UniProtKB - Q66H80 (COPD_RAT)
Coatomer subunit delta
Arcn1
Functioni
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
By similarityGO - Biological processi
- adult locomotory behavior Source: RGD
- cerebellar Purkinje cell layer maturation Source: RGD
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- Golgi localization Source: GO_Central
- Golgi vesicle transport Source: RGD
- pigmentation Source: RGD
- protein transport Source: UniProtKB-KW
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-6807878, COPI-mediated anterograde transport R-RNO-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Coatomer subunit deltaAlternative name(s): Archain Delta-coat protein Short name: Delta-COP |
Gene namesi | Name:Arcn1 Synonyms:Copd |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359110, Arcn1 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- COPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
Golgi apparatus
- COPI vesicle coat Source: GO_Central
- Golgi apparatus Source: RGD
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- COPI-coated vesicle Source: RGD
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193844 | 1 – 511 | Coatomer subunit deltaAdd BLAST | 511 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 223 | PhosphoserineBy similarity | 1 | |
Modified residuei | 233 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 241 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 244 | PhosphoserineBy similarity | 1 | |
Modified residuei | 309 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 351 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 493 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q66H80 |
PaxDbi | Q66H80 |
PRIDEi | Q66H80 |
PTM databases
iPTMneti | Q66H80 |
PhosphoSitePlusi | Q66H80 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000061108, Expressed in jejunum and 20 other tissues |
Genevisiblei | Q66H80, RN |
Interactioni
Subunit structurei
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
By similarityProtein-protein interaction databases
BioGRIDi | 256663, 2 interactors |
IntActi | Q66H80, 2 interactors |
STRINGi | 10116.ENSRNOP00000018598 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 271 – 511 | MHDPROSITE-ProRule annotationAdd BLAST | 241 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 168 – 188 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2635, Eukaryota |
GeneTreei | ENSGT00390000017207 |
HOGENOMi | CLU_019988_3_0_1 |
InParanoidi | Q66H80 |
OMAi | FLDMESH |
OrthoDBi | 1027200at2759 |
PhylomeDBi | Q66H80 |
TreeFami | TF105760 |
Family and domain databases
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR022775, AP_mu_sigma_su IPR027059, Coatomer_dsu IPR011012, Longin-like_dom_sf IPR028565, MHD |
PANTHERi | PTHR10121, PTHR10121, 1 hit |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit PF01217, Clat_adaptor_s, 1 hit |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS51072, MHD, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE
60 70 80 90 100
TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN
110 120 130 140 150
EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET
160 170 180 190 200
QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSSA VSGGSTAAMI
210 220 230 240 250
TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGETIM
260 270 280 290 300
SSNMGKRTSE AAKVHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM
310 320 330 340 350
IMLRISDDKF GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE
360 370 380 390 400
KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED
410 420 430 440 450
NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK
460 470 480 490 500
SGSLEFSIPG QPNDFFPVQV SFISKKNYCN IQVTKVTQVD GNSPVRFSTE
510
TTFLVDKYEI L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC081979 mRNA Translation: AAH81979.1 |
RefSeqi | NP_001007663.1, NM_001007662.1 |
Genome annotation databases
Ensembli | ENSRNOT00000082687; ENSRNOP00000072654; ENSRNOG00000061108 |
GeneIDi | 300674 |
KEGGi | rno:300674 |
UCSCi | RGD:1359110, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC081979 mRNA Translation: AAH81979.1 |
RefSeqi | NP_001007663.1, NM_001007662.1 |
3D structure databases
SMRi | Q66H80 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 256663, 2 interactors |
IntActi | Q66H80, 2 interactors |
STRINGi | 10116.ENSRNOP00000018598 |
PTM databases
iPTMneti | Q66H80 |
PhosphoSitePlusi | Q66H80 |
Proteomic databases
jPOSTi | Q66H80 |
PaxDbi | Q66H80 |
PRIDEi | Q66H80 |
Genome annotation databases
Ensembli | ENSRNOT00000082687; ENSRNOP00000072654; ENSRNOG00000061108 |
GeneIDi | 300674 |
KEGGi | rno:300674 |
UCSCi | RGD:1359110, rat |
Organism-specific databases
CTDi | 372 |
RGDi | 1359110, Arcn1 |
Phylogenomic databases
eggNOGi | KOG2635, Eukaryota |
GeneTreei | ENSGT00390000017207 |
HOGENOMi | CLU_019988_3_0_1 |
InParanoidi | Q66H80 |
OMAi | FLDMESH |
OrthoDBi | 1027200at2759 |
PhylomeDBi | Q66H80 |
TreeFami | TF105760 |
Enzyme and pathway databases
Reactomei | R-RNO-6807878, COPI-mediated anterograde transport R-RNO-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
PROi | PR:Q66H80 |
Gene expression databases
Bgeei | ENSRNOG00000061108, Expressed in jejunum and 20 other tissues |
Genevisiblei | Q66H80, RN |
Family and domain databases
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR022775, AP_mu_sigma_su IPR027059, Coatomer_dsu IPR011012, Longin-like_dom_sf IPR028565, MHD |
PANTHERi | PTHR10121, PTHR10121, 1 hit |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit PF01217, Clat_adaptor_s, 1 hit |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS51072, MHD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COPD_RAT | |
Accessioni | Q66H80Primary (citable) accession number: Q66H80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 23, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families