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UniProtKB - Q66K89 (E4F1_HUMAN)

Entry version 159 (26 Feb 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Transcription factor E4F1

Gene

E4F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.
Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 272C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri435 – 457C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, Transferase
Biological processCell cycle, Cell division, Growth regulation, Host-virus interaction, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q66K89

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q66K89

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor E4F1 (EC:2.3.2.271 Publication)
Alternative name(s):
E4F transcription factor 1
Putative E3 ubiquitin-protein ligase E4F1
RING-type E3 ubiquitin transferase E4F1Curated
Transcription factor E4F
p120E4F
p50E4F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:E4F1
Synonyms:E4F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3121 E4F1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603022 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q66K89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi194C → S: Increases DNA-binding; when associated with S-197. 1 Publication1
Mutagenesisi197C → S: Increases DNA-binding; when associated with S-194. 1 Publication1
Mutagenesisi210H → A: Alters DNA-binding. 1 Publication1
Mutagenesisi237R → L: Alters DNA-binding; when associated with N-238. 1 Publication1
Mutagenesisi238H → N: Alters DNA-binding; when associated with L-237. 1 Publication1
Mutagenesisi249K → M: Alters DNA-binding; when associated with S-250. 1 Publication1
Mutagenesisi250C → S: Alters DNA-binding; when associated with M-249. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1877

Open Targets

More...OpenTargetsi		ENSG00000167967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27579

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q66K89 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		E4F1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434488

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003243071 – 784Transcription factor E4F1Add BLAST784

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates transcription in presence of the adenoviral E1A protein. The major full-length protein (p120E4F) functions as a repressor of transcription.1 Publication
Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and differentially regulates DNA-binding activity and function of both forms.2 Publications
May be sumoylated by UBE2I upon interaction with CDKN2A.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q66K89

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q66K89

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q66K89

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q66K89

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q66K89

PeptideAtlas

More...PeptideAtlasi		Q66K89

PRoteomics IDEntifications database

More...PRIDEi		Q66K89

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q66K89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q66K89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in a variety of fetal tissues.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by estrogen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167967 Expressed in cerebellum and 89 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q66K89 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q66K89 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA052042
HPA069007
HPA071325
HPA072309

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; binds DNA as a dimer.

Forms a complex with CDKN2A and TP53. Interactions with TP53, RB1, ANP32A, BMI1 and FHL2 regulate E4F1 activity.

Interacts with HDAC1, HMGA2 and RASSF1.

10 Publications

(Microbial infection) Interacts with HBV protein X.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108209, 89 interactors

Protein interaction database and analysis system

More...IntActi		Q66K89, 73 interactors

Molecular INTeraction database

More...MINTi		Q66K89

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301727

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q66K89 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q66K89

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 85Required for ubiquitin ligase activityAdd BLAST45
Regioni184 – 263Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA21 PublicationAdd BLAST80
Regioni369 – 566Mediates interaction with CDKN2AAdd BLAST198
Regioni435 – 599Interaction with BMI11 PublicationAdd BLAST165
Regioni521 – 580Mediates interaction with TP53Add BLAST60
Regioni575 – 597Mediates interaction with RASSF11 PublicationAdd BLAST23

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 272C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri435 – 457C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00840000129970

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q66K89

KEGG Orthology (KO)

More...KOi		K22401

Identification of Orthologs from Complete Genome Data

More...OMAi		IEIMEHA

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q66K89

TreeFam database of animal gene trees

More...TreeFami		TF315387

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q66K89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGAMAVRVT AAHTAEAQAE AGREAGEGAV AAVAAALAPS GFLGLPAPFS 
        60         70         80         90        100
EEDEDDVHRC GRCQAEFTAL EDFVQHKIQK ACQRAPPEAL PATPATTALL 
       110        120        130        140        150
GQEVVPAAPG PEEPITVAHI VVEAASLAAD ISHASDLVGG GHIKEVIVAA 
       160        170        180        190        200
EAELGDGEMA EAPGSPRQQG LGLAGEGEQA QVKLLVNKDG RYVCALCHKT 
       210        220        230        240        250
FKTGSILKAH MVTHSSRKDH ECKLCGASFR TKGSLIRHHR RHTDERPYKC 
       260        270        280        290        300
SKCGKSFRES GALTRHLKSL TPCTEKIRFS VSKDVVVSKE DARAGSGAGA 
       310        320        330        340        350
AGLGTATSSV TGEPIETSPV IHLVTDAKGT VIHEVHVQMQ ELSLGMKALA 
       360        370        380        390        400
PEPPVSQELP CSSEGSRENL LHQAMQNSGI VLERAAGEEG ALEPAPAAGS 
       410        420        430        440        450
SPQPLAVAAP QLPVLEVQPL ETQVASEASA VPRTHPCPQC SETFPTAATL 
       460        470        480        490        500
EAHKRGHTGP RPFACAQCGK AFPKAYLLKK HQEVHVRERR FRCGDCGKLY 
       510        520        530        540        550
KTIAHVRGHR RVHSDERPYP CPKCGKRYKT KNAQQVHFRT HLEEKPHVCQ 
       560        570        580        590        600
FCSRGFREKG SLVRHVRHHT GEKPFKCYKC GRGFAEHGTL NRHLRTKGGC 
       610        620        630        640        650
LLEVEELLVS EDSPAAATTV LTEDPHTVLV EFSSVVADTQ EYIIEATADD 
       660        670        680        690        700
AETSEATEII EGTQTEVDSH IMKVVQQIVH QASAGHQIIV QNVTMDEETA 
       710        720        730        740        750
LGPEAAAADT ITIATPESLT EQVAMTLASA ISEGTVLAAR AGTSGTEQAT 
       760        770        780 
VTMVSSEDIE ILEHAGELVI ASPEGQLEVQ TVIV
Length:784
Mass (Da):83,496
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60F6E711F2748FD8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUJ7H3BUJ7_HUMAN
Transcription factor E4F1
E4F1
654Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSL4H3BSL4_HUMAN
Transcription factor E4F1
E4F1
607Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN24H3BN24_HUMAN
Transcription factor E4F1
E4F1
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQZ4H3BQZ4_HUMAN
Transcription factor E4F1
E4F1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4A → E in AAD09139 (PubMed:9121437).Curated1
Sequence conflicti363 – 364SE → RK in AAD09139 (PubMed:9121437).Curated2
Sequence conflicti425A → V in BAF83018 (PubMed:14702039).Curated1
Sequence conflicti480 – 481KH → TD in AAD09139 (PubMed:9121437).Curated2
Sequence conflicti544E → D in BAF83018 (PubMed:14702039).Curated1
Sequence conflicti681 – 682QA → PR in AAD09139 (PubMed:9121437).Curated2
Sequence conflicti704 – 705EA → RG in AAD09139 (PubMed:9121437).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060270167R → H4 PublicationsCorresponds to variant dbSNP:rs26839Ensembl.1
Natural variantiVAR_060271355V → I. Corresponds to variant dbSNP:rs59784157Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U87269 mRNA Translation: AAD09139.1
AK290329 mRNA Translation: BAF83018.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85532.1
BC080524 mRNA Translation: AAH80524.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32370.1

NCBI Reference Sequences

More...RefSeqi		NP_001275705.1, NM_001288776.1
NP_001275707.1, NM_001288778.1
NP_004415.3, NM_004424.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000301727; ENSP00000301727; ENSG00000167967

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1877

UCSC genome browser

More...UCSCi		uc002cpm.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87269 mRNA Translation: AAD09139.1
AK290329 mRNA Translation: BAF83018.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85532.1
BC080524 mRNA Translation: AAH80524.1
CCDSiCCDS32370.1
RefSeqiNP_001275705.1, NM_001288776.1
NP_001275707.1, NM_001288778.1
NP_004415.3, NM_004424.4

3D structure databases

SMRiQ66K89
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108209, 89 interactors
IntActiQ66K89, 73 interactors
MINTiQ66K89
STRINGi9606.ENSP00000301727

PTM databases

iPTMnetiQ66K89
PhosphoSitePlusiQ66K89

Polymorphism and mutation databases

BioMutaiE4F1
DMDMi296434488

Proteomic databases

EPDiQ66K89
jPOSTiQ66K89
MassIVEiQ66K89
MaxQBiQ66K89
PaxDbiQ66K89
PeptideAtlasiQ66K89
PRIDEiQ66K89
ProteomicsDBi65963

Genome annotation databases

EnsembliENST00000301727; ENSP00000301727; ENSG00000167967
GeneIDi1877
KEGGihsa:1877
UCSCiuc002cpm.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1877
DisGeNETi1877

GeneCards: human genes, protein and diseases

More...GeneCardsi		E4F1
HGNCiHGNC:3121 E4F1
HPAiHPA052042
HPA069007
HPA071325
HPA072309
MIMi603022 gene
neXtProtiNX_Q66K89
OpenTargetsiENSG00000167967
PharmGKBiPA27579

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129970
InParanoidiQ66K89
KOiK22401
OMAiIEIMEHA
OrthoDBi1318335at2759
PhylomeDBiQ66K89
TreeFamiTF315387

Enzyme and pathway databases

UniPathwayiUPA00143
SignaLinkiQ66K89
SIGNORiQ66K89

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		E4F1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		E4F1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1877
PharosiQ66K89 Tbio

Protein Ontology

More...PROi		PR:Q66K89
RNActiQ66K89 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000167967 Expressed in cerebellum and 89 other tissues
ExpressionAtlasiQ66K89 baseline and differential
GenevisibleiQ66K89 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE4F1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66K89
Secondary accession number(s): A8K2R4, O00146
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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