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Protein

Lantibiotic lichenicidin A1

Gene

lanA1

Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. When present individually, LchA1 exhibits activity towards L.lactis HP. When combined with LchA2, it displays activity towards a broad spectrum of non-pathogenic and pathogenic Gram-positive bacteria including strains of L.monocytogenes, methicillin-resistant S.aureus, S.pneumoniae and strains of vancomycin-resistant enterococci, but not towards E.faecium L4001 and BM4147-1. Combined LchA1 and LchA2 peptides also inhibit Bacillus sp. HIL-Y85/54728, L.lactis DPC3417 and B.halodurans C-125, which produce lantibiotics themselves. Inactivated by proteinase K and pronase E, but not by trypsin and chymotrypsin.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, Lantibiotic

Names & Taxonomyi

Protein namesi
Recommended name:
Lantibiotic lichenicidin A12 Publications
Short name:
LchA1By similarity
Alternative name(s):
BliA11 Publication
Gene namesi
Name:lanA11 Publication
Synonyms:lanAImported, licA11 Publication
Ordered Locus Names:BL05375, BLi04127
OrganismiBacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Taxonomic identifieri279010 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000000606 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-KW
  • Gram-positive-bacterium-type cell wall Source: UniProtKB

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003990381 – 42By similarityAdd BLAST42
PeptideiPRO_000039903943 – 74Lantibiotic lichenicidin A1By similarityAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei432-oxobutanoic acidBy similarity1
Cross-linki45 ↔ 49Beta-methyllanthionine (Thr-Cys)By similarity
Modified residuei472,3-didehydroalanine (Ser)By similarity1
Modified residuei48(Z)-2,3-didehydrobutyrineBy similarity1
Cross-linki53 ↔ 63Lanthionine (Ser-Cys)By similarity
Cross-linki64 ↔ 69Beta-methyllanthionine (Thr-Cys)By similarity
Cross-linki66 ↔ 73Beta-methyllanthionine (Thr-Cys)By similarity

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor (By similarity).By similarity

Keywords - PTMi

Thioether bond

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi279010.BLi04127

Structurei

3D structure databases

SMRiQ65DC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000140758
OMAiECMPSCN

Family and domain databases

InterProiView protein in InterPro
IPR029243 Lantibiotic_alpha
PfamiView protein in Pfam
PF14867 Lantibiotic_a, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q65DC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKEMILSW KNPMYRTESS YHPAGNILKE LQEEEQHSIA GGTITLSTCA
60 70
ILSKPLGNNG YLCTVTKECM PSCN
Length:74
Mass (Da):8,208
Last modified:October 25, 2004 - v1
Checksum:iA9B07B85B9118C56
GO

Mass spectrometryi

Molecular mass is 3250.66 Da from positions 43 - 74. Determined by MALDI. 2 Publications
Molecular mass is 3250.6 Da from positions 43 - 74. Determined by MALDI. 2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000002 Genomic DNA Translation: AAU25566.1
AE017333 Genomic DNA Translation: AAU42940.1
RefSeqiWP_003186381.1, NC_006322.1

Genome annotation databases

EnsemblBacteriaiAAU25566; AAU25566; BL05375
AAU42940; AAU42940; BLi04127
GeneIDi3028214
KEGGibld:BLi04127
bli:BL05375

Similar proteinsi

Entry informationi

Entry nameiLANLA_BACLD
AccessioniPrimary (citable) accession number: Q65DC4
Secondary accession number(s): Q62NU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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