UniProtKB - Q66LE6 (2ABD_HUMAN)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
PPP2R2D
Functioni
GO - Molecular functioni
- protein phosphatase regulator activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- exit from mitosis Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- peptidyl-serine dephosphorylation Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q66LE6 |
Reactomei | R-HSA-2465910, MASTL Facilitates Mitotic Progression |
SIGNORi | Q66LE6 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAlternative name(s): PP2A subunit B isoform B55-delta PP2A subunit B isoform PR55-delta PP2A subunit B isoform R2-delta PP2A subunit B isoform delta |
Gene namesi | Name:PPP2R2D Synonyms:KIAA1541 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23732, PPP2R2D |
MIMi | 613992, gene |
neXtProti | NX_Q66LE6 |
VEuPathDBi | HostDB:ENSG00000175470.18 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Other locations
- protein phosphatase type 2A complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55844 |
OpenTargetsi | ENSG00000175470 |
PharmGKBi | PA134899040 |
Miscellaneous databases
Pharosi | Q66LE6, Tbio |
Genetic variation databases
BioMutai | PPP2R2D |
DMDMi | 74736328 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071433 | 1 – 453 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAdd BLAST | 453 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 285 | PhosphoserineBy similarity | 1 | |
Modified residuei | 305 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 308 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q66LE6 |
jPOSTi | Q66LE6 |
MassIVEi | Q66LE6 |
MaxQBi | Q66LE6 |
PaxDbi | Q66LE6 |
PeptideAtlasi | Q66LE6 |
PRIDEi | Q66LE6 |
ProteomicsDBi | 65964 |
PTM databases
iPTMneti | Q66LE6 |
PhosphoSitePlusi | Q66LE6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175470, Expressed in pancreas and 214 other tissues |
ExpressionAtlasi | Q66LE6, baseline and differential |
Genevisiblei | Q66LE6, HS |
Organism-specific databases
HPAi | ENSG00000175470, Tissue enhanced (pancreas) |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity).
Interacts with IER5 (PubMed:25816751).
By similarity1 PublicationBinary interactionsi
Q66LE6
With | #Exp. | IntAct |
---|---|---|
ORF2 [Q76S40] from Human herpesvirus 8. | 2 | EBI-717262,EBI-14032793 |
Protein-protein interaction databases
BioGRIDi | 120946, 130 interactors |
IntActi | Q66LE6, 99 interactors |
MINTi | Q66LE6 |
STRINGi | 9606.ENSP00000399970 |
Miscellaneous databases
RNActi | Q66LE6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 32 – 71 | WD 1Add BLAST | 40 | |
Repeati | 97 – 138 | WD 2Add BLAST | 42 | |
Repeati | 181 – 219 | WD 3Add BLAST | 39 | |
Repeati | 230 – 270 | WD 4Add BLAST | 41 | |
Repeati | 289 – 327 | WD 5Add BLAST | 39 | |
Repeati | 344 – 385 | WD 6Add BLAST | 42 | |
Repeati | 420 – 452 | WD 7Add BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3 – 8 | Poly-Gly | 6 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
HOGENOMi | CLU_021713_3_3_1 |
InParanoidi | Q66LE6 |
OMAi | WHPMENI |
OrthoDBi | 810409at2759 |
PhylomeDBi | Q66LE6 |
TreeFami | TF105553 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA
60 70 80 90 100
TGDKGGRVVI FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE
110 120 130 140 150
KINKIRWLPQ QNAAHFLLST NDKTIKLWKI SERDKRAEGY NLKDEDGRLR
160 170 180 190 200
DPFRITALRV PILKPMDLMV EASPRRIFAN AHTYHINSIS VNSDHETYLS
210 220 230 240 250
ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF HPHQCNVFVY
260 270 280 290 300
SSSKGTIRLC DMRSSALCDR HSKFFEEPED PSSRSFFSEI ISSISDVKFS
310 320 330 340 350
HSGRYMMTRD YLSVKVWDLN MESRPVETHQ VHEYLRSKLC SLYENDCIFD
360 370 380 390 400
KFECCWNGSD SAIMTGSYNN FFRMFDRDTR RDVTLEASRE SSKPRASLKP
410 420 430 440 450
RKVCTGGKRR KDEISVDSLD FNKKILHTAW HPVDNVIAVA ATNNLYIFQD
KIN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YB06 | H0YB06_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2D | 150 | Annotation score: | ||
A0A0A6YYD6 | A0A0A6YYD6_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2D | 77 | Annotation score: | ||
A0A3B3IRK1 | A0A3B3IRK1_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2D | 61 | Annotation score: | ||
A0A096LPI9 | A0A096LPI9_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2D | 57 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 290 | I → V in BAF85754 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 311 | Y → H in BAF85754 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 321 | M → T in BAF85754 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 449 | Q → R in BAF85754 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057127 | 358 | G → S. Corresponds to variant dbSNP:rs34473884Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293065 mRNA Translation: BAF85754.1 AL732395 Genomic DNA No translation available. BC047379 mRNA Translation: AAH47379.1 AB040974 mRNA Translation: BAA96065.1 Different initiation. |
CCDSi | CCDS73224.1 |
RefSeqi | NP_001278239.1, NM_001291310.1 NP_060931.2, NM_018461.4 |
Genome annotation databases
Ensembli | ENST00000455566; ENSP00000399970; ENSG00000175470 |
GeneIDi | 55844 |
KEGGi | hsa:55844 |
UCSCi | uc031wxk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293065 mRNA Translation: BAF85754.1 AL732395 Genomic DNA No translation available. BC047379 mRNA Translation: AAH47379.1 AB040974 mRNA Translation: BAA96065.1 Different initiation. |
CCDSi | CCDS73224.1 |
RefSeqi | NP_001278239.1, NM_001291310.1 NP_060931.2, NM_018461.4 |
3D structure databases
SMRi | Q66LE6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120946, 130 interactors |
IntActi | Q66LE6, 99 interactors |
MINTi | Q66LE6 |
STRINGi | 9606.ENSP00000399970 |
PTM databases
iPTMneti | Q66LE6 |
PhosphoSitePlusi | Q66LE6 |
Genetic variation databases
BioMutai | PPP2R2D |
DMDMi | 74736328 |
Proteomic databases
EPDi | Q66LE6 |
jPOSTi | Q66LE6 |
MassIVEi | Q66LE6 |
MaxQBi | Q66LE6 |
PaxDbi | Q66LE6 |
PeptideAtlasi | Q66LE6 |
PRIDEi | Q66LE6 |
ProteomicsDBi | 65964 |
Protocols and materials databases
Antibodypediai | 55293, 61 antibodies |
DNASUi | 55844 |
Genome annotation databases
Ensembli | ENST00000455566; ENSP00000399970; ENSG00000175470 |
GeneIDi | 55844 |
KEGGi | hsa:55844 |
UCSCi | uc031wxk.2, human |
Organism-specific databases
CTDi | 55844 |
DisGeNETi | 55844 |
GeneCardsi | PPP2R2D |
HGNCi | HGNC:23732, PPP2R2D |
HPAi | ENSG00000175470, Tissue enhanced (pancreas) |
MIMi | 613992, gene |
neXtProti | NX_Q66LE6 |
OpenTargetsi | ENSG00000175470 |
PharmGKBi | PA134899040 |
VEuPathDBi | HostDB:ENSG00000175470.18 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
HOGENOMi | CLU_021713_3_3_1 |
InParanoidi | Q66LE6 |
OMAi | WHPMENI |
OrthoDBi | 810409at2759 |
PhylomeDBi | Q66LE6 |
TreeFami | TF105553 |
Enzyme and pathway databases
PathwayCommonsi | Q66LE6 |
Reactomei | R-HSA-2465910, MASTL Facilitates Mitotic Progression |
SIGNORi | Q66LE6 |
Miscellaneous databases
BioGRID-ORCSi | 55844, 2 hits in 153 CRISPR screens |
ChiTaRSi | PPP2R2D, human |
GenomeRNAii | 55844 |
Pharosi | Q66LE6, Tbio |
PROi | PR:Q66LE6 |
RNActi | Q66LE6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175470, Expressed in pancreas and 214 other tissues |
ExpressionAtlasi | Q66LE6, baseline and differential |
Genevisiblei | Q66LE6, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABD_HUMAN | |
Accessioni | Q66LE6Primary (citable) accession number: Q66LE6 Secondary accession number(s): A8KAK0, Q5SQJ2, Q9P1Y7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | October 11, 2004 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families