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Protein

Hydroxyphenylpyruvate reductase

Gene

HPPR

Organism
Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the preferred substrate.1 Publication

Catalytic activityi

3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230NADP; via carbonyl oxygen1 Publication1
Active sitei232By similarity1
Binding sitei256NADP1 Publication1
Active sitei261By similarity1
Active sitei279Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 155NADP1 Publication4
Nucleotide bindingi174 – 176NADP1 Publication3

GO - Molecular functioni

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Nucleotide-binding, Pyruvate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11763
BRENDAi1.1.1.237 1561

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyphenylpyruvate reductase (EC:1.1.1.237)
Short name:
HPPR
Gene namesi
Name:HPPR
OrganismiPlectranthus scutellarioides (Coleus) (Solenostemon scutellarioides)
Taxonomic identifieri4142 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesLamiaceaeNepetoideaeOcimeaeSolenostemon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004225811 – 313Hydroxyphenylpyruvate reductaseAdd BLAST313

Proteomic databases

PRIDEiQ65CJ7

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Helixi14 – 23Combined sources10
Beta strandi24 – 28Combined sources5
Helixi29 – 31Combined sources3
Helixi35 – 42Combined sources8
Turni43 – 45Combined sources3
Beta strandi46 – 51Combined sources6
Beta strandi53 – 55Combined sources3
Helixi59 – 64Combined sources6
Beta strandi70 – 76Combined sources7
Helixi83 – 89Combined sources7
Beta strandi92 – 94Combined sources3
Helixi101 – 116Combined sources16
Helixi119 – 127Combined sources9
Helixi130 – 133Combined sources4
Beta strandi147 – 150Combined sources4
Helixi154 – 164Combined sources11
Turni165 – 167Combined sources3
Beta strandi170 – 173Combined sources4
Beta strandi183 – 187Combined sources5
Helixi189 – 194Combined sources6
Beta strandi197 – 201Combined sources5
Helixi207 – 209Combined sources3
Helixi215 – 221Combined sources7
Beta strandi226 – 229Combined sources4
Helixi233 – 235Combined sources3
Helixi238 – 246Combined sources9
Beta strandi252 – 256Combined sources5
Turni259 – 262Combined sources4
Helixi266 – 270Combined sources5
Beta strandi274 – 276Combined sources3
Helixi285 – 303Combined sources19
Beta strandi309 – 311Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BA1X-ray1.47A1-313[»]
3BAZX-ray2.20A1-313[»]
ProteinModelPortaliQ65CJ7
SMRiQ65CJ7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ65CJ7

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q65CJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIGVLMMC PMSTYLEQEL DKRFKLFRYW TQPAQRDFLA LQAESIRAVV
60 70 80 90 100
GNSNAGADAE LIDALPKLEI VSSFSVGLDK VDLIKCEEKG VRVTNTPDVL
110 120 130 140 150
TDDVADLAIG LILAVLRRIC ECDKYVRRGA WKFGDFKLTT KFSGKRVGII
160 170 180 190 200
GLGRIGLAVA ERAEAFDCPI SYFSRSKKPN TNYTYYGSVV ELASNSDILV
210 220 230 240 250
VACPLTPETT HIINREVIDA LGPKGVLINI GRGPHVDEPE LVSALVEGRL
260 270 280 290 300
GGAGLDVFER EPEVPEKLFG LENVVLLPHV GSGTVETRKV MADLVVGNLE
310
AHFSGKPLLT PVV
Length:313
Mass (Da):34,128
Last modified:May 24, 2005 - v2
Checksum:i191F25E7E3226586
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507733 mRNA Translation: CAD47810.2

Similar proteinsi

Entry informationi

Entry nameiHPPR_PLESU
AccessioniPrimary (citable) accession number: Q65CJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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