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UniProtKB - Q66LE6 (2ABD_HUMAN)

Entry version 145 (13 Feb 2019)
Sequence version 1 (11 Oct 2004)
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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Gene

PPP2R2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • exit from mitosis Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • peptidyl-serine dephosphorylation Source: GO_Central
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2465910 MASTL Facilitates Mitotic Progression

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q66LE6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Alternative name(s):
PP2A subunit B isoform B55-delta
PP2A subunit B isoform PR55-delta
PP2A subunit B isoform R2-delta
PP2A subunit B isoform delta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP2R2D
Synonyms:KIAA1541
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000175470.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:23732 PPP2R2D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613992 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q66LE6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55844

Open Targets

More...OpenTargetsi		ENSG00000175470

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134899040

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP2R2D

Domain mapping of disease mutations (DMDM)

More...DMDMi		74736328

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714331 – 453Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei285PhosphoserineBy similarity1
Modified residuei305PhosphotyrosineBy similarity1
Modified residuei308PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q66LE6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q66LE6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q66LE6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q66LE6

PeptideAtlas

More...PeptideAtlasi		Q66LE6

PRoteomics IDEntifications database

More...PRIDEi		Q66LE6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q66LE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q66LE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175470 Expressed in 199 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q66LE6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q66LE6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA042122
HPA042770

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Interacts with IER5 (PubMed:25816751).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ORF2Q76S402EBI-717262,EBI-14032793From Human herpesvirus 8.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120946, 119 interactors

Protein interaction database and analysis system

More...IntActi		Q66LE6, 56 interactors

Molecular INTeraction database

More...MINTi		Q66LE6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000399970

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q66LE6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q66LE6

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati32 – 71WD 1Add BLAST40
Repeati97 – 138WD 2Add BLAST42
Repeati181 – 219WD 3Add BLAST39
Repeati230 – 270WD 4Add BLAST41
Repeati289 – 327WD 5Add BLAST39
Repeati344 – 385WD 6Add BLAST42
Repeati420 – 452WD 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 8Poly-Gly6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphatase 2A regulatory subunit B family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1354 Eukaryota
COG5170 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153436

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000089745

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG000012

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q66LE6

KEGG Orthology (KO)

More...KOi		K04354

Identification of Orthologs from Complete Genome Data

More...OMAi		ESKNRPH

Database of Orthologous Groups

More...OrthoDBi		810409at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q66LE6

TreeFam database of animal gene trees

More...TreeFami		TF105553

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11871 PTHR11871, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037309 PP2A_PR55, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00600 PP2APR55

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q66LE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA 
        60         70         80         90        100
TGDKGGRVVI FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE 
       110        120        130        140        150
KINKIRWLPQ QNAAHFLLST NDKTIKLWKI SERDKRAEGY NLKDEDGRLR 
       160        170        180        190        200
DPFRITALRV PILKPMDLMV EASPRRIFAN AHTYHINSIS VNSDHETYLS 
       210        220        230        240        250
ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF HPHQCNVFVY 
       260        270        280        290        300
SSSKGTIRLC DMRSSALCDR HSKFFEEPED PSSRSFFSEI ISSISDVKFS 
       310        320        330        340        350
HSGRYMMTRD YLSVKVWDLN MESRPVETHQ VHEYLRSKLC SLYENDCIFD 
       360        370        380        390        400
KFECCWNGSD SAIMTGSYNN FFRMFDRDTR RDVTLEASRE SSKPRASLKP 
       410        420        430        440        450
RKVCTGGKRR KDEISVDSLD FNKKILHTAW HPVDNVIAVA ATNNLYIFQD 

KIN
Length:453
Mass (Da):52,042
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0669CDB80AF4400E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YB06H0YB06_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2D
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYD6A0A0A6YYD6_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2D
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRK1A0A3B3IRK1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2D
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPI9A0A096LPI9_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2D
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96065 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti290I → V in BAF85754 (PubMed:14702039).Curated1
Sequence conflicti311Y → H in BAF85754 (PubMed:14702039).Curated1
Sequence conflicti321M → T in BAF85754 (PubMed:14702039).Curated1
Sequence conflicti449Q → R in BAF85754 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057127358G → S. Corresponds to variant dbSNP:rs34473884Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK293065 mRNA Translation: BAF85754.1
AL732395 Genomic DNA No translation available.
BC047379 mRNA Translation: AAH47379.1
AB040974 mRNA Translation: BAA96065.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73224.1

NCBI Reference Sequences

More...RefSeqi		NP_001278239.1, NM_001291310.1
NP_060931.2, NM_018461.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.380372
Hs.657480

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000455566; ENSP00000399970; ENSG00000175470

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55844

UCSC genome browser

More...UCSCi		uc031wxk.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293065 mRNA Translation: BAF85754.1
AL732395 Genomic DNA No translation available.
BC047379 mRNA Translation: AAH47379.1
AB040974 mRNA Translation: BAA96065.1 Different initiation.
CCDSiCCDS73224.1
RefSeqiNP_001278239.1, NM_001291310.1
NP_060931.2, NM_018461.4
UniGeneiHs.380372
Hs.657480

3D structure databases

ProteinModelPortaliQ66LE6
SMRiQ66LE6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120946, 119 interactors
IntActiQ66LE6, 56 interactors
MINTiQ66LE6
STRINGi9606.ENSP00000399970

PTM databases

iPTMnetiQ66LE6
PhosphoSitePlusiQ66LE6

Polymorphism and mutation databases

BioMutaiPPP2R2D
DMDMi74736328

Proteomic databases

EPDiQ66LE6
jPOSTiQ66LE6
MaxQBiQ66LE6
PaxDbiQ66LE6
PeptideAtlasiQ66LE6
PRIDEiQ66LE6

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		55844
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455566; ENSP00000399970; ENSG00000175470
GeneIDi55844
KEGGihsa:55844
UCSCiuc031wxk.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55844
DisGeNETi55844
EuPathDBiHostDB:ENSG00000175470.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP2R2D

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0009317
HGNCiHGNC:23732 PPP2R2D
HPAiHPA042122
HPA042770
MIMi613992 gene
neXtProtiNX_Q66LE6
OpenTargetsiENSG00000175470
PharmGKBiPA134899040

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00940000153436
HOGENOMiHOG000089745
HOVERGENiHBG000012
InParanoidiQ66LE6
KOiK04354
OMAiESKNRPH
OrthoDBi810409at2759
PhylomeDBiQ66LE6
TreeFamiTF105553

Enzyme and pathway databases

ReactomeiR-HSA-2465910 MASTL Facilitates Mitotic Progression
SIGNORiQ66LE6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP2R2D human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55844

Protein Ontology

More...PROi		PR:Q66LE6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175470 Expressed in 199 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ66LE6 baseline and differential
GenevisibleiQ66LE6 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2ABD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66LE6
Secondary accession number(s): A8KAK0, Q5SQJ2, Q9P1Y7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 11, 2004
Last modified: February 13, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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