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Entry version 90 (08 May 2019)
Sequence version 1 (11 Oct 2004)
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Protein

Transmembrane 9 superfamily member 2

Gene

Tm9sf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the intracellular compartments, may function as a channel or small molecule transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tm9sf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Rat genome database

More...
RGDi
1359230 Tm9sf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 300LumenalSequence analysisAdd BLAST272
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 374CytoplasmicSequence analysisAdd BLAST53
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 398LumenalSequence analysis3
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 466LumenalSequence analysis8
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 554LumenalSequence analysisAdd BLAST11
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21
Topological domaini576 – 591CytoplasmicSequence analysisAdd BLAST16
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 631LumenalSequence analysisAdd BLAST19
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003436829 – 663Transmembrane 9 superfamily member 2Add BLAST635

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q66HG5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q66HG5

PRoteomics IDEntifications database

More...
PRIDEi
Q66HG5

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q66HG5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012751 Expressed in 9 organ(s), highest expression level in Ammon's horn

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q66HG5 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000017211

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1278 Eukaryota
ENOG410XPIW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216679

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q66HG5

KEGG Orthology (KO)

More...
KOi
K17086

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFLFLCY

Database of Orthologous Groups

More...
OrthoDBi
641127at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004240 EMP70

The PANTHER Classification System

More...
PANTHERi
PTHR10766 PTHR10766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02990 EMP70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRPPASLP ARGPRLLLLS LLLLGTVPGP RPGSAFYLPG LAPVNFCTEE
60 70 80 90 100
KKSNECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL
110 120 130 140 150
FGERIEPSPY KFTFNKEETC KLVCTKTYHT EKAEDKQKLD FLKKSMLLNY
160 170 180 190 200
QHHWIVDNMP VTWCYEVEDN QKFCNPGFPI GCYITDKGHA KDACVISSEF
210 220 230 240 250
HERDTFYIFN HVDIKIQYHV VETGSMGARL VAAKLEPKSF RHTHIDKPDC
260 270 280 290 300
SGPAMDISNK ASGEIKIAYT YSISFEEEKN IRWASRWDYI LESMPHTHIQ
310 320 330 340 350
WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL
360 370 380 390 400
VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM
410 420 430 440 450
TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF
460 470 480 490 500
IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH
510 520 530 540 550
PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ
560 570 580 590 600
MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA
610 620 630 640 650
VYFLVYAIHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF
660
WFVTKIYSVV KVD
Length:663
Mass (Da):75,586
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD10FD1885D85AFD1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC081873 mRNA Translation: AAH81873.1

NCBI Reference Sequences

More...
RefSeqi
NP_001005554.1, NM_001005554.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
306197

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:306197

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081873 mRNA Translation: AAH81873.1
RefSeqiNP_001005554.1, NM_001005554.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017211

PTM databases

SwissPalmiQ66HG5

Proteomic databases

jPOSTiQ66HG5
PaxDbiQ66HG5
PRIDEiQ66HG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017211; ENSRNOP00000017211; ENSRNOG00000012751
GeneIDi306197
KEGGirno:306197

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9375
RGDi1359230 Tm9sf2

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00940000157563
HOGENOMiHOG000216679
InParanoidiQ66HG5
KOiK17086
OMAiGFLFLCY
OrthoDBi641127at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q66HG5

Gene expression databases

BgeeiENSRNOG00000012751 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ66HG5 RN

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM9S2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66HG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: May 8, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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