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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:54
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060531 – 289Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST289

Structurei

3D structure databases

ProteinModelPortaliQ66656
SMRiQ66656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 178Substrate bindingUniRule annotation3
Regioni283 – 284Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

Gene3Di2.70.40.10, 3 hits
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 2 hits
SUPFAMiSSF51283 SSF51283, 3 hits

Sequencei

Sequence statusi: Complete.

Q66656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRKQRQEI YYEFTSSSFE ITSPPESSKI TLTNLYPILV RPYVPAVIPL
60 70 80 90 100
GIRIIYGNKG QGFILAGSSQ KKVFCHTGLI DPGYRGEIKL IVLNTTKYNV
110 120 130 140 150
TLFAGELRVS LFSFFFSTPI IYDYDLLNRP QYSDDAGYDL YLQEDLMLFP
160 170 180 190 200
QASTTVTIDS RVPTTTKFFK PVVFGRSGLA TRGVVVDVVK WTHSPLTLKI
210 220 230 240 250
YNFTDNTLRY SAGTRICQVV FVHRRHFPSK LKHFFTYINL NSKTSFYWAN
260 270 280
VSFVDCQNDA YRSLVTLPCQ EDTDRGYRGD SGFGSSGMR
Length:289
Mass (Da):32,958
Last modified:November 1, 1996 - v1
Checksum:i6FCEB405630FA996
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA Translation: AAC13842.1
PIRiS55649
RefSeqiNP_042651.1, NC_001650.2

Genome annotation databases

GeneIDi1461064
KEGGivg:1461064

Similar proteinsi

Entry informationi

Entry nameiDUT_EHV2
AccessioniPrimary (citable) accession number: Q66656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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