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UniProtKB - Q66K74 (MAP1S_HUMAN)

Protein

Microtubule-associated protein 1S

Gene

MAP1S

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).By similarity2 Publications

Miscellaneous

Depletion of MAP1S by RNAi causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.

GO - Molecular functioni

  • actin binding Source: GO_Central
  • actin filament binding Source: HGNC
  • beta-tubulin binding Source: HGNC
  • DNA binding Source: HGNC
  • identical protein binding Source: Ensembl
  • microtubule binding Source: HGNC
  • tubulin binding Source: HGNC
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • autophagy Source: BHF-UCL
  • axonogenesis Source: GO_Central
  • brain development Source: HGNC
  • dendrite development Source: GO_Central
  • DNA metabolic process Source: GOC
  • microtubule bundle formation Source: HGNC
  • microtubule cytoskeleton organization Source: GO_Central
  • mitochondrion transport along microtubule Source: HGNC
  • nervous system development Source: HGNC
  • neuron projection morphogenesis Source: HGNC
  • regulation of chromatin disassembly Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 1S
Short name:
MAP-1S
Alternative name(s):
BPY2-interacting protein 1
Microtubule-associated protein 8
Variable charge Y chromosome 2-interacting protein 1
Short name:
VCY2-interacting protein 1
Short name:
VCY2IP-1
Cleaved into the following 2 chains:
MAP1S heavy chain
MAP1S light chain
Gene namesi
Name:MAP1S
Synonyms:BPY2IP1, C19orf5, MAP8, VCY2IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130479.10
HGNCiHGNC:15715 MAP1S
MIMi607573 gene
neXtProtiNX_Q66K74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55201
OpenTargetsiENSG00000130479
PharmGKBiPA38031

Polymorphism and mutation databases

BioMutaiMAP1S
DMDMi160410004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113791 – 1059Microtubule-associated protein 1SAdd BLAST1059
ChainiPRO_00003113801 – 829MAP1S heavy chainAdd BLAST829
ChainiPRO_0000311381830 – 1059MAP1S light chainAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei638PhosphothreonineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei731PhosphoserineBy similarity1
Modified residuei759PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ66K74
MaxQBiQ66K74
PaxDbiQ66K74
PeptideAtlasiQ66K74
PRIDEiQ66K74
ProteomicsDBi65957

PTM databases

iPTMnetiQ66K74
PhosphoSitePlusiQ66K74

Expressioni

Tissue specificityi

Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.3 Publications

Gene expression databases

BgeeiENSG00000130479 Expressed in 215 organ(s), highest expression level in testis
ExpressionAtlasiQ66K74 baseline and differential
GenevisibleiQ66K74 HS

Organism-specific databases

HPAiHPA050934
HPA054637

Interactioni

Subunit structurei

Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts (via C-terminus) with GAN (via Kelch domains) (By similarity). Interacts with ESR1, LRPPRC, RASSF1 isoform A and isoform C, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain).By similarity9 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120498, 41 interactors
IntActiQ66K74, 33 interactors
MINTiQ66K74
STRINGi9606.ENSP00000325313

Structurei

3D structure databases

ProteinModelPortaliQ66K74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 797Necessary for the microtubule-organizing center localizationAdd BLAST797
Regioni666 – 1059Necessary for interaction with RASSF1 isoform A and isoform CAdd BLAST394
Regioni714 – 966Necessary for association with microtubulesAdd BLAST253
Regioni960 – 1059Necessary for association with actinBy similarityAdd BLAST100
Regioni967 – 991Necessary for the mitochondrial aggregation and genome destructionAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi560 – 850Pro-richAdd BLAST291

Domaini

The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.By similarity

Sequence similaritiesi

Belongs to the MAP1 family.Curated

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00550000074593
HOVERGENiHBG108117
InParanoidiQ66K74
KOiK10429
OMAiAGKQQWD
OrthoDBiEOG091G12OH
PhylomeDBiQ66K74
TreeFamiTF350229

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR027322 MAP1S
PANTHERiPTHR13843 PTHR13843, 1 hit
PTHR13843:SF11 PTHR13843:SF11, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q66K74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAGSGAA AAPSSLLLVV GSEFGSPGLL TYVLEELERG IRSWDVDPGV 
        60         70         80         90        100
CNLDEQLKVF VSRHSATFSS IVKGQRSLHH RGDNLETLVL LNPSDKSLYD 
       110        120        130        140        150
ELRNLLLDPA SHKLLVLAGP CLEETGELLL QTGGFSPHHF LQVLKDREIR 
       160        170        180        190        200
DILATTPPPV QPPILTITCP TFGDWAQLAP AVPGLQGALR LQLRLNPPAQ 
       210        220        230        240        250
LPNSEGLCEF LEYVAESLEP PSPFELLEPP TSGGFLRLGR PCCYIFPGGL 
       260        270        280        290        300
GDAAFFAVNG FTVLVNGGSN PKSSFWKLVR HLDRVDAVLV THPGADSLPG 
       310        320        330        340        350
LNSLLRRKLA ERSEVAAGGG SWDDRLRRLI SPNLGVVFFN ACEAASRLAR 
       360        370        380        390        400
GEDEAELALS LLAQLGITPL PLSRGPVPAK PTVLFEKMGV GRLDMYVLHP 
       410        420        430        440        450
PSAGAERTLA SVCALLVWHP AGPGEKVVRV LFPGCTPPAC LLDGLVRLQH 
       460        470        480        490        500
LRFLREPVVT PQDLEGPGRA ESKESVGSRD SSKREGLLAT HPRPGQERPG 
       510        520        530        540        550
VARKEPARAE APRKTEKEAK TPRELKKDPK PSVSRTQPRE VRRAASSVPN 
       560        570        580        590        600
LKKTNAQAAP KPRKAPSTSH SGFPPVANGP RSPPSLRCGE ASPPSAACGS 
       610        620        630        640        650
PASQLVATPS LELGPIPAGE EKALELPLAA SSIPRPRTPS PESHRSPAEG 
       660        670        680        690        700
SERLSLSPLR GGEAGPDASP TVTTPTVTTP SLPAEVGSPH STEVDESLSV 
       710        720        730        740        750
SFEQVLPPSA PTSEAGLSLP LRGPRARRSA SPHDVDLCLV SPCEFEHRKA 
       760        770        780        790        800
VPMAPAPASP GSSNDSSARS QERAGGLGAE ETPPTSVSES LPTLSDSDPV 
       810        820        830        840        850
PLAPGAADSD EDTEGFGVPR HDPLPDPLKV PPPLPDPSSI CMVDPEMLPP 
       860        870        880        890        900
KTARQTENVS RTRKPLARPN SRAAAPKATP VAAAKTKGLA GGDRASRPLS 
       910        920        930        940        950
ARSEPSEKGG RAPLSRKSST PKTATRGPSG SASSRPGVSA TPPKSPVYLD 
       960        970        980        990       1000
LAYLPSGSSA HLVDEEFFQR VRALCYVISG QDQRKEEGMR AVLDALLASK 
      1010       1020       1030       1040       1050
QHWDRDLQVT LIPTFDSVAM HTWYAETHAR HQALGITVLG SNSMVSMQDD 

AFPACKVEF
Length:1,059
Mass (Da):112,211
Last modified:November 13, 2007 - v2
Checksum:i30AB33FFE26DDF91
GO
Isoform 2 (identifier: Q66K74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MAAVAGSGAAAAPSSLLLVVGSEFGSPGLLTYVLEELER → MAGMIDRFSPANT

Note: No experimental confirmation available.
Show »
Length:1,033
Mass (Da):109,788
Checksum:i0CCD0392292B2B08
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1M7M0R1M7_HUMAN
Microtubule-associated protein 1S
MAP1S
120Annotation score:
M0QY41M0QY41_HUMAN
Microtubule-associated protein 1S
MAP1S
189Annotation score:
M0QZ50M0QZ50_HUMAN
Microtubule-associated protein 1S
MAP1S
93Annotation score:
M0R1J2M0R1J2_HUMAN
Microtubule-associated protein 1S
MAP1S
188Annotation score:
M0QXQ9M0QXQ9_HUMAN
Microtubule-associated protein 1S
MAP1S
185Annotation score:
M0QXE8M0QXE8_HUMAN
Microtubule-associated protein 1S
MAP1S
82Annotation score:
M0QX37M0QX37_HUMAN
Microtubule-associated protein 1S
MAP1S
81Annotation score:
M0QXK6M0QXK6_HUMAN
Microtubule-associated protein 1S
MAP1S
79Annotation score:
M0QYI5M0QYI5_HUMAN
Microtubule-associated protein 1S
MAP1S
67Annotation score:

Sequence cautioni

The sequence AAH07253 differs from that shown. Contaminating sequence. At the N-terminus.Curated
The sequence AAH07253 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH67115 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91743 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14415 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55242 differs from that shown. Reason: Frameshift at position 851.Curated
The sequence BAB93493 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38911 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120P → L in CAD29574 (PubMed:14627543).Curated1
Sequence conflicti120P → L in BAB55242 (PubMed:14702039).Curated1
Sequence conflicti178L → P in CAD29574 (PubMed:14627543).Curated1
Sequence conflicti178L → P in BAB55242 (PubMed:14702039).Curated1
Sequence conflicti440C → Y in CAD38911 (PubMed:17974005).Curated1
Sequence conflicti521T → A in BAB93493 (Ref. 7) Curated1
Sequence conflicti526K → R in CAD29574 (PubMed:14627543).Curated1
Sequence conflicti526K → R in BAB55242 (PubMed:14702039).Curated1
Sequence conflicti967F → L in BAB14415 (PubMed:14702039).Curated1
Sequence conflicti1043S → G in BAA91743 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050023372L → V. Corresponds to variant dbSNP:rs17710707Ensembl.1
Natural variantiVAR_037236411S → C1 PublicationCorresponds to variant dbSNP:rs17710707Ensembl.1
Natural variantiVAR_037237538P → Q. Corresponds to variant dbSNP:rs7252905Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560431 – 39MAAVA…EELER → MAGMIDRFSPANT in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440784 mRNA Translation: CAD29574.1
DQ387861 mRNA Translation: ABD47682.1
AK027623 mRNA Translation: BAB55242.1 Frameshift.
AK001531 mRNA Translation: BAA91743.1 Different initiation.
AK023118 mRNA Translation: BAB14415.1 Different initiation.
AK294936 mRNA Translation: BAG58014.1
AL834233 mRNA Translation: CAD38911.1 Different initiation.
AC008761 Genomic DNA No translation available.
BC006358 mRNA Translation: AAH06358.2
BC007253 mRNA Translation: AAH07253.1 Different initiation.
BC008806 mRNA Translation: AAH08806.2
BC067115 mRNA Translation: AAH67115.1 Different initiation.
BC080547 mRNA Translation: AAH80547.1
BC113952 mRNA Translation: AAI13953.1
AB062430 mRNA Translation: BAB93493.1 Different initiation.
CCDSiCCDS32954.1 [Q66K74-1]
CCDS77262.1 [Q66K74-2]
RefSeqiNP_001295292.1, NM_001308363.1 [Q66K74-2]
NP_060644.4, NM_018174.5 [Q66K74-1]
UniGeneiHs.66048

Genome annotation databases

EnsembliENST00000324096; ENSP00000325313; ENSG00000130479 [Q66K74-1]
ENST00000544059; ENSP00000439243; ENSG00000130479 [Q66K74-2]
GeneIDi55201
KEGGihsa:55201
UCSCiuc002nhe.2 human [Q66K74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440784 mRNA Translation: CAD29574.1
DQ387861 mRNA Translation: ABD47682.1
AK027623 mRNA Translation: BAB55242.1 Frameshift.
AK001531 mRNA Translation: BAA91743.1 Different initiation.
AK023118 mRNA Translation: BAB14415.1 Different initiation.
AK294936 mRNA Translation: BAG58014.1
AL834233 mRNA Translation: CAD38911.1 Different initiation.
AC008761 Genomic DNA No translation available.
BC006358 mRNA Translation: AAH06358.2
BC007253 mRNA Translation: AAH07253.1 Different initiation.
BC008806 mRNA Translation: AAH08806.2
BC067115 mRNA Translation: AAH67115.1 Different initiation.
BC080547 mRNA Translation: AAH80547.1
BC113952 mRNA Translation: AAI13953.1
AB062430 mRNA Translation: BAB93493.1 Different initiation.
CCDSiCCDS32954.1 [Q66K74-1]
CCDS77262.1 [Q66K74-2]
RefSeqiNP_001295292.1, NM_001308363.1 [Q66K74-2]
NP_060644.4, NM_018174.5 [Q66K74-1]
UniGeneiHs.66048

3D structure databases

ProteinModelPortaliQ66K74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120498, 41 interactors
IntActiQ66K74, 33 interactors
MINTiQ66K74
STRINGi9606.ENSP00000325313

PTM databases

iPTMnetiQ66K74
PhosphoSitePlusiQ66K74

Polymorphism and mutation databases

BioMutaiMAP1S
DMDMi160410004

Proteomic databases

EPDiQ66K74
MaxQBiQ66K74
PaxDbiQ66K74
PeptideAtlasiQ66K74
PRIDEiQ66K74
ProteomicsDBi65957

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324096; ENSP00000325313; ENSG00000130479 [Q66K74-1]
ENST00000544059; ENSP00000439243; ENSG00000130479 [Q66K74-2]
GeneIDi55201
KEGGihsa:55201
UCSCiuc002nhe.2 human [Q66K74-1]

Organism-specific databases

CTDi55201
DisGeNETi55201
EuPathDBiHostDB:ENSG00000130479.10
GeneCardsiMAP1S
H-InvDBiHIX0014899
HGNCiHGNC:15715 MAP1S
HPAiHPA050934
HPA054637
MIMi607573 gene
neXtProtiNX_Q66K74
OpenTargetsiENSG00000130479
PharmGKBiPA38031
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
GeneTreeiENSGT00550000074593
HOVERGENiHBG108117
InParanoidiQ66K74
KOiK10429
OMAiAGKQQWD
OrthoDBiEOG091G12OH
PhylomeDBiQ66K74
TreeFamiTF350229

Miscellaneous databases

ChiTaRSiMAP1S human
GeneWikiiMAP1S
GenomeRNAii55201
PROiPR:Q66K74
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130479 Expressed in 215 organ(s), highest expression level in testis
ExpressionAtlasiQ66K74 baseline and differential
GenevisibleiQ66K74 HS

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR027322 MAP1S
PANTHERiPTHR13843 PTHR13843, 1 hit
PTHR13843:SF11 PTHR13843:SF11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAP1S_HUMAN
AccessioniPrimary (citable) accession number: Q66K74
Secondary accession number(s): B4DH53
, Q27QB1, Q6NXF1, Q8N3L8, Q8N3W5, Q8NI88, Q96H94, Q96IT4, Q96SP8, Q9BRC6, Q9H928, Q9NVK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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