Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 142 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Genome polyprotein

Gene
N/A
Organism
Brome streak virus (strain 11-Cal) (BStV) (Brome streak mosaic rymovirus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.By similarity
an RNA-dependent RNA polymerase that plays an essential role in the virus replication.By similarity
required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
has helicase activity. It may be involved in replication (By similarity).By similarity
Both 6K peptides are indispensable for virus replication.By similarity
has RNA-binding and proteolytic activities.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
  • Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei311For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei323For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei355For P1 proteinase activityPROSITE-ProRule annotation1
Active sitei698For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei769For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2082For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2121For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2193For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1228 – 1235ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
Cytoplasmic inclusion protein (EC:3.6.4.-)
Short name:
CI
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Coat protein
Short name:
CP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrome streak virus (strain 11-Cal) (BStV) (Brome streak mosaic rymovirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri117138 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaStelpaviricetesPatataviralesPotyviridaeTritimovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBromus [TaxID: 4501]
Hordeum murinum (Mouse barley) (Critesion murinum) [TaxID: 97361]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000521 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004199921 – 3093Genome polyproteinAdd BLAST3093
ChainiPRO_00000402331 – 403P1 proteinaseAdd BLAST403
ChainiPRO_0000040234404 – 809Helper component proteinaseAdd BLAST406
ChainiPRO_0000040235810 – 1087Protein P3Add BLAST278
ChainiPRO_00000402361088 – 11386 kDa protein 1Add BLAST51
ChainiPRO_00000402371139 – 1783Cytoplasmic inclusion proteinAdd BLAST645
ChainiPRO_00000402381784 – 18346 kDa protein 2Add BLAST51
ChainiPRO_00000402391835 – 2040Viral genome-linked proteinAdd BLAST206
ChainiPRO_00000402402041 – 2275Nuclear inclusion protein AAdd BLAST235
ChainiPRO_00000402412276 – 2773Nuclear inclusion protein BAdd BLAST498
ChainiPRO_00000402422774 – 3093Coat proteinAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1915O-(5'-phospho-RNA)-tyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Genome polyprotein of potyviruses undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least ten individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei403 – 404Cleavage; by P1 proteinasePROSITE-ProRule annotation2
Sitei809 – 810Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1087 – 1088Cleavage; by NIa-proBy similarity2
Sitei1138 – 1139Cleavage; by NIa-proBy similarity2
Sitei1783 – 1784Cleavage; by NIa-proBy similarity2
Sitei1834 – 1835Cleavage; by NIa-proBy similarity2
Sitei2040 – 2041Cleavage; by NIa-proBy similarity2
Sitei2275 – 2276Cleavage; by NIa-proBy similarity2
Sitei2773 – 2774Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
Q65730

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini255 – 403Peptidase S30PROSITE-ProRule annotationAdd BLAST149
Domaini690 – 809Peptidase C6PROSITE-ProRule annotationAdd BLAST120
Domaini1215 – 1366Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST152
Domaini1367 – 1546Helicase C-terminalPROSITE-ProRule annotationAdd BLAST180
Domaini2041 – 2257Peptidase C4PROSITE-ProRule annotationAdd BLAST217
Domaini2516 – 2639RdRp catalyticPROSITE-ProRule annotationAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1316 – 1319DEVH box4
Motifi1883 – 1895Nuclear localization signalSequence analysisAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR025910, P1_Ser_Pept_dom
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF13611, Peptidase_S76, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00966, NIAPOTYPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q65730-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQTHVKQVW RPKTASSKVK TSNMVYLAEE SSPLAKTELK EDAVVAADMS
60 70 80 90 100
VINADDAVYG HALEGKYSER KALPARSNET IVSFASGEDG LFLDRAACGS
110 120 130 140 150
IFKTRTGKDT PIATAIRAAT RRGLAYDIAA QLYMCPKCCS ASDKVLYFDT
160 170 180 190 200
NHNDSCQWYL DNCRAVINKD WTLDVIETYN VFPVLVTEEE ERRTLEAVDI
210 220 230 240 250
ALKPLGTVPV HDVVQVYDQK IGEHKEVERN QEAAHGSEPA IITTTPVLRR
260 270 280 290 300
QCIEKRLLRH VHQANKVIAN TVEIYDLMTE TSQICAEKAI PLVFVDYEKK
310 320 330 340 350
KRIRPRVPLR HVLESNNVDP SDDLYADVVP FLKHYGTCGR PVGVINPRDI
360 370 380 390 400
KPGWSGVVLL QDELPESLHQ ECVDGVFVVQ GIGPDGQLKN ALKTTTGERI
410 420 430 440 450
EYYSSKRRMA VNAHVPKAHS FCKYSSLTET LMELDYLRVI SALADVHDPQ
460 470 480 490 500
CVECHKERNE RSFIENLKYT QQGAQNLFNA GTGMGLAFVA SIASGQLMIQ
510 520 530 540 550
RQQPQSSSSI VDQTPRTNED GSLSHNINLL LTPEVVDIWR SMKQMVHLPN
560 570 580 590 600
RKLYMASFND QFGNFDFIPN STLQGVFPDF TMPVTIALND DDKVETNYRH
610 620 630 640 650
VDKNSTIETC VEGLYTQFDA AYWTKKAAQV HKIQPIDQCG MEIGNIALKL
660 670 680 690 700
CHWEGDVALF SPIIRPTPGH LMFGSTDRLL RIPDMTNARH YVPKVGYCYL
710 720 730 740 750
YLFALAMNFC DGENRVTVDA YINKTCRELG AWPKFGEVLR ALDRMATYYG
760 770 780 790 800
CYDAVVPVML VDHVQRTIHV PSPFGIVQSG MHMIQINNLG DLIKLDTMGA
810 820 830 840 850
SELKEYEIGG FRETYKSITK CVKSKSAFME KLNQDNEWLV DMICNPSTLF
860 870 880 890 900
VLSQLMDTHG LILKDVENSF DRLAALLALK ELGSALGPLL TTRKRVALYM
910 920 930 940 950
QSLSKVDELV PHLGMPTGAM NLLKSEIELI QNAIVEEQDM AEIDRVEGKK
960 970 980 990 1000
SILERRDEMF APCVYNEFIN SFGYVSLPGI AYRLTYTGVG ARIGRGCEHL
1010 1020 1030 1040 1050
KTVWSGSWIP EIHLPENLRS NTWSAIKKYT VYSGGTAWRY MKLKIVESAT
1060 1070 1080 1090 1100
QILVAAVITA IGSWLLKKLL KFIRHEKGRL NEVVVFQSKQ EELFISKFMA
1110 1120 1130 1140 1150
VCFVISTFFS LDMSNAIYSS LTKFRAIFSI LSVGSIYQSG ALEKLEEQLG
1160 1170 1180 1190 1200
HVDTFHEFKL YDHDATHANI APSVQSFGTW LDTRVLAGQQ GCDPLEGRHT
1210 1220 1230 1240 1250
KFEMNKNTRD AIAARVLADK DNEFLVMGHV GCGKSTYFPV ALSKQARVLI
1260 1270 1280 1290 1300
CEPTRVLVTN LHDSMMHTCQ VAPSVMMRNH RCITGSSIMV QTYGFALHYL
1310 1320 1330 1340 1350
VNNPENLQQY DFVLFDEVHH TCAEKVVLYN WLKGRDWGGK IVKLTATDRS
1360 1370 1380 1390 1400
PSAEIKAQKS LDIMTLPTMT PLDFVKEQGL STKADASKHG KVILVFLTSF
1410 1420 1430 1440 1450
REVDSCYDEL KRKENFDAIK ADSRNLRNKT SLADLISECK KEFIYIFATN
1460 1470 1480 1490 1500
ILQTGINIEA DVVVDFGYKI VPTYDVDNRM LTTTRKPVNK ADRIQRLGRV
1510 1520 1530 1540 1550
ARMKAGVAMK IGATIDPEAY DDEVTATEAA LLSFAMQVPP VLRNVNLQIF
1560 1570 1580 1590 1600
QRITREQVVT AARFEHQLSY MVWMVNKDGS MPTKLYDLFS PLLLSQGNMR
1610 1620 1630 1640 1650
LSPYYSSLYD SDTFMTVKNY VDIGYLKHDR TTNQRLPFHC HDVSTTFAMK
1660 1670 1680 1690 1700
VADRFEDSRA PSTYSIRVPA VNLRHTAVKL STDPAQVGMI LVVIGEALVH
1710 1720 1730 1740 1750
QKNILEQLKS TRTQLDNYNS CILVPNWNVR GKLDDAINRV ERNVSILENQ
1760 1770 1780 1790 1800
KNSVEKMSVA RGYDELKELL EENHAVAAHV MYQKGPQKFI DDVLLQKRDF
1810 1820 1830 1840 1850
SWMPYISVGA ACLMAGCAWY MLYRQRAKHE AKFEGKASRV KASKQKAFDD
1860 1870 1880 1890 1900
KMARADNYTY YETTDELHNH AREWNDYPTD WVDKVRKKAN VHAMQFGREA
1910 1920 1930 1940 1950
PRRDVRNDRP FFNFYGIDEK LYDTVTFHDM AASFSVEQPI TAMEVEEAFE
1960 1970 1980 1990 2000
KIYLNRQEDE AFFDHPMPKK ILAEFKGKDG KVINVEMEPH NPRKANRRGL
2010 2020 2030 2040 2050
PVGYADHRGE FRQAKPAEEG PIKFERKALN PKATPYAVFE SKALYGGPRC
2060 2070 2080 2090 2100
YEHITNNQVL LAGPSGYLNG LITGSKLLAP YHFVKDISSD SQDPSRMIAR
2110 2120 2130 2140 2150
FGTYNLGNIL NLQVVKFTMI DLIGLDLPVE FQPRRTLKCF RVPVIGEKAV
2160 2170 2180 2190 2200
LVLSRYSKEG WKSCVSAETE ITPYGENEEL LWRHRITTEV GDCGATMVAL
2210 2220 2230 2240 2250
SDQKIVGFHS LGGISMNYFV PVTQELLDFL SSKTEKPLVP WRFSEDQVDV
2260 2270 2280 2290 2300
GGLYIHNDFD KFPFVKTIQK LVGFQNGHMI KYCGEGFTPV ARSENRLSRQ
2310 2320 2330 2340 2350
HVISGQRESF IHFVEASSKW RPLITPMLGR LQPSALNREA YYKDVLKYDK
2360 2370 2380 2390 2400
PIRLGTVHEE AFQSAVINVI RILENAGFER GGVKACFDYG KIFNDLNLDA
2410 2420 2430 2440 2450
AMGALYAGKK KDYFVEATDE EIEEMFLRSA GKICANGHGV WSALLKAELR
2460 2470 2480 2490 2500
PAEKVAANKT RTFTSAPIDI LFGAKAVVDD FNKQFYKRHL LGPWTVGINK
2510 2520 2530 2540 2550
FNKGWDLLAR SLMRYEWFID ADGSQFDSSI TPLLMNAVLT IRLYFMERDD
2560 2570 2580 2590 2600
ITELMLRNLY TQIISTCMLA EDGLIVQKHR GNNSGQPSTV VDNTLCLMIA
2610 2620 2630 2640 2650
MEYARQRAIS DGHLNMQMRY VCNGDDLLIN ANEEAKDVVQ GKYEQYIKEL
2660 2670 2680 2690 2700
ELNYCFDDAF QSIEGVEFMS HKFMLRNGIY IPKLARHRIV AILEWQRSAE
2710 2720 2730 2740 2750
PQAIKSAILA ACVEAFGYDD LTELIREYAI SLEPVWGSFL PTDGEIEQLY
2760 2770 2780 2790 2800
FEGIAKQEVA RCLAGVDDVC KFESAASGTN EAVDEVLKAA GDDEALARAN
2810 2820 2830 2840 2850
AAATSGATTP AQNVGAGTTT PAKATPQSGR RPSFGSLIDN PIGGNGVQDV
2860 2870 2880 2890 2900
ADRTSGIVFP VPTRKSTSLY LPPKVKLRAT PERIEKVRKY LPDPQQIDLR
2910 2920 2930 2940 2950
YSTQQELNDW IKASADGLGQ TEEAFIDNIL PGWIVHCIVN TTSSENRKAG
2960 2970 2980 2990 3000
SWRCVTNAGT ADEEQVLYDI EPMYSAANPT MRAIMRHFSD LARLVIAESF
3010 3020 3030 3040 3050
KQGRPLIPKG YIKAGVLDAS SAAAACDFVV RDRHDTATFV QVQNQVLVNR
3060 3070 3080 3090
VSGITNRLFA QAMPSAGANE DMARHDAQDA AEGIHNLGGA RAF
Length:3,093
Mass (Da):348,106
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50F775CEF7ABCCB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48506 Genomic RNA Translation: CAA88417.1

NCBI Reference Sequences

More...
RefSeqi
NP_612585.1, NC_003501.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
935897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:935897

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48506 Genomic RNA Translation: CAA88417.1
RefSeqiNP_612585.1, NC_003501.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

MINTiQ65730

Genome annotation databases

GeneIDi935897
KEGGivg:935897

Family and domain databases

Gene3Di2.40.10.10, 2 hits
3.30.70.270, 1 hit
3.90.70.150, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001456, HC-pro
IPR031159, HC_PRO_CPD_dom
IPR042308, HC_PRO_CPD_sf
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR025910, P1_Ser_Pept_dom
IPR002540, Pept_S30_P1_potyvir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001592, Poty_coat
IPR001730, Potyv_NIa-pro_dom
IPR013648, PP_Potyviridae
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF00863, Peptidase_C4, 1 hit
PF00851, Peptidase_C6, 1 hit
PF13611, Peptidase_S76, 1 hit
PF00767, Poty_coat, 1 hit
PF08440, Poty_PP, 1 hit
PF00680, RdRP_1, 1 hit
PRINTSiPR00966, NIAPOTYPTASE
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51744, HC_PRO_CPD, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51436, POTYVIRUS_NIA_PRO, 1 hit
PS51871, PV_P1_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_BSTV1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q65730
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again