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UniProtKB - Q66H48 (Q66H48_RAT)

Entry version 142 (02 Dec 2020)
Sequence version 1 (11 Oct 2004)
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Protein
Submitted name:

Zinc finger protein 219

Gene

Zfp219

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 219Imported
Submitted name:
Zinc finger protein 219, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfp219Imported
ORF Names:rCG_61187Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Rat genome database

More...RGDi		1359259, Zfp219

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000011544, Expressed in female gonad and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000015418

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 88C2H2-typeInterPro annotationAdd BLAST28
Domaini89 – 116C2H2-typeInterPro annotationAdd BLAST28
Domaini277 – 304C2H2-typeInterPro annotationAdd BLAST28
Domaini305 – 332C2H2-typeInterPro annotationAdd BLAST28
Domaini501 – 528C2H2-typeInterPro annotationAdd BLAST28
Domaini529 – 556C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni139 – 164DisorderedSequence analysisAdd BLAST26
Regioni222 – 277DisorderedSequence analysisAdd BLAST56
Regioni391 – 498DisorderedSequence analysisAdd BLAST108
Regioni545 – 646DisorderedSequence analysisAdd BLAST102
Regioni672 – 726DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 242Pro-richSequence analysisAdd BLAST16
Compositional biasi243 – 257PolyampholyteSequence analysisAdd BLAST15
Compositional biasi258 – 275Pro-richSequence analysisAdd BLAST18
Compositional biasi447 – 461PolarSequence analysisAdd BLAST15
Compositional biasi469 – 486PolarSequence analysisAdd BLAST18
Compositional biasi560 – 574Pro-richSequence analysisAdd BLAST15
Compositional biasi575 – 610PolarSequence analysisAdd BLAST36

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008125_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		DASPPYV

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

TreeFam database of animal gene trees

More...TreeFami		TF332241

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q66H48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGSRPRILV GHLEPSPPAF DGELDLQRYS NGPGVSGTPG PGSPGMGAVG 
        60         70         80         90        100
WSETRAGERR FPCPVCGKRF RFNSILALHL RAHPGAQAFQ CPHCGHRAAQ 
       110        120        130        140        150
RALLRSHLRT HQPERPRSPA ARLLLELEER ALLREARLGR ARSSGGMQSS 
       160        170        180        190        200
PAAEGLARPQ VPSSSAFRCP FCKGKFRTSA ERERHLHILH RPWKCSLCSF 
       210        220        230        240        250
GSSQEEELLH HSLTAHGASE RPLAATATPE PQPPPQQEPR SALEPEPEPE 
       260        270        280        290        300
PRPEPEREAN PAPTPAPPEE PPAPPEFRCQ VCGQSFTQSW FLKGHMRKHK 
       310        320        330        340        350
ASFDHACPVC GRCFKEPWFL KNHMKVHTSK LGPLRAPGPG SAPARAPQPP 
       360        370        380        390        400
DLSLLAYEPL GPALLLAPAP TPAERREPPS LLGYLSVRAG EVRPNGEGAD 
       410        420        430        440        450
PGGGRSYGGF RPLPSALPNR ARRHRTEEPE EEEEVVEAEE ESWARGRSLG 
       460        470        480        490        500
SLTSLHPNPG EGSGQSAPAV GAQARSTATQ EENGLLVGGT RSEAGRGATG 
       510        520        530        540        550
KDCPFCGKSF RSAHHLKVHL RVHTGERPYK CPHCDYAGTQ SGSLKYHLQR 
       560        570        580        590        600
HHREQRSSAG PGPPPEPPPP SQRGSLQPQS GAKPTQASAT WVEGTASTRP 
       610        620        630        640        650
TSSSTGPGSR RKPASPGRTL RNGRGGEAEP LDLSLRAGPG GEAGSGGALH 
       660        670        680        690        700
RCLFCPFATG APELMALHLQ VHHSRRARGR RQPRADTSPP YVRAPSGETP 
       710        720 
PSPPLEEEGS PGLSRSGEAG LGGQER
Length:726
Mass (Da):77,859
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E2F4B2C858BA34
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC129736 Genomic DNA No translation available.
BC082017 mRNA Translation: AAH82017.1
CH474040 Genomic DNA Translation: EDL88461.1
CH474040 Genomic DNA Translation: EDL88462.1
CH474040 Genomic DNA Translation: EDL88463.1

NCBI Reference Sequences

More...RefSeqi		NP_001007682.1, NM_001007681.1
XP_006251940.1, XM_006251878.3
XP_006251941.1, XM_006251879.2
XP_006251942.1, XM_006251880.3
XP_008768744.1, XM_008770522.2
XP_017455156.1, XM_017599667.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000015418; ENSRNOP00000015418; ENSRNOG00000011544

Database of genes from NCBI RefSeq genomes

More...GeneIDi		305848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:305848

UCSC genome browser

More...UCSCi		RGD:1359259, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129736 Genomic DNA No translation available.
BC082017 mRNA Translation: AAH82017.1
CH474040 Genomic DNA Translation: EDL88461.1
CH474040 Genomic DNA Translation: EDL88462.1
CH474040 Genomic DNA Translation: EDL88463.1
RefSeqiNP_001007682.1, NM_001007681.1
XP_006251940.1, XM_006251878.3
XP_006251941.1, XM_006251879.2
XP_006251942.1, XM_006251880.3
XP_008768744.1, XM_008770522.2
XP_017455156.1, XM_017599667.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015418

Genome annotation databases

EnsembliENSRNOT00000015418; ENSRNOP00000015418; ENSRNOG00000011544
GeneIDi305848
KEGGirno:305848
UCSCiRGD:1359259, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		69890
RGDi1359259, Zfp219

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161408
HOGENOMiCLU_008125_1_0_1
OMAiDASPPYV
OrthoDBi1318335at2759
TreeFamiTF332241

Gene expression databases

BgeeiENSRNOG00000011544, Expressed in female gonad and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 9 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ66H48_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q66H48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: December 2, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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