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Protein

TBC1 domain family member 9B

Gene

TBC1D9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei555Arginine fingerBy similarity1
Sitei594Glutamine fingerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 9B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D9B
Synonyms:KIAA0676
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197226.12

Human Gene Nomenclature Database

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HGNCi
HGNC:29097 TBC1D9B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618039 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q66K14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei668 – 688HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000197226

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA145148062

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TBC1D9B

Domain mapping of disease mutations (DMDM)

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DMDMi
296452939

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002885011 – 1250TBC1 domain family member 9BAdd BLAST1250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei397PhosphothreonineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei1241PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q66K14

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q66K14

MaxQB - The MaxQuant DataBase

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MaxQBi
Q66K14

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q66K14

PeptideAtlas

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PeptideAtlasi
Q66K14

PRoteomics IDEntifications database

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PRIDEi
Q66K14

ProteomicsDB human proteome resource

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ProteomicsDBi
65950
65951 [Q66K14-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q66K14

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q66K14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000197226 Expressed in 229 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

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CleanExi
HS_TBC1D9B

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q66K14 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q66K14 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA038350

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116696, 34 interactors

Protein interaction database and analysis system

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IntActi
Q66K14, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000349291

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q66K14

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 209GRAM 1Add BLAST68
Domaini288 – 356GRAM 2Add BLAST69
Domaini508 – 695Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188
Domaini879 – 914EF-handPROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4347 Eukaryota
COG5210 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158554

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054142

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q66K14

KEGG Orthology (KO)

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KOi
K19951

Identification of Orthologs from Complete Genome Data

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OMAi
EGEAMTI

Database of Orthologous Groups

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OrthoDBi
450360at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q66K14

TreeFam database of animal gene trees

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TreeFami
TF313145

Family and domain databases

Conserved Domains Database

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CDDi
cd13351 PH-GRAM1_TCB1D9_TCB1D9B, 1 hit
cd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036014 TCB1D9/TCB1D9B_PH-GRAM1
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2

Pfam protein domain database

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Pfami
View protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q66K14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLSPEEVLV ANALWVTERA NPFFVLQRRR GHGRGGGLTG LLVGTLDVVL
60 70 80 90 100
DSSARVAPYR ILHQTQDSQV YWTVACGSSR KEITKHWEWL ENNLLQTLSI
110 120 130 140 150
FDSEEDITTF VKGKIHGIIA EENKNLQPQG DEDPGKFKEA ELKMRKQFGM
160 170 180 190 200
PEGEKLVNYY SCSYWKGRVP RQGWLYLTVN HLCFYSFLLG KEVSLVVQWV
210 220 230 240 250
DITRLEKNAT LLFPESIRVD TRDQELFFSM FLNIGETFKL MEQLANLAMR
260 270 280 290 300
QLLDSEGFLE DKALPRPIRP HRNISALKRD LDARAKNECY RATFRLPRDE
310 320 330 340 350
RLDGHTSCTL WTPFNKLHIP GQMFISNNYI CFASKEEDAC HLIIPLREVT
360 370 380 390 400
IVEKADSSSV LPSPLSISTK SKMTFLFANL KDRDFLVQRI SDFLQKTPSK
410 420 430 440 450
QPGSIGSRKA SVVDPSTESS PAPQEGSEQP ASPASPLSSR QSFCAQEAPT
460 470 480 490 500
ASQGLLKLFQ KNSPMEDLGA KGAKEKMKEE SWHIHFFEYG RGVCMYRTAK
510 520 530 540 550
TRALVLKGIP ESLRGELWLL FSGAWNEMVT HPGYYAELVE KSTGKYSLAT
560 570 580 590 600
EEIERDLHRS MPEHPAFQNE LGIAALRRVL TAYAFRNPTI GYCQAMNIVT
610 620 630 640 650
SVLLLYGSEE EAFWLLVALC ERMLPDYYNT RVVGALVDQG IFEELTRDFL
660 670 680 690 700
PQLSEKMQDL GVISSISLSW FLTLFLSVMP FESAVVIVDC FFYEGIKVIL
710 720 730 740 750
QVALAVLDAN MEQLLGCSDE GEAMTMLGRY LDNVVNKQSV SPPIPHLRAL
760 770 780 790 800
LSSSDDPPAE VDIFELLKVS YEKFSSLRAE DIEQMRFKQR LKVIQSLEDT
810 820 830 840 850
AKRSVVRAIP VDIGFSIEEL EDLYMVFKAK HLASQYWGCS RTMAGRRDPS
860 870 880 890 900
LPYLEQYRID ASQFRELFAS LTPWACGSHT PLLAGRMFRL LDENKDSLIN
910 920 930 940 950
FKEFVTGMSG MYHGDLTEKL KVLYKLHLPP ALSPEEAESA LEAAHYFTED
960 970 980 990 1000
SSSEASPLAS DLDLFLPWEA QEALPQEEQE GSGSEERGEE KGTSSPDYRH
1010 1020 1030 1040 1050
YLRMWAKEKE AQKETIKDLP KMNQEQFIEL CKTLYNMFSE DPMEQDLYHA
1060 1070 1080 1090 1100
IATVASLLLR IGEVGKKFSA RTGRKPRDCA TEEDEPPAPE LHQDAARELQ
1110 1120 1130 1140 1150
PPAAGDPQAK AGGDTHLGKA PQESQVVVEG GSGEGQGSPS QLLSDDETKD
1160 1170 1180 1190 1200
DMSMSSYSVV STGSLQCEDL ADDTVLVGGE ACSPTARIGG TVDTDWCISF
1210 1220 1230 1240 1250
EQILASILTE SVLVNFFEKR VDIGLKIKDQ KKVERQFSTA SDHEQPGVSG
Length:1,250
Mass (Da):140,525
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35D9E4914B1D8311
GO
Isoform 2 (identifier: Q66K14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     955-971: Missing.

Show »
Length:1,233
Mass (Da):138,670
Checksum:i0CF4629B30598F6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V133G3V133_HUMAN
KIAA0676 protein, isoform CRA_d
TBC1D9B KIAA0676, hCG_15288
409Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB08H0YB08_HUMAN
TBC1 domain family member 9B
TBC1D9B
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB58H0YB58_HUMAN
TBC1 domain family member 9B
TBC1D9B
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIN2E5RIN2_HUMAN
TBC1 domain family member 9B
TBC1D9B
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti893E → G in BAD97229 (Ref. 5) Curated1
Sequence conflicti1231K → R in CAE46050 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032440240L → P. Corresponds to variant dbSNP:rs1057078Ensembl.1
Natural variantiVAR_032441706V → I. Corresponds to variant dbSNP:rs10037618Ensembl.1
Natural variantiVAR_0361961086P → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0324421119K → T4 PublicationsCorresponds to variant dbSNP:rs30386Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025699955 – 971Missing in isoform 2. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB014576 mRNA Translation: BAA31651.1
AC008393 Genomic DNA No translation available.
AC010285 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53780.1
CH471165 Genomic DNA Translation: EAW53782.1
CH471165 Genomic DNA Translation: EAW53777.1
CH471165 Genomic DNA Translation: EAW53779.1
BC008919 mRNA Translation: AAH08919.3 Different initiation.
BC080659 mRNA Translation: AAH80659.1
AK223509 mRNA Translation: BAD97229.1
BX641107 mRNA Translation: CAE46050.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43408.1 [Q66K14-1]
CCDS4450.1 [Q66K14-2]

NCBI Reference Sequences

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RefSeqi
NP_055858.2, NM_015043.3 [Q66K14-2]
NP_942568.2, NM_198868.2 [Q66K14-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.155829

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355235; ENSP00000347375; ENSG00000197226 [Q66K14-2]
ENST00000356834; ENSP00000349291; ENSG00000197226 [Q66K14-1]
ENST00000639361; ENSP00000491970; ENSG00000284400 [Q66K14-1]
ENST00000639711; ENSP00000491373; ENSG00000284400 [Q66K14-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23061

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23061

UCSC genome browser

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UCSCi
uc003mlh.4 human [Q66K14-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014576 mRNA Translation: BAA31651.1
AC008393 Genomic DNA No translation available.
AC010285 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53780.1
CH471165 Genomic DNA Translation: EAW53782.1
CH471165 Genomic DNA Translation: EAW53777.1
CH471165 Genomic DNA Translation: EAW53779.1
BC008919 mRNA Translation: AAH08919.3 Different initiation.
BC080659 mRNA Translation: AAH80659.1
AK223509 mRNA Translation: BAD97229.1
BX641107 mRNA Translation: CAE46050.1
CCDSiCCDS43408.1 [Q66K14-1]
CCDS4450.1 [Q66K14-2]
RefSeqiNP_055858.2, NM_015043.3 [Q66K14-2]
NP_942568.2, NM_198868.2 [Q66K14-1]
UniGeneiHs.155829

3D structure databases

ProteinModelPortaliQ66K14
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116696, 34 interactors
IntActiQ66K14, 10 interactors
STRINGi9606.ENSP00000349291

PTM databases

iPTMnetiQ66K14
PhosphoSitePlusiQ66K14

Polymorphism and mutation databases

BioMutaiTBC1D9B
DMDMi296452939

Proteomic databases

EPDiQ66K14
jPOSTiQ66K14
MaxQBiQ66K14
PaxDbiQ66K14
PeptideAtlasiQ66K14
PRIDEiQ66K14
ProteomicsDBi65950
65951 [Q66K14-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23061
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355235; ENSP00000347375; ENSG00000197226 [Q66K14-2]
ENST00000356834; ENSP00000349291; ENSG00000197226 [Q66K14-1]
ENST00000639361; ENSP00000491970; ENSG00000284400 [Q66K14-1]
ENST00000639711; ENSP00000491373; ENSG00000284400 [Q66K14-2]
GeneIDi23061
KEGGihsa:23061
UCSCiuc003mlh.4 human [Q66K14-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23061
EuPathDBiHostDB:ENSG00000197226.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D9B
HGNCiHGNC:29097 TBC1D9B
HPAiHPA038350
MIMi618039 gene
neXtProtiNX_Q66K14
OpenTargetsiENSG00000197226
PharmGKBiPA145148062

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000158554
HOVERGENiHBG054142
InParanoidiQ66K14
KOiK19951
OMAiEGEAMTI
OrthoDBi450360at2759
PhylomeDBiQ66K14
TreeFamiTF313145

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D9B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23061

Protein Ontology

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PROi
PR:Q66K14

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197226 Expressed in 229 organ(s), highest expression level in cerebellum
CleanExiHS_TBC1D9B
ExpressionAtlasiQ66K14 baseline and differential
GenevisibleiQ66K14 HS

Family and domain databases

CDDicd13351 PH-GRAM1_TCB1D9_TCB1D9B, 1 hit
cd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036014 TCB1D9/TCB1D9B_PH-GRAM1
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC9B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66K14
Secondary accession number(s): D3DWQ5
, D3DWQ6, O75163, Q53EY0, Q6MZI2, Q96H49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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