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UniProtKB - Q66KG0 (S22AG_XENLA)
Protein
Solute carrier family 22 member 16
Gene
slc22a16
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
High affinity carnitine transporter.
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 22 member 16Alternative name(s): Carnitine transporter 2 Short name: CT2 |
Gene namesi | Name:slc22a16 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 40 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 261 – 281 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 351 – 371 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 381 – 401 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 408 – 428 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 436 – 456 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 468 – 488 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 493 – 513 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318993 | 1 – 566 | Solute carrier family 22 member 16Add BLAST | 566 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q66KG0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHLFDYVGH FGRFQAYLYF ASAFQTISCG IHYLASVFIA VTPKFICRAP
60 70 80 90 100
GNISTVLLPN ASTLRLEDAW ESWTSKDYLV VQQENGDIWE LNQCSRLKRE
110 120 130 140 150
DASYLTYFYD GNKTLFSCSN GYHYDKSNLE SSIVTEWDLV CDREWLAKLI
160 170 180 190 200
QPIFMLGVLI GAVIFGDIAD RVGRRPIIWI TSTGQFLFGI AVAFTFDYYS
210 220 230 240 250
FVIVRFLLAM VSSGYYVVVF VYLTEYVGIK ARTWASMHVH AFFAVGVMIV
260 270 280 290 300
SLVGFLVRTW WIYQIILSLT TLPFVLCCWM LPETPFWLYS QGKYKEVEKL
310 320 330 340 350
IRTIEKWNKI STPCKLSELC PAQETHVDQP NTLKNHNVLD LFYNWSFARR
360 370 380 390 400
TITVWLIWFT GSLGYYVFAL NSVNLGGNEY LNLFLTGAVE IPSYIVACLG
410 420 430 440 450
MDKIGRRNTL APFLIISAVI CGVIMLIPQD HSTVTIAMSM AGKFSIAVAF
460 470 480 490 500
GLIYLYTAEL YPTIVRSLAV GSGSMMCRIG SVVAPFCVYL TDVWIFMPQM
510 520 530 540 550
LVGIMAFLTG ILTLTLPETL GIPLTSTMEE AAEMGTTSGI TKRKALTESN
560
GVVMEKLDQT TDNAAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC080416 mRNA Translation: AAH80416.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC080416 mRNA Translation: AAH80416.1 |
3D structure databases
SMRi | Q66KG0 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S22AG_XENLA | |
Accessioni | Q66KG0Primary (citable) accession number: Q66KG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 23, 2022 | |
This is version 62 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |