Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 116 (12 Aug 2020)
Sequence version 2 (25 Oct 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Catenin alpha-3

Gene

Ctnna3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in formation of stretch-resistant cell-cell adhesion complexes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catenin alpha-3
Alternative name(s):
Alpha T-catenin
Cadherin-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ctnna3Imported
Synonyms:Catna3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2661445, Ctnna3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642671 – 895Catenin alpha-3Add BLAST895

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160PhosphoserineCombined sources1
Modified residuei361PhosphothreonineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei649PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q65CL1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q65CL1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q65CL1

PRoteomics IDEntifications database

More...
PRIDEi
Q65CL1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q65CL1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q65CL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000060843, Expressed in interventricular septum and 85 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q65CL1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229691, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101080

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q65CL1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q65CL1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 107Sequence analysisAdd BLAST34
Coiled coili325 – 379Sequence analysisAdd BLAST55

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3681, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015314_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q65CL1

KEGG Orthology (KO)

More...
KOi
K05691

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFKRQQD

Database of Orthologous Groups

More...
OrthoDBi
953344at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q65CL1

TreeFam database of animal gene trees

More...
TreeFami
TF313686

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR001033, Alpha_catenin
IPR030044, CTNNA3
IPR006077, Vinculin/catenin

The PANTHER Classification System

More...
PANTHERi
PTHR18914, PTHR18914, 1 hit
PTHR18914:SF21, PTHR18914:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01044, Vinculin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00805, ALPHACATENIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47220, SSF47220, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q65CL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAETPITLN MDTQDLQIQT FTVEKLLEPL IIQVTTLVNC PQNPSNRKKG
60 70 80 90 100
RSKRARVLLA SVEEATWNLL DKGEMIAKEA TVLKEELAAA LQEVRKESKA
110 120 130 140 150
LKVSAERFTD DPCYLPKREA VVQAARALLA AVTRLLVLAD MIDVMCLLQH
160 170 180 190 200
VSSFQRTFES LKNVSNKSDL QRTYQKLGKE LESLDYLAFK RQQDLKSPSQ
210 220 230 240 250
RDEIAGARAT LKENSPLLHS ICSACLEHSD VASLKASKDT VCEEIQNALD
260 270 280 290 300
VISNASQGIQ NAPAPPEPQA ATLGSAFDEL ENLIVLNPLT VTEEDVRPSL
310 320 330 340 350
EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLTEYMSNT
360 370 380 390 400
GKTERSNTLN TAIVNMSKKT RDLRRQLRKA IIDHISDSFL DTTVPLLVLI
410 420 430 440 450
EAAKNGRVKE IKDYAAIFHE HTGRLVEVAN LACSMSTNED GIKIVRIAAN
460 470 480 490 500
HLETLCPQII NAALALASRP KSQVVKNTME MYKRTWEHYI HVLTEAVDDI
510 520 530 540 550
TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI RGRAARVAHI
560 570 580 590 600
VAGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL DALSKNSLTA
610 620 630 640 650
LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE DDHEVRSHTS
660 670 680 690 700
IQTEGKTDRA KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND
710 720 730 740 750
IIVLAKKMCM IMMEMTDFTR GKGPLKHTTD VIYAAKMISE SGSRMDVLAR
760 770 780 790 800
QIANQCPDPP CKQDLLAYLE QIKFYSHQLK ICSQVKAEIQ NLGGELIVSA
810 820 830 840 850
LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSSAG PRHPVVMWRM
860 870 880 890
KAPAKKPLIK REKPEETWAA VRRGSAKKKI HPVQVMSEFR GRQVY
Length:895
Mass (Da):99,803
Last modified:October 25, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82355DA239D17A6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti439E → K in BAC26817 (PubMed:16141072).Curated1
Sequence conflicti838S → C in BAC26817 (PubMed:16141072).Curated1
Sequence conflicti869A → V in BAC26817 (PubMed:16141072).Curated1
Sequence conflicti871V → A in AAQ14965 (PubMed:12596047).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF344871 mRNA Translation: AAQ14965.1
AK030166 mRNA Translation: BAC26817.1
AK142745 mRNA Translation: BAE25182.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23901.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157848.1, NM_001164376.1
NP_808280.2, NM_177612.3
XP_006513538.1, XM_006513475.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000075099; ENSMUSP00000074606; ENSMUSG00000060843
ENSMUST00000105440; ENSMUSP00000101080; ENSMUSG00000060843
ENSMUST00000105441; ENSMUSP00000101081; ENSMUSG00000060843

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
216033

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:216033

UCSC genome browser

More...
UCSCi
uc007fkh.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF344871 mRNA Translation: AAQ14965.1
AK030166 mRNA Translation: BAC26817.1
AK142745 mRNA Translation: BAE25182.1
CCDSiCCDS23901.1
RefSeqiNP_001157848.1, NM_001164376.1
NP_808280.2, NM_177612.3
XP_006513538.1, XM_006513475.2

3D structure databases

SMRiQ65CL1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229691, 1 interactor
STRINGi10090.ENSMUSP00000101080

PTM databases

iPTMnetiQ65CL1
PhosphoSitePlusiQ65CL1

Proteomic databases

jPOSTiQ65CL1
MaxQBiQ65CL1
PaxDbiQ65CL1
PRIDEiQ65CL1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2926, 165 antibodies

Genome annotation databases

EnsembliENSMUST00000075099; ENSMUSP00000074606; ENSMUSG00000060843
ENSMUST00000105440; ENSMUSP00000101080; ENSMUSG00000060843
ENSMUST00000105441; ENSMUSP00000101081; ENSMUSG00000060843
GeneIDi216033
KEGGimmu:216033
UCSCiuc007fkh.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29119
MGIiMGI:2661445, Ctnna3

Phylogenomic databases

eggNOGiKOG3681, Eukaryota
GeneTreeiENSGT00990000203614
HOGENOMiCLU_015314_2_0_1
InParanoidiQ65CL1
KOiK05691
OMAiAFKRQQD
OrthoDBi953344at2759
PhylomeDBiQ65CL1
TreeFamiTF313686

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
216033, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ctnna3, mouse

Protein Ontology

More...
PROi
PR:Q65CL1
RNActiQ65CL1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000060843, Expressed in interventricular septum and 85 other tissues
GenevisibleiQ65CL1, MM

Family and domain databases

InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR001033, Alpha_catenin
IPR030044, CTNNA3
IPR006077, Vinculin/catenin
PANTHERiPTHR18914, PTHR18914, 1 hit
PTHR18914:SF21, PTHR18914:SF21, 1 hit
PfamiView protein in Pfam
PF01044, Vinculin, 2 hits
PRINTSiPR00805, ALPHACATENIN
SUPFAMiSSF47220, SSF47220, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTNA3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q65CL1
Secondary accession number(s): Q3UQ61, Q8C0N3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: August 12, 2020
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again