UniProtKB - Q66K89 (E4F1_HUMAN)

BLAST

>sp|Q66K89|E4F1_HUMAN Transcription factor E4F1 OS=Homo sapiens OX=9606 GN=E4F1 PE=1 SV=2
MEGAMAVRVTAAHTAEAQAEAGREAGEGAVAAVAAALAPSGFLGLPAPFSEEDEDDVHRC
GRCQAEFTALEDFVQHKIQKACQRAPPEALPATPATTALLGQEVVPAAPGPEEPITVAHI
VVEAASLAADISHASDLVGGGHIKEVIVAAEAELGDGEMAEAPGSPRQQGLGLAGEGEQA
QVKLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHECKLCGASFRTKGSLIRHHR
RHTDERPYKCSKCGKSFRESGALTRHLKSLTPCTEKIRFSVSKDVVVSKEDARAGSGAGA
AGLGTATSSVTGEPIETSPVIHLVTDAKGTVIHEVHVQMQELSLGMKALAPEPPVSQELP
CSSEGSRENLLHQAMQNSGIVLERAAGEEGALEPAPAAGSSPQPLAVAAPQLPVLEVQPL
ETQVASEASAVPRTHPCPQCSETFPTAATLEAHKRGHTGPRPFACAQCGKAFPKAYLLKK
HQEVHVRERRFRCGDCGKLYKTIAHVRGHRRVHSDERPYPCPKCGKRYKTKNAQQVHFRT
HLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGC
LLEVEELLVSEDSPAAATTVLTEDPHTVLVEFSSVVADTQEYIIEATADDAETSEATEII
EGTQTEVDSHIMKVVQQIVHQASAGHQIIVQNVTMDEETALGPEAAAADTITIATPESLT
EQVAMTLASAISEGTVLAARAGTSGTEQATVTMVSSEDIEILEHAGELVIASPEGQLEVQ
TVIV

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History
Entry version 150 (07 Nov 2018)
Sequence version 2 (18 May 2010)
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Protein

Transcription factor E4F1

Gene

E4F1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.

Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	192 – 214	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	220 – 242	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	248 – 272	C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	435 – 457	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	463 – 485	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	491 – 513	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	519 – 541	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	547 – 569	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	575 – 597	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

cAMP response element binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14645522
DNA binding
Source: ProtInc
Traceable author statementⁱ
- 10869426
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 10869426
- 9121437
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 2169022
transcription coactivator activity
Source: ProtInc
Traceable author statementⁱ
- 9121437
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 10869426
transferase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10869426
DNA replication Source: Ensembl
mitotic cell cycle arrest
Source: UniProtKB
Traceable author statementⁱ
- 14645522
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 14645522
protein ubiquitination Source: UniProtKB-UniPathway
regulation of cell cycle process
Source: UniProtKB
Inferred from direct assayⁱ
- 14645522
regulation of growth Source: UniProtKB-KW
regulation of mitotic cell cycle, embryonic Source: Ensembl
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor, Transferase
Biological process	Cell cycle, Cell division, Growth regulation, Host-virus interaction, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	Q66K89
SIGNORⁱ	Q66K89
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor E4F1 (EC:2.3.2.271 Publication) Alternative name(s): E4F transcription factor 1 Putative E3 ubiquitin-protein ligase E4F1 RING-type E3 ubiquitin transferase E4F1Curated Transcription factor E4F p120E4F p50E4F
Gene namesⁱ	Name:E4F1 Synonyms:E4F
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167967.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3121 E4F1
MIMⁱ	603022 gene
neXtProtⁱ	NX_Q66K89

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	194	C → S: Increases DNA-binding; when associated with S-197. 1 Publication	1
Mutagenesisⁱ	197	C → S: Increases DNA-binding; when associated with S-194. 1 Publication	1
Mutagenesisⁱ	210	H → A: Alters DNA-binding. 1 Publication	1
Mutagenesisⁱ	237	R → L: Alters DNA-binding; when associated with N-238. 1 Publication	1
Mutagenesisⁱ	238	H → N: Alters DNA-binding; when associated with L-237. 1 Publication	1
Mutagenesisⁱ	249	K → M: Alters DNA-binding; when associated with S-250. 1 Publication	1
Mutagenesisⁱ	250	C → S: Alters DNA-binding; when associated with M-249. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1877
Open Targets More...OpenTargetsⁱ	ENSG00000167967
PharmGKBⁱ	PA27579

Polymorphism and mutation databases

DMDMⁱ	296434488

DMDMⁱ

296434488

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000324307	1 – 784	Transcription factor E4F1Add BLAST		784

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	50	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates transcription in presence of the adenoviral E1A protein. The major full-length protein (p120E4F) functions as a repressor of transcription.1 Publication

Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and differentially regulates DNA-binding activity and function of both forms.2 Publications

May be sumoylated by UBE2I upon interaction with CDKN2A.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q66K89
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q66K89
PaxDbⁱ	Q66K89
PeptideAtlas More...PeptideAtlasⁱ	Q66K89
PRIDEⁱ	Q66K89
ProteomicsDBⁱ	65963

PTM databases

iPTMnetⁱ	Q66K89
PhosphoSitePlusⁱ	Q66K89

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Developmental stageⁱ

Expressed in a variety of fetal tissues.1 Publication

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167967 Expressed in 90 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_E4F1
ExpressionAtlasⁱ	Q66K89 baseline and differential
Genevisibleⁱ	Q66K89 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052042 HPA071325

HPAⁱ

HPA052042
HPA071325

Interactionⁱ

Subunit structureⁱ

Homodimer; binds DNA as a dimer. Forms a complex with CDKN2A and TP53. Interactions with TP53, RB1, ANP32A, BMI1 and FHL2 regulate E4F1 activity. Interacts with HDAC1, HMGA2 and RASSF1.10 Publications

(Microbial infection) Interacts with HBV protein X.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
8	Q64770	4	EBI-1227043,EBI-8642971	From Fowl adenovirus A serotype 1 (strain CELO / Phelps).
ANP32A	P39687	3	EBI-1227043,EBI-359234
HDAC1	Q13547	3	EBI-1227043,EBI-301834
HDAC1	Q6IT96	2	EBI-1227043,EBI-6979193
lnx2b	A4VCF7	3	EBI-1227043,EBI-6979266	From Danio rerio.
RASSF1	Q9NS23-2	7	EBI-1227043,EBI-438698
tcf7l1a	Q9YHE8	2	EBI-1227043,EBI-6979298	From Danio rerio.

Protein-protein interaction databases

BioGridⁱ	108209, 89 interactors
IntActⁱ	Q66K89, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q66K89
STRINGⁱ	9606.ENSP00000301727

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q66K89
SMRⁱ	Q66K89
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	41 – 85	Required for ubiquitin ligase activityAdd BLAST	45
Regionⁱ	184 – 263	Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA21 PublicationAdd BLAST	80
Regionⁱ	369 – 566	Mediates interaction with CDKN2AAdd BLAST	198
Regionⁱ	435 – 599	Interaction with BMI11 PublicationAdd BLAST	165
Regionⁱ	521 – 580	Mediates interaction with TP53Add BLAST	60
Regionⁱ	575 – 597	Mediates interaction with RASSF11 PublicationAdd BLAST	23

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	192 – 214	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	220 – 242	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	248 – 272	C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	435 – 457	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	463 – 485	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	491 – 513	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	519 – 541	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	547 – 569	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	575 – 597	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129970
HOGENOMⁱ	HOG000168447
HOVERGENⁱ	HBG052707
InParanoidⁱ	Q66K89
KEGG Orthology (KO) More...KOⁱ	K22401
OMAⁱ	SGHQIIV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03X5
PhylomeDBⁱ	Q66K89
TreeFamⁱ	TF315387

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q66K89-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGAMAVRVT AAHTAEAQAE AGREAGEGAV AAVAAALAPS GFLGLPAPFS 
        60         70         80         90        100
EEDEDDVHRC GRCQAEFTAL EDFVQHKIQK ACQRAPPEAL PATPATTALL 
       110        120        130        140        150
GQEVVPAAPG PEEPITVAHI VVEAASLAAD ISHASDLVGG GHIKEVIVAA 
       160        170        180        190        200
EAELGDGEMA EAPGSPRQQG LGLAGEGEQA QVKLLVNKDG RYVCALCHKT 
       210        220        230        240        250
FKTGSILKAH MVTHSSRKDH ECKLCGASFR TKGSLIRHHR RHTDERPYKC 
       260        270        280        290        300
SKCGKSFRES GALTRHLKSL TPCTEKIRFS VSKDVVVSKE DARAGSGAGA 
       310        320        330        340        350
AGLGTATSSV TGEPIETSPV IHLVTDAKGT VIHEVHVQMQ ELSLGMKALA 
       360        370        380        390        400
PEPPVSQELP CSSEGSRENL LHQAMQNSGI VLERAAGEEG ALEPAPAAGS 
       410        420        430        440        450
SPQPLAVAAP QLPVLEVQPL ETQVASEASA VPRTHPCPQC SETFPTAATL 
       460        470        480        490        500
EAHKRGHTGP RPFACAQCGK AFPKAYLLKK HQEVHVRERR FRCGDCGKLY 
       510        520        530        540        550
KTIAHVRGHR RVHSDERPYP CPKCGKRYKT KNAQQVHFRT HLEEKPHVCQ 
       560        570        580        590        600
FCSRGFREKG SLVRHVRHHT GEKPFKCYKC GRGFAEHGTL NRHLRTKGGC 
       610        620        630        640        650
LLEVEELLVS EDSPAAATTV LTEDPHTVLV EFSSVVADTQ EYIIEATADD 
       660        670        680        690        700
AETSEATEII EGTQTEVDSH IMKVVQQIVH QASAGHQIIV QNVTMDEETA 
       710        720        730        740        750
LGPEAAAADT ITIATPESLT EQVAMTLASA ISEGTVLAAR AGTSGTEQAT 
       760        770        780 
VTMVSSEDIE ILEHAGELVI ASPEGQLEVQ TVIV

Length:784

Mass (Da):83,496

Last modified:May 18, 2010 - v2

Checksum:ⁱ60F6E711F2748FD8

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BUJ7	H3BUJ7_HUMAN	Transcription factor E4F1 Transcription factor E4F1	E4F1	654	Annotation score:
H3BSL4	H3BSL4_HUMAN	Transcription factor E4F1 Transcription factor E4F1	E4F1	607	Annotation score:
H3BN24	H3BN24_HUMAN	Transcription factor E4F1 Transcription factor E4F1	E4F1	272	Annotation score:
H3BQZ4	H3BQZ4_HUMAN	Transcription factor E4F1 Transcription factor E4F1	E4F1	208	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4	A → E in AAD09139 (PubMed:9121437).Curated	1
Sequence conflictⁱ	363 – 364	SE → RK in AAD09139 (PubMed:9121437).Curated	2
Sequence conflictⁱ	425	A → V in BAF83018 (PubMed:14702039).Curated	1
Sequence conflictⁱ	480 – 481	KH → TD in AAD09139 (PubMed:9121437).Curated	2
Sequence conflictⁱ	544	E → D in BAF83018 (PubMed:14702039).Curated	1
Sequence conflictⁱ	681 – 682	QA → PR in AAD09139 (PubMed:9121437).Curated	2
Sequence conflictⁱ	704 – 705	EA → RG in AAD09139 (PubMed:9121437).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060270	167	R → H4 PublicationsCorresponds to variant dbSNP:rs26839Ensembl.		1
Natural variantⁱVAR_060271	355	V → I. Corresponds to variant dbSNP:rs59784157Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U87269 mRNA Translation: AAD09139.1 AK290329 mRNA Translation: BAF83018.1 AC009065 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85532.1 BC080524 mRNA Translation: AAH80524.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32370.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001275705.1, NM_001288776.1 NP_001275707.1, NM_001288778.1 NP_004415.3, NM_004424.4
UniGeneⁱ	Hs.513268

Genome annotation databases

Ensemblⁱ	ENST00000301727; ENSP00000301727; ENSG00000167967
GeneIDⁱ	1877
KEGGⁱ	hsa:1877
UCSC genome browser More...UCSCⁱ	uc002cpm.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q66K89	E4F transcription factor 1		CALJA		786	UniRef90_Q66K89
Uncharacterized protein		Cebus capucinus imitator		786
Uncharacterized protein		PANPA		785
Uncharacterized protein		MANLE		785
E4F transcription factor 1		PANTR		785
+60

Protein	Similar proteins		Species	Score	Length	Source
Q66K89	Transcription factor E4F1		MOUSE		783	UniRef50_Q66K89
Uncharacterized protein		Cebus capucinus imitator		786
E4F transcription factor 1		CALJA		786
Uncharacterized protein		PANPA		785
Uncharacterized protein		MANLE		785
+457

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U87269 mRNA Translation: AAD09139.1 AK290329 mRNA Translation: BAF83018.1 AC009065 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85532.1 BC080524 mRNA Translation: AAH80524.1
CCDSⁱ	CCDS32370.1
RefSeqⁱ	NP_001275705.1, NM_001288776.1 NP_001275707.1, NM_001288778.1 NP_004415.3, NM_004424.4
UniGeneⁱ	Hs.513268

3D structure databases

ProteinModelPortalⁱ	Q66K89
SMRⁱ	Q66K89
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108209, 89 interactors
IntActⁱ	Q66K89, 13 interactors
MINTⁱ	Q66K89
STRINGⁱ	9606.ENSP00000301727

PTM databases

iPTMnetⁱ	Q66K89
PhosphoSitePlusⁱ	Q66K89

Polymorphism and mutation databases

DMDMⁱ	296434488

DMDMⁱ

296434488

Proteomic databases

EPDⁱ	Q66K89
MaxQBⁱ	Q66K89
PaxDbⁱ	Q66K89
PeptideAtlasⁱ	Q66K89
PRIDEⁱ	Q66K89
ProteomicsDBⁱ	65963

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000301727; ENSP00000301727; ENSG00000167967
GeneIDⁱ	1877
KEGGⁱ	hsa:1877
UCSCⁱ	uc002cpm.5 human

Organism-specific databases

CTDⁱ	1877
DisGeNETⁱ	1877
EuPathDBⁱ	HostDB:ENSG00000167967.15
GeneCardsⁱ	E4F1
HGNCⁱ	HGNC:3121 E4F1
HPAⁱ	HPA052042 HPA071325
MIMⁱ	603022 gene
neXtProtⁱ	NX_Q66K89
OpenTargetsⁱ	ENSG00000167967
PharmGKBⁱ	PA27579
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00840000129970
HOGENOMⁱ	HOG000168447
HOVERGENⁱ	HBG052707
InParanoidⁱ	Q66K89
KOⁱ	K22401
OMAⁱ	SGHQIIV
OrthoDBⁱ	EOG091G03X5
PhylomeDBⁱ	Q66K89
TreeFamⁱ	TF315387

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
SignaLinkⁱ	Q66K89
SIGNORⁱ	Q66K89

Miscellaneous databases

GeneWikiⁱ	E4F1
GenomeRNAiⁱ	1877
Protein Ontology More...PROⁱ	PR:Q66K89
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167967 Expressed in 90 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_E4F1
ExpressionAtlasⁱ	Q66K89 baseline and differential
Genevisibleⁱ	Q66K89 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E4F1_HUMAN
Accessionⁱ	Q66K89Primary (citable) accession number: Q66K89 Secondary accession number(s): A8K2R4, O00146
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q66K89 (E4F1_HUMAN)

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Transcription factor E4F1

E4F1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ