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Protein

Mitoferrin-1

Gene

Slc25a37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-1
Alternative name(s):
Mitochondrial iron transporter 1
Solute carrier family 25 member 37
Gene namesi
Name:Slc25a37
Synonyms:Mfrn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1359361 Slc25a37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 64Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei106 – 125Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei143 – 162Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei200 – 219Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei234 – 253Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei301 – 320Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352531 – 338Mitoferrin-1Add BLAST338

Proteomic databases

PaxDbiQ66H23
PRIDEiQ66H23

PTM databases

PhosphoSitePlusiQ66H23

Expressioni

Gene expression databases

BgeeiENSRNOG00000015495
GenevisibleiQ66H23 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021636

Structurei

3D structure databases

ProteinModelPortaliQ66H23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 131Solcar 1Add BLAST89
Repeati141 – 225Solcar 2Add BLAST85
Repeati232 – 326Solcar 3Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760 Eukaryota
ENOG410XNT2 LUCA
GeneTreeiENSGT00550000074721
HOGENOMiHOG000038810
HOVERGENiHBG079464
InParanoidiQ66H23
KOiK15113
OMAiYFLTKHK
OrthoDBiEOG091G0PU8
PhylomeDBiQ66H23
TreeFamiTF314118

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q66H23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRRGGVGS QAAGRRMDGD CRDGGCGSKD AGSEDYENLP TSASVSTHMT
60 70 80 90 100
AGAMAGILEH SIMYPVDSVK TRMQSLNPDP KARYTSIYGA LKRIMHTEGF
110 120 130 140 150
WRPLRGLNVM MMGAGPAHAM YFACYENMKR TLNDVFSHQG NSHLANGIAG
160 170 180 190 200
SMATLLHDAV MNPAEVVKQR LQMYNSQHQS ALSCIRTVWR TEGLGAFYRS
210 220 230 240 250
YTTQLTMNIP FQSIHFITYE FLQEQVNPRR DYNPQSHIIS GGLAGALAAA
260 270 280 290 300
ATTPLDVCKT LLNTQENMAL SLANVSGRLS GMANAFRTVY QLNGLAGYFK
310 320 330
GIQARVIYQM PSTAISWSVY EFFKYFLTKR QLENRTLY
Length:338
Mass (Da):37,497
Last modified:October 11, 2004 - v1
Checksum:iC5F6DE138530700E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082071 mRNA Translation: AAH82071.1
RefSeqiNP_001014018.1, NM_001013996.1
UniGeneiRn.102664

Genome annotation databases

EnsembliENSRNOT00000021636; ENSRNOP00000021636; ENSRNOG00000015495
GeneIDi306000
KEGGirno:306000
UCSCiRGD:1359361 rat

Similar proteinsi

Entry informationi

Entry nameiMFRN1_RAT
AccessioniPrimary (citable) accession number: Q66H23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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