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Protein

Cleavage and polyadenylation specificity factor subunit 4

Gene

cpsf4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Cpsf4 binds RNA polymers with a preference for poly(U) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 61C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri62 – 89C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri90 – 117C3H1-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri118 – 145C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri146 – 169C3H1-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri243 – 260CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 4
Gene namesi
Name:cpsf4
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-948302 cpsf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173651 – 269Cleavage and polyadenylation specificity factor subunit 4Add BLAST269

Proteomic databases

PaxDbiQ66KE3

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of cpsf1, cpsf2, cpsf3, cpsf4 and fip1l1.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000021783

Structurei

3D structure databases

ProteinModelPortaliQ66KE3
SMRiQ66KE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 232Gln-richAdd BLAST55

Sequence similaritiesi

Belongs to the CPSF4/YTH1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 61C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri62 – 89C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri90 – 117C3H1-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri118 – 145C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri146 – 169C3H1-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri243 – 260CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040 Eukaryota
COG5084 LUCA
HOVERGENiHBG051108
InParanoidiQ66KE3
KOiK14404
OrthoDBiEOG091G0JUF

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SM00356 ZnF_C3H1, 5 hits
SUPFAMiSSF57756 SSF57756, 1 hit
SSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 5 hits
PS50158 ZF_CCHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q66KE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQELIACVDH IRFDLELAVE QQLGAQPLPF PGMDKSGAAV CEFFLKSACG
60 70 80 90 100
KGGMCPFRHI SGEKTVVCKH WLRGLCKKGD QCEFLHEYDM TKMPECYFYS
110 120 130 140 150
KFGECSNKEC PFLHIDPESK IKDCPWYDRG FCKHGPLCRH RHTRRVICVN
160 170 180 190 200
YLVGFCIEGP NCKFMHPRFE LPMGTTEQPP LPQQTQTQQK QNNNQVLQRS
210 220 230 240 250
SSLIQLTSQN SPVSQQRSPQ TIGVMQSQSG NQGNRGPRPL DQVTCYKCGE
260
KGHYANRCTK GHLAFLSGQ
Length:269
Mass (Da):30,496
Last modified:October 11, 2004 - v1
Checksum:i1BDD49987CED6618
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q28FZ4Q28FZ4_XENTR
Cleavage and polyadenylation-specif...
cpsf4 TGas053l04.1-001
279Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC080440 mRNA Translation: AAH80440.1
RefSeqiNP_001007933.1, NM_001007932.1
UniGeneiStr.3196

Genome annotation databases

GeneIDi493312
KEGGixtr:493312

Similar proteinsi

Entry informationi

Entry nameiCPSF4_XENTR
AccessioniPrimary (citable) accession number: Q66KE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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