We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q65IH4 (ODO1_BACLD)
Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)
Status
Functioni
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO2.
UniRule annotationCatalytic activityi
- 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N6-lipoyl-L-lysine + H+ = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N6-(S8-succinyldihydrolipoyl)-L-lysine + CO2UniRule annotationEC:1.2.4.2UniRule annotation
Cofactori
thiamine diphosphateUniRule annotation
GO - Molecular functioni
- oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-UniRule
- thiamine pyrophosphate binding Source: UniProtKB-UniRule
GO - Biological processi
- glycolytic process Source: UniProtKB-UniRule
- tricarboxylic acid cycle Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glycolysis |
Ligand | Thiamine pyrophosphate |
Enzyme and pathway databases
BioCyci | BLIC279010:BLI_RS11210-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)Alternative name(s): Alpha-ketoglutarate dehydrogenaseUniRule annotation |
Gene namesi | Name:odhAUniRule annotation Ordered Locus Names:BLi02260, BL01452 |
Organismi | Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) |
Taxonomic identifieri | 279010 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162167 | 1 – 944 | 2-oxoglutarate dehydrogenase E1 componentAdd BLAST | 944 |
Interactioni
Subunit structurei
Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).
UniRule annotationProtein-protein interaction databases
STRINGi | 279010.BL01452 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 914 – 944 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0567, Bacteria |
HOGENOMi | CLU_004709_1_0_9 |
OMAi | RDSYCRT |
OrthoDBi | 29166at2 |
Family and domain databases
Gene3Di | 3.40.50.11610, 1 hit |
HAMAPi | MF_01169, SucA_OdhA, 1 hit |
InterProi | View protein in InterPro IPR011603, 2oxoglutarate_DH_E1 IPR023784, 2oxoglutarate_DH_E1_bac IPR001017, DH_E1 IPR031717, KGD_C IPR042179, KGD_C_sf IPR029061, THDP-binding IPR005475, Transketolase-like_Pyr-bd |
PANTHERi | PTHR23152, PTHR23152, 1 hit |
Pfami | View protein in Pfam PF00676, E1_dh, 1 hit PF16870, OxoGdeHyase_C, 1 hit PF02779, Transket_pyr, 1 hit |
PIRSFi | PIRSF000157, Oxoglu_dh_E1, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 2 hits |
TIGRFAMsi | TIGR00239, 2oxo_dh_E1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q65IH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFQNSMKQRM TWEEFHGPNL GYVLELYDQY VKDPESLDAD LKEMFDELGA
60 70 80 90 100
PPGDIRAASQ KNEEADFTAG SIQKIASAVK LAEDIRTYGH LNASVNPLRK
110 120 130 140 150
TQEKQELFPL AEYGLTEQDV KKIPASVICK DAPKEVTNGL EAIQYLRNTY
160 170 180 190 200
KKSISFEFDH VHIFEERNWL MKKIESGELF TPKSKEKLVE VLRRLTEVES
210 220 230 240 250
LEQFLHKTFV GQKRFSIEGL DALVPMLDDI IAKSVSAGTT NVNIGMAHRG
260 270 280 290 300
RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSTGINYG WTGDVKYHLG
310 320 330 340 350
ANRQIQDEHT KTARIALANN PSHLEFIDPI VEGSTRAAQE TRTESGYPVQ
360 370 380 390 400
DVKKSMAILI HGDAAFPGEG IVAETLNLSQ LKGYQVGGAI HIIANNMIGF
410 420 430 440 450
TTESNESRST KYASDLAKGF EIPIVHVNAD DPEACLSAVQ LAVEYRMTFN
460 470 480 490 500
KDFLIDLIGY RRFGHNEMDE PSATQPMLYD AVRKHPTVKN IFAEKLIHKG
510 520 530 540 550
IVDKETVGKI KDAVQKRLEE AYRKVPAKKE DMTHEIVLPE PVSNGFPDVD
560 570 580 590 600
TSVDFETLRK INQELVSWPE NFNVFDKLKR ILERRAKAFE DDRKVDWSLA
610 620 630 640 650
EAMAFASILK DGTPLRLTGQ DSERGTFAHR NLVLHDSKTG DEFIALHHLA
660 670 680 690 700
DTKASFAVHN SPLSEGSVLG FEYGYNVSSP ETMVIWEAQF GDFANAAQVY
710 720 730 740 750
FDQFISAGRA KWGQKSGLVV LLPHGYEGQG PEHSSGRTER FLQLAAENNW
760 770 780 790 800
TVANLTSAAQ YFHILRRQAK MLLREEIRPL IIMTPKSLLR NPNTVSEVQE
810 820 830 840 850
LSNSSFKPVY EMSGLSHQYD KVTRLVLSSG KVSIDISDHF NKMEGEKDWL
860 870 880 890 900
HIARVEELYP FPAKHIKAIF SKLPNLEEIV WVQEEPQNMG AWNYIEPYLR
910 920 930 940
EVAPKDVKVR YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017333 Genomic DNA Translation: AAU41140.1 CP000002 Genomic DNA Translation: AAU23783.1 |
RefSeqi | WP_003182695.1, NC_006322.1 |
Genome annotation databases
EnsemblBacteriai | AAU23783; AAU23783; BL01452 |
GeneIDi | 66215737 |
KEGGi | bld:BLi02260 bli:BL01452 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017333 Genomic DNA Translation: AAU41140.1 CP000002 Genomic DNA Translation: AAU23783.1 |
RefSeqi | WP_003182695.1, NC_006322.1 |
3D structure databases
SMRi | Q65IH4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 279010.BL01452 |
Genome annotation databases
EnsemblBacteriai | AAU23783; AAU23783; BL01452 |
GeneIDi | 66215737 |
KEGGi | bld:BLi02260 bli:BL01452 |
Phylogenomic databases
eggNOGi | COG0567, Bacteria |
HOGENOMi | CLU_004709_1_0_9 |
OMAi | RDSYCRT |
OrthoDBi | 29166at2 |
Enzyme and pathway databases
BioCyci | BLIC279010:BLI_RS11210-MONOMER |
Family and domain databases
Gene3Di | 3.40.50.11610, 1 hit |
HAMAPi | MF_01169, SucA_OdhA, 1 hit |
InterProi | View protein in InterPro IPR011603, 2oxoglutarate_DH_E1 IPR023784, 2oxoglutarate_DH_E1_bac IPR001017, DH_E1 IPR031717, KGD_C IPR042179, KGD_C_sf IPR029061, THDP-binding IPR005475, Transketolase-like_Pyr-bd |
PANTHERi | PTHR23152, PTHR23152, 1 hit |
Pfami | View protein in Pfam PF00676, E1_dh, 1 hit PF16870, OxoGdeHyase_C, 1 hit PF02779, Transket_pyr, 1 hit |
PIRSFi | PIRSF000157, Oxoglu_dh_E1, 1 hit |
SMARTi | View protein in SMART SM00861, Transket_pyr, 1 hit |
SUPFAMi | SSF52518, SSF52518, 2 hits |
TIGRFAMsi | TIGR00239, 2oxo_dh_E1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ODO1_BACLD | |
Accessioni | Q65IH4Primary (citable) accession number: Q65IH4 Secondary accession number(s): Q62TX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2006 |
Last sequence update: | October 25, 2004 | |
Last modified: | February 23, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families