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UniProtKB - Q65YW7 (Q65YW7_STRLA)
Protein
Alanine racemase
Gene
alr
Organism
Streptomyces lavendulae subsp. lavendulae
Status
Functioni
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
UniRule annotationCatalytic activityi
- EC:5.1.1.1UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotationARBA annotation
: D-alanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 38 | Proton acceptor; specific for D-alanineUniRule annotation | 1 | |
Binding sitei | 136 | SubstrateUniRule annotation | 1 | |
Active sitei | 270 | Proton acceptor; specific for L-alanineUniRule annotation | 1 | |
Binding sitei | 318 | Substrate; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- alanine racemase activity Source: UniProtKB-UniRule
- pyridoxal phosphate binding Source: UniProtKB-UniRule
GO - Biological processi
- D-alanine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | IsomeraseUniRule annotationARBA annotation |
Ligand | Pyridoxal phosphateUniRule annotation |
Enzyme and pathway databases
BRENDAi | 5.1.1.1, 133 |
UniPathwayi | UPA00042;UER00497 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:alrImported |
Organismi | Streptomyces lavendulae subsp. lavendulaeImported |
Taxonomic identifieri | 58340 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Structurei
3D structure databases
SMRi | Q65YW7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q65YW7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 249 – 376 | Ala_racemase_CInterPro annotationAdd BLAST | 128 |
Sequence similaritiesi
Belongs to the alanine racemase family.UniRule annotation
Family and domain databases
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_01201, Ala_racemase, 1 hit |
InterProi | View protein in InterPro IPR000821, Ala_racemase IPR009006, Ala_racemase/Decarboxylase_C IPR011079, Ala_racemase_C IPR001608, Ala_racemase_N IPR020622, Ala_racemase_pyridoxalP-BS IPR029066, PLP-binding_barrel |
Pfami | View protein in Pfam PF00842, Ala_racemase_C, 1 hit PF01168, Ala_racemase_N, 1 hit |
PRINTSi | PR00992, ALARACEMASE |
SMARTi | View protein in SMART SM01005, Ala_racemase_C, 1 hit |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR00492, alr, 1 hit |
PROSITEi | View protein in PROSITE PS00395, ALANINE_RACEMASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q65YW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNETPTRVYA EIDLDAVRAN VRALRARAPR SALMAVVKSN AYGHGAVPCA
60 70 80 90 100
RAAQEAGAAW LGTATPEEAL ELRAAGIQGR IMCWLWTPGG PWREAIETDI
110 120 130 140 150
DVSVSGMWAL DEVRAAARAA GRTARIQLKA DTGLGRNGCQ PADWAELVGA
160 170 180 190 200
AVAAQAEGTV QVTGVWSHFA CADEPGHPSI RLQLDAFRDM LAYAEKEGVD
210 220 230 240 250
PEVRHIANSP ATLTLPETHF DLVRTGLAVY GVSPSPELGT PAQLGLRPAM
260 270 280 290 300
TLRASLALVK TVPAGHGVSY GHHYVTESET HLALVPAGYA DGIPRNASGR
310 320 330 340 350
GPVLVAGKIR RAAGRIAMDQ FVVDLGEDLA EAGDEAVILG DAERGEPTAE
360 370
DWAQAAHTIA YEIVTRIGGR VPRVYLGG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB176676 Genomic DNA Translation: BAD44772.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB176676 Genomic DNA Translation: BAD44772.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VFH | X-ray | 2.00 | A | 1-378 | [»] | |
1VFS | X-ray | 1.90 | A/B | 1-378 | [»] | |
1VFT | X-ray | 2.30 | A/B | 1-378 | [»] | |
SMRi | Q65YW7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00042;UER00497 |
BRENDAi | 5.1.1.1, 133 |
Miscellaneous databases
EvolutionaryTracei | Q65YW7 |
Family and domain databases
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_01201, Ala_racemase, 1 hit |
InterProi | View protein in InterPro IPR000821, Ala_racemase IPR009006, Ala_racemase/Decarboxylase_C IPR011079, Ala_racemase_C IPR001608, Ala_racemase_N IPR020622, Ala_racemase_pyridoxalP-BS IPR029066, PLP-binding_barrel |
Pfami | View protein in Pfam PF00842, Ala_racemase_C, 1 hit PF01168, Ala_racemase_N, 1 hit |
PRINTSi | PR00992, ALARACEMASE |
SMARTi | View protein in SMART SM01005, Ala_racemase_C, 1 hit |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR00492, alr, 1 hit |
PROSITEi | View protein in PROSITE PS00395, ALANINE_RACEMASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q65YW7_STRLA | |
Accessioni | Q65YW7Primary (citable) accession number: Q65YW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 25, 2004 |
Last sequence update: | October 25, 2004 | |
Last modified: | April 7, 2021 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |