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Protein
Submitted name:

Envelope glycoprotein

Gene

E

Organism
Dengue virus 2
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
Envelope glycoproteinImported
Gene namesi
Name:EImported
OrganismiDengue virus 2Imported
Taxonomic identifieri11060 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirus

Subcellular locationi

  • Host endoplasmic reticulum membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Host endoplasmic reticulum membrane SAAS annotation; Peripheral membrane protein SAAS annotation; Lumenal side SAAS annotation
  • Secreted SAAS annotation
  • Virion membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei439 – 463HelicalSequence analysisAdd BLAST25
Transmembranei475 – 493HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host endoplasmic reticulumSAAS annotation, Host membraneSAAS annotation, Membrane, SecretedSAAS annotation, Viral envelope proteinImported, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ66394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 296Flavi_glycoprotInterPro annotationAdd BLAST295
Domaini298 – 393Flavi_glycop_CInterPro annotationAdd BLAST96

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd12149 Flavi_E_C, 1 hit
Gene3Di1.20.1280.260, 1 hit
2.60.40.350, 1 hit
2.60.98.10, 3 hits
3.30.387.10, 2 hits
3.30.67.10, 4 hits
InterProiView protein in InterPro
IPR013755 Flav_gly_cen_dom_subdom1
IPR027287 Flavi_E_Ig-like
IPR026470 Flavi_E_Stem/Anchor_dom
IPR038345 Flavi_E_Stem/Anchor_dom_sf
IPR000336 Flavivir/Alphavir_Ig-like_sf
IPR011998 Glycoprot_cen/dimer
IPR036253 Glycoprot_cen/dimer_sf
IPR038055 Glycoprot_E_dimer_dom
IPR013756 GlyE_cen_dom_subdom2
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02832 Flavi_glycop_C, 1 hit
PF00869 Flavi_glycoprot, 1 hit
SUPFAMiSSF56983 SSF56983, 1 hit
SSF81296 SSF81296, 1 hit
TIGRFAMsiTIGR04240 flavi_E_stem, 1 hit

Sequencei

Sequence statusi: Fragment.

Q66394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCIGISNRD FVEGVSGGSW VDIVLEHGSC VTTMAKNKPT LDFELIKTEA
60 70 80 90 100
KQPATLRKYC IEAKLTNTTT DSRCPTQGEP TLNEEQDKRF VCKHSMVDRG
110 120 130 140 150
WGNGCGLFGK GGIVTCAMFT CKKNMEGKIV QPENLEYTVV ITPHSGEEHA
160 170 180 190 200
VGNDTGKHGK EVKITPQSSI TEAELTGYGT VTMECSPRTG LDFNEMVLLQ
210 220 230 240 250
MKDKAWLVHR QWFLDLPLPW LPGADTQGSN WIQKETLVTF KNPHAKKQDV
260 270 280 290 300
VVLGSQEGAM HTALTGATEI QMSSGNLLFT GHLKCRLRMD KLQLKGMSYS
310 320 330 340 350
MCTGKFKVVK EIAETQHGTI VIRVQYEGDG SPCKIPFEIM DLEKRHVLGR
360 370 380 390 400
LITVNPIVTE KDSPVNIEAE PPFGDSYIII GVEPGQLKLD WFKKGSSIGQ
410 420 430 440 450
MFETTMRGAK RMAILGDTAW DFGSLGGVFT SIGKALHQVF GAIYGAAFSG
460 470 480 490
VSWTMKILIG VIITWIGMNS RSTSLSVSLV LVGIVTLYLG VMVQA
Length:495
Mass (Da):54,338
Last modified:November 1, 1996 - v1
Checksum:i870C924704B5ABAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei495Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10046 Unassigned RNA Translation: AAA17504.1

Similar proteinsi

Entry informationi

Entry nameiQ66394_9FLAV
AccessioniPrimary (citable) accession number: Q66394
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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