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UniProtKB - Q66HH3 (LYL1_RAT)
Protein
Protein lyl-1
Gene
Lyl1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- B cell differentiation Source: UniProtKB
- blood vessel maturation Source: UniProtKB
- definitive hemopoiesis Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lyl-1Alternative name(s): Lymphoblastic leukemia-derived sequence 1 |
Gene namesi | Name:Lyl1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359244, Lyl1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000369264 | 1 – 278 | Protein lyl-1Add BLAST | 278 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 274 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q66HH3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000002950, Expressed in spleen and 22 other tissues |
Genevisiblei | Q66HH3, RN |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003980 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 201 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 213 – 278 | DisorderedSequence analysisAdd BLAST | 66 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162404 |
HOGENOMi | CLU_047980_1_0_1 |
InParanoidi | Q66HH3 |
OMAi | HRVPDDG |
OrthoDBi | 1453623at2759 |
PhylomeDBi | Q66HH3 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q66HH3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCPPQAQAEV GSAMTEKTEM VCTSSPAPAP PSKPASPGPL PAEEVDHRNT
60 70 80 90 100
CNPWLPPGVP VINLGHTRPT GAAMPTTELS AFRPSLLQLA ALGTAPPTLA
110 120 130 140 150
LHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHGELDLV DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQAA VLASGPSAPG SRKPPAHRGV EGNARCGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKMEQ TALSPEVR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC081864 mRNA Translation: AAH81864.1 |
RefSeqi | NP_001007678.1, NM_001007677.1 |
Genome annotation databases
Ensembli | ENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950 |
GeneIDi | 304663 |
KEGGi | rno:304663 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC081864 mRNA Translation: AAH81864.1 |
RefSeqi | NP_001007678.1, NM_001007677.1 |
3D structure databases
AlphaFoldDBi | Q66HH3 |
SMRi | Q66HH3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003980 |
Proteomic databases
PaxDbi | Q66HH3 |
Genome annotation databases
Ensembli | ENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950 |
GeneIDi | 304663 |
KEGGi | rno:304663 |
Organism-specific databases
CTDi | 4066 |
RGDi | 1359244, Lyl1 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162404 |
HOGENOMi | CLU_047980_1_0_1 |
InParanoidi | Q66HH3 |
OMAi | HRVPDDG |
OrthoDBi | 1453623at2759 |
PhylomeDBi | Q66HH3 |
TreeFami | TF315153 |
Miscellaneous databases
PROi | PR:Q66HH3 |
Gene expression databases
Bgeei | ENSRNOG00000002950, Expressed in spleen and 22 other tissues |
Genevisiblei | Q66HH3, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LYL1_RAT | |
Accessioni | Q66HH3Primary (citable) accession number: Q66HH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | October 11, 2004 | |
Last modified: | May 25, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |