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Protein

Hydroxyphenylpyruvate reductase

Gene

HPPR

Organism
Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NAD(P)H-dependent reduction of 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the preferred substrate.1 Publication

Catalytic activityi

3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei230NADP; via carbonyl oxygen1 Publication1
Active sitei232By similarity1
Binding sitei256NADP1 Publication1
Active sitei261By similarity1
Active sitei279Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 155NADP1 Publication4
Nucleotide bindingi174 – 176NADP1 Publication3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Nucleotide-binding, Pyruvate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11763
BRENDAi1.1.1.237 1561

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyphenylpyruvate reductase (EC:1.1.1.237)
Short name:
HPPR
Gene namesi
Name:HPPR
OrganismiPlectranthus scutellarioides (Coleus) (Solenostemon scutellarioides)
Taxonomic identifieri4142 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesLamiaceaeNepetoideaeOcimeaePlectranthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004225811 – 313Hydroxyphenylpyruvate reductaseAdd BLAST313

Proteomic databases

PRIDEiQ65CJ7

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ65CJ7
SMRiQ65CJ7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ65CJ7

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q65CJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAIGVLMMC PMSTYLEQEL DKRFKLFRYW TQPAQRDFLA LQAESIRAVV
60 70 80 90 100
GNSNAGADAE LIDALPKLEI VSSFSVGLDK VDLIKCEEKG VRVTNTPDVL
110 120 130 140 150
TDDVADLAIG LILAVLRRIC ECDKYVRRGA WKFGDFKLTT KFSGKRVGII
160 170 180 190 200
GLGRIGLAVA ERAEAFDCPI SYFSRSKKPN TNYTYYGSVV ELASNSDILV
210 220 230 240 250
VACPLTPETT HIINREVIDA LGPKGVLINI GRGPHVDEPE LVSALVEGRL
260 270 280 290 300
GGAGLDVFER EPEVPEKLFG LENVVLLPHV GSGTVETRKV MADLVVGNLE
310
AHFSGKPLLT PVV
Length:313
Mass (Da):34,128
Last modified:May 24, 2005 - v2
Checksum:i191F25E7E3226586
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507733 mRNA Translation: CAD47810.2

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507733 mRNA Translation: CAD47810.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BA1X-ray1.47A1-313[»]
3BAZX-ray2.20A1-313[»]
ProteinModelPortaliQ65CJ7
SMRiQ65CJ7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ65CJ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11763
BRENDAi1.1.1.237 1561

Miscellaneous databases

EvolutionaryTraceiQ65CJ7

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHPPR_PLESU
AccessioniPrimary (citable) accession number: Q65CJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: May 24, 2005
Last modified: September 12, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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