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Entry version 85 (02 Dec 2020)
Sequence version 2 (01 Jun 2002)
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Protein

Serine protease

Gene
N/A
Organism
Cucurbit aphid-borne yellows virus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseARBA annotation, Serine proteaseARBA annotation, Transferase
Biological processViral RNA replicationARBA annotation
LigandNucleotide-bindingARBA annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S39.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine proteaseARBA annotation (EC:2.7.7.48ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCucurbit aphid-borne yellows virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri91753 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaTolucaviricetesToliviralesLuteoviridaePolerovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000204367 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei122 – 140HelicalSequence analysisAdd BLAST19
Transmembranei147 – 168HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini202 – 395Peptidase S39InterPro annotationAdd BLAST194
Domaini852 – 966RdRp catalyticInterPro annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni528 – 549DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi528 – 545PolarSequence analysisAdd BLAST18

Keywords - Domaini

SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000382, Peptidase_S39B_luteovirus
IPR001795, RNA-dir_pol_luteovirus
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02122, Peptidase_S39, 1 hit
PF02123, RdRP_4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00914, LVIRUSRNAPOL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51868, PEPTIDASE_S39, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q65969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPTYFAFFL LVCLCSSVSS YQGTMFIPLE PANASYWLDS TDIAVPPSHP
60 70 80 90 100
QVQLIYDCPP QKMLRDFSSR DITLELWERG YNETRQAFSE AMQNLQNLLM
110 120 130 140 150
SGVRQFHTGL ESLLHVILQT AAYLWTSLIW ATACATWYLL SKYTIEMLTL
160 170 180 190 200
ASLYISTVYM VKMAAWIFGD LPISLLKAGL SMVRGVSRAL WYKRSYNAEK
210 220 230 240 250
SVEGYLSFKI PQNPPKNSVL QVQYKDGSHA GYATCVTLYN GTNGLLTAYH
260 270 280 290 300
VAVPGSKVVS TRNGNKVPLS EFRSIMESEK RDLVLLAGPP NWEGTLACKA
310 320 330 340 350
VQFQSAQNLC KSKASFYAYD GEGWISSNAE IVGIAEGKTH ASVLSNTDAG
360 370 380 390 400
HSGTPYFNGR TVLGVHVGGA KDENFNYMAP IPPVYGLTSP SYEFETTAPQ
410 420 430 440 450
GRLFTQEEIE ELIEEFSFSE ITSIMGHRRF HQMHDSQRHQ ADYEYESGKR
460 470 480 490 500
AGGGDRRNNR TRCHPRGWAH KWRRTVSCCS LFPEGQHVHT SEQTGKPHCF
510 520 530 540 550
CSIPHHQCFY RHFVGNQTGN NGQNRCPFNR EASGPSLGGQ SHEETEVAQT
560 570 580 590 600
RQEKFEELAT DFSSFFDAQY TWEQGGEEAP GFDKVGSLPQ FYHAKQKKSS
610 620 630 640 650
NWGDKICKQH PEMGDLTKGF GWPQFGAKAE LKSLRLQAAR WLERAQSVKI
660 670 680 690 700
PSSEEREHVI ERCCRAYQAA KTNGPMATRG DRLSWDNFLQ DFKQAVLSLE
710 720 730 740 750
MDAGIGVPYI AYGKPTHRGW VEDKKLLPIL ARLTFNRLQK MLEVRYVDLS
760 770 780 790 800
PAELVRRGLC DPIRVFVKGE PHKQAKLDEG RYRLIMSVSL VDQLVARVLF
810 820 830 840 850
QNQNKREIAL WRVVPSKPGF GLSTDEQVAE FMQILSAQVG LTPSDLITEW
860 870 880 890 900
RAHMIATDCS GFDWSVSDWL LEDDMEVRNR LTLDLNETTR RLRSWLYCIS
910 920 930 940 950
NSVLCLSDGT LLAQRVPGVQ KSGSYNTSSS NSRIRVMAAY HCGAEWAMAM
960 970 980 990 1000
GDDALESACS NLERYKSLGF KVEESSKLEF CSHIFEKEDL AIPVNKAKML
1010 1020 1030 1040 1050
YKLIHGYEPE CGNVEVLINY LAACFSILNE LRSDPSLVET LHQWLVAPVQ

PQKI
Length:1,054
Mass (Da):118,846
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34EF88EE4D6DC647
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X76931 Genomic RNA Translation: CAA54251.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S41315

NCBI Reference Sequences

More...
RefSeqi
NP_620101.2, NC_003688.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
940451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:940451

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76931 Genomic RNA Translation: CAA54251.2
PIRiS41315
RefSeqiNP_620101.2, NC_003688.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiS39.002

Genome annotation databases

GeneIDi940451
KEGGivg:940451

Family and domain databases

Gene3Di2.40.10.10, 2 hits
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000382, Peptidase_S39B_luteovirus
IPR001795, RNA-dir_pol_luteovirus
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF02122, Peptidase_S39, 1 hit
PF02123, RdRP_4, 1 hit
PRINTSiPR00914, LVIRUSRNAPOL
SUPFAMiSSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51868, PEPTIDASE_S39, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ65969_9LUTE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q65969
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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