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Entry version 58 (18 Sep 2019)
Sequence version 2 (28 Jun 2011)
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Protein

Cation-chloride cotransporter 2

Gene

CCC2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable cation/chloride cotransporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Symport, Transport
LigandPotassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-chloride cotransporter 2
Short name:
OsCCC2
Alternative name(s):
Potassium-chloride cotransporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCC2
Synonyms:KCC2
Ordered Locus Names:Os01g0304100, LOC_Os01g19850
ORF Names:P0475H04.13, P0475H04.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 139CytoplasmicSequence analysisAdd BLAST139
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 174ExtracellularSequence analysisAdd BLAST14
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 221CytoplasmicSequence analysisAdd BLAST26
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 287ExtracellularSequence analysisAdd BLAST45
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 311CytoplasmicSequence analysis3
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 372ExtracellularSequence analysisAdd BLAST40
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 412CytoplasmicSequence analysisAdd BLAST19
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 448ExtracellularSequence analysisAdd BLAST15
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 505CytoplasmicSequence analysisAdd BLAST36
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 529ExtracellularSequence analysis3
Transmembranei530 – 552HelicalSequence analysisAdd BLAST23
Topological domaini553 – 558CytoplasmicSequence analysis6
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21
Topological domaini580 – 585ExtracellularSequence analysis6
Transmembranei586 – 606HelicalSequence analysisAdd BLAST21
Topological domaini607 – 994CytoplasmicSequence analysisAdd BLAST388

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004104681 – 994Cation-chloride cotransporter 2Add BLAST994

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q657W3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4530.OS01T0304100-00

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q657W3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2082 Eukaryota
COG0531 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000092644

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q657W3

Database of Orthologous Groups

More...
OrthoDBi
349744at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q657W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGGFGGAG RHDEEAPAMR PAPQQRYRTV ESHDRAVVQM APMEFGSSAD
60 70 80 90 100
ASASAGPRYI KPGTNLRTDA RMHMASSNGR SSNGSQGDSK LELFGFDSLV
110 120 130 140 150
NILGLKRMVG EQAQASASTR DGENAGIAIG HPKETETKLD TMMGVFVPCL
160 170 180 190 200
QNILGIIYYI RFTWIVGMGG VWQSLVLVAF CGSCTFLTTI SLSAIATNGA
210 220 230 240 250
MKGGGPYYLI GRALGPEVGV SIGLCFFLGN AVAGAMYVLG AVETFLDAVP
260 270 280 290 300
SAEFFQESVT VVTNTFVNGT AAGNATTIST PNLHDLQVYG IIVTILLCFI
310 320 330 340 350
VFGGVKIINK VAPAFLIPVL FSILCIYIGV FIAPRPNASK WITGLSITTL
360 370 380 390 400
KDNWSSDYQR TNNAGVPDPN GSIYWDFNAL LGLYFPAVTG IMAGSNRSAS
410 420 430 440 450
LKDTQRSIPI GTLHATISTT MMYLLSVFLF GALSTREGLL TDRLLCAAVA
460 470 480 490 500
WPSPAVVYAG IILSTLGAAL QSLTGAPRLL AAIANDDILP VLNYFKAYEG
510 520 530 540 550
SEPHVATLFT SFICISCVII GNLDVITPTI TMFFLLCYAG VNLSCFLLDL
560 570 580 590 600
LDAPSWRPRW KLHHWSLSLI GALLCIVIMF MISWTFTVVS LALASLIYYY
610 620 630 640 650
VSLKGKAGDW GDGFKSAYFQ LALRSLRSMG ANQVHPKNWY PIPLIFCRPW
660 670 680 690 700
GKLPEDVPCH PKLADFANCM KKKGRGMSIF VSIIDGDYHE SAEDAKTACR
710 720 730 740 750
QLSAYIDYRR CEGVAEIIVA PSTSIGFRSI VQTMGLGNLK PNIVVMRYPE
760 770 780 790 800
IWRRENLTQI PSTFVSIIND CITANKAVVI VKGLDEWPNE YQRQYGTIDL
810 820 830 840 850
YWIVRDGGLM LLLSQLLLTK ESFESCKIQV FCIAEEDTEA EELKADVKKF
860 870 880 890 900
LYDLRMQADV IVVTVKSWEA DPDRSGGSKK DDPEVYRSAQ SRIRTYISQL
910 920 930 940 950
KEAAERERRP LMEGGKQVVV DEQKVEKFLY TMLKLNATIL RHSRMAVVVL
960 970 980 990
VSLPPPPLNH LAYCYMEYMD LLVENIPRIL IVRGYRRDVV TLFT
Length:994
Mass (Da):109,326
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25B35BD1DA90CE60
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0P0V1L1A0A0P0V1L1_ORYSJ
Os01g0304100 protein
Os01g0304100, OSNPB_010304100
774Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD44902 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD44903 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF04751 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP002871 Genomic DNA Translation: BAD44902.1 Sequence problems.
AP002871 Genomic DNA Translation: BAD44903.1 Sequence problems.
AP008207 Genomic DNA Translation: BAF04751.2 Sequence problems.
AP014957 Genomic DNA No translation available.
BN000835 mRNA Translation: CAJ40614.1

NCBI Reference Sequences

More...
RefSeqi
XP_015632062.1, XM_015776576.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4323905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
osa:4323905

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002871 Genomic DNA Translation: BAD44902.1 Sequence problems.
AP002871 Genomic DNA Translation: BAD44903.1 Sequence problems.
AP008207 Genomic DNA Translation: BAF04751.2 Sequence problems.
AP014957 Genomic DNA No translation available.
BN000835 mRNA Translation: CAJ40614.1
RefSeqiXP_015632062.1, XM_015776576.1

3D structure databases

SMRiQ657W3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS01T0304100-00

Proteomic databases

PaxDbiQ657W3

Genome annotation databases

GeneIDi4323905
KEGGiosa:4323905

Phylogenomic databases

eggNOGiKOG2082 Eukaryota
COG0531 LUCA
HOGENOMiHOG000092644
InParanoidiQ657W3
OrthoDBi349744at2759

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCC2_ORYSJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q657W3
Secondary accession number(s): A4VCJ9, Q0JNC7, Q657W2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 18, 2019
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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