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Protein

Tripartite terminase subunit 3

Gene

TRM3

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei319For ATPase activityUniRule annotation1
Active sitei475For nuclease activityUniRule annotation1
Active sitei548For nuclease activityUniRule annotation1
Active sitei660For nuclease activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processViral genome packaging, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 3UniRule annotation (EC:3.1.-.-UniRule annotation)
Alternative name(s):
Terminase large subunitUniRule annotation
Gene namesi
Name:TRM3UniRule annotation
Ordered Locus Names:29a/29b
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060591 – 686Tripartite terminase subunit 3Add BLAST686

Proteomic databases

PRIDEiQ66632

Interactioni

Subunit structurei

Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.UniRule annotation

Structurei

3D structure databases

SMRiQ66632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi219 – 226Walker A motifUniRule annotation8
Motifi314 – 319Walker B motifUniRule annotation6

Sequence similaritiesi

Belongs to the herpesviridae TRM3 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900002F

Family and domain databases

Gene3Di3.30.420.320, 1 hit
HAMAPiMF_04013 HSV_TRM3, 1 hit
InterProiView protein in InterPro
IPR003498 DNA_pack_C
IPR038435 DNA_pack_C_sf
IPR003499 DNA_pack_N
IPR033663 HSV_TRM3
PfamiView protein in Pfam
PF02499 DNA_pack_C, 1 hit
PF02500 DNA_pack_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q66632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILSGKKRML LDNYKNARAP GGDDERDWVF DRPAIVTRRD KSDRMAHPYI
60 70 80 90 100
GIIPRTNIYS AVLDSYCKSL NPVYKERIPP VLGTGRDVPV TPANVTGELA
110 120 130 140 150
RAARALCGDL ASGDPEALVE FASAVQTQRT SRGCPVFREL SEFLVNLASF
160 170 180 190 200
LNRCYSVKSD TIEPFQKQLI LHTFYFLISI KAPHAANTLF EVFKEYFGLF
210 220 230 240 250
DMGREALQTF KQKSTVYLIP RRHGKTWIVV AIISMLLTSV ENIHVGYVAH
260 270 280 290 300
QKHVANSVFA EIINTIYRWF PAKNVYIKKE NGTIMYTNEN RRPSTLMCAT
310 320 330 340 350
CFNKNSIRGQ TFNLLYVDEA NFIKKDSLPS ILGFMLQKDA KIIFISSVNS
360 370 380 390 400
SDQTTSFLYN LKNAKEKMLN VVNYVCPQHR EDFSLQESVV SCPCYRLHIP
410 420 430 440 450
TYIAIDENIK DTTNLFMEGA FTTELMGDGA AATTQTNMHK VVGEPALVQF
460 470 480 490 500
DLCRVDTGSP EAQRGLNPTL FLYVDPAYTN NTEASGTGMG AVVSMKNSDR
510 520 530 540 550
CVVVGVEHFF LKELTGASSL QIASCAAALI RSLATLHPFV REAHVAIEGN
560 570 580 590 600
SSQDSAVAIA TLLHERSPLP VKFLHHADKA TGVQWPMYIL GAEKARAFET
610 620 630 640 650
FIYALNSNTL SCGQAIVSNT IKLSFDPVAY LIEQIRAIKC YPLKDGTVSY
660 670 680
CAKHKGGSDD TLVAVVMAHY FATSDRHVFK NHMKQI
Length:686
Mass (Da):76,458
Last modified:March 8, 2011 - v2
Checksum:iBC38099FB2A57A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA Translation: AAC13821.2
PIRiS55628
RefSeqiNP_042630.2, NC_001650.2

Genome annotation databases

GeneIDi1461057
KEGGivg:1461057

Similar proteinsi

Entry informationi

Entry nameiTRM3_EHV2
AccessioniPrimary (citable) accession number: Q66632
Secondary accession number(s): Q66637
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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