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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

addB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi801Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi1121Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi1124Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi1130Iron-sulfur (4Fe-4S)UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi8 – 15ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
Ligand4Fe-4S, ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BLIC279010:BLI_RS05740-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease AddBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:addBUniRule annotation
Ordered Locus Names:BLi01156, BL01351
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri279010 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000606 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003791621 – 1166ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1166

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of AddA and AddB.UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
279010.BLi01156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q65LK0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q65LK0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 285UvrD-like helicase ATP-bindingUniRule annotationAdd BLAST285
Domaini279 – 586UvrD-like helicase C-terminalUniRule annotationAdd BLAST308

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 1 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3857 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285805

KEGG Orthology (KO)

More...
KOi
K16899

Identification of Orthologs from Complete Genome Data

More...
OMAi
HFASHGL

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01452 AddB_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014140 DNA_helicase_suAddB
IPR014017 DNA_helicase_UvrD-like_C
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type
IPR014016 UvrD-like_ATP-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12705 PDDEXK_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02773 addB_Gpos, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51198 UVRD_HELICASE_ATP_BIND, 1 hit
PS51217 UVRD_HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q65LK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAVFLSGRS GSGKTTFILN EIREKLRDEP LGKPIIFLVP DQMTFLMEYE
60 70 80 90 100
LSKTPDLGGT IRAQVYSFSR LAWRVLQHTG GMNRPFLTGT GIQMLLRRLI
110 120 130 140 150
EEHKGEFKVY QNASDKSGFT EQVERMLTEF KRHCLPPQSI RDMMEGTGKS
160 170 180 190 200
EYEDERILSD KLHDLYILYS KLEENLENQY VQSEDYLTLL AEQIPYAEEI
210 220 230 240 250
RNAAVYVDGF HQFTPQEMSV LEQLMVHAEE ITFSLTADKP FTANSPNDLH
260 270 280 290 300
LFRMTGKAYY DLYQKAKELG LDPSEVRLEE TKRHRHHPEL QHLERYFDER
310 320 330 340 350
PAKPYPGQTE SLRIMQASNR RTEIEGIARE IHSLIRQGRF RLRDIAVIAR
360 370 380 390 400
NVEDYKDTIK EVFKDCELPF FIDGKESMQN HPLIELIRST LDIIKGNWRY
410 420 430 440 450
EAVFRCVKTE LLFPEGQPKE RLREQIDQLE NYCIAYGIKG DRWTSKDPFV
460 470 480 490 500
YRRYASLDED FAKTDKEIET ENMLNELKGW IVPPIHRLQK RLKKAETVRE
510 520 530 540 550
MAEAVYLYLE EADVPMKLEQ ERRLAEEGGR IAESRQHEQV WDAVIQLLDE
560 570 580 590 600
FVEMMGTERI SFALFQQMIE TGLESLKFAL IPPALDQVFI GNMDLSRMYG
610 620 630 640 650
TKCTFLIGVN DGILPARPAD DGVLSDEDRE WLKRNGAQLA ATGREQLLDE
660 670 680 690 700
NFLIYMTLSS PSEKLYVSYP IADSEGKTLL PSTVVKRLNE LFPDSEEKML
710 720 730 740 750
IHEPEQLDDE AQLEFLVNKG IALSHLAGQL GIWTRQYAIS DVWWSTYNFL
760 770 780 790 800
MNEPDRIFSQ NILSSLFFRN KVENLNRHVS RDLYGEHIQG SVSRMETFKA
810 820 830 840 850
CPFSHFASHG LKLKERQFFK LEAPDIGQLF HSALKLISDR LHELKLDWRD
860 870 880 890 900
LTKAQCETLS SDAVERLAPK LQKEILLSSN RHHYVKQKLQ KIIARVSGIL
910 920 930 940 950
SEHAKASGFA PVGIELGFGG KGPLPPMRFT LKNGCTMELV GRIDRVDKAE
960 970 980 990 1000
SSKGLLLRIV DYKSSDKGLD LAEVYYGLAL QMLTYLDLSI THSTDWLGMK
1010 1020 1030 1040 1050
ASPAGVLYFH VHDPMIQASV PLGLDEIEKE IFKKFKMKGL LLGDQEAVKL
1060 1070 1080 1090 1100
MDTTLEQGRS NIISAGLKKD GSLRSDSDVV AEEDFHVLRR HIRRTFQQAG
1110 1120 1130 1140 1150
EEITDGKVSI EPYKLKDRTP CTYCSYRSFC QFDESLEENE YRILKPEKDS
1160
VILERLKKED EADGDF
Length:1,166
Mass (Da):134,408
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD234A27685429F28
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000002 Genomic DNA Translation: AAU22717.1
AE017333 Genomic DNA Translation: AAU40064.1

NCBI Reference Sequences

More...
RefSeqi
WP_009328899.1, NC_006322.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAU22717; AAU22717; BL01351
AAU40064; AAU40064; BLi01156

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3030124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bld:BLi01156
bli:BL01351

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA Translation: AAU22717.1
AE017333 Genomic DNA Translation: AAU40064.1
RefSeqiWP_009328899.1, NC_006322.1

3D structure databases

ProteinModelPortaliQ65LK0
SMRiQ65LK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BLi01156

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU22717; AAU22717; BL01351
AAU40064; AAU40064; BLi01156
GeneIDi3030124
KEGGibld:BLi01156
bli:BL01351

Phylogenomic databases

eggNOGiCOG3857 LUCA
HOGENOMiHOG000285805
KOiK16899
OMAiHFASHGL

Enzyme and pathway databases

BioCyciBLIC279010:BLI_RS05740-MONOMER

Family and domain databases

HAMAPiMF_01452 AddB_type1, 1 hit
InterProiView protein in InterPro
IPR014140 DNA_helicase_suAddB
IPR014017 DNA_helicase_UvrD-like_C
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type
IPR014016 UvrD-like_ATP-bd
PfamiView protein in Pfam
PF12705 PDDEXK_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02773 addB_Gpos, 1 hit
PROSITEiView protein in PROSITE
PS51198 UVRD_HELICASE_ATP_BIND, 1 hit
PS51217 UVRD_HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADDB_BACLD
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q65LK0
Secondary accession number(s): Q62WZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 25, 2004
Last modified: December 5, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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