UniProtKB - Q66H48 (Q66H48_RAT)
Protein
Submitted name:
Zinc finger protein 219
Gene
Zfp219
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- limb bud formation Source: RGD
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of chondrocyte differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger protein 219ImportedSubmitted name: Zinc finger protein 219, isoform CRA_aImported |
Gene namesi | Name:Zfp219Imported ORF Names:rCG_61187Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359259, Zfp219 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000011544, Expressed in female gonad and 21 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 88 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 89 – 116 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 277 – 304 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 305 – 332 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 501 – 528 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 529 – 556 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 139 – 164 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 222 – 277 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 391 – 498 | DisorderedSequence analysisAdd BLAST | 108 | |
Regioni | 545 – 646 | DisorderedSequence analysisAdd BLAST | 102 | |
Regioni | 672 – 726 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 227 – 242 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 243 – 257 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 258 – 275 | Pro-richSequence analysisAdd BLAST | 18 | |
Compositional biasi | 447 – 461 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 469 – 486 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 560 – 574 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 575 – 610 | PolarSequence analysisAdd BLAST | 36 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161408 |
HOGENOMi | CLU_008125_1_0_1 |
OMAi | DASPPYV |
OrthoDBi | 1318335at2759 |
TreeFami | TF332241 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
i Sequence
Sequence statusi: Complete.
Q66H48-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGSRPRILV GHLEPSPPAF DGELDLQRYS NGPGVSGTPG PGSPGMGAVG
60 70 80 90 100
WSETRAGERR FPCPVCGKRF RFNSILALHL RAHPGAQAFQ CPHCGHRAAQ
110 120 130 140 150
RALLRSHLRT HQPERPRSPA ARLLLELEER ALLREARLGR ARSSGGMQSS
160 170 180 190 200
PAAEGLARPQ VPSSSAFRCP FCKGKFRTSA ERERHLHILH RPWKCSLCSF
210 220 230 240 250
GSSQEEELLH HSLTAHGASE RPLAATATPE PQPPPQQEPR SALEPEPEPE
260 270 280 290 300
PRPEPEREAN PAPTPAPPEE PPAPPEFRCQ VCGQSFTQSW FLKGHMRKHK
310 320 330 340 350
ASFDHACPVC GRCFKEPWFL KNHMKVHTSK LGPLRAPGPG SAPARAPQPP
360 370 380 390 400
DLSLLAYEPL GPALLLAPAP TPAERREPPS LLGYLSVRAG EVRPNGEGAD
410 420 430 440 450
PGGGRSYGGF RPLPSALPNR ARRHRTEEPE EEEEVVEAEE ESWARGRSLG
460 470 480 490 500
SLTSLHPNPG EGSGQSAPAV GAQARSTATQ EENGLLVGGT RSEAGRGATG
510 520 530 540 550
KDCPFCGKSF RSAHHLKVHL RVHTGERPYK CPHCDYAGTQ SGSLKYHLQR
560 570 580 590 600
HHREQRSSAG PGPPPEPPPP SQRGSLQPQS GAKPTQASAT WVEGTASTRP
610 620 630 640 650
TSSSTGPGSR RKPASPGRTL RNGRGGEAEP LDLSLRAGPG GEAGSGGALH
660 670 680 690 700
RCLFCPFATG APELMALHLQ VHHSRRARGR RQPRADTSPP YVRAPSGETP
710 720
PSPPLEEEGS PGLSRSGEAG LGGQER
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129736 Genomic DNA No translation available. BC082017 mRNA Translation: AAH82017.1 CH474040 Genomic DNA Translation: EDL88461.1 CH474040 Genomic DNA Translation: EDL88462.1 CH474040 Genomic DNA Translation: EDL88463.1 |
RefSeqi | NP_001007682.1, NM_001007681.1 XP_006251940.1, XM_006251878.3 XP_006251941.1, XM_006251879.2 XP_006251942.1, XM_006251880.3 XP_008768744.1, XM_008770522.2 XP_017455156.1, XM_017599667.1 |
Genome annotation databases
Ensembli | ENSRNOT00000015418; ENSRNOP00000015418; ENSRNOG00000011544 |
GeneIDi | 305848 |
KEGGi | rno:305848 |
UCSCi | RGD:1359259, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129736 Genomic DNA No translation available. BC082017 mRNA Translation: AAH82017.1 CH474040 Genomic DNA Translation: EDL88461.1 CH474040 Genomic DNA Translation: EDL88462.1 CH474040 Genomic DNA Translation: EDL88463.1 |
RefSeqi | NP_001007682.1, NM_001007681.1 XP_006251940.1, XM_006251878.3 XP_006251941.1, XM_006251879.2 XP_006251942.1, XM_006251880.3 XP_008768744.1, XM_008770522.2 XP_017455156.1, XM_017599667.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015418 |
Proteomic databases
PRIDEi | Q66H48 |
Genome annotation databases
Ensembli | ENSRNOT00000015418; ENSRNOP00000015418; ENSRNOG00000011544 |
GeneIDi | 305848 |
KEGGi | rno:305848 |
UCSCi | RGD:1359259, rat |
Organism-specific databases
CTDi | 69890 |
RGDi | 1359259, Zfp219 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161408 |
HOGENOMi | CLU_008125_1_0_1 |
OMAi | DASPPYV |
OrthoDBi | 1318335at2759 |
TreeFami | TF332241 |
Gene expression databases
Bgeei | ENSRNOG00000011544, Expressed in female gonad and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q66H48_RAT | |
Accessioni | Q66H48Primary (citable) accession number: Q66H48 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 10, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |