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Entry version 85 (11 Dec 2019)
Sequence version 1 (11 Oct 2004)
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Protein
Submitted name:

CENP-C

Gene

Cenpc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CENP-CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CenpcImported
Synonyms:Cenpc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
1303061 Cenpc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q66LH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q66LH7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q66LH7

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 279CENP_C_NInterPro annotationAdd BLAST273
Domaini283 – 533CENP-C_midInterPro annotationAdd BLAST251
Domaini829 – 913CENP-C_CInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 144DisorderedSequence analysisAdd BLAST98
Regioni160 – 186DisorderedSequence analysisAdd BLAST27
Regioni208 – 244DisorderedSequence analysisAdd BLAST37
Regioni316 – 684DisorderedSequence analysisAdd BLAST369

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 83PolarSequence analysisAdd BLAST37
Compositional biasi107 – 128PolarSequence analysisAdd BLAST22
Compositional biasi208 – 226PolarSequence analysisAdd BLAST19
Compositional biasi227 – 241PolyampholyteSequence analysisAdd BLAST15
Compositional biasi338 – 352PolarSequence analysisAdd BLAST15
Compositional biasi374 – 392PolyampholyteSequence analysisAdd BLAST19
Compositional biasi403 – 435PolarSequence analysisAdd BLAST33
Compositional biasi436 – 452PolyampholyteSequence analysisAdd BLAST17
Compositional biasi459 – 479PolyampholyteSequence analysisAdd BLAST21
Compositional biasi486 – 506PolyampholyteSequence analysisAdd BLAST21
Compositional biasi519 – 538PolarSequence analysisAdd BLAST20
Compositional biasi542 – 570PolyampholyteSequence analysisAdd BLAST29
Compositional biasi571 – 627PolarSequence analysisAdd BLAST57

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEH1 Eukaryota
ENOG41123PF LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090256

KEGG Orthology (KO)

More...
KOi
K11497

Database of Orthologous Groups

More...
OrthoDBi
215502at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028386 CENP-C/Mif2/cnp3
IPR028931 CENP-C_mid
IPR028052 CENP_C_N_dom
IPR025974 Mif2/CENP-C_cupin
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16684 PTHR16684, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11699 CENP-C_C, 1 hit
PF15620 CENP-C_mid, 1 hit
PF15622 CENP_C_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51182 SSF51182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q66LH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASFHLDHLK NYHRRFCRPS RAPNIPTKQG QNMLEILQDC FEEQNSTESL
60 70 80 90 100
SCSTPKEKDI YVQSTGKERQ ASHSESVPIS SRRKEASLQV PAKPSDPADE
110 120 130 140 150
PVQANEVHQK ILSTDVVSKS TPDSTKTSSK GVKGHHGASD ELYLPGGSPV
160 170 180 190 200
VLLGARVSGS QKAISSGGQK RVTSRRSADM QSSNTDISFK TRKRLNFEDK
210 220 230 240 250
VISNTAEIES SASQVEDSIS EEQEGTSSET SQKRDDLSSE IQPQSKKSFS
260 270 280 290 300
ELYLETVNRK SKCSSVVRHT AAVPSPPYPP NDMKLLEDEF IIDGPDRSFS
310 320 330 340 350
SQPWVVIPRK GHHMPFPENI AVPQGKKSRE KPHRLSEKTL VSNTQTDKTG
360 370 380 390 400
PVEEAQLSVE EKLGTTLTNE LENDCRSTEN KTHSENAKKP SARKRTVKQK
410 420 430 440 450
QRRPSKPNIA QELSMGQNET ENRNMSKIGQ DKLQINSKRN MEDHEEVRNE
460 470 480 490 500
PTPKKPVPAL GNKKEKDSTQ ANKEKSRKKC FSRESKRKSV PKEVTLASRR
510 520 530 540 550
GRRTSQHPSE WWLVKPSEGS VDGNSSKENE SSILYPNRKK QTKRNHVSEN
560 570 580 590 600
TEKKPVPSKR KKKEISSREL KSLNVKGSGG NDDISTSQRK PLQNIDADPT
610 620 630 640 650
QKSLHCSGPT RGSEDQNSDM ISQNVHLKTR SEQHRSKTQM ESTSNSEVCK
660 670 680 690 700
HSVWEESGPS RFKNLEMPGR SNSEVGDEKD QKSLDLKTRS SNMVPNRNLH
710 720 730 740 750
HKLVLPSNSP NVRRSNRIRL KPLEYWRGER IDYQESSSGR LVLEIVSPAS
760 770 780 790 800
ESVKRKAKRN LDKVNKETNK KRIHLDNPTK TKIKVSLDIP LGDPFQATLA
810 820 830 840 850
KDPETREIVP MDLIRPRDTY HFFVEQHGLK VYKTLNTTFF STGKLVLGPH
860 870 880 890 900
EEKGKQHVGQ DILVFYVNFG DLLCTLHETP YMLTTGDSFY VPSGNHYNIK
910
NLLNVESCLL FTQIKR
Length:916
Mass (Da):103,334
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i015E3614EC926C74
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY693788 mRNA Translation: AAU04621.1

NCBI Reference Sequences

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RefSeqi
NP_001004098.1, NM_001004098.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
305270

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:305270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693788 mRNA Translation: AAU04621.1
RefSeqiNP_001004098.1, NM_001004098.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4X23X-ray3.50U/V/W/X710-734[»]
SMRiQ66LH7
ModBaseiSearch...
PDBe-KBiSearch...

PTM databases

iPTMnetiQ66LH7
PhosphoSitePlusiQ66LH7

Genome annotation databases

GeneIDi305270
KEGGirno:305270

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1060
RGDi1303061 Cenpc

Phylogenomic databases

eggNOGiENOG410IEH1 Eukaryota
ENOG41123PF LUCA
HOGENOMiHOG000090256
KOiK11497
OrthoDBi215502at2759

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR028386 CENP-C/Mif2/cnp3
IPR028931 CENP-C_mid
IPR028052 CENP_C_N_dom
IPR025974 Mif2/CENP-C_cupin
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR16684 PTHR16684, 1 hit
PfamiView protein in Pfam
PF11699 CENP-C_C, 1 hit
PF15620 CENP-C_mid, 1 hit
PF15622 CENP_C_N, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ66LH7_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66LH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: December 11, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources
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