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Protein

Chromosome partition protein MukB

Gene

mukB

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 71ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Chromosome partition, DNA condensation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSUC221988:MS_RS05005-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukBUniRule annotation
Alternative name(s):
Structural maintenance of chromosome-related proteinUniRule annotation
Gene namesi
Name:mukBUniRule annotation
Ordered Locus Names:MS1084
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
Proteomesi
  • UP000000607 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000682221 – 1499Chromosome partition protein MukBAdd BLAST1499

Proteomic databases

PRIDEiQ65TL9

Interactioni

Subunit structurei

Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.UniRule annotation

Protein-protein interaction databases

STRINGi221988.MS1084

Structurei

3D structure databases

ProteinModelPortaliQ65TL9
SMRiQ65TL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni696 – 813Flexible hingeUniRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili335 – 501UniRule annotationAdd BLAST167
Coiled coili540 – 622UniRule annotationAdd BLAST83
Coiled coili666 – 695UniRule annotationAdd BLAST30
Coiled coili865 – 940UniRule annotationAdd BLAST76
Coiled coili1007 – 1053UniRule annotationAdd BLAST47
Coiled coili1100 – 1143UniRule annotationAdd BLAST44
Coiled coili1238 – 1294UniRule annotationAdd BLAST57

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.UniRule annotation

Sequence similaritiesi

Belongs to the SMC family. MukB subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105DUC Bacteria
COG3096 LUCA
HOGENOMiHOG000278243
KOiK03632
OMAiFIAVYQH
OrthoDBiPOG091H0669

Family and domain databases

HAMAPiMF_01800 MukB, 1 hit
InterProiView protein in InterPro
IPR012090 MukB
IPR032520 MukB_hinge
IPR007406 MukB_N_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF04310 MukB, 1 hit
PF16330 MukB_hinge, 1 hit
PIRSFiPIRSF005246 MukB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q65TL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEELELESE FLPEEKSETI VPATVLTQSA GIERGKFRSL TLINWNGFFA
60 70 80 90 100
RTFDLDELVT TLSGGNGAGK STTMAGFVTA LIPDLTLLHF RNTTEAGASG
110 120 130 140 150
GSRDKGLHGK LRPGVCYAVL DAVNSRQQRI LAGVRLQQVA GRDKKVDIKT
160 170 180 190 200
FSIQGLEISQ NPTAVLTETV SQRQARVLSL TELKDRIEEQ GAQFKQYHSV
210 220 230 240 250
ADYHAMMFEL GMIPRRLRSS SDRSKFYKLI EASLYGGISS AITKSLRDYL
260 270 280 290 300
LPENLGVRKA FQDMESALRE NRMTLEAIKM TQSDRDLFKH LITETTNYVA
310 320 330 340 350
SDYMRNANER QGNIETALSF RKEWYAAKSE QDLSQHRLID LSREAAELTE
360 370 380 390 400
NEKALEIDHQ SASDHLNLVL NALRHQERIE RYQEDVNELT EKLEEQKIVV
410 420 430 440 450
ENANEQLEES QLQFETLETE VDQIRGQLAD YQQALDAQQT RALQYQQAIQ
460 470 480 490 500
ALEKAKALCG LADLSVKNAE VYHEEFEAQV ETLTDRVLQL EQKMSISEAA
510 520 530 540 550
KTQFDKAYQL VCKIAGEIPR SAAWDSAKEL LREYPTQKLQ AQQTPQLRAK
560 570 580 590 600
LHELEQRYQQ QQSAVKILKD FNQRAGLSLE TADELEDYHA EQEALIENLT
610 620 630 640 650
AEFSEQVETR STLRQKLEQL TALFEEKARS APAWITAKSA LERLTEQSGE
660 670 680 690 700
QFEDNQDVMN FMQAQLEKER EFTMQRDQLE HKRQQLDEQI SRLSQPDGSE
710 720 730 740 750
DARLNVLAER FGGVLLSELY DDVAIEDAPY FSALYGPARH AIVVRDLNAV
760 770 780 790 800
KEQLAHLDDC PDDLYLIEGD PAAFDDSVHS AQELAQGVVV QVSERELRYS
810 820 830 840 850
KFPEIPLFGR AAREKYLTEL EAERDKIVEQ YAQRAFDVQK CQRLHQQFSQ
860 870 880 890 900
FVGLHLALAF QPDPEQQMRE INQQRNEINR ELTALSTDEQ QLRIKLDNAK
910 920 930 940 950
EQMQLLNKLI PQLNVIADES LSDKVEECRE QLDIAEQDEI FIRQHGMTLS
960 970 980 990 1000
QLEPIANTLQ SDPENYERLK DDLYQAIDMQ KQAQQKAFAL ADVIHRQAHF
1010 1020 1030 1040 1050
SYEDTVKTET NDLNEKLRVR LEQVQAKREQ QRDQVRQKQQ QFAQYNQVYI
1060 1070 1080 1090 1100
QLQSSFETKN QMLKELMDEV GELGLTVDEN SEQRARVRKD ELHHQLSTSR
1110 1120 1130 1140 1150
QRRSFVEKQL TLIESEAENL TRRIRKAERD YKQQRELVVA AKVSWCVVLR
1160 1170 1180 1190 1200
LSRNSDVEKR LTRREFAYLS ADELRSMSDK ALGSLRTAVA DNEYLRDALR
1210 1220 1230 1240 1250
ISEDSRKPEN KVRFFIAVYQ HLRERIRQDI IKTDDPIDAI EQMEIELSRL
1260 1270 1280 1290 1300
TDELTGREQK LAISSESVAN IMRKTIQREQ NRIRMLNQGL QNISFGQVKS
1310 1320 1330 1340 1350
VRLVVNIRDT HAMLLDALSG NQEEYQDLFN DNRMTFSEAI AKLYQRLNPH
1360 1370 1380 1390 1400
IDMGQRTAQT IGEELLDYRN YLDLQVEVYR GADGWLQAES GALSTGEAIG
1410 1420 1430 1440 1450
TGMSILLMVV QSWEEESRRI RGKDIIPCRL LFLDEAARLD GKSISTLFEL
1460 1470 1480 1490
CERLDMQLLI AAPENISPEK GTTYKLVRKI SGNQEHVHVV GLRGFGAKE
Length:1,499
Mass (Da):172,208
Last modified:October 25, 2004 - v1
Checksum:i749BE709C7619494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA Translation: AAU37691.1
RefSeqiWP_011200259.1, NC_006300.1

Genome annotation databases

EnsemblBacteriaiAAU37691; AAU37691; MS1084
KEGGimsu:MS1084

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA Translation: AAU37691.1
RefSeqiWP_011200259.1, NC_006300.1

3D structure databases

ProteinModelPortaliQ65TL9
SMRiQ65TL9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi221988.MS1084

Proteomic databases

PRIDEiQ65TL9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU37691; AAU37691; MS1084
KEGGimsu:MS1084

Phylogenomic databases

eggNOGiENOG4105DUC Bacteria
COG3096 LUCA
HOGENOMiHOG000278243
KOiK03632
OMAiFIAVYQH
OrthoDBiPOG091H0669

Enzyme and pathway databases

BioCyciMSUC221988:MS_RS05005-MONOMER

Family and domain databases

HAMAPiMF_01800 MukB, 1 hit
InterProiView protein in InterPro
IPR012090 MukB
IPR032520 MukB_hinge
IPR007406 MukB_N_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF04310 MukB, 1 hit
PF16330 MukB_hinge, 1 hit
PIRSFiPIRSF005246 MukB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMUKB_MANSM
AccessioniPrimary (citable) accession number: Q65TL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 25, 2004
Last modified: November 7, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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