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Protein

Thymocyte selection-associated high mobility group box protein TOX

Gene

Tox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in regulating T-cell development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi261 – 329HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymocyte selection-associated high mobility group box protein TOX
Alternative name(s):
Thymus high mobility group box protein TOX
Gene namesi
Name:Tox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2181659 Tox

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445701 – 526Thymocyte selection-associated high mobility group box protein TOXAdd BLAST526

Proteomic databases

PaxDbiQ66JW3
PeptideAtlasiQ66JW3
PRIDEiQ66JW3

PTM databases

iPTMnetiQ66JW3
PhosphoSitePlusiQ66JW3

Expressioni

Tissue specificityi

Detected in brain, liver, small intestine, spleen, stomach, testis and thymus.1 Publication

Inductioni

Up-regulated during the early stages of T-cell differentiation. Down-regulated during later stages of maturation of CD4 and CD8 T-cells. Up-regulated in immature thymocytes upon activation of pre-T-cell receptor or T-cell receptor. Activation of T-cell receptor of mature thymocytes has no effect.1 Publication

Gene expression databases

BgeeiENSMUSG00000041272 Expressed in 279 organ(s), highest expression level in telencephalon
GenevisibleiQ66JW3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037966

Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ66JW3
SMRiQ66JW3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ66JW3

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi237 – 256Nuclear localization signalSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi417 – 420Poly-Pro4

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiQ66JW3
OMAiCRNPPAQ
OrthoDBiEOG091G0CPH
PhylomeDBiQ66JW3
TreeFamiTF106481

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q66JW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVRFYPPPA QPAAAPAAPC LGPSPCLDPY YCNKFDGENM YMSMTEPSQD
60 70 80 90 100
YVPASQSYPG PSLESEDFNI PPITPPSLPD HSLVHLNEVE SGYHSLCHPM
110 120 130 140 150
NHNGLLPFHP QTMDLPEITV SNMLGQDGAL LSNSISVMQE IGNAEGAQYS
160 170 180 190 200
SHPQMAAMRP RGQPTDIRQQ ASMMQPGQLT TINQSQLSAQ LGLNMGGTNV
210 220 230 240 250
AHNSPSPPGS KSATPSPSSS VHEDECEDAS KINGGEKRPA SDMGKKPKTP
260 270 280 290 300
KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD
310 320 330 340 350
GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYTDP VDVKTSQPPQ
360 370 380 390 400
LVNSKPSVFH GPSQAHSALY LSSHYHQQPG MTPQLTAMHP SLPRNIAPKP
410 420 430 440 450
NNQMPVTVSI ANMAVSPPPP LQISPPLHQH LSMQQHQSLA MQQPLGSQLP
460 470 480 490 500
MQVQTALHSP TMQQGFTLQP DYQTIINPTS TAAQVVTQAM EYVRSGCRNP
510 520
PPQPVDWSTD YCSSGGMQRD KALYLT
Length:526
Mass (Da):57,203
Last modified:June 27, 2006 - v2
Checksum:iF6E7EE5EFCC6CC03
GO
Isoform 2 (identifier: Q66JW3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-232: I → V
     233-526: Missing.

Show »
Length:232
Mass (Da):24,844
Checksum:iEBEED93E558EB600
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27L → Q in BAC30091 (PubMed:16141072).Curated1
Sequence conflicti140E → D in AAH80732 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019598232I → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_019599233 – 526Missing in isoform 2. 1 PublicationAdd BLAST294

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF472514 mRNA Translation: AAL78656.1
AK029694 mRNA Translation: BAC26568.1
AK038671 mRNA Translation: BAC30091.1
AK051947 mRNA Translation: BAC34818.1
BC080732 mRNA Translation: AAH80732.1
CCDSiCCDS17953.1 [Q66JW3-1]
RefSeqiNP_663757.3, NM_145711.4 [Q66JW3-1]
XP_006538007.1, XM_006537944.3 [Q66JW3-1]
XP_006538008.1, XM_006537945.2 [Q66JW3-1]
UniGeneiMm.435828
Mm.488241

Genome annotation databases

EnsembliENSMUST00000039987; ENSMUSP00000037966; ENSMUSG00000041272 [Q66JW3-1]
GeneIDi252838
KEGGimmu:252838
UCSCiuc008rxs.2 mouse [Q66JW3-1]
uc008rxt.1 mouse [Q66JW3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF472514 mRNA Translation: AAL78656.1
AK029694 mRNA Translation: BAC26568.1
AK038671 mRNA Translation: BAC30091.1
AK051947 mRNA Translation: BAC34818.1
BC080732 mRNA Translation: AAH80732.1
CCDSiCCDS17953.1 [Q66JW3-1]
RefSeqiNP_663757.3, NM_145711.4 [Q66JW3-1]
XP_006538007.1, XM_006537944.3 [Q66JW3-1]
XP_006538008.1, XM_006537945.2 [Q66JW3-1]
UniGeneiMm.435828
Mm.488241

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CO9NMR-A251-339[»]
ProteinModelPortaliQ66JW3
SMRiQ66JW3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037966

PTM databases

iPTMnetiQ66JW3
PhosphoSitePlusiQ66JW3

Proteomic databases

PaxDbiQ66JW3
PeptideAtlasiQ66JW3
PRIDEiQ66JW3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039987; ENSMUSP00000037966; ENSMUSG00000041272 [Q66JW3-1]
GeneIDi252838
KEGGimmu:252838
UCSCiuc008rxs.2 mouse [Q66JW3-1]
uc008rxt.1 mouse [Q66JW3-2]

Organism-specific databases

CTDi9760
MGIiMGI:2181659 Tox

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00560000076898
HOGENOMiHOG000230949
HOVERGENiHBG051183
InParanoidiQ66JW3
OMAiCRNPPAQ
OrthoDBiEOG091G0CPH
PhylomeDBiQ66JW3
TreeFamiTF106481

Miscellaneous databases

ChiTaRSiTox mouse
EvolutionaryTraceiQ66JW3
PROiPR:Q66JW3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041272 Expressed in 279 organ(s), highest expression level in telencephalon
GenevisibleiQ66JW3 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOX_MOUSE
AccessioniPrimary (citable) accession number: Q66JW3
Secondary accession number(s): Q8BKH9, Q8BYQ5, Q8R4H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 12, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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