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Entry version 108 (10 Apr 2019)
Sequence version 1 (25 Oct 2004)
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Protein

Lactate utilization protein B

Gene

lutB

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi313Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi316Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi319Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi323Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi366Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi369Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi373Iron-sulfur 1 (4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
BLIC279010:BLI_RS18065-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lactate utilization protein BUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lutBUniRule annotation
Synonyms:yvfW
Ordered Locus Names:BLi03674, BL03457
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri279010 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000606 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003839751 – 477Lactate utilization protein BAdd BLAST477

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q65EM0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
279010.BL03457

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q65EM0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q65EM0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini304 – 3344Fe-4S ferredoxin-type 1UniRule annotationAdd BLAST31
Domaini353 – 3824Fe-4S ferredoxin-type 2UniRule annotationAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LutB/YkgF family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG1139 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000262102

KEGG Orthology (KO)

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KOi
K18929

Identification of Orthologs from Complete Genome Data

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OMAi
HCPVYDK

Database of Orthologous Groups

More...
OrthoDBi
688908at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10420, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_02103 LutB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004452 4Fe-4S-bd
IPR024569 4Fe-4S-bd_C
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR024185 FTHF_cligase-like_sf
IPR009051 Helical_ferredxn
IPR003741 LUD_dom
IPR022825 LutB
IPR037171 NagB/RpiA_transferase-like

The PANTHER Classification System

More...
PANTHERi
PTHR32479:SF10 PTHR32479:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11870 DUF3390, 1 hit
PF13183 Fer4_8, 1 hit
PF02589 LUD_dom, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 1 hit
SSF46548 SSF46548, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00273 TIGR00273, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q65EM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMKIGTQKF KERVSDGLDN EFMRGAVSSA QERLRARRLE AAKELGNWEE
60 70 80 90 100
WRSLAEEIRQ HVLENLDYYL EQLAENVAKK GGHVFFAQTA EEATGYIRDV
110 120 130 140 150
VKKKNGKKIV KSKSMVTEEI NMNEALESDG CEVVETDLGE YILQIDDHDP
160 170 180 190 200
PSHIVAPALH KNKEQIRDVF KERIGYRNTE KPEELVMHAR AVLRKKFLEA
210 220 230 240 250
DIGITGCNFA IADTGSVSLV TNEGNGRLVT TIPKTQITVM GMERIVPSFD
260 270 280 290 300
EFEVLVGMLT RSAVGQRLTS YITALTGPRL PGEADGPEEF HLVIVDNGRS
310 320 330 340 350
NILGTEFQSV LQCIRCAACI NVCPVYRHVG GHSYGSIYSG PIGAVLSPLL
360 370 380 390 400
GGYDDYKELP YASSLCAACS EACPVKIPLH ELLLKHRQRI VEKEGRAPIS
410 420 430 440 450
EKLAMKAFGL GTSAPSLYKM GSKWAPAAMK PFKEDGKITK GPGPLKQWTQ
460 470
IRDFPAPNKS RFRDWFEDRR KEKGEDK
Length:477
Mass (Da):53,214
Last modified:October 25, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i892CD0FAF8303A03
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017333 Genomic DNA Translation: AAU42494.1
CP000002 Genomic DNA Translation: AAU25123.1

NCBI Reference Sequences

More...
RefSeqi
WP_003185481.1, NC_006322.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAU25123; AAU25123; BL03457
AAU42494; AAU42494; BLi03674

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3029355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bld:BLi03674
bli:BL03457

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017333 Genomic DNA Translation: AAU42494.1
CP000002 Genomic DNA Translation: AAU25123.1
RefSeqiWP_003185481.1, NC_006322.1

3D structure databases

ProteinModelPortaliQ65EM0
SMRiQ65EM0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279010.BL03457

Proteomic databases

PRIDEiQ65EM0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU25123; AAU25123; BL03457
AAU42494; AAU42494; BLi03674
GeneIDi3029355
KEGGibld:BLi03674
bli:BL03457

Phylogenomic databases

eggNOGiCOG1139 LUCA
HOGENOMiHOG000262102
KOiK18929
OMAiHCPVYDK
OrthoDBi688908at2

Enzyme and pathway databases

BioCyciBLIC279010:BLI_RS18065-MONOMER

Family and domain databases

Gene3Di3.40.50.10420, 1 hit
HAMAPiMF_02103 LutB, 1 hit
InterProiView protein in InterPro
IPR004452 4Fe-4S-bd
IPR024569 4Fe-4S-bd_C
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR024185 FTHF_cligase-like_sf
IPR009051 Helical_ferredxn
IPR003741 LUD_dom
IPR022825 LutB
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR32479:SF10 PTHR32479:SF10, 1 hit
PfamiView protein in Pfam
PF11870 DUF3390, 1 hit
PF13183 Fer4_8, 1 hit
PF02589 LUD_dom, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
SSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR00273 TIGR00273, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLUTB_BACLD
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q65EM0
Secondary accession number(s): Q62Q37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 25, 2004
Last modified: April 10, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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