Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Canine distemper virus (strain A92-27/4) (CDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. The cellular receptor might be SLAM, and may explain the lymphotropism of the virus (By similarity).By similarity

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiCanine distemper virus (strain A92-27/4) (CDV)
Taxonomic identifieri82826 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiAiluropoda melanoleuca (Giant panda) [TaxID: 9646]
Ailurus fulgens (Lesser panda) (Red panda) [TaxID: 9649]
Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]
Mustela [TaxID: 9665]
Panthera leo (Lion) [TaxID: 9689]
Procyon lotor (Raccoon) [TaxID: 9654]
Zalophus californianus (California sealion) [TaxID: 9704]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 607Virion surfaceSequence analysisAdd BLAST549

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425941 – 607Hemagglutinin glycoproteinAdd BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi587N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi603N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ66001

Interactioni

Subunit structurei

Binds canine SLAMF1 at the cell surface.By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q66001-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSYQDKVGA FYKDNARANS SRLSLVTEDQ GGRRPPYLLF VLLILLVGIM
60 70 80 90 100
ALLAITGVRF HQVSTSNMEF SRLLKEDMEK SEAVHHQVID VLTPLFKIIG
110 120 130 140 150
DEIGLRLPQK LNEIKQFILQ KTNFFNPNRE FDFRDLHWCI NPPSKIKVNF
160 170 180 190 200
TNYCDTIGIR KSIASAANPI LLSALSRSRG DIFPPYRCSG ATTSVGSVFP
210 220 230 240 250
LSVSLSMSLI SRTSEIINML TAISDGVYGK TYLLVPDYLE GEFDTQKIRV
260 270 280 290 300
FEIGFIKRWL NNMPLLQTTN YMVLPENSKA KVCTIAVGEL TLASLCVDES
310 320 330 340 350
TVLLYHDSNG SQGGILVVTL GIFGATPMDQ VEEVIPVPHP SVEKIHITNH
360 370 380 390 400
RGFIKDSIAT WMVPALVSEK QEEQKNCLES ACQRKSYPMC NQTSWEPFGG
410 420 430 440 450
GQLPSYGRLT LPLDPSIDLQ LNISFTYGPV ILNGDGMDYY ESPLLDSGWL
460 470 480 490 500
TIPPKNGTVL GLINKASRGD QFTVIPHVLT FAPRESSGNC YLPIQTSQIM
510 520 530 540 550
DKDVLTESNL VVLPTQNFIY VIATYDISRG DHAIVYYVYD PIRTISYTHA
560 570 580 590 600
FRLTTKGRPD FLRIECFVWD DDLWCHQFYR FEADSTNSTT SVENLVRIRF

SCNRSKP
Length:607
Mass (Da):68,260
Last modified:November 1, 1996 - v1
Checksum:iA1B711D2840B59C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54156 Genomic RNA Translation: CAA90867.1

Similar proteinsi

Entry informationi

Entry nameiHEMA_CDVA4
AccessioniPrimary (citable) accession number: Q66001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again