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Protein

Protein lyl-1

Gene

Lyl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:Lyl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1359244 Lyl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003692641 – 278Protein lyl-1Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66HH3

Expressioni

Gene expression databases

BgeeiENSRNOG00000002950 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiQ66HH3 RN

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003980

Structurei

3D structure databases

ProteinModelPortaliQ66HH3
SMRiQ66HH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 201bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
InParanoidiQ66HH3
KOiK15604
OMAiIKMEQTA
OrthoDBiEOG091G0ESI
PhylomeDBiQ66HH3
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q66HH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPPQAQAEV GSAMTEKTEM VCTSSPAPAP PSKPASPGPL PAEEVDHRNT
60 70 80 90 100
CNPWLPPGVP VINLGHTRPT GAAMPTTELS AFRPSLLQLA ALGTAPPTLA
110 120 130 140 150
LHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHGELDLV DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQAA VLASGPSAPG SRKPPAHRGV EGNARCGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKMEQ TALSPEVR
Length:278
Mass (Da):29,957
Last modified:October 11, 2004 - v1
Checksum:i8B2873F2BA288839
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081864 mRNA Translation: AAH81864.1
RefSeqiNP_001007678.1, NM_001007677.1
UniGeneiRn.17352

Genome annotation databases

EnsembliENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950
GeneIDi304663
KEGGirno:304663

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081864 mRNA Translation: AAH81864.1
RefSeqiNP_001007678.1, NM_001007677.1
UniGeneiRn.17352

3D structure databases

ProteinModelPortaliQ66HH3
SMRiQ66HH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003980

Proteomic databases

PaxDbiQ66HH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950
GeneIDi304663
KEGGirno:304663

Organism-specific databases

CTDi4066
RGDi1359244 Lyl1

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
InParanoidiQ66HH3
KOiK15604
OMAiIKMEQTA
OrthoDBiEOG091G0ESI
PhylomeDBiQ66HH3
TreeFamiTF315153

Miscellaneous databases

PROiPR:Q66HH3

Gene expression databases

BgeeiENSRNOG00000002950 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiQ66HH3 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYL1_RAT
AccessioniPrimary (citable) accession number: Q66HH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 11, 2004
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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