UniProtKB - Q66K74 (MAP1S_HUMAN)
Microtubule-associated protein 1S
MAP1S
Functioni
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
By similarity2 PublicationsMiscellaneous
GO - Molecular functioni
- actin binding Source: GO_Central
- actin filament binding Source: HGNC-UCL
- beta-tubulin binding Source: HGNC-UCL
- DNA binding Source: HGNC-UCL
- identical protein binding Source: Ensembl
- microtubule binding Source: HGNC-UCL
- tubulin binding Source: HGNC-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- autophagy Source: BHF-UCL
- axonogenesis Source: GO_Central
- brain development Source: HGNC-UCL
- dendrite development Source: GO_Central
- microtubule bundle formation Source: HGNC-UCL
- microtubule cytoskeleton organization Source: GO_Central
- mitochondrion transport along microtubule Source: HGNC-UCL
- nervous system development Source: HGNC-UCL
- neuron projection morphogenesis Source: HGNC-UCL
- regulation of chromatin disassembly Source: BHF-UCL
- regulation of microtubule depolymerization Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q66K74 |
SignaLinki | Q66K74 |
Names & Taxonomyi
Protein namesi | Recommended name: Microtubule-associated protein 1SShort name: MAP-1S Alternative name(s): BPY2-interacting protein 1 Microtubule-associated protein 8 Variable charge Y chromosome 2-interacting protein 1 Short name: VCY2-interacting protein 1 Short name: VCY2IP-1 Cleaved into the following 2 chains: |
Gene namesi | Name:MAP1S Synonyms:BPY2IP1, C19orf5, MAP8, VCY2IP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15715, MAP1S |
MIMi | 607573, gene |
neXtProti | NX_Q66K74 |
VEuPathDBi | HostDB:ENSG00000130479 |
Subcellular locationi
Nucleus
Cytoplasm and Cytosol
Cytoskeleton
- cytoskeleton 1 Publication
- spindle 1 Publication
Note: Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.By similarity
Cytoskeleton
- microtubule Source: UniProtKB
- microtubule associated complex Source: GO_Central
- spindle Source: UniProtKB
Cytosol
- cytosol Source: HGNC-UCL
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: HGNC-UCL
Other locations
- cell junction Source: HPA
- cell projection Source: UniProtKB
- dendrite Source: HGNC-UCL
- neuronal cell body Source: HGNC-UCL
- perinuclear region of cytoplasm Source: HGNC-UCL
- synapse Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Microtubule, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55201 |
OpenTargetsi | ENSG00000130479 |
PharmGKBi | PA38031 |
Miscellaneous databases
Pharosi | Q66K74, Tbio |
Genetic variation databases
BioMutai | MAP1S |
DMDMi | 160410004 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311379 | 1 – 1059 | Microtubule-associated protein 1SAdd BLAST | 1059 | |
ChainiPRO_0000311380 | 1 – 829 | MAP1S heavy chainAdd BLAST | 829 | |
ChainiPRO_0000311381 | 830 – 1059 | MAP1S light chainAdd BLAST | 230 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 321 | PhosphoserineCombined sources | 1 | |
Modified residuei | 472 | PhosphoserineCombined sources | 1 | |
Modified residuei | 582 | PhosphoserineCombined sources | 1 | |
Modified residuei | 638 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 640 | PhosphoserineCombined sources | 1 | |
Modified residuei | 655 | PhosphoserineCombined sources | 1 | |
Modified residuei | 657 | PhosphoserineCombined sources | 1 | |
Modified residuei | 731 | PhosphoserineBy similarity | 1 | |
Modified residuei | 759 | PhosphoserineCombined sources | 1 | |
Modified residuei | 809 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q66K74 |
jPOSTi | Q66K74 |
MassIVEi | Q66K74 |
MaxQBi | Q66K74 |
PaxDbi | Q66K74 |
PeptideAtlasi | Q66K74 |
PRIDEi | Q66K74 |
ProteomicsDBi | 4197 65957 [Q66K74-1] |
PTM databases
GlyGeni | Q66K74, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q66K74 |
MetOSitei | Q66K74 |
PhosphoSitePlusi | Q66K74 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130479, Expressed in testis and 230 other tissues |
ExpressionAtlasi | Q66K74, baseline and differential |
Genevisiblei | Q66K74, HS |
Organism-specific databases
HPAi | ENSG00000130479, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Heterodimer of a heavy and a light chain.
Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin.
Interacts (via C-terminus) with GAN (via Kelch domains) (By similarity).
Interacts with ESR1, LRPPRC, RASSF1 isoform A and isoform C, microtubules and VCY2.
Interacts with WDR47 (via N-terminus of light chain).
By similarity9 PublicationsBinary interactionsi
Q66K74
With | #Exp. | IntAct |
---|---|---|
BPY2B [O14599] | 3 | EBI-2133734,EBI-2133713 |
MAP1LC3A [Q9H492] | 3 | EBI-2133734,EBI-720768 |
SOCS3 [O14543] | 6 | EBI-2133734,EBI-714146 |
GO - Molecular functioni
- actin binding Source: GO_Central
- actin filament binding Source: HGNC-UCL
- beta-tubulin binding Source: HGNC-UCL
- identical protein binding Source: Ensembl
- microtubule binding Source: HGNC-UCL
- tubulin binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 120498, 107 interactors |
IntActi | Q66K74, 49 interactors |
MINTi | Q66K74 |
STRINGi | 9606.ENSP00000325313 |
Miscellaneous databases
RNActi | Q66K74, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q66K74 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 797 | Necessary for the microtubule-organizing center localizationAdd BLAST | 797 | |
Regioni | 461 – 733 | DisorderedSequence analysisAdd BLAST | 273 | |
Regioni | 666 – 1059 | Necessary for interaction with RASSF1 isoform A and isoform CAdd BLAST | 394 | |
Regioni | 714 – 966 | Necessary for association with microtubulesAdd BLAST | 253 | |
Regioni | 751 – 942 | DisorderedSequence analysisAdd BLAST | 192 | |
Regioni | 960 – 1059 | Necessary for association with actinBy similarityAdd BLAST | 100 | |
Regioni | 967 – 991 | Necessary for the mitochondrial aggregation and genome destructionAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 467 – 537 | Basic and acidic residuesSequence analysisAdd BLAST | 71 | |
Compositional biasi | 539 – 554 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 669 – 708 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 824 – 839 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 916 – 940 | Polar residuesSequence analysisAdd BLAST | 25 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3592, Eukaryota |
GeneTreei | ENSGT00940000160221 |
HOGENOMi | CLU_000285_2_0_1 |
InParanoidi | Q66K74 |
OMAi | ECGCSGL |
OrthoDBi | 86642at2759 |
PhylomeDBi | Q66K74 |
TreeFami | TF350229 |
Family and domain databases
InterProi | View protein in InterPro IPR026074, MAP1 IPR027322, MAP1S |
PANTHERi | PTHR13843, PTHR13843, 2 hits PTHR13843:SF11, PTHR13843:SF11, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAVAGSGAA AAPSSLLLVV GSEFGSPGLL TYVLEELERG IRSWDVDPGV
60 70 80 90 100
CNLDEQLKVF VSRHSATFSS IVKGQRSLHH RGDNLETLVL LNPSDKSLYD
110 120 130 140 150
ELRNLLLDPA SHKLLVLAGP CLEETGELLL QTGGFSPHHF LQVLKDREIR
160 170 180 190 200
DILATTPPPV QPPILTITCP TFGDWAQLAP AVPGLQGALR LQLRLNPPAQ
210 220 230 240 250
LPNSEGLCEF LEYVAESLEP PSPFELLEPP TSGGFLRLGR PCCYIFPGGL
260 270 280 290 300
GDAAFFAVNG FTVLVNGGSN PKSSFWKLVR HLDRVDAVLV THPGADSLPG
310 320 330 340 350
LNSLLRRKLA ERSEVAAGGG SWDDRLRRLI SPNLGVVFFN ACEAASRLAR
360 370 380 390 400
GEDEAELALS LLAQLGITPL PLSRGPVPAK PTVLFEKMGV GRLDMYVLHP
410 420 430 440 450
PSAGAERTLA SVCALLVWHP AGPGEKVVRV LFPGCTPPAC LLDGLVRLQH
460 470 480 490 500
LRFLREPVVT PQDLEGPGRA ESKESVGSRD SSKREGLLAT HPRPGQERPG
510 520 530 540 550
VARKEPARAE APRKTEKEAK TPRELKKDPK PSVSRTQPRE VRRAASSVPN
560 570 580 590 600
LKKTNAQAAP KPRKAPSTSH SGFPPVANGP RSPPSLRCGE ASPPSAACGS
610 620 630 640 650
PASQLVATPS LELGPIPAGE EKALELPLAA SSIPRPRTPS PESHRSPAEG
660 670 680 690 700
SERLSLSPLR GGEAGPDASP TVTTPTVTTP SLPAEVGSPH STEVDESLSV
710 720 730 740 750
SFEQVLPPSA PTSEAGLSLP LRGPRARRSA SPHDVDLCLV SPCEFEHRKA
760 770 780 790 800
VPMAPAPASP GSSNDSSARS QERAGGLGAE ETPPTSVSES LPTLSDSDPV
810 820 830 840 850
PLAPGAADSD EDTEGFGVPR HDPLPDPLKV PPPLPDPSSI CMVDPEMLPP
860 870 880 890 900
KTARQTENVS RTRKPLARPN SRAAAPKATP VAAAKTKGLA GGDRASRPLS
910 920 930 940 950
ARSEPSEKGG RAPLSRKSST PKTATRGPSG SASSRPGVSA TPPKSPVYLD
960 970 980 990 1000
LAYLPSGSSA HLVDEEFFQR VRALCYVISG QDQRKEEGMR AVLDALLASK
1010 1020 1030 1040 1050
QHWDRDLQVT LIPTFDSVAM HTWYAETHAR HQALGITVLG SNSMVSMQDD
AFPACKVEF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QY41 | M0QY41_HUMAN | Microtubule-associated protein 1S | MAP1S | 189 | Annotation score: | ||
M0QXQ9 | M0QXQ9_HUMAN | Microtubule-associated protein 1S | MAP1S | 185 | Annotation score: | ||
M0R1J2 | M0R1J2_HUMAN | Microtubule-associated protein 1S | MAP1S | 188 | Annotation score: | ||
M0R1M7 | M0R1M7_HUMAN | Microtubule-associated protein 1S | MAP1S | 120 | Annotation score: | ||
M0QZ50 | M0QZ50_HUMAN | Microtubule-associated protein 1S | MAP1S | 93 | Annotation score: | ||
M0QXE8 | M0QXE8_HUMAN | Microtubule-associated protein 1S | MAP1S | 82 | Annotation score: | ||
M0QX37 | M0QX37_HUMAN | Microtubule-associated protein 1S | MAP1S | 81 | Annotation score: | ||
M0QXK6 | M0QXK6_HUMAN | Microtubule-associated protein 1S | MAP1S | 79 | Annotation score: | ||
M0QYI5 | M0QYI5_HUMAN | Microtubule-associated protein 1S | MAP1S | 67 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 120 | P → L in CAD29574 (PubMed:14627543).Curated | 1 | |
Sequence conflicti | 120 | P → L in BAB55242 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 178 | L → P in CAD29574 (PubMed:14627543).Curated | 1 | |
Sequence conflicti | 178 | L → P in BAB55242 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 440 | C → Y in CAD38911 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 521 | T → A in BAB93493 (Ref. 7) Curated | 1 | |
Sequence conflicti | 526 | K → R in CAD29574 (PubMed:14627543).Curated | 1 | |
Sequence conflicti | 526 | K → R in BAB55242 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 967 | F → L in BAB14415 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1043 | S → G in BAA91743 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050023 | 372 | L → V. Corresponds to variant dbSNP:rs17710707Ensembl. | 1 | |
Natural variantiVAR_037236 | 411 | S → C1 PublicationCorresponds to variant dbSNP:rs17710707Ensembl. | 1 | |
Natural variantiVAR_037237 | 538 | P → Q. Corresponds to variant dbSNP:rs7252905Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056043 | 1 – 39 | MAAVA…EELER → MAGMIDRFSPANT in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ440784 mRNA Translation: CAD29574.1 DQ387861 mRNA Translation: ABD47682.1 AK027623 mRNA Translation: BAB55242.1 Frameshift. AK001531 mRNA Translation: BAA91743.1 Different initiation. AK023118 mRNA Translation: BAB14415.1 Different initiation. AK294936 mRNA Translation: BAG58014.1 AL834233 mRNA Translation: CAD38911.1 Different initiation. AC008761 Genomic DNA No translation available. BC006358 mRNA Translation: AAH06358.2 BC007253 mRNA Translation: AAH07253.1 Different initiation. BC008806 mRNA Translation: AAH08806.2 BC067115 mRNA Translation: AAH67115.1 Different initiation. BC080547 mRNA Translation: AAH80547.1 BC113952 mRNA Translation: AAI13953.1 AB062430 mRNA Translation: BAB93493.1 Different initiation. |
CCDSi | CCDS32954.1 [Q66K74-1] CCDS77262.1 [Q66K74-2] |
RefSeqi | NP_001295292.1, NM_001308363.1 [Q66K74-2] NP_060644.4, NM_018174.5 [Q66K74-1] |
Genome annotation databases
Ensembli | ENST00000324096.9; ENSP00000325313.3; ENSG00000130479.11 ENST00000544059.2; ENSP00000439243.1; ENSG00000130479.11 [Q66K74-2] |
GeneIDi | 55201 |
KEGGi | hsa:55201 |
MANE-Selecti | ENST00000324096.9; ENSP00000325313.3; NM_018174.6; NP_060644.4 |
UCSCi | uc002nhe.2, human [Q66K74-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ440784 mRNA Translation: CAD29574.1 DQ387861 mRNA Translation: ABD47682.1 AK027623 mRNA Translation: BAB55242.1 Frameshift. AK001531 mRNA Translation: BAA91743.1 Different initiation. AK023118 mRNA Translation: BAB14415.1 Different initiation. AK294936 mRNA Translation: BAG58014.1 AL834233 mRNA Translation: CAD38911.1 Different initiation. AC008761 Genomic DNA No translation available. BC006358 mRNA Translation: AAH06358.2 BC007253 mRNA Translation: AAH07253.1 Different initiation. BC008806 mRNA Translation: AAH08806.2 BC067115 mRNA Translation: AAH67115.1 Different initiation. BC080547 mRNA Translation: AAH80547.1 BC113952 mRNA Translation: AAI13953.1 AB062430 mRNA Translation: BAB93493.1 Different initiation. |
CCDSi | CCDS32954.1 [Q66K74-1] CCDS77262.1 [Q66K74-2] |
RefSeqi | NP_001295292.1, NM_001308363.1 [Q66K74-2] NP_060644.4, NM_018174.5 [Q66K74-1] |
3D structure databases
AlphaFoldDBi | Q66K74 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120498, 107 interactors |
IntActi | Q66K74, 49 interactors |
MINTi | Q66K74 |
STRINGi | 9606.ENSP00000325313 |
PTM databases
GlyGeni | Q66K74, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q66K74 |
MetOSitei | Q66K74 |
PhosphoSitePlusi | Q66K74 |
Genetic variation databases
BioMutai | MAP1S |
DMDMi | 160410004 |
Proteomic databases
EPDi | Q66K74 |
jPOSTi | Q66K74 |
MassIVEi | Q66K74 |
MaxQBi | Q66K74 |
PaxDbi | Q66K74 |
PeptideAtlasi | Q66K74 |
PRIDEi | Q66K74 |
ProteomicsDBi | 4197 65957 [Q66K74-1] |
Protocols and materials databases
Antibodypediai | 27783, 195 antibodies from 24 providers |
DNASUi | 55201 |
Genome annotation databases
Ensembli | ENST00000324096.9; ENSP00000325313.3; ENSG00000130479.11 ENST00000544059.2; ENSP00000439243.1; ENSG00000130479.11 [Q66K74-2] |
GeneIDi | 55201 |
KEGGi | hsa:55201 |
MANE-Selecti | ENST00000324096.9; ENSP00000325313.3; NM_018174.6; NP_060644.4 |
UCSCi | uc002nhe.2, human [Q66K74-1] |
Organism-specific databases
CTDi | 55201 |
DisGeNETi | 55201 |
GeneCardsi | MAP1S |
HGNCi | HGNC:15715, MAP1S |
HPAi | ENSG00000130479, Tissue enhanced (brain) |
MIMi | 607573, gene |
neXtProti | NX_Q66K74 |
OpenTargetsi | ENSG00000130479 |
PharmGKBi | PA38031 |
VEuPathDBi | HostDB:ENSG00000130479 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3592, Eukaryota |
GeneTreei | ENSGT00940000160221 |
HOGENOMi | CLU_000285_2_0_1 |
InParanoidi | Q66K74 |
OMAi | ECGCSGL |
OrthoDBi | 86642at2759 |
PhylomeDBi | Q66K74 |
TreeFami | TF350229 |
Enzyme and pathway databases
PathwayCommonsi | Q66K74 |
SignaLinki | Q66K74 |
Miscellaneous databases
BioGRID-ORCSi | 55201, 16 hits in 1085 CRISPR screens |
ChiTaRSi | MAP1S, human |
GeneWikii | MAP1S |
GenomeRNAii | 55201 |
Pharosi | Q66K74, Tbio |
PROi | PR:Q66K74 |
RNActi | Q66K74, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130479, Expressed in testis and 230 other tissues |
ExpressionAtlasi | Q66K74, baseline and differential |
Genevisiblei | Q66K74, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026074, MAP1 IPR027322, MAP1S |
PANTHERi | PTHR13843, PTHR13843, 2 hits PTHR13843:SF11, PTHR13843:SF11, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MAP1S_HUMAN | |
Accessioni | Q66K74Primary (citable) accession number: Q66K74 Secondary accession number(s): B4DH53 Q9NVK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families