UniProtKB - Q66MH4 (Q66MH4_RAT)
Protein
Submitted name:
Breast cancer susceptibility protein 2
Gene
Brca2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- gamma-tubulin binding Source: Ensembl
- H3 histone acetyltransferase activity Source: Ensembl
- H4 histone acetyltransferase activity Source: Ensembl
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- single-stranded DNA binding Source: Ensembl
GO - Biological processi
- brain development Source: Ensembl
- cell aging Source: Ensembl
- centrosome duplication Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
- double-strand break repair via homologous recombination Source: Ensembl
- establishment of protein localization to telomere Source: Ensembl
- female gonad development Source: Ensembl
- hemopoiesis Source: Ensembl
- inner cell mass cell proliferation Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- male meiosis I Source: Ensembl
- mitotic recombination-dependent replication fork processing Source: Ensembl
- negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
- nucleotide-excision repair Source: Ensembl
- oocyte maturation Source: Ensembl
- positive regulation of mitotic cell cycle Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of cytokinesis Source: Ensembl
- replication fork protection Source: Ensembl
- response to gamma radiation Source: Ensembl
- response to UV-C Source: Ensembl
- response to X-ray Source: Ensembl
- spermatogenesis Source: Ensembl
- telomere maintenance via recombination Source: Ensembl
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | DNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Breast cancer susceptibility protein 2ImportedSubmitted name: Breast cancer type 2 susceptibility protein homologImported |
Gene namesi | Name:Brca2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2219, Brca2 |
Subcellular locationi
Cytoskeleton
- centrosome Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Nucleus
- lateral element Source: Ensembl
- nuclear chromosome, telomeric region Source: Ensembl
- nucleoplasm Source: Ensembl
Other locations
- BRCA2-MAGE-D1 complex Source: Ensembl
- secretory granule Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000001111, Expressed in brain and 21 other tissues |
Interactioni
GO - Molecular functioni
- gamma-tubulin binding Source: Ensembl
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 984 – 1018 | BRCA2PROSITE-ProRule annotationAdd BLAST | 35 | |
Repeati | 1197 – 1231 | BRCA2PROSITE-ProRule annotationAdd BLAST | 35 | |
Repeati | 1405 – 1439 | BRCA2PROSITE-ProRule annotationAdd BLAST | 35 | |
Repeati | 1503 – 1537 | BRCA2PROSITE-ProRule annotationAdd BLAST | 35 | |
Repeati | 1939 – 1973 | BRCA2PROSITE-ProRule annotationAdd BLAST | 35 | |
Repeati | 2019 – 2053 | BRCA2PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 2761 – 2802 | TowerInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 38 – 66 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 348 – 381 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 2059 – 2139 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 2296 – 2356 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 2377 – 2407 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 3114 – 3163 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 3231 – 3255 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 3289 – 3343 | DisorderedSequence analysisAdd BLAST | 55 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2775 – 2795 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 356 – 381 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 2081 – 2139 | PolarSequence analysisAdd BLAST | 59 | |
Compositional biasi | 2300 – 2346 | PolarSequence analysisAdd BLAST | 47 | |
Compositional biasi | 3115 – 3163 | PolarSequence analysisAdd BLAST | 49 | |
Compositional biasi | 3289 – 3313 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 3314 – 3335 | PolyampholyteSequence analysisAdd BLAST | 22 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000003602 |
HOGENOMi | CLU_000344_0_0_1 |
OMAi | KMEQNIK |
OrthoDBi | 257485at2759 |
TreeFami | TF105041 |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit cd04495, BRCA2DBD_OB3, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR002093, BRCA2_repeat IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 3 hits |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF00634, BRCA2, 7 hits PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
PROSITEi | View protein in PROSITE PS50138, BRCA2_REPEAT, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q66MH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVEYKRRPT FWEIFKARCS TADLGPISLN WFEELSSEAP PYNTEPPEES
60 70 80 90 100
EYKPQGHEPQ LFKTPQRNPS YHQFASTPIM FKEQSQTLPL DQSPFKELGN
110 120 130 140 150
VVANSKRKHH SKKKARKDPV VDVASLPLKA CPSESPCTPR CTQVAPQRRK
160 170 180 190 200
PVVSGSLFYT PKLEETPKHI SESLGVEVDP DMSWTSSLAT PPTLSSTVLI
210 220 230 240 250
ARDEEAHRNA FPADSPASLK SYFSNHNESL KKNDRFIPSV SDSENKSQQE
260 270 280 290 300
AFSQGLEKML GDSSSKINRF RDCLRKPIPN VLEDGETAVD TSGEDSFSLC
310 320 330 340 350
FPKRRTRNLQ KTRMGKMKKK IFSETRTDGL SEEARGQADD KNSFALEIEP
360 370 380 390 400
RDSEPLDPSV TNQKPLYSQS GDISSEAGQC SDSIWSQPDP SGLNGTQTRK
410 420 430 440 450
IPLLHISSHK QSILEDFIDM KKEGTGSITF PHISSLPEPE KMFSEETLVD
460 470 480 490 500
KEHEGQHLES LEDSISGKQM VSGTSQTACL SPSIRKSIVK MREPLEETLD
510 520 530 540 550
TVFSDSMTSS AFTEELDASA GGLEIHTACS QREDSLCPSS VDTGSWPTTL
560 570 580 590 600
TDTSATVKNA GLITTLKNKR RKFIYSVSDD ASHQGKKLQT QRQSELTNLS
610 620 630 640 650
APFEASAFEV PFPFTNVDSG IPDSSIKRSN LPNDPEEPSL SLTNSFVTAA
660 670 680 690 700
SKEISYIHAL ISQDLNDKEA ILSEEKPQPY TALEADFLSC LPERSCENDQ
710 720 730 740 750
KSPKVSDRKE KVLVSACRPS GRLAAAVQLS SISFDSQENP LGSHNVTSTL
760 770 780 790 800
KLTPSPKTPL SKPVVVSRGK MCKMPEKLQC KSCKDNIELS KNIPLGVNEM
810 820 830 840 850
CVLSENSETP ELLPPLEYIT EVSSSVKSQF NQNTKIAVVQ KDQKDSTFIS
860 870 880 890 900
EVTVHMNSEE LFPEKENNFA FQVTNESNKP NIGSTVEFQE EDLSHTKGHS
910 920 930 940 950
LKNSPMTVDR DLDDEQAGQV LITEDSDSLA VVHDCTKKSR NTIEQHQKGT
960 970 980 990 1000
ADKDFKSNSS LYLKSDGNND YLDKWSEFLD PLMNHKFGGS FRTASNKEIK
1010 1020 1030 1040 1050
LSEDNVKKSK MFFKDIEEQY PTSLDCIDTV STLQLANKKR LSEPHTFDLK
1060 1070 1080 1090 1100
SGTTVSTQCH SQSSVSHEDT HTAPQMLSSK QDFHSSHNLT PSQKAEITEL
1110 1120 1130 1140 1150
STILEESGSQ FEFTQFKNPS HIAQNNTSAV LGNQMAVVRT ASEEWKDVDL
1160 1170 1180 1190 1200
HLPLNPSSVG QIDHNKKFEC LVGVKQSSSH LLEDTCNQNT SCFLPIKEME
1210 1220 1230 1240 1250
FGGFCSALGT KLSVSNEALR KAMKLFSDIE NISEEPSTKV GPRGFSSCAH
1260 1270 1280 1290 1300
HDSVASVFKI KKQNTDKSFD EKSSKCQVTV QNNKEMTTCI LVDENPENYV
1310 1320 1330 1340 1350
KNIKQDNNYT GSQRNAYKLE NSDVSKSSTS GTVYINKGDS DLPFAAEKGN
1360 1370 1380 1390 1400
KYPESCTQYV REENAQIKES VSDLTCLEVM KAEETCHMKS SDKEQLPSDK
1410 1420 1430 1440 1450
MEQNMKEFNI SFQTASGKNI RVSKESLNKS VNILDQETED LTVTSDSLNS
1460 1470 1480 1490 1500
KILCGINKDK MHISCHKKSI NIKKVFEEHF PIGTVSQLPA LQQYPEYEIE
1510 1520 1530 1540 1550
SIKEPTLLSF HTASGKKVKI MQESLDKVKN LFDETQYVRK TTNFGHQESK
1560 1570 1580 1590 1600
PLKDREDYKE RLTLAYEKIE VTASKCEEMQ NFVSKQTEML PQQNDHMYRQ
1610 1620 1630 1640 1650
TENLTSNGSS PKVHGNIENK IEKNPRICCI CQSSYFVTED SALACYTGDS
1660 1670 1680 1690 1700
RKTCVGESSL SKGKKWLREQ SDKLGTRNTI EIQCVKEHTE DFAGNALYEH
1710 1720 1730 1740 1750
SLVIIRTEID TSHVSENQAS TLFSDPNVCH SYLSHSSFCH HDDMHNDSGY
1760 1770 1780 1790 1800
FLKDKIDSDV QPDMKNTEGN AIFPKISATK EIKLHPQTVN EECVQKLETN
1810 1820 1830 1840 1850
ASPYANKNIA IDSAMLDLRN CKVGSPVFIT THSQETVRMK EIFTDNCSKI
1860 1870 1880 1890 1900
VEQNRESKPD TCQTSCHKAL DNSEDFICPS SSGDVCINSP MAIFYPQSEQ
1910 1920 1930 1940 1950
ILQHNQSVSG LKKAATPPVS LETWDTCKSI RGSPQEVHPS RTYGIFSTAS
1960 1970 1980 1990 2000
GKAVQVSDAS LEKARQVFSE IDGDAKQLAS MVSLEGNEKS HHSVKRESSV
2010 2020 2030 2040 2050
VHNTHGVLSL RKTLPGNVSS SVFSGFSTAG GKLVTVSESA LHKVKGMLEE
2060 2070 2080 2090 2100
FDLIRTEHTL QHSPTPEDVS KIPPQPCLES RTPEYSVSSK LQKTYNDKSR
2110 2120 2130 2140 2150
SPSNYKESGS SGNTQSLEVS PQLSQMERKQ ETQSVLGTKV SQRKTNILEK
2160 2170 2180 2190 2200
KQNLPQNIKI ESNKMETFSD VSMKTNVGEY YSKEPENYFE TEAVEIAKAF
2210 2220 2230 2240 2250
MEDDELTDSE QTHAKCSLFA CPQNEALLNS RTRKRGGMAG VAVGQPPIKR
2260 2270 2280 2290 2300
SLLNEFDRII ESKGKSLTPS KSTPDGTIKD RRLFTHHMSL EPVTCGPFCS
2310 2320 2330 2340 2350
SKERQETQSP HVTSPAQGLQ SKGHPSRHSA VGKSSSNPTV SALRSERTRH
2360 2370 2380 2390 2400
SVSDKSTKVF VPPFKVKSRF HRDEHFDSKN VNLEGKNQKS ADGVSEDGND
2410 2420 2430 2440 2450
SDFPQFNKDL MSSLQNARDL QDIRIKNKER HHLCPQPGSL YLTKSSTLPR
2460 2470 2480 2490 2500
ISLQAAVGDS VPSACSPKQL YMYGVSKACI SVNSKNAEYF QFAIEDHFGK
2510 2520 2530 2540 2550
EALCAGKGFR LADGGWLIPS DDGKAGKEEF YRALCDTPGV DPKLISSVWV
2560 2570 2580 2590 2600
SNHYRWIVWK LAAMEFAFPK EFANRCLNPE RVLLQLKYRY DVEIDNSSRS
2610 2620 2630 2640 2650
ALKKILERDD TAAKTLVLCV SDIISLSTNV SETSGSKASS EDSNKVDTIE
2660 2670 2680 2690 2700
LTDGWYAVKA QLDPPLLALV KSGRLTVGQK IITQGAELVG SPDACAPLEA
2710 2720 2730 2740 2750
PDSLRLKISA NSTRPARWHS KLGFFHDPRP FPLPLSSLFS DGGNVGCVDV
2760 2770 2780 2790 2800
IVQRVYPLQW VEKTVSGSYI FRNEREEEKE ALRFAEAQQK KLEALFTKVH
2810 2820 2830 2840 2850
TELKEHEEDI AQRRVLSRAL TRQQVHALQD GAELYAAVQD ASDPEHLETC
2860 2870 2880 2890 2900
FSEEQLRALN NYRQMLSDKK QARIQSEFRK ALEAAEKEEG LSRDVSTVWK
2910 2920 2930 2940 2950
LRVTSYKKRE KSALLSIWRP SSDLPSLLTE GQRYRIYHLS VSKSKNKFEW
2960 2970 2980 2990 3000
PSIQLTATKR TQYQQLPVSS ETLLQLYQPR ELLPFSKLSD PAFQPPCSEV
3010 3020 3030 3040 3050
DVVGVVVSVV KPIGLAPLVY LSDECLHLLV VKFGIDLNED IKPRVLIAAS
3060 3070 3080 3090 3100
NLQWRPESTS RVPTLFAGNF SVFSASPKEA HFQERVTNMK HAIENIDTFY
3110 3120 3130 3140 3150
KEAEKKLIQV LKGDSPKWST PNKDPTREPY PASTCSASDL ASGGQLPRSS
3160 3170 3180 3190 3200
PTDQQSYRSP LSCCTPTGKS TPLAHSAWMA AKSCSGENEI EDPKTCRKKR
3210 3220 3230 3240 3250
ALDLLSRLPL PPPLSPVCTF VSPAAQKAFQ PPRSCGTKYP TPLKKEGPSS
3260 3270 3280 3290 3300
PWSRAPFQKA SGVSLLDCDS VADEELALLS TQALVPHSVG GSEQVFPSDS
3310 3320 3330 3340
TRTEGPSAST EARPANRSKR ESLRDCRDDS DGKLAAETVP DYS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO35923 | BRCA2_RAT | Breast cancer type 2 susceptibility... | Brca2 Fancd1 | 3,343 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07034923 Genomic DNA No translation available. AH014113 , AY691432, AY691434, AY691435, AY691436, AY691437, AY691438, AY691439, AY691440, AY691441, AY691442, AY691443, AY691444, AY691445, AY691446, AY691447, AY691448, AY691449, AY691450, AY691451, AY691452, AY691453, AY691454, AY691455, AY691456 Genomic DNA Translation: AAU09084.1 AH014114 , AY691459, AY691460, AY691461, AY691462, AY691463, AY691464, AY691465, AY691466, AY691467, AY691468, AY691469, AY691470, AY691471, AY691472, AY691473, AY691474, AY691475, AY691477, AY691478, AY691479, AY691480, AY691481, AY691482, AY691483 Genomic DNA Translation: AAU09085.1 |
RefSeqi | NP_113730.2, NM_031542.2 XP_017453861.1, XM_017598372.1 |
Genome annotation databases
Ensembli | ENSRNOT00000001475; ENSRNOP00000001475; ENSRNOG00000001111 |
GeneIDi | 360254 |
KEGGi | rno:360254 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07034923 Genomic DNA No translation available. AH014113 , AY691432, AY691434, AY691435, AY691436, AY691437, AY691438, AY691439, AY691440, AY691441, AY691442, AY691443, AY691444, AY691445, AY691446, AY691447, AY691448, AY691449, AY691450, AY691451, AY691452, AY691453, AY691454, AY691455, AY691456 Genomic DNA Translation: AAU09084.1 AH014114 , AY691459, AY691460, AY691461, AY691462, AY691463, AY691464, AY691465, AY691466, AY691467, AY691468, AY691469, AY691470, AY691471, AY691472, AY691473, AY691474, AY691475, AY691477, AY691478, AY691479, AY691480, AY691481, AY691482, AY691483 Genomic DNA Translation: AAU09085.1 |
RefSeqi | NP_113730.2, NM_031542.2 XP_017453861.1, XM_017598372.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSRNOT00000001475; ENSRNOP00000001475; ENSRNOG00000001111 |
GeneIDi | 360254 |
KEGGi | rno:360254 |
Organism-specific databases
CTDi | 675 |
RGDi | 2219, Brca2 |
Phylogenomic databases
GeneTreei | ENSGT00390000003602 |
HOGENOMi | CLU_000344_0_0_1 |
OMAi | KMEQNIK |
OrthoDBi | 257485at2759 |
TreeFami | TF105041 |
Gene expression databases
Bgeei | ENSRNOG00000001111, Expressed in brain and 21 other tissues |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit cd04495, BRCA2DBD_OB3, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR002093, BRCA2_repeat IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 3 hits |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF00634, BRCA2, 7 hits PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
PROSITEi | View protein in PROSITE PS50138, BRCA2_REPEAT, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q66MH4_RAT | |
Accessioni | Q66MH4Primary (citable) accession number: Q66MH4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |