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Protein

Metalloreductase STEAP3

Gene

STEAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.2 Publications

Caution

Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36NADP1 Publication1
Binding sitei38NADP; via amide nitrogen1 Publication1
Binding sitei39NADP; via amide nitrogen1 Publication1
Binding sitei58NADP1 Publication1
Binding sitei59NADP1 Publication1
Binding sitei91NADP; via carbonyl oxygen1 Publication1
Binding sitei116NADP; via amide nitrogen1 Publication1
Binding sitei151NADP; via amide nitrogen1 Publication1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi316Iron (heme axial ligand)Curated1
Metal bindingi409Iron (heme axial ligand)Curated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cupric reductase activity Source: GO_Central
  • ferric-chelate reductase (NADPH) activity Source: GO_Central
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis, Cell cycle, Ion transport, Iron transport, Transport
LigandCopper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-917977 Transferrin endocytosis and recycling

Protein family/group databases

Transport Classification Database

More...
TCDBi
5.B.6.1.1 the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metalloreductase STEAP3 (EC:1.16.1.-)
Alternative name(s):
Dudulin-2
Six-transmembrane epithelial antigen of prostate 3
Tumor suppressor-activated pathway protein 6
Short name:
hTSAP6
pHyde
Short name:
hpHyde
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STEAP3
Synonyms:TSAP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115107.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24592 STEAP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609671 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q658P3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 207CytoplasmicSequence analysisAdd BLAST207
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 258VesicularSequence analysisAdd BLAST30
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 304CytoplasmicSequence analysisAdd BLAST25
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 358VesicularSequence analysisAdd BLAST33
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 390CytoplasmicSequence analysisAdd BLAST11
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 433VesicularSequence analysisAdd BLAST22
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 488CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly.
See also OMIM:615234

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi256N → I: Inhibits glycosylation and does not inhibit RHBDL4/RHBDD1-induced cleavage; when associated with A-344. 1 Publication1
Mutagenesisi325L → F: Strongly inhibits RHBDL4/RHBDD1-induced cleavage. 1 Publication1
Mutagenesisi344N → I: Inhibits glycosylation and does not inhibit RHBDL4/RHBDD1-induced cleavage; when associated with A-256. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55240

MalaCards human disease database

More...
MalaCardsi
STEAP3
MIMi615234 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115107

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
300298 Severe congenital hypochromic anemia with ringed sideroblasts

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670863

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STEAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146325737

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002851711 – 488Metalloreductase STEAP3Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi256N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi344N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei474PhosphothreonineCombined sources1
Modified residuei486PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.1 Publication
Glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei325 – 326Cleavage; by RHBDL4/RHBDD1Curated2

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q658P3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q658P3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q658P3

PeptideAtlas

More...
PeptideAtlasi
Q658P3

PRoteomics IDEntifications database

More...
PRIDEi
Q658P3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65924
65925 [Q658P3-2]
65926 [Q658P3-3]
65927 [Q658P3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q658P3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q658P3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q658P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By p53/TP53.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115107 Expressed in 212 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q658P3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q658P3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050510

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP.4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120533, 39 interactors

Protein interaction database and analysis system

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IntActi
Q658P3, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376822

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q658P3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q658P3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q658P3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini259 – 407Ferric oxidoreductaseAdd BLAST149

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the STEAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4F Eukaryota
COG2085 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008042

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054379

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q658P3

KEGG Orthology (KO)

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KOi
K10142

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLQSGPR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F9X

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q658P3

TreeFam database of animal gene trees

More...
TreeFami
TF332031

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013130 Fe3_Rdtase_TM_dom
IPR036291 NAD(P)-bd_dom_sf
IPR028939 P5C_Rdtase_cat_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03807 F420_oxidored, 1 hit
PF01794 Ferric_reduct, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q658P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS
60 70 80 90 100
GFKVVVGSRN PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC
110 120 130 140 150
SLSDQLAGKI LVDVSNPTEQ EHLQHRESNA EYLASLFPTC TVVKAFNVIS
160 170 180 190 200
AWTLQAGPRD GNRQVPICGD QPEAKRAVSE MALAMGFMPV DMGSLASAWE
210 220 230 240 250
VEAMPLRLLP AWKVPTLLAL GLFVCFYAYN FVRDVLQPYV QESQNKFFKL
260 270 280 290 300
PVSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ
310 320 330 340 350
HRKQIGLLSF FCAALHALYS FCLPLRRAHR YDLVNLAVKQ VLANKSHLWV
360 370 380 390 400
EEEVWRMEIY LSLGVLALGT LSLLAVTSLP SIANSLNWRE FSFVQSSLGF
410 420 430 440 450
VALVLSTLHT LTYGWTRAFE ESRYKFYLPP TFTLTLLVPC VVILAKALFL
460 470 480
LPCISRRLAR IRRGWEREST IKFTLPTDHA LAEKTSHV
Length:488
Mass (Da):54,601
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC89EB0D0430F9BFB
GO
Isoform 2 (identifier: Q658P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSHQPAVATKM

Show »
Length:498
Mass (Da):55,652
Checksum:i69DD201AA00C2D6B
GO
Isoform 3 (identifier: Q658P3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: Missing.

Show »
Length:487
Mass (Da):54,472
Checksum:i4A279EE7C8964412
GO
Isoform 4 (identifier: Q658P3-4) [UniParc]FASTAAdd to basket
Also known as: pHyde II

The sequence of this isoform differs from the canonical sequence as follows:
     351-351: Missing.
     396-488: SSLGFVALVL...HALAEKTSHV → CVATSSAGNT...GHQEDLSWTR

Show »
Length:456
Mass (Da):50,499
Checksum:i2ECEEB9C1515A9B7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZX6B8ZZX6_HUMAN
Metalloreductase STEAP3
STEAP3 hCG_18273
457Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32G → S in AAL78206 (PubMed:10969787).Curated1
Sequence conflicti32G → S in AAM08128 (PubMed:10969787).Curated1
Sequence conflicti32G → S in AAM45136 (PubMed:14702039).Curated1
Sequence conflicti68F → Y in AAK50538 (Ref. 4) Curated1
Sequence conflicti68F → Y in BAA91839 (PubMed:17974005).Curated1
Sequence conflicti163R → G in AAL78206 (PubMed:10969787).Curated1
Sequence conflicti163R → G in AAM08128 (PubMed:10969787).Curated1
Sequence conflicti478D → G in CAD97986 (PubMed:15815621).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031975184A → T. Corresponds to variant dbSNP:rs17013371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0248291M → MSHQPAVATKM in isoform 2. 2 Publications1
Alternative sequenceiVSP_024830351Missing in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_024831396 – 488SSLGF…KTSHV → CVATSSAGNTGSGTRRPESQ SQDPHLPAPHHQTSFLGPRS FCCSLVPVSTPYGHQEDLSW TR in isoform 4. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY214461 mRNA Translation: AAO38238.1
AF423424 mRNA Translation: AAQ04065.1
AF238864 mRNA Translation: AAL78206.1
AF262322 mRNA Translation: AAM08128.1
AY029585 mRNA Translation: AAK50538.1
AY082673 mRNA Translation: AAM45136.1
AK001691 mRNA Translation: BAA91839.1
AK291608 mRNA Translation: BAF84297.1
AL833624 mRNA Translation: CAH56204.1
BX538047 mRNA Translation: CAD97986.1
AC016673 Genomic DNA Translation: AAX88963.1
AC016736 Genomic DNA Translation: AAY14872.1
CH471103 Genomic DNA Translation: EAW95209.1
BC042150 mRNA Translation: AAH42150.1
BC095421 mRNA Translation: AAH95421.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS2125.1 [Q658P3-1]
CCDS42738.1 [Q658P3-2]

NCBI Reference Sequences

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RefSeqi
NP_001008410.1, NM_001008410.1 [Q658P3-1]
NP_060704.2, NM_018234.2 [Q658P3-1]
NP_619543.2, NM_138637.2
NP_878919.2, NM_182915.2 [Q658P3-2]
XP_006712677.1, XM_006712614.3 [Q658P3-1]
XP_006712678.1, XM_006712615.1 [Q658P3-1]
XP_011509705.1, XM_011511403.1 [Q658P3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.647822

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000393106; ENSP00000376818; ENSG00000115107 [Q658P3-1]
ENST00000393107; ENSP00000376819; ENSG00000115107 [Q658P3-1]
ENST00000393110; ENSP00000376822; ENSG00000115107 [Q658P3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55240

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55240

UCSC genome browser

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UCSCi
uc002tlp.4 human [Q658P3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214461 mRNA Translation: AAO38238.1
AF423424 mRNA Translation: AAQ04065.1
AF238864 mRNA Translation: AAL78206.1
AF262322 mRNA Translation: AAM08128.1
AY029585 mRNA Translation: AAK50538.1
AY082673 mRNA Translation: AAM45136.1
AK001691 mRNA Translation: BAA91839.1
AK291608 mRNA Translation: BAF84297.1
AL833624 mRNA Translation: CAH56204.1
BX538047 mRNA Translation: CAD97986.1
AC016673 Genomic DNA Translation: AAX88963.1
AC016736 Genomic DNA Translation: AAY14872.1
CH471103 Genomic DNA Translation: EAW95209.1
BC042150 mRNA Translation: AAH42150.1
BC095421 mRNA Translation: AAH95421.2
CCDSiCCDS2125.1 [Q658P3-1]
CCDS42738.1 [Q658P3-2]
RefSeqiNP_001008410.1, NM_001008410.1 [Q658P3-1]
NP_060704.2, NM_018234.2 [Q658P3-1]
NP_619543.2, NM_138637.2
NP_878919.2, NM_182915.2 [Q658P3-2]
XP_006712677.1, XM_006712614.3 [Q658P3-1]
XP_006712678.1, XM_006712615.1 [Q658P3-1]
XP_011509705.1, XM_011511403.1 [Q658P3-1]
UniGeneiHs.647822

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VNSX-ray2.00A/B1-215[»]
2VQ3X-ray2.00A/B1-215[»]
ProteinModelPortaliQ658P3
SMRiQ658P3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120533, 39 interactors
IntActiQ658P3, 8 interactors
STRINGi9606.ENSP00000376822

Protein family/group databases

TCDBi5.B.6.1.1 the transmembrane epithelial antigen protein-3 ferric reductase (steap) family

PTM databases

iPTMnetiQ658P3
PhosphoSitePlusiQ658P3
SwissPalmiQ658P3

Polymorphism and mutation databases

BioMutaiSTEAP3
DMDMi146325737

Proteomic databases

EPDiQ658P3
MaxQBiQ658P3
PaxDbiQ658P3
PeptideAtlasiQ658P3
PRIDEiQ658P3
ProteomicsDBi65924
65925 [Q658P3-2]
65926 [Q658P3-3]
65927 [Q658P3-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55240
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393106; ENSP00000376818; ENSG00000115107 [Q658P3-1]
ENST00000393107; ENSP00000376819; ENSG00000115107 [Q658P3-1]
ENST00000393110; ENSP00000376822; ENSG00000115107 [Q658P3-2]
GeneIDi55240
KEGGihsa:55240
UCSCiuc002tlp.4 human [Q658P3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55240
DisGeNETi55240
EuPathDBiHostDB:ENSG00000115107.19

GeneCards: human genes, protein and diseases

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GeneCardsi
STEAP3
HGNCiHGNC:24592 STEAP3
HPAiHPA050510
MalaCardsiSTEAP3
MIMi609671 gene
615234 phenotype
neXtProtiNX_Q658P3
OpenTargetsiENSG00000115107
Orphaneti300298 Severe congenital hypochromic anemia with ringed sideroblasts
PharmGKBiPA142670863

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF4F Eukaryota
COG2085 LUCA
GeneTreeiENSGT00390000008042
HOVERGENiHBG054379
InParanoidiQ658P3
KOiK10142
OMAiTLQSGPR
OrthoDBiEOG091G0F9X
PhylomeDBiQ658P3
TreeFamiTF332031

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-917977 Transferrin endocytosis and recycling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STEAP3 human
EvolutionaryTraceiQ658P3

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STEAP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55240

Protein Ontology

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PROi
PR:Q658P3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115107 Expressed in 212 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ658P3 baseline and differential
GenevisibleiQ658P3 HS

Family and domain databases

InterProiView protein in InterPro
IPR013130 Fe3_Rdtase_TM_dom
IPR036291 NAD(P)-bd_dom_sf
IPR028939 P5C_Rdtase_cat_N
PfamiView protein in Pfam
PF03807 F420_oxidored, 1 hit
PF01794 Ferric_reduct, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTEA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q658P3
Secondary accession number(s): A8K6E3
, Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6, Q8TDP3, Q8TF03, Q9NVB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: December 5, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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