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Protein

Acetate kinase

Gene

ackA

Organism
Borreliella bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) (Borrelia bavariensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei92SubstrateUniRule annotation1
Active sitei149Proton donor/acceptorUniRule annotation1
Sitei181Transition state stabilizerUniRule annotation1
Sitei242Transition state stabilizerUniRule annotation1
Metal bindingi389MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 213ATPUniRule annotation5
Nucleotide bindingi284 – 286ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00340;UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:BG0641
OrganismiBorreliella bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) (Borrelia bavariensis)
Taxonomic identifieri290434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000002276 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075371 – 405Acetate kinaseAdd BLAST405

Proteomic databases

PRIDEiQ660Q0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290434.BG0641

Structurei

3D structure databases

ProteinModelPortaliQ660Q0
SMRiQ660Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q660Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILIINTGS SSLKFAIYQY ENSKKLISGV IEKIKEQKSI IKIINTDGSI
60 70 80 90 100
TERFEKGIEN HPKAIEKMFK ILLNSNSKIL KNISEIKIIG HRVVHGGSYF
110 120 130 140 150
KNSVILKNSN LDKLKQSSKL APLHNPSAIA AIETVLKILP HAKQVLCFDT
160 170 180 190 200
SWHQTIKKHA FLYATPYSWY KEHNIRKYGF HGLSYSYVTK RSSEILNKKI
210 220 230 240 250
DNLNLIILHL GNGASINAVK DGKSYDTSMG ITPLEGLVMG TRSGDIDPSI
260 270 280 290 300
INLMSTILNK NTKQIEEILN KESGILGISE KSNDMRDIWN KIEEGEYQSK
310 320 330 340 350
LAVEIMTYRV KKYIGSYIAI LDFNVDAIVF TGGIGVVDYE VRELALKGFE
360 370 380 390 400
KIGIELDLEK NKMAQNKNLE SEISTIKSKV KILAIPTNEE STILEDIYNL

IPKNL
Length:405
Mass (Da):45,619
Last modified:October 11, 2004 - v1
Checksum:iCE70B4048DB2770E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000013 Genomic DNA Translation: AAU07471.1
RefSeqiWP_011193929.1, NC_006156.1

Genome annotation databases

EnsemblBacteriaiAAU07471; AAU07471; BG0641
KEGGibga:BG0641

Similar proteinsi

Entry informationi

Entry nameiACKA_BORBP
AccessioniPrimary (citable) accession number: Q660Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: June 7, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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