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UniProtKB - Q65Z69 (Q65Z69_9GAMM)

Entry version 96 (12 Aug 2020)
Sequence version 1 (25 Oct 2004)
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Protein
Submitted name:

Alkaline serine protease

Gene

apa1

Organism
Pseudoalteromonas sp. AS-11
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi146Calcium 1Combined sources1
Metal bindingi146Calcium 2Combined sources1
Metal bindingi183Calcium 1Combined sources1
Metal bindingi183Calcium 2Combined sources1
Metal bindingi220Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi220Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi222Calcium 1Combined sources1
Metal bindingi222Calcium 2Combined sources1
Metal bindingi224Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi224Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi226Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi226Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi313Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi313Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi315Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi315Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi318Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi318Magnesium 1; via carbonyl oxygenCombined sources1
Metal bindingi318Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi339Calcium 3Combined sources1
Metal bindingi339Magnesium 1Combined sources1
Metal bindingi339Magnesium 2; via carbonyl oxygenCombined sources1
Metal bindingi341Magnesium 2Combined sources1
Metal bindingi548Calcium 4Combined sources1
Metal bindingi549Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi551Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi553Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi555Calcium 4Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseARBA annotation
LigandCalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sourcesARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alkaline serine proteaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apa1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudoalteromonas sp. AS-11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri247492 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas ›

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500426848827 – 817Sequence analysisAdd BLAST791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi171 ↔ 261Combined sources
Disulfide bondi404 ↔ 413Combined sources
Disulfide bondi421 ↔ 442Combined sources
Disulfide bondi533 ↔ 576Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q65Z69

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q65Z69

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini702 – 817P/Homo BInterPro annotationAdd BLAST116

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...CDDi		cd07477, Peptidases_S8_Subtilisin_subset, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.260, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR002884, P_dom
IPR003137, PA_domain
IPR007280, Peptidase_C_arc/bac
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR010259, S8pro/Inhibitor_I9
IPR034202, Subtilisin_Carlsberg-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05922, Inhibitor_I9, 1 hit
PF01483, P_proprotein, 1 hit
PF02225, PA, 1 hit
PF00082, Peptidase_S8, 2 hits
PF04151, PPC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00723, SUBTILISIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785, SSF49785, 1 hit
SSF52743, SSF52743, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51829, P_HOMO_B, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q65Z69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKNKNSAVV LSMTALALAI STQVNAAPSP LQLYATNQQI DQQSPLPKRY 
        60         70         80         90        100
IVKFKNDNAA QTLSSSSVTQ NVGVQPETNS MSYQPRSNEV FSQFRALNSV 
       110        120        130        140        150
KAREMKRVGR SNSYSVKLDS PSIKALRLRQ DVEYVEEDLP RRLLAETTPW 
       160        170        180        190        200
GQTFVGATVL SDSQAGNRTI CIIDSGYDRS HNDLNANNVT GTNNSGTGNW 
       210        220        230        240        250
YQPGNNNAHG THVAGTIAAI ANNEGVVGVM PNQNANIHIV KVFNEAGWGY 
       260        270        280        290        300
SSSLVAAIDT CVNSGGANVV TMSLGGSGST TTERNALNTH YNNGVLLIAA 
       310        320        330        340        350
AGNAGDSSYS YPASYDSVMS VAAVDSNLDH AAFSQYTDQV EISGPGEAIL 
       360        370        380        390        400
STVTVGEGRL ADITIGGQSY FSNGVVPHNR LTPSGTSYAP APINASATGA 
       410        420        430        440        450
LAECTVNGTS FSCGNMANKI CLVERVGNQG SSYPEINSTK ACKTAGAKGI 
       460        470        480        490        500
IVYSNSALPG LQNPFLVDAN SDITVPSVSV DRATGLALKA KLGQSTTVSN 
       510        520        530        540        550
QGNQDYEYYN GTSMATPHVS GVATLVWSYH PECSASQVRA ALNATADDLS 
       560        570        580        590        600
VAGRDNQTGY GMINAVAAKA YLDESCTGPT DPGTGPGTGD SVLVKGVAKT 
       610        620        630        640        650
GLAGAKSDEL YFSLDVPAGA KDLTFTMNGG TGDADLYVQY GASPTSSSYD 
       660        670        680        690        700
CRPWKSGNAE SCPIATPQTG TYYVMVQGYS AFSNVNLMAN YTAATTSGGN 
       710        720        730        740        750
TGGPASYTNT GNYTIPDNNT TGITSPITVS RTGDSGSVSV SIGIIHTYIG 
       760        770        780        790        800
DLKIQLVSPT GQTVVLHNNT GGGTDNLTQT YTANMAGVES SGVWTLKAVD 
       810 
NAKQDTGYID TWSLSFQ
Length:817
Mass (Da):85,145
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83A11C17B1A39513
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB120714 Genomic DNA Translation: BAD51450.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120714 Genomic DNA Translation: BAD51450.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V6CX-ray1.80A/B145-585[»]
1WVMX-ray1.60A/B145-585[»]
1Y9ZX-ray1.40A/B145-585[»]
SMRiQ65Z69
ModBaseiSearch...
PDBe-KBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ65Z69

Family and domain databases

CDDicd07477, Peptidases_S8_Subtilisin_subset, 1 hit
Gene3Di2.60.120.260, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR002884, P_dom
IPR003137, PA_domain
IPR007280, Peptidase_C_arc/bac
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR010259, S8pro/Inhibitor_I9
IPR034202, Subtilisin_Carlsberg-like
PfamiView protein in Pfam
PF05922, Inhibitor_I9, 1 hit
PF01483, P_proprotein, 1 hit
PF02225, PA, 1 hit
PF00082, Peptidase_S8, 2 hits
PF04151, PPC, 1 hit
PRINTSiPR00723, SUBTILISIN
SUPFAMiSSF49785, SSF49785, 1 hit
SSF52743, SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829, P_HOMO_B, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ65Z69_9GAMM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q65Z69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: August 12, 2020
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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