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Entry version 101 (10 Feb 2021)
Sequence version 1 (11 Oct 2004)
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Protein

Coatomer subunit beta

Gene

copb1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-6798695, Neutrophil degranulation
R-DRE-6807878, COPI-mediated anterograde transport
R-DRE-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coatomer subunit betaImported
Alternative name(s):
Beta-coat proteinBy similarity
Short name:
Beta-COPBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:copb1Imported
Synonyms:hap1 Publication, happy1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030219-38, copb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

From 28 hours post-fertilization (hpf) onward, embryos show an anterior-posterior gradient of pigmentation defects. While the head is fully pigmented, more posterior regions are decreasingly pigmented until midtrunk levels, where pigmentation is not detectable. Melanophores are present at midtrunk levels and migrate correctly, but are not properly pigmented. Embryos show severe reduction in pigmentation and widespread degeneration from 48 hpf onward. Failure to form perinotochordal basement membrane (PBM), without the loss of laminin immunoreactivity. Embryos are significantly shorter, because the notochord cells fail to differentiate and the notochord fails to lengthen properly. Vacuoles fail to inflate fully. Many notochord cells die by apoptosis. In 32 hpf embryos the endoplasmic reticulum is abnormally swollen and filled with a relatively electron dense material and the Golgi complex is fragmented into large vesicles throughout the cytoplasm. PBM is thin, disorganized and essentially lacks the medial layer. However, cells have a distinctive inner layer.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004089441 – 953Coatomer subunit betaAdd BLAST953

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q66HV4

PRoteomics IDEntifications database

More...
PRIDEi
Q66HV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000056557, Expressed in caudal fin and 34 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000073498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati96 – 131HEAT 1Sequence analysisAdd BLAST36
Repeati132 – 168HEAT 2Sequence analysisAdd BLAST37
Repeati240 – 276HEAT 3Sequence analysisAdd BLAST37
Repeati277 – 314HEAT 4Sequence analysisAdd BLAST38
Repeati316 – 353HEAT 5Sequence analysisAdd BLAST38
Repeati396 – 433HEAT 6Sequence analysisAdd BLAST38

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1058, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005270

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006949_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q66HV4

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCHANPA

Database of Orthologous Groups

More...
OrthoDBi
195812at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105737

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR011710, Coatomer_bsu_C
IPR016460, COPB1
IPR029446, COPB1_appendage_platform_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10635, PTHR10635, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01602, Adaptin_N, 1 hit
PF07718, Coatamer_beta_C, 1 hit
PF14806, Coatomer_b_Cpla, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005727, Coatomer_beta_subunit, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q66HV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAAENVCYT LINVTNDSEP PSEVSLKTDL EKGEIKAKTE ALKKVIIMIL
60 70 80 90 100
NGEKLPGLLM TIIRFVLPLQ DHTIKKLLLV FWEIVPKTTP DGKLLQEMIL
110 120 130 140 150
VCDAYRKDLQ HPNEFIRGST LRFLCKLKES ELLEPLMPAI RACLEHRHSY
160 170 180 190 200
VRRNAVLAIY TIYRNFEHLI PDAPELIHDF LVNEKDASCK RNAFMMLIHA
210 220 230 240 250
DQDRALDYLS TCIDQVHTFG DILQLVIVEL IYKVCHANPS ERARFIRCIY
260 270 280 290 300
NLLQSSSPAV KYEAAGTLVT LSSAPTAIKA AAQCYIDLII KESDNNVKLI
310 320 330 340 350
VLDRLIELKE HPTHERVLQD LVMDILRVLT TPDLEVRKKT LQLALDLVSS
360 370 380 390 400
RNVEELVIVL KKEVIKTNNV TEHEDTDKYR QLLVRTLHSC SVRFPDMAAN
410 420 430 440 450
VIPVLMEFLS DTNEAAAADV LEFVREAIQR FDNLRPLIIE KMLEVFHAIK
460 470 480 490 500
TVKIYRGALW ILGEYCSTKE DIQSVMTEVR RSLGEIPIVE NELKKEAGEV
510 520 530 540 550
KPEEEVTAAP APKLVTEMGT YVTQSALSTS RPSKKEEDRP PLRGFLMDGD
560 570 580 590 600
FYVAASLATT LTKVALRYVA LAEDKRRQNS FVAEAMLIMA TVLHLGKSSL
610 620 630 640 650
PKKPITDDDV DRISLCLKVL SECSPLMNDI FNKECRRSLS HMLAVRLEEE
660 670 680 690 700
KLSQKKESEK RNVTVQADDP ISFMQLTAKN EMASKEDQFQ LSLLAAMGNT
710 720 730 740 750
QRKEATDPLA SKLNKVTQLT GFSDPVYAEA YVHVNQYDIV LDVLVVNQTS
760 770 780 790 800
DTLQNCTLEL ATLGDLKLVE KPSPLTLAPH DFANIKANVK VASTENGIIF
810 820 830 840 850
GNIVYDVSGA ASDRNCVVLS DIHIDIMDYI QPASCTDAEF RQMWAEFEWE
860 870 880 890 900
NKVTVNTNIT DLNDYLLHIL KSTNMKCLTP EKALSGICGF MAANLYARSI
910 920 930 940 950
FGEDALANVS IEKPIHLGVD APVNGHIRIR AKSQGMALSL GDKINLSQKR

TAS
Length:953
Mass (Da):107,032
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i293B52FD3451C773
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146H → R in AAQ63171 (PubMed:15469843).Curated1
Sequence conflicti935G → V in AAQ63171 (PubMed:15469843).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY294010 mRNA Translation: AAQ63171.1
BC081657 mRNA Translation: AAH81657.1

NCBI Reference Sequences

More...
RefSeqi
NP_001002013.1, NM_001002013.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000079042; ENSDARP00000073498; ENSDARG00000056557
ENSDART00000185811; ENSDARP00000147390; ENSDARG00000116045

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
338138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:338138

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY294010 mRNA Translation: AAQ63171.1
BC081657 mRNA Translation: AAH81657.1
RefSeqiNP_001002013.1, NM_001002013.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073498

Proteomic databases

PaxDbiQ66HV4
PRIDEiQ66HV4

Genome annotation databases

EnsembliENSDART00000079042; ENSDARP00000073498; ENSDARG00000056557
ENSDART00000185811; ENSDARP00000147390; ENSDARG00000116045
GeneIDi338138
KEGGidre:338138

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1315
ZFINiZDB-GENE-030219-38, copb1

Phylogenomic databases

eggNOGiKOG1058, Eukaryota
GeneTreeiENSGT00390000005270
HOGENOMiCLU_006949_0_0_1
InParanoidiQ66HV4
OMAiVCHANPA
OrthoDBi195812at2759
TreeFamiTF105737

Enzyme and pathway databases

ReactomeiR-DRE-6798695, Neutrophil degranulation
R-DRE-6807878, COPI-mediated anterograde transport
R-DRE-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q66HV4

Gene expression databases

BgeeiENSDARG00000056557, Expressed in caudal fin and 34 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR011710, Coatomer_bsu_C
IPR016460, COPB1
IPR029446, COPB1_appendage_platform_dom
PANTHERiPTHR10635, PTHR10635, 1 hit
PfamiView protein in Pfam
PF01602, Adaptin_N, 1 hit
PF07718, Coatamer_beta_C, 1 hit
PF14806, Coatomer_b_Cpla, 1 hit
PIRSFiPIRSF005727, Coatomer_beta_subunit, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOPB_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66HV4
Secondary accession number(s): Q6JWU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: October 11, 2004
Last modified: February 10, 2021
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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