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Protein

Protein disulfide isomerase-like 1-6

Gene

PDIL1-6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104NucleophileBy similarity1
Active sitei446NucleophileBy similarity1
Active sitei449NucleophileBy similarity1

GO - Molecular functioni

  • protein disulfide isomerase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-6 (EC:5.3.4.1)
Short name:
AtPDIL1-6
Alternative name(s):
Protein disulfide isomerase 4
Short name:
AtPDI4
Protein disulfide isomerase-like 3-2
Short name:
AtPDIL3-2
Gene namesi
Name:PDIL1-6
Synonyms:PDI4, PDIL3-2
Ordered Locus Names:At3g16110
ORF Names:MSL1.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G16110
TAIRilocus:2093447 AT3G16110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000040002131 – 534Protein disulfide isomerase-like 1-6Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi446 ↔ 449Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ66GQ3
PRIDEiQ66GQ3

PTM databases

iPTMnetiQ66GQ3

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ExpressionAtlasiQ66GQ3 baseline and differential
GenevisibleiQ66GQ3 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G16110.1

Structurei

3D structure databases

ProteinModelPortaliQ66GQ3
SMRiQ66GQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 182Thioredoxin 1PROSITE-ProRule annotationAdd BLAST127
Domaini407 – 524Thioredoxin 2PROSITE-ProRule annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi531 – 534Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
HOGENOMiHOG000241706
InParanoidiQ66GQ3
KOiK09580
OMAiSNENLAM
OrthoDBiEOG093608OJ
PhylomeDBiQ66GQ3

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66GQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKPKPNSK FSILFTFLLL LSFLIFVARS SDVAVEAGSE EELDDLEQLL
60 70 80 90 100
AVDEQLQEER PEQQSEAETV SKAQRIVVEL NGDNTKRLID GNEYVMVLGY
110 120 130 140 150
APWCARSAEL MPRFAEAATD LKEIGSSVLM AKIDGERYSK VASQLEIKGF
160 170 180 190 200
PTLLLFVNGT SQSYTGGFSS EEIVIWVQKK TGASTIKLDT VDEASGFLKK
210 220 230 240 250
HHTFILGLFE KSEDSSGHDE FVKAASLDNE IQFVETSSID VAKLLFPNLK
260 270 280 290 300
TNNVFVGLVK TEAEKYTSYD GPCQAEKIVE FLNSNKFPLV TKLTESNTVR
310 320 330 340 350
VYSSPVKLQV MVFSKTDDFE SLAQPLEDIA RKFKSKLMLI YIDISNENLA
360 370 380 390 400
MPFLTLFGIE DAKKTVVAAF DNNLNSKYLL ESDPSPSNIE EFCFGLAHGT
410 420 430 440 450
VSAYYKSQPI PDNQNASVVA VVGRTFDEVV LRSSENVLLE VHTPWCINCE
460 470 480 490 500
ALSKQVEKLS QHFKGFENLV FARIDASANE HPKLTVDDYP TILLYKTGEK
510 520 530
ENPLKLSTKS SAKDMAVLIN KELKWKDQSG KDEL
Length:534
Mass (Da):59,571
Last modified:October 11, 2004 - v1
Checksum:i66FA90F57CF5FF85
GO

Sequence cautioni

The sequence BAB02677 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326L → P in BAD94313 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012247 Genomic DNA Translation: BAB02677.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE75772.1
BT015349 mRNA Translation: AAU05472.1
BT015798 mRNA Translation: AAU93570.1
AK221388 mRNA Translation: BAD94313.1
RefSeqiNP_188232.2, NM_112481.4
UniGeneiAt.50187

Genome annotation databases

EnsemblPlantsiAT3G16110.1; AT3G16110.1; AT3G16110
GeneIDi820856
GrameneiAT3G16110.1; AT3G16110.1; AT3G16110
KEGGiath:AT3G16110

Similar proteinsi

Entry informationi

Entry nameiPDI16_ARATH
AccessioniPrimary (citable) accession number: Q66GQ3
Secondary accession number(s): Q56YD5, Q9LW75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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