectin and RHOA.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
234677, 13 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q66T02

Protein interaction database and analysis system

More...
IntActi
Q66T02, 10 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081132

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q66T02, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q66T02

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini406 – 598DHPROSITE-ProRule annotationAdd BLAST193
Domaini654 – 754PHPROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi107 – 111Poly-Glu5
Compositional biasi369 – 373Poly-Glu5
Compositional biasi778 – 790Poly-GluAdd BLAST13

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3521, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000046843

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q66T02

KEGG Orthology (KO)

More...
KOi
K19464

Database of Orthologous Groups

More...
OrthoDBi
556467at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q66T02

TreeFam database of animal gene trees

More...
TreeFami
TF316755

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR040181, PKHG5/7
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR13217, PTHR13217, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q66T02-1) [UniParc]FASTAAdd to basket
Also known as: SYX1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTGPGVSGR RAAARPSSEL PSPDSQLLWV GGHAHSSDSQ VCHHADCQQL
60 70 80 90 100
HHRGPLNLCE TCDSKFHSTL HYDGHVRFDL PPQGSVLARN VSTRSCPPRT
110 120 130 140 150
SPAADLEEEE EGCTDGKGDR KSAGLKISKK KARRRHTDDP SKECFTLKFD
160 170 180 190 200
LNVDIETEIV PAMKKKSLGE VLLPVFERKG IALGKVDIYL DQSNTPLSLT
210 220 230 240 250
FEAYRFGGHY LRVKAKPGDE GKVEQGVKDS KSLSLPALRP SGAGPPVSER
260 270 280 290 300
VDPQSRRESS LDILAPGRRR KNMSEFLGEA GIPGHEPPAP SSCSLPVGSS
310 320 330 340 350
GGTSSGINES WKNRAASRFS GFFSSSPSTS AFSREVDKME QLESKLHAYS
360 370 380 390 400
LFGLPRMPRR LRFDHDSWEE EEEDDEEDEE SSGLRLEDSW RELTDGHEKL
410 420 430 440 450
TRRQCHQQEA VWELLHTEVS YIRKLRVITN LFLCCLLNLQ ESGLLCEVEA
460 470 480 490 500
ERLFSNIPEI AKLHRGLWGS VMVPVLEKAR RTRALLQPSD FLKGFKMFGS
510 520 530 540 550
LFKPYIRYCM EEEGCMEYMR GLLRDNDLFR AYVTWAEKHQ QCQRLKLSDM
560 570 580 590 600
LAKPHQRLTK YPLLLKSVLR KTDDPRTKEA IVTMISSVER FIHHVNTCMR
610 620 630 640 650
QRQERQRLAG VVSRIDAYEV VEGSNDEVDK LLKEFLHLDL TAPMPGTSPE
660 670 680 690 700
ETRQLLLEGS LRMKEGKDSK MDVYCFLFTD LLLVTKAVKK AERTKVIRPP
710 720 730 740 750
LLVDKIVCRE LRDPGSFLLI YLNEFHSAVG AYTFQASSQA LCRSWVDTIY
760 770 780 790 800
NAQNQLQQLR AQLSAQEHPG SQHLQSLEEE EDEQEEEGEE SGTSAASSPT
810 820 830 840 850
ILRKSSNSLD SEHCTSDGST ETLAMVVVEP GATLSSPEFE GGPVSSQSDE
860 870 880 890 900
SSLSNTASSV TPTSELLPLG PVDGRSCSMD SAYGTLSPTS LQDFVAPHPV
910 920 930 940 950
VEPAPVPQTP SPQPSPRLRR RTPVQLLPRP PRLLKSKSEA SLLQLLSGTP
960 970 980 990 1000
AARGVPPAPS RSLSELCLIS VAPGVRTQRP LQEGGPGWNG PGMCDPCHGP
1010 1020 1030 1040 1050
QLSESENRPS HMTGGPADSA RRRCREMPSG TMSRVQSEPP SGVSAQHRKL
1060 1070
TLAQLYRIRT TLLLNSTLTA SEV
Length:1,073
Mass (Da):118,924
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE34A0B88D61CEE2B
GO
Isoform 2 (identifier: Q66T02-2) [UniParc]FASTAAdd to basket
Also known as: SYX2

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1073: Missing.

Show »
Length:1,071
Mass (Da):118,696
Checksum:i9B88D61CEE2BFEDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AS67B1AS67_MOUSE
Pleckstrin homology domain-containi...
Plekhg5
1,060Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQC2A0A0A0MQC2_MOUSE
Pleckstrin homology domain-containi...
Plekhg5
1,041Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPI8A0A5F8MPI8_MOUSE
Pleckstrin homology domain-containi...
Plekhg5
1,103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM24581 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285871072 – 1073Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY605057 mRNA Translation: AAU04953.1
AY605058 mRNA Translation: AAU04954.1
AL772240, AL611927 Genomic DNA Translation: CAM19697.1
AL772240, AL611927 Genomic DNA Translation: CAM19699.2
AL611927, AL772240 Genomic DNA Translation: CAM24581.1 Sequence problems.
AL611927, AL772240 Genomic DNA Translation: CAM24582.2
AK129198 mRNA Translation: BAC98008.1
BC023181 mRNA Translation: AAH23181.1
BC064091 mRNA Translation: AAH64091.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18987.2 [Q66T02-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001272928.1, NM_001285999.1 [Q66T02-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084115; ENSMUSP00000081132; ENSMUSG00000039713 [Q66T02-2]
ENSMUST00000105661; ENSMUSP00000101286; ENSMUSG00000039713 [Q66T02-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
269608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:269608

UCSC genome browser

More...
UCSCi
uc008vzh.2, mouse [Q66T02-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY605057 mRNA Translation: AAU04953.1
AY605058 mRNA Translation: AAU04954.1
AL772240, AL611927 Genomic DNA Translation: CAM19697.1
AL772240, AL611927 Genomic DNA Translation: CAM19699.2
AL611927, AL772240 Genomic DNA Translation: CAM24581.1 Sequence problems.
AL611927, AL772240 Genomic DNA Translation: CAM24582.2
AK129198 mRNA Translation: BAC98008.1
BC023181 mRNA Translation: AAH23181.1
BC064091 mRNA Translation: AAH64091.1
CCDSiCCDS18987.2 [Q66T02-1]
RefSeqiNP_001272928.1, NM_001285999.1 [Q66T02-1]

3D structure databases

SMRiQ66T02
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234677, 13 interactors
ELMiQ66T02
IntActiQ66T02, 10 interactors
STRINGi10090.ENSMUSP00000081132

PTM databases

iPTMnetiQ66T02
PhosphoSitePlusiQ66T02

Proteomic databases

jPOSTiQ66T02
PaxDbiQ66T02
PRIDEiQ66T02

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27380, 142 antibodies

The DNASU plasmid repository

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DNASUi
269608

Genome annotation databases

EnsembliENSMUST00000084115; ENSMUSP00000081132; ENSMUSG00000039713 [Q66T02-2]
ENSMUST00000105661; ENSMUSP00000101286; ENSMUSG00000039713 [Q66T02-1]
GeneIDi269608
KEGGimmu:269608
UCSCiuc008vzh.2, mouse [Q66T02-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57449
MGIiMGI:2652860, Plekhg5

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3521, Eukaryota
GeneTreeiENSGT00510000046843
InParanoidiQ66T02
KOiK19464
OrthoDBi556467at2759
PhylomeDBiQ66T02
TreeFamiTF316755

Enzyme and pathway databases

ReactomeiR-MMU-193648, NRAGE signals death through JNK
R-MMU-194840, Rho GTPase cycle
R-MMU-416482, G alpha (12/13) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
269608, 5 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plekhg5, mouse

Protein Ontology

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PROi
PR:Q66T02
RNActiQ66T02, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000039713, Expressed in primary visual cortex and 240 other tissues
ExpressionAtlasiQ66T02, baseline and differential
GenevisibleiQ66T02, MM

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR040181, PKHG5/7
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR13217, PTHR13217, 1 hit
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHG5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66T02
Secondary accession number(s): A2A8B6
, A2A8B7, Q66T00, Q6P3B1, Q6ZQ62, Q8R571
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 11, 2004
Last modified: August 12, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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