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Protein

Transmembrane 9 superfamily member 1

Gene

Tm9sf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an essential role in autophagy.By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 1
Gene namesi
Name:Tm9sf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1307085 Tm9sf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei518 – 538HelicalSequence analysisAdd BLAST21
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003436428 – 589Transmembrane 9 superfamily member 1Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi542N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ66HF2
PeptideAtlasiQ66HF2
PRIDEiQ66HF2

Expressioni

Gene expression databases

BgeeiENSRNOG00000019710 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiQ66HF2 RN

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1277 Eukaryota
ENOG410XSVB LUCA
GeneTreeiENSGT00530000062897
HOGENOMiHOG000216680
HOVERGENiHBG108585
InParanoidiQ66HF2
KOiK17085
OMAiLWTHLDF
OrthoDBiEOG091G04HE
PhylomeDBiQ66HF2

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66HF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVLGHPRSW SCHCLPVLIL LLGIGHGPRV EGVTHYKPGD PVILYVNKVG
60 70 80 90 100
PYHNPQETYH YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN
110 120 130 140 150
VEKRILCHMQ LSSAQVEQLR QAIEELYYFE FVVDDLPIRG FVGYMEESGF
160 170 180 190 200
LPHSHKIGLW THLDFHLEFH GDRIIFANVS VRDVKPHSLD GLRSDELLGL
210 220 230 240 250
THTYSVRWSE TSVEHRSDRR RADDGGFFPR TLEIHWLSII NSMVLVFLLV
260 270 280 290 300
GFVAVILMRV LRNDLARYNL DEETSSGGSS DDFDQGDNGW KIIHTDVFRF
310 320 330 340 350
PPCRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA
360 370 380 390 400
LTCCISGYVS SHFYRQIGGE RWVWNIILTT SLFSVPFFLT WSVVNSVHWA
410 420 430 440 450
NGSTQALPVT TILLLLTVWL LVGFPLTVIG GIFGKNNASP FDAPCRTKNI
460 470 480 490 500
AREIPPQPCA ISVELYYIFA TVWGREQYTL YGILFFVFAI LLSVGACISI
510 520 530 540 550
ALTYFQLSGE DYRWWWRSVL SVGSTGLFIF LYSVFYYARR SNMSGAVQTV
560 570 580
EFFGYSLLTG YVFFLMLGTI SFFSSLKFIR YIYVNLKMD
Length:589
Mass (Da):66,918
Last modified:October 11, 2004 - v1
Checksum:iC429C098C911E3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081891 mRNA Translation: AAH81891.1
RefSeqiNP_001012155.1, NM_001012155.1
UniGeneiRn.12071

Genome annotation databases

EnsembliENSRNOT00000026734; ENSRNOP00000026734; ENSRNOG00000019710
GeneIDi361043
KEGGirno:361043
UCSCiRGD:1307085 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081891 mRNA Translation: AAH81891.1
RefSeqiNP_001012155.1, NM_001012155.1
UniGeneiRn.12071

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ66HF2
PeptideAtlasiQ66HF2
PRIDEiQ66HF2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026734; ENSRNOP00000026734; ENSRNOG00000019710
GeneIDi361043
KEGGirno:361043
UCSCiRGD:1307085 rat

Organism-specific databases

CTDi10548
RGDi1307085 Tm9sf1

Phylogenomic databases

eggNOGiKOG1277 Eukaryota
ENOG410XSVB LUCA
GeneTreeiENSGT00530000062897
HOGENOMiHOG000216680
HOVERGENiHBG108585
InParanoidiQ66HF2
KOiK17085
OMAiLWTHLDF
OrthoDBiEOG091G04HE
PhylomeDBiQ66HF2

Miscellaneous databases

PROiPR:Q66HF2

Gene expression databases

BgeeiENSRNOG00000019710 Expressed in 10 organ(s), highest expression level in liver
GenevisibleiQ66HF2 RN

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM9S1_RAT
AccessioniPrimary (citable) accession number: Q66HF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 11, 2004
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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