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Protein

Protein FAM91A1

Gene

FAM91A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.1 Publication

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • vesicle tethering to Golgi Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM91A1
Gene namesi
Name:FAM91A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000176853.15
HGNCiHGNC:26306 FAM91A1
neXtProtiNX_Q658Y4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176853
PharmGKBiPA142671820

Polymorphism and mutation databases

BioMutaiFAM91A1
DMDMi212276508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825521 – 838Protein FAM91A1Add BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ658Y4
MaxQBiQ658Y4
PaxDbiQ658Y4
PeptideAtlasiQ658Y4
PRIDEiQ658Y4
ProteomicsDBi65930

PTM databases

iPTMnetiQ658Y4
PhosphoSitePlusiQ658Y4

Expressioni

Gene expression databases

BgeeiENSG00000176853 Expressed in 195 organ(s), highest expression level in intestine
CleanExiHS_FAM91A1
ExpressionAtlasiQ658Y4 baseline and differential
GenevisibleiQ658Y4 HS

Organism-specific databases

HPAiHPA027978

Interactioni

Subunit structurei

Component of the complex WDR11 composed of C17orf75, FAM91A1 and WDR11; FAM91A1 and WDR11 are required for proper location of the complex (PubMed:29426865). Interacts with golgins GOLGA1 and GOLGA4 and with TBC1D23; interaction with golgins may be mediated by TBC1D23 and interaction with TBC1D23 recruits TBC1D23 to AP-1-derived vesicles (PubMed:29084197, PubMed:29426865).2 Publications

Protein-protein interaction databases

BioGridi127622, 28 interactors
IntActiQ658Y4, 9 interactors
STRINGi9606.ENSP00000335082

Structurei

3D structure databases

ProteinModelPortaliQ658Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM91 family.Curated

Phylogenomic databases

eggNOGiKOG3707 Eukaryota
ENOG410XT0G LUCA
GeneTreeiENSGT00390000009543
HOGENOMiHOG000006787
HOVERGENiHBG105677
InParanoidiQ658Y4
OMAiEFHIRQN
OrthoDBiEOG091G011H
PhylomeDBiQ658Y4
TreeFamiTF314641

Family and domain databases

InterProiView protein in InterPro
IPR039199 FAM91
IPR028097 FAM91_C_dom
IPR028091 FAM91_N_dom
PANTHERiPTHR28441 PTHR28441, 1 hit
PfamiView protein in Pfam
PF14648 FAM91_C, 1 hit
PF14647 FAM91_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q658Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIDVEFHIR HNYPWNKLPA NVRQSLGNSQ REYEKQVVLY SIRNQLRYRN
60 70 80 90 100
NLVKHVKKDE RRYYEELLKY SRDHLMLYPY HLSDIMVKGL RITPFSYYTG
110 120 130 140 150
IMEDIMNSEK SYDSLPNFTA ADCLRLLGIG RNQYIDLMNQ CRSSKKFFRR
160 170 180 190 200
KTARDLLPIK PVEIAIEAWW VVQAGYITED DIKICTLPEK CAVDKIIDSG
210 220 230 240 250
PQLSGSLDYN VVHSLYNKGF IYLDVPISDD SCIAVPPLEG FVMNRVQGDY
260 270 280 290 300
FETLLYKIFV SIDEHTNVAE LANVLEIDLS LVKNAVSMYC RLGFAHKKGQ
310 320 330 340 350
VINLDQLHSS WKNVPSVNRL KSTLDPQKML LSWDGGESRS PVQEASSATD
360 370 380 390 400
TDTNSQEDPA DTASVSSLSL STGHTKRIAF LFDSTLTAFL MMGNLSPNLK
410 420 430 440 450
SHAVTMFEVG KLSDESLDSF LIELEKVQST GEGEAQRYFD HALTLRNTIL
460 470 480 490 500
FLRHNKDLVA QTAQPDQPNY GFPLDLLRCE SLLGLDPATC SRVLNKNYTL
510 520 530 540 550
LVSMAPLTNE IRPVSSCTPQ HIGPAIPEVS SVWFKLYIYH VTGQGPPSLL
560 570 580 590 600
LSKGTRLRKL PDIFQSYDRL LITSWGHDPG VVPTSNVLTM LNDALTHSAV
610 620 630 640 650
LIQGHGLHGI GETVHVPFPF DETELQGEFT RVNMGVHKAL QILRNRVDLQ
660 670 680 690 700
HLCGYVTMLN ASSQLADRKL SDASDERGEP DLASGSDVNG STESFEMVIE
710 720 730 740 750
EATIDSATKQ TSGATTEADW VPLELCFGIP LFSSELNRKV CRKIAAHGLC
760 770 780 790 800
RKESLQNLLH SSRKLSLQVL NFVHSFQEGA SILDIHTEPS FSSLLSQSSC
810 820 830
ADMGVPLPAK NLIFKDGVLS EWSGRSPSSL LIANLHLQ
Length:838
Mass (Da):93,909
Last modified:November 4, 2008 - v3
Checksum:i1F50F89A4BFB6B08
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ER68E7ER68_HUMAN
Protein FAM91A1
FAM91A1
789Annotation score:
H0YC80H0YC80_HUMAN
Protein FAM91A1
FAM91A1
60Annotation score:
H0YBR6H0YBR6_HUMAN
Protein FAM91A1
FAM91A1
114Annotation score:
G3V120G3V120_HUMAN
Family with sequence similarity 91,...
FAM91A1 hCG_2008985
218Annotation score:

Sequence cautioni

The sequence BAB85063 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057768704I → V. Corresponds to variant dbSNP:rs6470187Ensembl.1
Natural variantiVAR_067449800C → Y3 PublicationsCorresponds to variant dbSNP:rs1946586Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228141 mRNA Translation: ABB17070.1
AC011134 Genomic DNA No translation available.
AK074370 mRNA Translation: BAB85063.1 Different initiation.
AL832830 mRNA Translation: CAH56231.1
AL832999 mRNA Translation: CAH56297.1
CCDSiCCDS6346.2
RefSeqiNP_001304846.1, NM_001317917.1
NP_001304847.1, NM_001317918.1
NP_659400.2, NM_144963.3
UniGeneiHs.459174

Genome annotation databases

EnsembliENST00000334705; ENSP00000335082; ENSG00000176853
GeneIDi157769
KEGGihsa:157769
UCSCiuc003yqv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228141 mRNA Translation: ABB17070.1
AC011134 Genomic DNA No translation available.
AK074370 mRNA Translation: BAB85063.1 Different initiation.
AL832830 mRNA Translation: CAH56231.1
AL832999 mRNA Translation: CAH56297.1
CCDSiCCDS6346.2
RefSeqiNP_001304846.1, NM_001317917.1
NP_001304847.1, NM_001317918.1
NP_659400.2, NM_144963.3
UniGeneiHs.459174

3D structure databases

ProteinModelPortaliQ658Y4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127622, 28 interactors
IntActiQ658Y4, 9 interactors
STRINGi9606.ENSP00000335082

PTM databases

iPTMnetiQ658Y4
PhosphoSitePlusiQ658Y4

Polymorphism and mutation databases

BioMutaiFAM91A1
DMDMi212276508

Proteomic databases

EPDiQ658Y4
MaxQBiQ658Y4
PaxDbiQ658Y4
PeptideAtlasiQ658Y4
PRIDEiQ658Y4
ProteomicsDBi65930

Protocols and materials databases

DNASUi157769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334705; ENSP00000335082; ENSG00000176853
GeneIDi157769
KEGGihsa:157769
UCSCiuc003yqv.4 human

Organism-specific databases

CTDi157769
EuPathDBiHostDB:ENSG00000176853.15
GeneCardsiFAM91A1
H-InvDBiHIX0000998
HIX0007769
HGNCiHGNC:26306 FAM91A1
HPAiHPA027978
neXtProtiNX_Q658Y4
OpenTargetsiENSG00000176853
PharmGKBiPA142671820
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3707 Eukaryota
ENOG410XT0G LUCA
GeneTreeiENSGT00390000009543
HOGENOMiHOG000006787
HOVERGENiHBG105677
InParanoidiQ658Y4
OMAiEFHIRQN
OrthoDBiEOG091G011H
PhylomeDBiQ658Y4
TreeFamiTF314641

Miscellaneous databases

GenomeRNAii157769
PROiPR:Q658Y4

Gene expression databases

BgeeiENSG00000176853 Expressed in 195 organ(s), highest expression level in intestine
CleanExiHS_FAM91A1
ExpressionAtlasiQ658Y4 baseline and differential
GenevisibleiQ658Y4 HS

Family and domain databases

InterProiView protein in InterPro
IPR039199 FAM91
IPR028097 FAM91_C_dom
IPR028091 FAM91_N_dom
PANTHERiPTHR28441 PTHR28441, 1 hit
PfamiView protein in Pfam
PF14648 FAM91_C, 1 hit
PF14647 FAM91_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF91A1_HUMAN
AccessioniPrimary (citable) accession number: Q658Y4
Secondary accession number(s): B6YY23, Q658T5, Q8TE89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 4, 2008
Last modified: November 7, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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