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UniProtKB - Q66MH4 (Q66MH4_RAT)

Entry version 146 (29 Sep 2021)
Sequence version 1 (11 Oct 2004)
Previous versions | rss
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Protein
Submitted name:

Breast cancer susceptibility protein 2

Gene

Brca2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processDNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Breast cancer susceptibility protein 2Imported
Submitted name:
Breast cancer type 2 susceptibility protein homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brca2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...RGDi		2219, Brca2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q66MH4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q66MH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000001111, Expressed in brain and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q66MH4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati984 – 1018BRCA2PROSITE-ProRule annotationAdd BLAST35
Repeati1197 – 1231BRCA2PROSITE-ProRule annotationAdd BLAST35
Repeati1405 – 1439BRCA2PROSITE-ProRule annotationAdd BLAST35
Repeati1503 – 1537BRCA2PROSITE-ProRule annotationAdd BLAST35
Repeati1939 – 1973BRCA2PROSITE-ProRule annotationAdd BLAST35
Repeati2019 – 2053BRCA2PROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2761 – 2802TowerInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 66DisorderedSequence analysisAdd BLAST29
Regioni348 – 381DisorderedSequence analysisAdd BLAST34
Regioni2059 – 2139DisorderedSequence analysisAdd BLAST81
Regioni2296 – 2356DisorderedSequence analysisAdd BLAST61
Regioni2377 – 2407DisorderedSequence analysisAdd BLAST31
Regioni3114 – 3163DisorderedSequence analysisAdd BLAST50
Regioni3231 – 3255DisorderedSequence analysisAdd BLAST25
Regioni3289 – 3343DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2775 – 2795Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 381Polar residuesSequence analysisAdd BLAST26
Compositional biasi2081 – 2139Polar residuesSequence analysisAdd BLAST59
Compositional biasi2300 – 2346Polar residuesSequence analysisAdd BLAST47
Compositional biasi3115 – 3163Polar residuesSequence analysisAdd BLAST49
Compositional biasi3289 – 3313Polar residuesSequence analysisAdd BLAST25
Compositional biasi3314 – 3335Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000344_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		NCELYYQ

Database of Orthologous Groups

More...OrthoDBi		257485at2759

TreeFam database of animal gene trees

More...TreeFami		TF105041

Family and domain databases

Conserved Domains Database

More...CDDi		cd04493, BRCA2DBD_OB1, 1 hit
cd04495, BRCA2DBD_OB3, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR002093, BRCA2_repeat
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom

The PANTHER Classification System

More...PANTHERi		PTHR11289, PTHR11289, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF00634, BRCA2, 7 hits
PF09121, Tower, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002397, BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01341, Tower, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50138, BRCA2_REPEAT, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q66MH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVEYKRRPT FWEIFKARCS TADLGPISLN WFEELSSEAP PYNTEPPEES 
        60         70         80         90        100
EYKPQGHEPQ LFKTPQRNPS YHQFASTPIM FKEQSQTLPL DQSPFKELGN 
       110        120        130        140        150
VVANSKRKHH SKKKARKDPV VDVASLPLKA CPSESPCTPR CTQVAPQRRK 
       160        170        180        190        200
PVVSGSLFYT PKLEETPKHI SESLGVEVDP DMSWTSSLAT PPTLSSTVLI 
       210        220        230        240        250
ARDEEAHRNA FPADSPASLK SYFSNHNESL KKNDRFIPSV SDSENKSQQE 
       260        270        280        290        300
AFSQGLEKML GDSSSKINRF RDCLRKPIPN VLEDGETAVD TSGEDSFSLC 
       310        320        330        340        350
FPKRRTRNLQ KTRMGKMKKK IFSETRTDGL SEEARGQADD KNSFALEIEP 
       360        370        380        390        400
RDSEPLDPSV TNQKPLYSQS GDISSEAGQC SDSIWSQPDP SGLNGTQTRK 
       410        420        430        440        450
IPLLHISSHK QSILEDFIDM KKEGTGSITF PHISSLPEPE KMFSEETLVD 
       460        470        480        490        500
KEHEGQHLES LEDSISGKQM VSGTSQTACL SPSIRKSIVK MREPLEETLD 
       510        520        530        540        550
TVFSDSMTSS AFTEELDASA GGLEIHTACS QREDSLCPSS VDTGSWPTTL 
       560        570        580        590        600
TDTSATVKNA GLITTLKNKR RKFIYSVSDD ASHQGKKLQT QRQSELTNLS 
       610        620        630        640        650
APFEASAFEV PFPFTNVDSG IPDSSIKRSN LPNDPEEPSL SLTNSFVTAA 
       660        670        680        690        700
SKEISYIHAL ISQDLNDKEA ILSEEKPQPY TALEADFLSC LPERSCENDQ 
       710        720        730        740        750
KSPKVSDRKE KVLVSACRPS GRLAAAVQLS SISFDSQENP LGSHNVTSTL 
       760        770        780        790        800
KLTPSPKTPL SKPVVVSRGK MCKMPEKLQC KSCKDNIELS KNIPLGVNEM 
       810        820        830        840        850
CVLSENSETP ELLPPLEYIT EVSSSVKSQF NQNTKIAVVQ KDQKDSTFIS 
       860        870        880        890        900
EVTVHMNSEE LFPEKENNFA FQVTNESNKP NIGSTVEFQE EDLSHTKGHS 
       910        920        930        940        950
LKNSPMTVDR DLDDEQAGQV LITEDSDSLA VVHDCTKKSR NTIEQHQKGT 
       960        970        980        990       1000
ADKDFKSNSS LYLKSDGNND YLDKWSEFLD PLMNHKFGGS FRTASNKEIK 
      1010       1020       1030       1040       1050
LSEDNVKKSK MFFKDIEEQY PTSLDCIDTV STLQLANKKR LSEPHTFDLK 
      1060       1070       1080       1090       1100
SGTTVSTQCH SQSSVSHEDT HTAPQMLSSK QDFHSSHNLT PSQKAEITEL 
      1110       1120       1130       1140       1150
STILEESGSQ FEFTQFKNPS HIAQNNTSAV LGNQMAVVRT ASEEWKDVDL 
      1160       1170       1180       1190       1200
HLPLNPSSVG QIDHNKKFEC LVGVKQSSSH LLEDTCNQNT SCFLPIKEME 
      1210       1220       1230       1240       1250
FGGFCSALGT KLSVSNEALR KAMKLFSDIE NISEEPSTKV GPRGFSSCAH 
      1260       1270       1280       1290       1300
HDSVASVFKI KKQNTDKSFD EKSSKCQVTV QNNKEMTTCI LVDENPENYV 
      1310       1320       1330       1340       1350
KNIKQDNNYT GSQRNAYKLE NSDVSKSSTS GTVYINKGDS DLPFAAEKGN 
      1360       1370       1380       1390       1400
KYPESCTQYV REENAQIKES VSDLTCLEVM KAEETCHMKS SDKEQLPSDK 
      1410       1420       1430       1440       1450
MEQNMKEFNI SFQTASGKNI RVSKESLNKS VNILDQETED LTVTSDSLNS 
      1460       1470       1480       1490       1500
KILCGINKDK MHISCHKKSI NIKKVFEEHF PIGTVSQLPA LQQYPEYEIE 
      1510       1520       1530       1540       1550
SIKEPTLLSF HTASGKKVKI MQESLDKVKN LFDETQYVRK TTNFGHQESK 
      1560       1570       1580       1590       1600
PLKDREDYKE RLTLAYEKIE VTASKCEEMQ NFVSKQTEML PQQNDHMYRQ 
      1610       1620       1630       1640       1650
TENLTSNGSS PKVHGNIENK IEKNPRICCI CQSSYFVTED SALACYTGDS 
      1660       1670       1680       1690       1700
RKTCVGESSL SKGKKWLREQ SDKLGTRNTI EIQCVKEHTE DFAGNALYEH 
      1710       1720       1730       1740       1750
SLVIIRTEID TSHVSENQAS TLFSDPNVCH SYLSHSSFCH HDDMHNDSGY 
      1760       1770       1780       1790       1800
FLKDKIDSDV QPDMKNTEGN AIFPKISATK EIKLHPQTVN EECVQKLETN 
      1810       1820       1830       1840       1850
ASPYANKNIA IDSAMLDLRN CKVGSPVFIT THSQETVRMK EIFTDNCSKI 
      1860       1870       1880       1890       1900
VEQNRESKPD TCQTSCHKAL DNSEDFICPS SSGDVCINSP MAIFYPQSEQ 
      1910       1920       1930       1940       1950
ILQHNQSVSG LKKAATPPVS LETWDTCKSI RGSPQEVHPS RTYGIFSTAS 
      1960       1970       1980       1990       2000
GKAVQVSDAS LEKARQVFSE IDGDAKQLAS MVSLEGNEKS HHSVKRESSV 
      2010       2020       2030       2040       2050
VHNTHGVLSL RKTLPGNVSS SVFSGFSTAG GKLVTVSESA LHKVKGMLEE 
      2060       2070       2080       2090       2100
FDLIRTEHTL QHSPTPEDVS KIPPQPCLES RTPEYSVSSK LQKTYNDKSR 
      2110       2120       2130       2140       2150
SPSNYKESGS SGNTQSLEVS PQLSQMERKQ ETQSVLGTKV SQRKTNILEK 
      2160       2170       2180       2190       2200
KQNLPQNIKI ESNKMETFSD VSMKTNVGEY YSKEPENYFE TEAVEIAKAF 
      2210       2220       2230       2240       2250
MEDDELTDSE QTHAKCSLFA CPQNEALLNS RTRKRGGMAG VAVGQPPIKR 
      2260       2270       2280       2290       2300
SLLNEFDRII ESKGKSLTPS KSTPDGTIKD RRLFTHHMSL EPVTCGPFCS 
      2310       2320       2330       2340       2350
SKERQETQSP HVTSPAQGLQ SKGHPSRHSA VGKSSSNPTV SALRSERTRH 
      2360       2370       2380       2390       2400
SVSDKSTKVF VPPFKVKSRF HRDEHFDSKN VNLEGKNQKS ADGVSEDGND 
      2410       2420       2430       2440       2450
SDFPQFNKDL MSSLQNARDL QDIRIKNKER HHLCPQPGSL YLTKSSTLPR 
      2460       2470       2480       2490       2500
ISLQAAVGDS VPSACSPKQL YMYGVSKACI SVNSKNAEYF QFAIEDHFGK 
      2510       2520       2530       2540       2550
EALCAGKGFR LADGGWLIPS DDGKAGKEEF YRALCDTPGV DPKLISSVWV 
      2560       2570       2580       2590       2600
SNHYRWIVWK LAAMEFAFPK EFANRCLNPE RVLLQLKYRY DVEIDNSSRS 
      2610       2620       2630       2640       2650
ALKKILERDD TAAKTLVLCV SDIISLSTNV SETSGSKASS EDSNKVDTIE 
      2660       2670       2680       2690       2700
LTDGWYAVKA QLDPPLLALV KSGRLTVGQK IITQGAELVG SPDACAPLEA 
      2710       2720       2730       2740       2750
PDSLRLKISA NSTRPARWHS KLGFFHDPRP FPLPLSSLFS DGGNVGCVDV 
      2760       2770       2780       2790       2800
IVQRVYPLQW VEKTVSGSYI FRNEREEEKE ALRFAEAQQK KLEALFTKVH 
      2810       2820       2830       2840       2850
TELKEHEEDI AQRRVLSRAL TRQQVHALQD GAELYAAVQD ASDPEHLETC 
      2860       2870       2880       2890       2900
FSEEQLRALN NYRQMLSDKK QARIQSEFRK ALEAAEKEEG LSRDVSTVWK 
      2910       2920       2930       2940       2950
LRVTSYKKRE KSALLSIWRP SSDLPSLLTE GQRYRIYHLS VSKSKNKFEW 
      2960       2970       2980       2990       3000
PSIQLTATKR TQYQQLPVSS ETLLQLYQPR ELLPFSKLSD PAFQPPCSEV 
      3010       3020       3030       3040       3050
DVVGVVVSVV KPIGLAPLVY LSDECLHLLV VKFGIDLNED IKPRVLIAAS 
      3060       3070       3080       3090       3100
NLQWRPESTS RVPTLFAGNF SVFSASPKEA HFQERVTNMK HAIENIDTFY 
      3110       3120       3130       3140       3150
KEAEKKLIQV LKGDSPKWST PNKDPTREPY PASTCSASDL ASGGQLPRSS 
      3160       3170       3180       3190       3200
PTDQQSYRSP LSCCTPTGKS TPLAHSAWMA AKSCSGENEI EDPKTCRKKR 
      3210       3220       3230       3240       3250
ALDLLSRLPL PPPLSPVCTF VSPAAQKAFQ PPRSCGTKYP TPLKKEGPSS 
      3260       3270       3280       3290       3300
PWSRAPFQKA SGVSLLDCDS VADEELALLS TQALVPHSVG GSEQVFPSDS 
      3310       3320       3330       3340 
TRTEGPSAST EARPANRSKR ESLRDCRDDS DGKLAAETVP DYS
Length:3,343
Mass (Da):371,954
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2FEF8247821CAD1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O35923BRCA2_RAT
Breast cancer type 2 susceptibility...
Brca2 Fancd1
3,343Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07034923 Genomic DNA No translation available.
AH014113 AY691456 Genomic DNA Translation: AAU09084.1
AH014114 AY691483 Genomic DNA Translation: AAU09085.1

NCBI Reference Sequences

More...RefSeqi		NP_113730.2, NM_031542.2
XP_017453861.1, XM_017598372.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000001475; ENSRNOP00000001475; ENSRNOG00000001111

Database of genes from NCBI RefSeq genomes

More...GeneIDi		360254

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:360254

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034923 Genomic DNA No translation available.
AH014113 AY691456 Genomic DNA Translation: AAU09084.1
AH014114 AY691483 Genomic DNA Translation: AAU09085.1
RefSeqiNP_113730.2, NM_031542.2
XP_017453861.1, XM_017598372.1

3D structure databases

SMRiQ66MH4
ModBaseiSearch...

PTM databases

PhosphoSitePlusiQ66MH4

Proteomic databases

PRIDEiQ66MH4

Genome annotation databases

EnsembliENSRNOT00000001475; ENSRNOP00000001475; ENSRNOG00000001111
GeneIDi360254
KEGGirno:360254

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		675
RGDi2219, Brca2

Phylogenomic databases

GeneTreeiENSGT00390000003602
HOGENOMiCLU_000344_0_0_1
OMAiNCELYYQ
OrthoDBi257485at2759
TreeFamiTF105041

Gene expression databases

BgeeiENSRNOG00000001111, Expressed in brain and 21 other tissues

Family and domain databases

CDDicd04493, BRCA2DBD_OB1, 1 hit
cd04495, BRCA2DBD_OB3, 1 hit
InterProiView protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR002093, BRCA2_repeat
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom
PANTHERiPTHR11289, PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF00634, BRCA2, 7 hits
PF09121, Tower, 1 hit
PIRSFiPIRSF002397, BRCA2, 1 hit
SMARTiView protein in SMART
SM01341, Tower, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit
PROSITEiView protein in PROSITE
PS50138, BRCA2_REPEAT, 6 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ66MH4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66MH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 29, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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